Eplerenone_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Eplerenone perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Eplerenone_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.11874
PDE10A phosphodiesterase 10A 0.10871
FGFR2 fibroblast growth factor receptor 2 0.0937305
TRIO trio Rho guanine nucleotide exchange factor 0.0906484
POTEF POTE ankyrin domain family, member F 0.0881999
MAML2 mastermind-like 2 (Drosophila) 0.0853876
NALF1 NALCN channel auxiliary factor 1 0.0836032
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0822039
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0819813
RORA RAR-related orphan receptor A 0.0812996
INHBA inhibin, beta A 0.0740314
VEGFA vascular endothelial growth factor A 0.071243
CALD1 caldesmon 1 0.0708866
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0692021
KMT2C lysine (K)-specific methyltransferase 2C 0.0690748
NCOR1 nuclear receptor corepressor 1 0.0689008
ZBTB20 zinc finger and BTB domain containing 20 0.0686938
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0686184
LOXL2 lysyl oxidase-like 2 0.0682807
SHB Src homology 2 domain containing adaptor protein B 0.0680907
NDRG1 N-myc downstream regulated 1 0.0666435
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0658607
HELZ helicase with zinc finger 0.0621555
ZEB1 zinc finger E-box binding homeobox 1 0.0611753
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0596524
FBXO11 F-box protein 11 0.0594635
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0592216
MATR3 matrin 3 0.0577117
EEF2 eukaryotic translation elongation factor 2 0.0576985
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0562948
IGFBP3 insulin-like growth factor binding protein 3 0.0545208
NKD1 naked cuticle homolog 1 (Drosophila) 0.0527266
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.052567
ELL2 elongation factor, RNA polymerase II, 2 0.0521419
LIMCH1 LIM and calponin homology domains 1 0.0517431
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0501677
DST dystonin 0.0490763
FAT1 FAT atypical cadherin 1 0.0473036
FLNB filamin B, beta 0.0472429
SBF2 SET binding factor 2 0.0465997
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0463993
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0463806
PTK2 protein tyrosine kinase 2 0.0461302
PGK1 phosphoglycerate kinase 1 0.0460988
OGA O-GlcNAcase 0.0457175
NF1 neurofibromin 1 0.0451157
UBE2H ubiquitin-conjugating enzyme E2H 0.0434275
GPHN gephyrin 0.043146
FTH1 ferritin, heavy polypeptide 1 0.0426112
ACTG1 actin gamma 1 0.041854
AHNAK AHNAK nucleoprotein 0.0413419
RNF213 ring finger protein 213 0.0407422
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0396766
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0378697
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0346609
TXNRD1 thioredoxin reductase 1 0.03457
NAP1L1 nucleosome assembly protein 1-like 1 0.0341054
RTN4 reticulon 4 0.0336077
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0328826
PRRC2B proline-rich coiled-coil 2B 0.032692
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0318361
APLP2 amyloid beta (A4) precursor-like protein 2 0.0301833
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0299504
RPL13A ribosomal protein L13a 0.0294745
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0289325
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.028762
PKM pyruvate kinase, muscle 0.0286478
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0284446
UBA6 ubiquitin-like modifier activating enzyme 6 0.0282465
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0280429
SAMD4A sterile alpha motif domain containing 4A 0.0277706
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0274413
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.026977
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0266455
ZNF292 zinc finger protein 292 0.0264007
EML4 echinoderm microtubule associated protein like 4 0.0249262
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0247638
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0237832
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0231438
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0230135
BIRC6 baculoviral IAP repeat containing 6 0.022514
RPL5 ribosomal protein L5 0.0225022
VMP1 vacuole membrane protein 1 0.0219304
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0216276
ASPH aspartate beta-hydroxylase 0.0210876
ESYT2 extended synaptotagmin-like protein 2 0.0194625
GPC6 glypican 6 0.0193549
SLC38A2 solute carrier family 38, member 2 0.0186312
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0185307
GOLGA4 golgin A4 0.0185187
CDH13 cadherin 13 0.0185015
HLA-A major histocompatibility complex, class I, A 0.0181037
RUNX1 runt-related transcription factor 1 0.0174956
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0172392
LDHA lactate dehydrogenase A 0.017146
SETD5 SET domain containing 5 0.0171228
