Eptifibatide Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/448812
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Genes

200 proteins with high or low expression in Eptifibatide relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
DNAH12 dynein, axonemal, heavy chain 12 0.81
SYN2 synapsin II 0.73
SEMG1 semenogelin I 0.7
AKT1S1 AKT1 substrate 1 (proline-rich) 0.6
SYTL2 synaptotagmin-like 2 0.6
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.6
RAB26 RAB26, member RAS oncogene family 0.52
ETV3 ets variant 3 0.48
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.47
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 0.47
ZNF92 zinc finger protein 92 0.45
ELF4 E74-like factor 4 (ets domain transcription factor) 0.43
TENT5A terminal nucleotidyltransferase 5A 0.41
PCGF5 polycomb group ring finger 5 0.41
STARD3 StAR-related lipid transfer (START) domain containing 3 0.4
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.4
JAK2 Janus kinase 2 0.4
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 0.39
COMMD6 COMM domain containing 6 0.39
FSTL3 follistatin-like 3 (secreted glycoprotein) 0.38
FCHO1 FCH domain only 1 0.38
RNF4 ring finger protein 4 0.38
TSC22D2 TSC22 domain family, member 2 0.37
LRRCC1 leucine rich repeat and coiled-coil centrosomal protein 1 0.36
CCDC85B coiled-coil domain containing 85B 0.36
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.36
DUSP7 dual specificity phosphatase 7 0.36
BRSK2 BR serine/threonine kinase 2 0.35
FBXW8 F-box and WD repeat domain containing 8 0.35
PRR3 proline rich 3 0.35
SYTL3 synaptotagmin-like 3 0.35
SGSH N-sulfoglucosamine sulfohydrolase 0.35
UBE3D ubiquitin protein ligase E3D 0.35
RELT RELT tumor necrosis factor receptor 0.35
AMMECR1L AMMECR1-like 0.35
EGR1 early growth response 1 0.34
SLC25A39 solute carrier family 25, member 39 0.34
TSPAN15 tetraspanin 15 0.34
THAP9 THAP domain containing 9 0.34
TTC30B tetratricopeptide repeat domain 30B 0.34
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 0.34
E2F7 E2F transcription factor 7 0.33
TET2 tet methylcytosine dioxygenase 2 0.33
FAT4 FAT atypical cadherin 4 0.33
ELL3 elongation factor RNA polymerase II-like 3 0.33
TGFBR3 transforming growth factor, beta receptor III 0.32
SETD5 SET domain containing 5 0.32
AUNIP aurora kinase A and ninein interacting protein 0.32
PPP1R2B PPP1R2 family member B 0.31
ZNF532 zinc finger protein 532 0.31
THSD4 thrombospondin, type I, domain containing 4 0.31
CLTB clathrin, light chain B 0.3
CCDC57 coiled-coil domain containing 57 0.3
SOX12 SRY (sex determining region Y)-box 12 0.3
GATA6 GATA binding protein 6 0.3
PPP2R2D protein phosphatase 2, regulatory subunit B, delta 0.3
B2M beta-2-microglobulin 0.29
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 0.29
RHOQ ras homolog family member Q 0.29
ERVMER34-1 endogenous retrovirus group MER34, member 1 0.29
DUOX1 dual oxidase 1 0.29
NR2C1 nuclear receptor subfamily 2, group C, member 1 0.29
DTX3L deltex 3 like, E3 ubiquitin ligase 0.29
SORT1 sortilin 1 0.28
ACTB actin, beta 0.28
CERK ceramide kinase 0.28
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.28
ZNF777 zinc finger protein 777 0.28
C1ORF109 chromosome 1 open reading frame 109 0.28
FBXO46 F-box protein 46 0.28
ZUP1 zinc finger containing ubiquitin peptidase 1 0.27
F3 coagulation factor III (thromboplastin, tissue factor) 0.27
MZT2B mitotic spindle organizing protein 2B 0.27
ERCC6 excision repair cross-complementation group 6 0.27
KCTD21 potassium channel tetramerization domain containing 21 0.27
KIF1B kinesin family member 1B 0.27
CNTRL centriolin 0.26
CDC37L1 cell division cycle 37-like 1 0.26
PITX1 paired-like homeodomain 1 0.26
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.26
CPA4 carboxypeptidase A4 0.26
RCAN1 regulator of calcineurin 1 0.26
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 0.26
PHC1 polyhomeotic homolog 1 (Drosophila) 0.25
PHLDB3 pleckstrin homology-like domain, family B, member 3 0.25
CEP112 centrosomal protein 112kDa 0.25
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.25
FMNL1 formin-like 1 0.25
RNF19B ring finger protein 19B 0.25
IQCB1 IQ motif containing B1 0.25
LMLN leishmanolysin-like (metallopeptidase M8 family) 0.25
WDR60 WD repeat domain 60 0.25
PDZD11 PDZ domain containing 11 0.25
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.24
CDCA7 cell division cycle associated 7 0.24
FAM86B2 family with sequence similarity 86, member B2 0.24
PDE3B phosphodiesterase 3B, cGMP-inhibited 0.24
GAS8 growth arrest-specific 8 0.24
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C 0.24
BCL9 B-cell CLL/lymphoma 9 0.24

