| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Eplerenone perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Eplerenone_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TSC22D2 | TSC22 domain family, member 2 | 0.0510637 |
| POTEF | POTE ankyrin domain family, member F | 0.0500135 |
| HDAC9 | histone deacetylase 9 | 0.0480494 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0435702 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0411502 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0341419 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0333202 |
| TMSB4X | thymosin beta 4, X-linked | 0.0329201 |
| QKI | QKI, KH domain containing, RNA binding | 0.0322513 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0287219 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0281416 |
| CCN2 | cellular communication network factor 2 | 0.0265333 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0261536 |
| RPS6 | ribosomal protein S6 | 0.025403 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0248661 |
| MB21D2 | Mab-21 domain containing 2 | 0.0246899 |
| MTF2 | metal response element binding transcription factor 2 | 0.024425 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0241519 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0238454 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.023587 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0232336 |
| MTMR3 | myotubularin related protein 3 | 0.0227528 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | 0.0226829 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0217583 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0217065 |
| ZFR | zinc finger RNA binding protein | 0.0216251 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.0214792 |
| TBC1D12 | TBC1 domain family, member 12 | 0.0207114 |
| ANXA1 | annexin A1 | 0.0205564 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0203548 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.0203191 |
| ZNF217 | zinc finger protein 217 | 0.0202652 |
| GRB2 | growth factor receptor-bound protein 2 | 0.0202224 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0201299 |
| DST | dystonin | 0.0201025 |
| FERMT2 | fermitin family member 2 | 0.0200351 |
| FBXO11 | F-box protein 11 | 0.0199954 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0199066 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0194974 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.019356 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0192497 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0191921 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0185819 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0182191 |
| CECR2 | cat eye syndrome chromosome region, candidate 2 | 0.0181838 |
| RBM25 | RNA binding motif protein 25 | 0.0176675 |
| POU3F2 | POU class 3 homeobox 2 | 0.0176048 |
| MT2A | metallothionein 2A | 0.017472 |
| KIF20B | kinesin family member 20B | 0.0169751 |
| PNN | pinin, desmosome associated protein | 0.016583 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.0165003 |
| COASY | CoA synthase | 0.0163427 |
| CCNA2 | cyclin A2 | 0.0161949 |
| PDS5B | PDS5 cohesin associated factor B | 0.0161639 |
| PDGFC | platelet derived growth factor C | 0.0159587 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0159196 |
| SIK3 | SIK family kinase 3 | 0.0158804 |
| BRD2 | bromodomain containing 2 | 0.0157042 |
| RPL28 | ribosomal protein L28 | 0.0156346 |
| KLHDC10 | kelch domain containing 10 | 0.0156138 |
| NDUFS5 | NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) | 0.0155446 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0152866 |
| GOLGA4 | golgin A4 | 0.0152088 |
| COTL1 | coactosin-like F-actin binding protein 1 | 0.0151091 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0150018 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0148927 |
| RPL7 | ribosomal protein L7 | 0.0147884 |
| TLK2 | tousled-like kinase 2 | 0.0147858 |
| SSU72 | SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) | 0.0147407 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0147404 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | 0.0146349 |
| CALR | calreticulin | 0.0145484 |
| TCERG1 | transcription elongation regulator 1 | 0.014456 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0144076 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.0143484 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0143007 |
| ACTG1 | actin gamma 1 | 0.0142988 |
| DEK | DEK proto-oncogene | 0.0142 |
| RLF | rearranged L-myc fusion | 0.0141252 |
| NF2 | neurofibromin 2 (merlin) | 0.0140146 |
| DSEL | dermatan sulfate epimerase-like | 0.0139359 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0139156 |
| LARP4 | La ribonucleoprotein domain family, member 4 | 0.0138542 |
| PPM1B | protein phosphatase, Mg2+/Mn2+ dependent, 1B | 0.0138375 |
| U2AF2 | U2 small nuclear RNA auxiliary factor 2 | 0.0137767 |
| RPL21 | ribosomal protein L21 | 0.0137204 |
| AAK1 | AP2 associated kinase 1 | 0.0137174 |
| USP25 | ubiquitin specific peptidase 25 | 0.0136891 |
| WDR3 | WD repeat domain 3 | 0.0136586 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0136582 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0136288 |
| MATR3 | matrin 3 | 0.0136269 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0136004 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0135305 |
| TMEM64 | transmembrane protein 64 | 0.013468 |
| PRPF4B | pre-mRNA processing factor 4B | 0.013448 |
| NCAPG | non-SMC condensin I complex, subunit G | 0.0134364 |
