Eplerenone_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Eplerenone perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Eplerenone_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.178256
SOD2 superoxide dismutase 2, mitochondrial 0.156405
FN1 fibronectin 1 0.117662
MYH9 myosin, heavy chain 9, non-muscle 0.0974053
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0877269
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0850327
FNDC3B fibronectin type III domain containing 3B 0.0800857
ELL2 elongation factor, RNA polymerase II, 2 0.0775616
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0737627
FTH1 ferritin, heavy polypeptide 1 0.0690708
UGCG UDP-glucose ceramide glucosyltransferase 0.0687114
CD44 CD44 molecule (Indian blood group) 0.0675298
EEF2 eukaryotic translation elongation factor 2 0.0633205
PABPC1 poly(A) binding protein, cytoplasmic 1 0.057176
PGK1 phosphoglycerate kinase 1 0.0542409
TPM4 tropomyosin 4 0.0538997
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0506638
LAMP2 lysosomal-associated membrane protein 2 0.0491718
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0488523
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0475105
ANLN anillin, actin binding protein 0.0472351
ZFAND3 zinc finger, AN1-type domain 3 0.0452162
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0448903
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0445371
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0436846
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0424661
RB1CC1 RB1-inducible coiled-coil 1 0.0424208
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0413829
HLA-E major histocompatibility complex, class I, E 0.0413455
SPAG9 sperm associated antigen 9 0.0411958
ARRDC3 arrestin domain containing 3 0.0404181
KYNU kynureninase 0.0397649
DENND5A DENN/MADD domain containing 5A 0.0391106
MKI67 marker of proliferation Ki-67 0.0390631
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0388818
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0385348
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0373214
ATP13A3 ATPase type 13A3 0.0372201
WDFY1 WD repeat and FYVE domain containing 1 0.0365867
THBS1 thrombospondin 1 0.0365693
USP9X ubiquitin specific peptidase 9, X-linked 0.0360936
JMJD1C jumonji domain containing 1C 0.0353483
UBA6 ubiquitin-like modifier activating enzyme 6 0.0349689
MSN moesin 0.0345794
UBE2H ubiquitin-conjugating enzyme E2H 0.0343354
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0336231
OGA O-GlcNAcase 0.0335658
NT5C2 5'-nucleotidase, cytosolic II 0.0335142
SNX9 sorting nexin 9 0.0332751
OSMR oncostatin M receptor 0.0332492
ZNF292 zinc finger protein 292 0.0331311
CENPF centromere protein F, 350/400kDa 0.0324767
CANX calnexin 0.0324628
TENT5A terminal nucleotidyltransferase 5A 0.031968
KPNB1 karyopherin (importin) beta 1 0.0316631
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.031446
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0314237
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0311684
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.030955
LCORL ligand dependent nuclear receptor corepressor-like 0.029652
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0296235
INHBA inhibin, beta A 0.0295228
ZBTB38 zinc finger and BTB domain containing 38 0.0292873
KDM6A lysine (K)-specific demethylase 6A 0.0291404
WTAP Wilms tumor 1 associated protein 0.0290615
STC1 stanniocalcin 1 0.0285546
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0285248
KTN1 kinectin 1 (kinesin receptor) 0.0282483
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.02786
PHIP pleckstrin homology domain interacting protein 0.0271258
LDHA lactate dehydrogenase A 0.0270234
PICALM phosphatidylinositol binding clathrin assembly protein 0.026979
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0268331
CADM1 cell adhesion molecule 1 0.0266911
ERRFI1 ERBB receptor feedback inhibitor 1 0.0266129
NAV2 neuron navigator 2 0.0265691
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0264759
LPP LIM domain containing preferred translocation partner in lipoma 0.0263524
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0261378
APP amyloid beta (A4) precursor protein 0.0254664
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0251636
EPS8 epidermal growth factor receptor pathway substrate 8 0.0248223
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0248073
TXNRD1 thioredoxin reductase 1 0.0245398
CALD1 caldesmon 1 0.0244581
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0241848
AHR aryl hydrocarbon receptor 0.0240451
NEK7 NIMA-related kinase 7 0.0239299
LOXL2 lysyl oxidase-like 2 0.0239088
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0239006
BTG1 B-cell translocation gene 1, anti-proliferative 0.0237871
TNIP1 TNFAIP3 interacting protein 1 0.0237729
