Eplerenone_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Eplerenone perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Eplerenone_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.239003
TXNRD1 thioredoxin reductase 1 0.153174
GRAMD1B GRAM domain containing 1B 0.122924
ERRFI1 ERBB receptor feedback inhibitor 1 0.091471
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0790595
TRIO trio Rho guanine nucleotide exchange factor 0.06863
TFPI2 tissue factor pathway inhibitor 2 0.0683355
PABPC1 poly(A) binding protein, cytoplasmic 1 0.067324
TPM3 tropomyosin 3 0.0668329
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0640545
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0638745
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0627693
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0621418
KDM2A lysine (K)-specific demethylase 2A 0.0591771
ZFAND3 zinc finger, AN1-type domain 3 0.058717
ADAR adenosine deaminase, RNA-specific 0.0576173
RTN4 reticulon 4 0.0570531
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0554138
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0547126
KTN1 kinectin 1 (kinesin receptor) 0.0536796
PTK2 protein tyrosine kinase 2 0.0525218
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0497651
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0497086
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0492731
EEF2 eukaryotic translation elongation factor 2 0.0492722
OSMR oncostatin M receptor 0.0467789
PDE4D phosphodiesterase 4D, cAMP-specific 0.0467377
MACF1 microtubule-actin crosslinking factor 1 0.0464705
XPO1 exportin 1 0.0463183
NIPBL Nipped-B homolog (Drosophila) 0.0459352
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0452281
JMJD1C jumonji domain containing 1C 0.0447949
IGF1R insulin-like growth factor 1 receptor 0.0447273
DOCK5 dedicator of cytokinesis 5 0.0445179
SMAD3 SMAD family member 3 0.0436273
YBX3 Y box binding protein 3 0.0429261
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0419783
MKI67 marker of proliferation Ki-67 0.0419118
FBXO11 F-box protein 11 0.041622
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0415085
CSDE1 cold shock domain containing E1, RNA-binding 0.0412691
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0403175
MYH9 myosin, heavy chain 9, non-muscle 0.0400495
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0395435
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0395182
TRIP12 thyroid hormone receptor interactor 12 0.0387124
IL6ST interleukin 6 signal transducer 0.0387031
PHIP pleckstrin homology domain interacting protein 0.0380052
PUM2 pumilio RNA-binding family member 2 0.0377408
CSNK1A1 casein kinase 1, alpha 1 0.0375317
POTEF POTE ankyrin domain family, member F 0.0372938
VMP1 vacuole membrane protein 1 0.0372706
EML4 echinoderm microtubule associated protein like 4 0.0370882
USP34 ubiquitin specific peptidase 34 0.0369699
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0368746
RAD51B RAD51 paralog B 0.0368161
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0367315
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0365781
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0363637
RICTOR RPTOR independent companion of MTOR, complex 2 0.0361889
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0360969
EXOC6B exocyst complex component 6B 0.0358507
LATS2 large tumor suppressor kinase 2 0.0355301
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0354584
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0352604
MED13L mediator complex subunit 13-like 0.0349638
KMT2C lysine (K)-specific methyltransferase 2C 0.0347937
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0347457
CDK17 cyclin-dependent kinase 17 0.0344833
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0344465
CCNL1 cyclin L1 0.0341172
NF1 neurofibromin 1 0.0339939
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.033738
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0333524
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0331355
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0328988
IPO7 importin 7 0.0328803
UBE2H ubiquitin-conjugating enzyme E2H 0.0328597
SPRED2 sprouty-related, EVH1 domain containing 2 0.0326114
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0324519
SENP6 SUMO1/sentrin specific peptidase 6 0.0324297
RB1CC1 RB1-inducible coiled-coil 1 0.0322525
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0320601
SLC38A2 solute carrier family 38, member 2 0.0320271
ANKRD17 ankyrin repeat domain 17 0.0318854
WDR43 WD repeat domain 43 0.0317515
NFE2L2 nuclear factor, erythroid 2-like 2 0.0315857
RAB10 RAB10, member RAS oncogene family 0.0314917
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0314226
ARID1A AT rich interactive domain 1A (SWI-like) 0.0311974
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0311549
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0311335
