Eplerenone_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Eplerenone perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Eplerenone_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.0728076
TRIO trio Rho guanine nucleotide exchange factor 0.0587371
EFNA5 ephrin-A5 0.0534138
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0532591
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0506769
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.047256
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0469777
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0444169
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0419929
PCBP3 poly(rC) binding protein 3 0.0403655
GRAMD1B GRAM domain containing 1B 0.0387304
TXNRD1 thioredoxin reductase 1 0.03863
EEF2 eukaryotic translation elongation factor 2 0.0374565
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0372676
GDA guanine deaminase 0.0342718
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.034197
DOCK4 dedicator of cytokinesis 4 0.0339465
PDLIM5 PDZ and LIM domain 5 0.0336686
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0331211
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0321023
POTEF POTE ankyrin domain family, member F 0.0319308
MSN moesin 0.0318369
DST dystonin 0.031762
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.031277
TPM3 tropomyosin 3 0.0284316
LIMCH1 LIM and calponin homology domains 1 0.027784
SMOC1 SPARC related modular calcium binding 1 0.0270225
PCBP2 poly(rC) binding protein 2 0.0260746
PSD3 pleckstrin and Sec7 domain containing 3 0.024832
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0246548
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0242985
SAMD4A sterile alpha motif domain containing 4A 0.0241915
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0239094
PTEN phosphatase and tensin homolog 0.0238124
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0235492
KYNU kynureninase 0.0234922
MYOF myoferlin 0.0234676
CTIF CBP80/20-dependent translation initiation factor 0.0231132
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0228632
PDE4D phosphodiesterase 4D, cAMP-specific 0.0228302
COL4A6 collagen, type IV, alpha 6 0.0226921
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0222899
FNDC3B fibronectin type III domain containing 3B 0.0222184
DOCK5 dedicator of cytokinesis 5 0.0215086
FLNB filamin B, beta 0.0212798
AKAP13 A kinase (PRKA) anchor protein 13 0.0212223
UBXN4 UBX domain protein 4 0.0210138
ZFAND3 zinc finger, AN1-type domain 3 0.020983
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0207072
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0206208
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0205741
VMP1 vacuole membrane protein 1 0.0201418
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0200862
NALF1 NALCN channel auxiliary factor 1 0.0200517
FTH1 ferritin, heavy polypeptide 1 0.0200033
CENPF centromere protein F, 350/400kDa 0.0199881
PTK2 protein tyrosine kinase 2 0.0199198
ANKRD11 ankyrin repeat domain 11 0.0198933
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0195268
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0194799
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0194685
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.01932
SMYD3 SET and MYND domain containing 3 0.0190873
SETD5 SET domain containing 5 0.0189605
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.018941
BCAR3 breast cancer anti-estrogen resistance 3 0.0186223
TMX4 thioredoxin-related transmembrane protein 4 0.0185698
PRRC2B proline-rich coiled-coil 2B 0.0184611
WDR43 WD repeat domain 43 0.0183606
COL8A1 collagen, type VIII, alpha 1 0.018335
MYH9 myosin, heavy chain 9, non-muscle 0.0182411
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0181937
WWTR1 WW domain containing transcription regulator 1 0.0181418
JMJD1C jumonji domain containing 1C 0.0180919
SFPQ splicing factor proline/glutamine-rich 0.017988
TBXT T-box transcription factor T 0.0179858
MAML3 mastermind-like 3 (Drosophila) 0.0179502
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.017758
ECPAS Ecm29 proteasome adaptor and scaffold 0.0177431
EXOC4 exocyst complex component 4 0.0173401
PPP4R3B protein phosphatase 4 regulatory subunit 3B 0.0171769
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0170987
SFSWAP splicing factor, suppressor of white-apricot family 0.0168995
PHF14 PHD finger protein 14 0.0168224
ZNF638 zinc finger protein 638 0.0167455
ADAM17 ADAM metallopeptidase domain 17 0.0164544
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0162139
NPAS2 neuronal PAS domain protein 2 0.0161907
CHD1 chromodomain helicase DNA binding protein 1 0.0161354
APLP2 amyloid beta (A4) precursor-like protein 2 0.0160776
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0160309
NCOR2 nuclear receptor corepressor 2 0.0159763