BIRC2 baculoviral IAP repeat containing 2 0.0237468
IL6ST interleukin 6 signal transducer 0.0235279
IQGAP1 IQ motif containing GTPase activating protein 1 0.0233982
KDM3A lysine (K)-specific demethylase 3A 0.0233215
SCAF8 SR-related CTD-associated factor 8 0.023296
DIAPH3 diaphanous-related formin 3 0.0231963
AFF4 AF4/FMR2 family, member 4 0.0231555
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0231336

decreased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A -0.173329
TMSB10 thymosin beta 10 -0.116993
RPS12 ribosomal protein S12 -0.0891077
VIM vimentin -0.0890274
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.086741
RPLP2 ribosomal protein, large, P2 -0.0807869
TPT1 tumor protein, translationally-controlled 1 -0.0767693
RPL37A ribosomal protein L37a -0.0740462
MT2A metallothionein 2A -0.0717866
RPS3 ribosomal protein S3 -0.0714089
HLA-B major histocompatibility complex, class I, B -0.0686094
COL6A3 collagen, type VI, alpha 3 -0.0681144
RPS6 ribosomal protein S6 -0.0652383
RPS19 ribosomal protein S19 -0.0629015
GLIS3 GLIS family zinc finger 3 -0.0598528
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0575293
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0566521
RPL36 ribosomal protein L36 -0.054502
RPL23 ribosomal protein L23 -0.0522022
HMGA2 high mobility group AT-hook 2 -0.0505651
RPS8 ribosomal protein S8 -0.0489806
RPL9 ribosomal protein L9 -0.0463999
RPS23 ribosomal protein S23 -0.0453798
TRIO trio Rho guanine nucleotide exchange factor -0.0427441
RPS17 ribosomal protein S17 -0.0424806
RPL26 ribosomal protein L26 -0.0408316
FTL ferritin, light polypeptide -0.0402593
HDAC9 histone deacetylase 9 -0.040115
RPL36A ribosomal protein L36a -0.040048
MYOF myoferlin -0.0392431
RPL32 ribosomal protein L32 -0.0390925
RPS24 ribosomal protein S24 -0.0389943
RPS10 ribosomal protein S10 -0.0377176
MARCKS myristoylated alanine-rich protein kinase C substrate -0.037123
RPL27 ribosomal protein L27 -0.0366665
RPS29 ribosomal protein S29 -0.0365572
RPL7A ribosomal protein L7a -0.035791
RPS4X ribosomal protein S4, X-linked -0.0356731
RPL35 ribosomal protein L35 -0.0353833
RPL19 ribosomal protein L19 -0.0352873
RPL31 ribosomal protein L31 -0.0352486
INTS6 integrator complex subunit 6 -0.0351537
RPLP1 ribosomal protein, large, P1 -0.0346584
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0345346
RAB7A RAB7A, member RAS oncogene family -0.034409
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0341109
S100A9 S100 calcium binding protein A9 -0.0340557
RPL12 ribosomal protein L12 -0.0319562
SDK1 sidekick cell adhesion molecule 1 -0.0307135
RPS13 ribosomal protein S13 -0.0305104
COL5A1 collagen, type V, alpha 1 -0.0302764
RPS21 ribosomal protein S21 -0.0302301
RPS14 ribosomal protein S14 -0.0291416
RPL8 ribosomal protein L8 -0.0288046
RPS25 ribosomal protein S25 -0.0286194
RPL28 ribosomal protein L28 -0.028461
RPL13A ribosomal protein L13a -0.0277399
RPL11 ribosomal protein L11 -0.0276722
RPL18 ribosomal protein L18 -0.0274062
IER3 immediate early response 3 -0.026841
RPS27A ribosomal protein S27a -0.0268195
COL6A2 collagen, type VI, alpha 2 -0.0264053
RPL5 ribosomal protein L5 -0.0263553
RPS16 ribosomal protein S16 -0.0262003
IFI6 interferon, alpha-inducible protein 6 -0.0261639
RPL37 ribosomal protein L37 -0.0257801
NCKAP5 NCK-associated protein 5 -0.025712
IFITM3 interferon induced transmembrane protein 3 -0.0255357
RPL38 ribosomal protein L38 -0.0253644
TENM2 teneurin transmembrane protein 2 -0.0250869
SEPTIN9 septin 9 -0.0250139
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0240927
EGFR epidermal growth factor receptor -0.0240927
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.024043
COL1A1 collagen, type I, alpha 1 -0.0239767
CTSD cathepsin D -0.0239361
ACTG1 actin gamma 1 -0.0232195
HLA-A major histocompatibility complex, class I, A -0.0230249
DTNA dystrobrevin, alpha -0.0229713
LMNA lamin A/C -0.0226064
RRBP1 ribosome binding protein 1 -0.0223005
ZMIZ1 zinc finger, MIZ-type containing 1 -0.022296
TGFBI transforming growth factor, beta-induced, 68kDa -0.0221441
FBXL7 F-box and leucine-rich repeat protein 7 -0.0219982
NAV1 neuron navigator 1 -0.0215116
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0211521
FRMPD4 FERM and PDZ domain containing 4 -0.0204691
LOX lysyl oxidase -0.0203532
RAB2A RAB2A, member RAS oncogene family -0.0199217
PRKCA protein kinase C, alpha -0.0197577
WFDC10B WAP four-disulfide core domain 10B -0.0196033
TIMP2 TIMP metallopeptidase inhibitor 2 -0.01934
SLC35F3 solute carrier family 35, member F3 -0.019317
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0189358
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0188303
RPS11 ribosomal protein S11 -0.0187185
RPS27 ribosomal protein S27 -0.0185898
PFN1 profilin 1 -0.0179515
RACK1 receptor for activated C kinase 1 -0.0178669
TBCA tubulin folding cofactor A -0.017839