| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Eplerenone perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Eplerenone_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.190883 |
| VIM | vimentin | 0.111623 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.080595 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0745366 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0719046 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.063241 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0611068 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0589478 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | 0.0584301 |
| NAV2 | neuron navigator 2 | 0.0573033 |
| RPL23 | ribosomal protein L23 | 0.0548382 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0540706 |
| POTEF | POTE ankyrin domain family, member F | 0.0532916 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0530417 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0526342 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0521989 |
| B2M | beta-2-microglobulin | 0.0521383 |
| VEGFA | vascular endothelial growth factor A | 0.0508267 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0502226 |
| ENAH | enabled homolog (Drosophila) | 0.0493314 |
| DSG2 | desmoglein 2 | 0.0480196 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0480104 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0477102 |
| CLTC | clathrin, heavy chain (Hc) | 0.0476128 |
| FMN1 | formin 1 | 0.0467255 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0466813 |
| NCKAP1 | NCK-associated protein 1 | 0.0439396 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0436789 |
| MEIS2 | Meis homeobox 2 | 0.0435463 |
| WWOX | WW domain containing oxidoreductase | 0.0431618 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0429117 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0415011 |
| S100A8 | S100 calcium binding protein A8 | 0.0411517 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.040979 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0396631 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.0389907 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0387183 |
| NKTR | natural killer cell triggering receptor | 0.0385939 |
| ATP13A3 | ATPase type 13A3 | 0.0383922 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0381229 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0366299 |
| HELZ | helicase with zinc finger | 0.0366141 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0362774 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0362323 |
| MYO1B | myosin IB | 0.0357632 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.035759 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0354948 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0353872 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0350964 |
| VMP1 | vacuole membrane protein 1 | 0.0348686 |
| AUTS2 | autism susceptibility candidate 2 | 0.0347128 |
| NUP58 | nucleoporin 58 | 0.0342087 |
| KYNU | kynureninase | 0.0341763 |
| CALR | calreticulin | 0.0341401 |
| ATXN1 | ataxin 1 | 0.0340019 |
| KRT17 | keratin 17, type I | 0.0339871 |
| USP53 | ubiquitin specific peptidase 53 | 0.0339422 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0339153 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0338355 |
| BPTF | bromodomain PHD finger transcription factor | 0.033438 |
| RND3 | Rho family GTPase 3 | 0.0330351 |
| MORF4L2 | mortality factor 4 like 2 | 0.0329321 |
| SH3D19 | SH3 domain containing 19 | 0.0328042 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0323909 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0320782 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0318366 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.031229 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0310931 |
| MSI2 | musashi RNA-binding protein 2 | 0.0308697 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0305913 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0304541 |
| IL6ST | interleukin 6 signal transducer | 0.0302039 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0301829 |
| CCNL1 | cyclin L1 | 0.0297277 |
| PHF14 | PHD finger protein 14 | 0.0296964 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0295801 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0295097 |
| TXNIP | thioredoxin interacting protein | 0.0293135 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0291828 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0288176 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0284674 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0280698 |
| FUS | FUS RNA binding protein | 0.027968 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0279514 |
| PPP4R3B | protein phosphatase 4 regulatory subunit 3B | 0.0272003 |
| VGLL4 | vestigial-like family member 4 | 0.0269594 |
| OSMR | oncostatin M receptor | 0.0267964 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0265084 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0263783 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.025801 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0257843 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0257606 |
| RPL5 | ribosomal protein L5 | 0.0257542 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0256213 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0253388 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.02432 |
| TMOD3 | tropomodulin 3 (ubiquitous) | 0.0242862 |
| SON | SON DNA binding protein | 0.0237781 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0236193 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.023535 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MYO1E | myosin IE | -0.176096 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.153729 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.122694 |
| LMO7 | LIM domain 7 | -0.118667 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.100697 |
| PLAUR | plasminogen activator, urokinase receptor | -0.094713 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0910864 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.090043 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0897863 |
| FN1 | fibronectin 1 | -0.0794736 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0771922 |
| EFNA5 | ephrin-A5 | -0.0753069 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0676613 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0576736 |
| ABHD17C | abhydrolase domain containing 17C | -0.0571406 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0559997 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0553993 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0549812 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.053984 |
| EGFR | epidermal growth factor receptor | -0.0536702 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0494432 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0492293 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0483 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0478192 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0475177 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0468844 |
| CDK13 | cyclin-dependent kinase 13 | -0.0467369 |
| RBM47 | RNA binding motif protein 47 | -0.0457875 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0457757 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0444621 |
| DSPP | dentin sialophosphoprotein | -0.0444298 |
| AHNAK | AHNAK nucleoprotein | -0.0438844 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.043716 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0433628 |
| LAMC2 | laminin, gamma 2 | -0.0429345 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0417197 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0415801 |
| INTS6 | integrator complex subunit 6 | -0.0411691 |
| HMGA2 | high mobility group AT-hook 2 | -0.0406826 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0405613 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0402834 |
| GPC6 | glypican 6 | -0.0396487 |
| SVIL | supervillin | -0.0391621 |
| MUC16 | mucin 16, cell surface associated | -0.0388642 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.03878 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0384723 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0383747 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0382423 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0377787 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.037694 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.0376613 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0375627 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | -0.036527 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0362782 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0352395 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0350654 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0349279 |
| ERBIN | erbb2 interacting protein | -0.0341706 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0340336 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0338829 |
| DENND4A | DENN/MADD domain containing 4A | -0.0338533 |
| OXR1 | oxidation resistance 1 | -0.0337474 |
| SEPTIN10 | septin 10 | -0.0336816 |
| FRMD5 | FERM domain containing 5 | -0.0331637 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.032811 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.032793 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0325518 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0323827 |
| FBXO11 | F-box protein 11 | -0.0321984 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0312984 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0310746 |
| ACTG1 | actin gamma 1 | -0.0305622 |
| NEBL | nebulette | -0.0304921 |
| SSH2 | slingshot protein phosphatase 2 | -0.0301698 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0301207 |
| WASF2 | WAS protein family, member 2 | -0.0297665 |
| CMIP | c-Maf inducing protein | -0.029729 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0293943 |
| ANXA2 | annexin A2 | -0.029058 |
| NABP1 | nucleic acid binding protein 1 | -0.028961 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0288144 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0286473 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0286142 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0285417 |
| NPC1 | Niemann-Pick disease, type C1 | -0.02852 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0284799 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0281974 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0280645 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0274691 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0273194 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0271602 |
| HOMER1 | homer scaffolding protein 1 | -0.0270252 |
| FMNL2 | formin-like 2 | -0.0268752 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0268647 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0267059 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.026697 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0264818 |
| THBS1 | thrombospondin 1 | -0.0264284 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0257743 |
| RORA | RAR-related orphan receptor A | -0.0256769 |