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0170325
MON2 MON2 homolog (S. cerevisiae) 0.0158321
SPAG9 sperm associated antigen 9 0.0156069
PSD3 pleckstrin and Sec7 domain containing 3 0.0155289

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.230302
PRKCA protein kinase C, alpha -0.117133
EGFR epidermal growth factor receptor -0.10762
MYO1E myosin IE -0.0977824
TMSB10 thymosin beta 10 -0.0974796
TPT1 tumor protein, translationally-controlled 1 -0.0953126
THSD4 thrombospondin, type I, domain containing 4 -0.0922273
SLTM SAFB-like, transcription modulator -0.0839091
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0819754
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0760163
PTMA prothymosin, alpha -0.0749432
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0722027
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0712794
JMJD1C jumonji domain containing 1C -0.0686391
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0669286
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0647066
ANKRD12 ankyrin repeat domain 12 -0.0628888
TTC3 tetratricopeptide repeat domain 3 -0.0612627
PDE8A phosphodiesterase 8A -0.0594315
RPL34 ribosomal protein L34 -0.0586196
LPP LIM domain containing preferred translocation partner in lipoma -0.0582202
ITGA6 integrin, alpha 6 -0.057623
RPS6 ribosomal protein S6 -0.0556943
LMO7 LIM domain 7 -0.0556578
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0541314
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.053518
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.053301
ARHGAP26 Rho GTPase activating protein 26 -0.0516349
RPL15 ribosomal protein L15 -0.0509419
RAD51B RAD51 paralog B -0.0507036
RPLP1 ribosomal protein, large, P1 -0.049923
RPS3 ribosomal protein S3 -0.0492462
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0489829
GSK3B glycogen synthase kinase 3 beta -0.047331
AREG amphiregulin -0.0463961
AKAP12 A kinase (PRKA) anchor protein 12 -0.0461591
FNDC3B fibronectin type III domain containing 3B -0.0457534
RPL26 ribosomal protein L26 -0.0454359
OSMR oncostatin M receptor -0.045278
MCL1 myeloid cell leukemia 1 -0.0451311
ATP11A ATPase, class VI, type 11A -0.0449421
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0442506
ERRFI1 ERBB receptor feedback inhibitor 1 -0.04417
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0439331
DSCAM Down syndrome cell adhesion molecule -0.0436652
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.042895
RPS25 ribosomal protein S25 -0.0425413
RPS8 ribosomal protein S8 -0.0425289
RPL37A ribosomal protein L37a -0.0420912
MT2A metallothionein 2A -0.0416949
EGR1 early growth response 1 -0.041195
TXNIP thioredoxin interacting protein -0.0411814
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0405866
LAMC2 laminin, gamma 2 -0.0405035
PARD3 par-3 family cell polarity regulator -0.0401973
LAMA4 laminin, alpha 4 -0.0401865
RPL31 ribosomal protein L31 -0.0400356
HMGA2 high mobility group AT-hook 2 -0.0386007
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0384713
RPLP2 ribosomal protein, large, P2 -0.0376718
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0365067
DOCK5 dedicator of cytokinesis 5 -0.0355795
UBAC2 UBA domain containing 2 -0.0344828
PCBP2 poly(rC) binding protein 2 -0.0341903
TJP1 tight junction protein 1 -0.0341863
VCL vinculin -0.0340933
PATJ PATJ crumbs cell polarity complex component -0.0336632
CD44 CD44 molecule (Indian blood group) -0.0331984
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0329185
H3-3B H3.3 histone B -0.0328331
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0322432
SEC31A SEC31 homolog A (S. cerevisiae) -0.0318399
DLG1 discs, large homolog 1 (Drosophila) -0.0316725
VIM vimentin -0.0312911
RPS27A ribosomal protein S27a -0.0307183
RPS19 ribosomal protein S19 -0.0298119
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0292232
NAMPT nicotinamide phosphoribosyltransferase -0.0266315
RPL23 ribosomal protein L23 -0.0257996
RPL37 ribosomal protein L37 -0.0252209
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0251614
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0239292
RPS13 ribosomal protein S13 -0.0237456
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0236551
SON SON DNA binding protein -0.0229693
FOXP1 forkhead box P1 -0.0217617
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0215703
ALCAM activated leukocyte cell adhesion molecule -0.020502
ANXA2 annexin A2 -0.0195913
RPS4X ribosomal protein S4, X-linked -0.0193174
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0187307
ENO1 enolase 1, (alpha) -0.0184908
TOP1 topoisomerase (DNA) I -0.0182062
NHSL1 NHS-like 1 -0.0179257
ANKRD17 ankyrin repeat domain 17 -0.0177317
RBM25 RNA binding motif protein 25 -0.0173915
TRA2A transformer 2 alpha homolog (Drosophila) -0.017157
ANKRD11 ankyrin repeat domain 11 -0.0167709
ARHGAP5 Rho GTPase activating protein 5 -0.0165409
PRELID2 PRELI domain containing 2 -0.0162942