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0157839
HDAC4 histone deacetylase 4 0.0157622
CSNK1A1 casein kinase 1, alpha 1 0.0157221
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0156943
PRRC2C proline-rich coiled-coil 2C 0.0156501
PUM2 pumilio RNA-binding family member 2 0.0156316
EIF4B eukaryotic translation initiation factor 4B 0.015521
GSK3B glycogen synthase kinase 3 beta 0.015494

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.246406
TPT1 tumor protein, translationally-controlled 1 -0.139402
TMSB10 thymosin beta 10 -0.132746
VIM vimentin -0.108998
PTMA prothymosin, alpha -0.099295
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0981091
RPLP1 ribosomal protein, large, P1 -0.0968987
RPL37A ribosomal protein L37a -0.0891767
RPS24 ribosomal protein S24 -0.087989
RPS12 ribosomal protein S12 -0.0808976
RPL26 ribosomal protein L26 -0.0791698
RPL12 ribosomal protein L12 -0.0780127
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0778397
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0768995
RPS3 ribosomal protein S3 -0.0751493
RPS6 ribosomal protein S6 -0.0721991
RPL31 ribosomal protein L31 -0.0713701
RPLP2 ribosomal protein, large, P2 -0.068071
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0676039
RPL36A ribosomal protein L36a -0.0672371
RPS8 ribosomal protein S8 -0.0664149
RPS19 ribosomal protein S19 -0.0653552
RPS23 ribosomal protein S23 -0.0636366
TM4SF1 transmembrane 4 L six family member 1 -0.061841
RPL35A ribosomal protein L35a -0.0608111
RPS29 ribosomal protein S29 -0.0583907
FTL ferritin, light polypeptide -0.0580967
RPL9 ribosomal protein L9 -0.0566222
RPL19 ribosomal protein L19 -0.0561005
RPL23 ribosomal protein L23 -0.0545163
RPS27A ribosomal protein S27a -0.0525514
RPL36 ribosomal protein L36 -0.0491118
RPL34 ribosomal protein L34 -0.0473771
NAP1L1 nucleosome assembly protein 1-like 1 -0.0466468
RACK1 receptor for activated C kinase 1 -0.0458413
S100A6 S100 calcium binding protein A6 -0.0455833
RPS25 ribosomal protein S25 -0.0453758
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0452884
RPLP0 ribosomal protein, large, P0 -0.0450578
RPS16 ribosomal protein S16 -0.0424424
MT2A metallothionein 2A -0.0423353
RPL7A ribosomal protein L7a -0.0420744
RPS27 ribosomal protein S27 -0.041946
FN1 fibronectin 1 -0.0415696
RPL11 ribosomal protein L11 -0.0405363
RPL32 ribosomal protein L32 -0.040346
RPL13A ribosomal protein L13a -0.0392672
RPL38 ribosomal protein L38 -0.0392173
EIF1 eukaryotic translation initiation factor 1 -0.0390016
S100A10 S100 calcium binding protein A10 -0.0387237
SRGN serglycin -0.03698
RPS14 ribosomal protein S14 -0.0369526
RPS4X ribosomal protein S4, X-linked -0.0367845
PGK1 phosphoglycerate kinase 1 -0.0361075
RPS17 ribosomal protein S17 -0.0346002
RPL37 ribosomal protein L37 -0.0342637
HLA-B major histocompatibility complex, class I, B -0.0324324
RPL35 ribosomal protein L35 -0.0323912
RPS21 ribosomal protein S21 -0.0321941
IER3 immediate early response 3 -0.0320564
RPL18 ribosomal protein L18 -0.0318416
RGS2 regulator of G-protein signaling 2 -0.0317397
RPL28 ribosomal protein L28 -0.0317052
RPS11 ribosomal protein S11 -0.0307999
ISG15 ISG15 ubiquitin-like modifier -0.0307708
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0301766
TFPI2 tissue factor pathway inhibitor 2 -0.0300837
RPL27 ribosomal protein L27 -0.0300599
RPS28 ribosomal protein S28 -0.0296604
ATP5F1E ATP synthase F1 subunit epsilon -0.0294685
LDHA lactate dehydrogenase A -0.0291822
PDGFA platelet-derived growth factor alpha polypeptide -0.0289429
RPS10 ribosomal protein S10 -0.0282315
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0281237
B2M beta-2-microglobulin -0.027763
RPL10A ribosomal protein L10a -0.0276967
RPS13 ribosomal protein S13 -0.0271263
S100A9 S100 calcium binding protein A9 -0.02647
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0260362
RPS15 ribosomal protein S15 -0.02548
RPL5 ribosomal protein L5 -0.0251198
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0239478
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0225936
ACTG1 actin gamma 1 -0.0224506
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0223593
WSB1 WD repeat and SOCS box containing 1 -0.0223297
GNAS GNAS complex locus -0.0219325
RPL8 ribosomal protein L8 -0.021851
RPL30 ribosomal protein L30 -0.0215118
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0213022
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -0.0211716
LOC112694756 uncharaterized LOC112694756 -0.0210171
BZW1 basic leucine zipper and W2 domains 1 -0.0209746
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0208771
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0207253
NDRG1 N-myc downstream regulated 1 -0.0204073
RPL7 ribosomal protein L7 -0.0199343
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0198038
LMNA lamin A/C -0.0192841
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0190846