YAP1 Yes-associated protein 1 0.0310878
PCBP2 poly(rC) binding protein 2 0.031003
RBM39 RNA binding motif protein 39 0.0309514
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0307644
GATAD2B GATA zinc finger domain containing 2B 0.0306258
THSD4 thrombospondin, type I, domain containing 4 0.0305902
SINHCAF SIN3-HDAC complex associated factor 0.0305739
BIRC2 baculoviral IAP repeat containing 2 0.0305424

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.145179
TMSB10 thymosin beta 10 -0.0961482
RPS3 ribosomal protein S3 -0.0842163
PTMA prothymosin, alpha -0.0744131
RPL37A ribosomal protein L37a -0.0595189
RPS12 ribosomal protein S12 -0.0551603
RPL26 ribosomal protein L26 -0.0546343
RPL23 ribosomal protein L23 -0.0531701
RPS8 ribosomal protein S8 -0.0519055
TPT1 tumor protein, translationally-controlled 1 -0.0504322
MT2A metallothionein 2A -0.0495974
RPL36 ribosomal protein L36 -0.0457761
RPS19 ribosomal protein S19 -0.0446778
RPS21 ribosomal protein S21 -0.0442604
RPS29 ribosomal protein S29 -0.0435944
RPLP2 ribosomal protein, large, P2 -0.0435118
RPL12 ribosomal protein L12 -0.0425979
RPS27 ribosomal protein S27 -0.0408626
RPL9 ribosomal protein L9 -0.0377476
RPL31 ribosomal protein L31 -0.0372018
RPS10 ribosomal protein S10 -0.0368648
RPS27A ribosomal protein S27a -0.0365391
RPLP1 ribosomal protein, large, P1 -0.0347052
RPS15 ribosomal protein S15 -0.0343071
RPL11 ribosomal protein L11 -0.034063
RPS6 ribosomal protein S6 -0.0334603
RPL37 ribosomal protein L37 -0.0326495
RPL19 ribosomal protein L19 -0.0323539
RPL35A ribosomal protein L35a -0.0307415
RPS17 ribosomal protein S17 -0.0306072
FTL ferritin, light polypeptide -0.0295782
RPL32 ribosomal protein L32 -0.029346
RPL18 ribosomal protein L18 -0.0282788
RPL34 ribosomal protein L34 -0.0277744
RPS24 ribosomal protein S24 -0.0277208
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0274813
AEBP2 AE binding protein 2 -0.0272359
RPL27 ribosomal protein L27 -0.0269675
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0252712
RPL5 ribosomal protein L5 -0.0250602
RPL28 ribosomal protein L28 -0.0249285
RPL13A ribosomal protein L13a -0.0245415
RPL36A ribosomal protein L36a -0.0231733
RPL7A ribosomal protein L7a -0.0230416
RPL8 ribosomal protein L8 -0.0230115
RPS14 ribosomal protein S14 -0.0224489
RPL38 ribosomal protein L38 -0.0221339
RPS16 ribosomal protein S16 -0.0221049
RPS13 ribosomal protein S13 -0.0219324
RPS25 ribosomal protein S25 -0.0214384
ACTG1 actin gamma 1 -0.0197751
RPS4X ribosomal protein S4, X-linked -0.0193475
RPL35 ribosomal protein L35 -0.0191029
RPS23 ribosomal protein S23 -0.0189386
RACK1 receptor for activated C kinase 1 -0.0189167
WNT2B wingless-type MMTV integration site family, member 2B -0.0186789
NACA nascent polypeptide-associated complex alpha subunit -0.0179975
RPS11 ribosomal protein S11 -0.0179711
PRELID2 PRELI domain containing 2 -0.0173144
GPX4 glutathione peroxidase 4 -0.0158477
NEK10 NIMA-related kinase 10 -0.0155682
INTS6 integrator complex subunit 6 -0.0149247
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0147879
EIF1 eukaryotic translation initiation factor 1 -0.0146197
SEC61G Sec61 gamma subunit -0.0144859
RPS2 ribosomal protein S2 -0.0143355
STYK1 serine/threonine/tyrosine kinase 1 -0.0143303
RPS20 ribosomal protein S20 -0.0142277
TRIM59 tripartite motif containing 59 -0.0137481
ATP5F1E ATP synthase F1 subunit epsilon -0.0135641
MT1E metallothionein 1E -0.0133612
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0131982
SEM1 SEM1 26S proteasome subunit -0.0130934
RPL21 ribosomal protein L21 -0.0130397
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0128195
S100A11 S100 calcium binding protein A11 -0.0127983
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -0.0126974
S100A9 S100 calcium binding protein A9 -0.0125258
GSTP1 glutathione S-transferase pi 1 -0.012282
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0122677
RPL7 ribosomal protein L7 -0.0121703
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0119988
S100A10 S100 calcium binding protein A10 -0.0119441
CALR calreticulin -0.0117687
PFN1 profilin 1 -0.0117117
RYR3 ryanodine receptor 3 -0.0116259
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0113128
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0111882
LMNA lamin A/C -0.0111527
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0109645
RCC1 regulator of chromosome condensation 1 -0.0109518
HSPB1 heat shock 27kDa protein 1 -0.0108082
SF3B6 splicing factor 3b, subunit 6, 14kDa -0.0105346
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0104035
GCNA germ cell nuclear acidic peptidase -0.0101259
RPLP0 ribosomal protein, large, P0 -0.010104
C1S complement component 1, s subcomponent -0.0100621
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.00995796
BTN3A3 butyrophilin, subfamily 3, member A3 -0.0099535
COX5B cytochrome c oxidase subunit Vb -0.00980962