| TMX3 | thioredoxin-related transmembrane protein 3 | 0.0134099 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | 0.0133219 |
| SPNS1 | spinster homolog 1 (Drosophila) | 0.0132864 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.110373 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.104444 |
| CADM2 | cell adhesion molecule 2 | -0.09664 |
| TMSB10 | thymosin beta 10 | -0.0958923 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0884851 |
| VIM | vimentin | -0.0859962 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0832455 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.083176 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0806081 |
| GPC3 | glypican 3 | -0.0785992 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0768795 |
| COL11A1 | collagen, type XI, alpha 1 | -0.0760099 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0720354 |
| PCDH9 | protocadherin 9 | -0.0712742 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.068804 |
| ITGAV | integrin, alpha V | -0.0650021 |
| COL5A2 | collagen, type V, alpha 2 | -0.0570713 |
| UBC | ubiquitin C | -0.0564445 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0548428 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0541018 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0494903 |
| RPS27A | ribosomal protein S27a | -0.0484071 |
| AHNAK | AHNAK nucleoprotein | -0.0457396 |
| ENO1 | enolase 1, (alpha) | -0.0453475 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.044226 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.0420493 |
| SET | SET nuclear proto-oncogene | -0.0415 |
| PGK1 | phosphoglycerate kinase 1 | -0.0396031 |
| RPL23 | ribosomal protein L23 | -0.0377945 |
| ANK2 | ankyrin 2, neuronal | -0.0370704 |
| LRRC4C | leucine rich repeat containing 4C | -0.0370182 |
| S100A10 | S100 calcium binding protein A10 | -0.0369717 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0359356 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.035226 |
| PHIP | pleckstrin homology domain interacting protein | -0.0345334 |
| COL1A2 | collagen, type I, alpha 2 | -0.0345061 |
| PLPP1 | phospholipid phosphatase 1 | -0.0344625 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.0343507 |
| NHSL1 | NHS-like 1 | -0.033162 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.0331246 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0328307 |
| COL3A1 | collagen, type III, alpha 1 | -0.0322129 |
| PCDH7 | protocadherin 7 | -0.0316354 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0315665 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0315581 |
| RPL12 | ribosomal protein L12 | -0.0314297 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0301438 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0300338 |
| RAD51B | RAD51 paralog B | -0.0298064 |
| FOXP2 | forkhead box P2 | -0.0296158 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0295744 |
| SMYD3 | SET and MYND domain containing 3 | -0.0290212 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0286574 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.028346 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.028231 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | -0.0282179 |
| PRELID2 | PRELI domain containing 2 | -0.0281694 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0276736 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0274969 |
| RPLP1 | ribosomal protein, large, P1 | -0.0274131 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | -0.0266366 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0264605 |
| APP | amyloid beta (A4) precursor protein | -0.0259824 |
| MEIS2 | Meis homeobox 2 | -0.02562 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0255604 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0241017 |
| PHF21A | PHD finger protein 21A | -0.0237777 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0236183 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0234826 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0231731 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0230727 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | -0.0230562 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0229781 |
| MED13L | mediator complex subunit 13-like | -0.0227258 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0227245 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0226666 |
| RPL31 | ribosomal protein L31 | -0.0224407 |
| RPS8 | ribosomal protein S8 | -0.0223117 |
| LDHA | lactate dehydrogenase A | -0.0222612 |
| RAI1 | retinoic acid induced 1 | -0.0222285 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0221719 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0218275 |
| CALU | calumenin | -0.0215452 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0212848 |
| ATXN2 | ataxin 2 | -0.0210932 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0210773 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0209469 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | -0.0208995 |
| WWC2 | WW and C2 domain containing 2 | -0.0208776 |
| SLC30A8 | solute carrier family 30 (zinc transporter), member 8 | -0.0207152 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.020696 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0206719 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0205641 |
| PROS1 | protein S (alpha) | -0.0204721 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0204474 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0203071 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0200522 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0200389 |
| THOC2 | THO complex 2 | -0.0197763 |
| PTMA | prothymosin, alpha | -0.0197176 |