low expression

Symbol Name Standardized Value
VAV1 vav 1 guanine nucleotide exchange factor -2.14
FGG fibrinogen gamma chain -1.44
PTPRD protein tyrosine phosphatase, receptor type, D -0.81
GGACT gamma-glutamylamine cyclotransferase -0.59
C12ORF60 chromosome 12 open reading frame 60 -0.53
TACSTD2 tumor-associated calcium signal transducer 2 -0.52
GDF15 growth differentiation factor 15 -0.47
ZNF623 zinc finger protein 623 -0.45
C4BPA complement component 4 binding protein, alpha -0.44
FTH1 ferritin, heavy polypeptide 1 -0.42
RAB40C RAB40C, member RAS oncogene family -0.42
ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit -0.41
FTL ferritin, light polypeptide -0.41
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 -0.39
TDRD9 tudor domain containing 9 -0.39
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast) -0.36
OASL 2'-5'-oligoadenylate synthetase-like -0.35
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -0.33
BORCS7 BLOC-1 related complex subunit 7 -0.33
HBA1 hemoglobin, alpha 1 -0.33
CEMIP cell migration inducing protein, hyaluronan binding -0.33
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -0.33
NOTCH3 notch 3 -0.32
JOSD1 Josephin domain containing 1 -0.32
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta -0.31
TMEM63A transmembrane protein 63A -0.31
HAS3 hyaluronan synthase 3 -0.31
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 -0.31
FGFBP1 fibroblast growth factor binding protein 1 -0.3
ARL6IP6 ADP-ribosylation factor-like 6 interacting protein 6 -0.3
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.3
FBXL17 F-box and leucine-rich repeat protein 17 -0.3
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -0.3
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) -0.29
ABHD3 abhydrolase domain containing 3 -0.29
XTBD1 XRN2 binding domain containing 1 -0.29
LRP10 low density lipoprotein receptor-related protein 10 -0.29
BRD9 bromodomain containing 9 -0.29
NEK3 NIMA-related kinase 3 -0.28
NDRG1 N-myc downstream regulated 1 -0.28
NR1H2 nuclear receptor subfamily 1, group H, member 2 -0.28
KLHL12 kelch-like family member 12 -0.28
ALG3 ALG3, alpha-1,3- mannosyltransferase -0.28
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 -0.28
CDK18 cyclin-dependent kinase 18 -0.27
TMOD2 tropomodulin 2 (neuronal) -0.27
BHLHE40 basic helix-loop-helix family, member e40 -0.27
USP30 ubiquitin specific peptidase 30 -0.27
TTLL5 tubulin tyrosine ligase-like family member 5 -0.27
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) -0.27
SRR serine racemase -0.27
MARCHF7 membrane associated ring-CH-type finger 7 -0.26
TIMP3 TIMP metallopeptidase inhibitor 3 -0.26
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.26
GLRX glutaredoxin (thioltransferase) -0.26
TSPAN3 tetraspanin 3 -0.26
PLAUR plasminogen activator, urokinase receptor -0.26
S100A6 S100 calcium binding protein A6 -0.26
REPIN1 replication initiator 1 -0.26
SERINC5 serine incorporator 5 -0.26
DNPEP aspartyl aminopeptidase -0.26
POM121C POM121 transmembrane nucleoporin C -0.25
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) -0.25
PTGES prostaglandin E synthase -0.25
NBR1 neighbor of BRCA1 gene 1 -0.25
C18ORF32 chromosome 18 open reading frame 32 -0.25
PEX19 peroxisomal biogenesis factor 19 -0.25
BAG4 BCL2-associated athanogene 4 -0.25
CCDC90B coiled-coil domain containing 90B -0.25
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.25
FAM104A family with sequence similarity 104, member A -0.25
ERG28 ergosterol biosynthesis 28 homolog -0.25
FGFR2 fibroblast growth factor receptor 2 -0.25
HSBP1 heat shock factor binding protein 1 -0.24
MT1X metallothionein 1X -0.24
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.24
LGALS1 lectin, galactoside-binding, soluble, 1 -0.24
TMEM59 transmembrane protein 59 -0.24
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 -0.24
EPN3 epsin 3 -0.24
PGPEP1 pyroglutamyl-peptidase I -0.24
GLDC glycine dehydrogenase (decarboxylating) -0.24
CRTC3 CREB regulated transcription coactivator 3 -0.24
LGALS3 lectin, galactoside-binding, soluble, 3 -0.24
MYH16 myosin, heavy chain 16 pseudogene -0.24
F5 coagulation factor V (proaccelerin, labile factor) -0.23
MT-ND4 NADH dehydrogenase, subunit 4 (complex I) -0.23
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 -0.23
NDFIP1 Nedd4 family interacting protein 1 -0.23
SLFN5 schlafen family member 5 -0.23
TMEM87B transmembrane protein 87B -0.23
APOL2 apolipoprotein L, 2 -0.23
BAK1 BCL2-antagonist/killer 1 -0.23
GXYLT1 glucoside xylosyltransferase 1 -0.23
SS18 synovial sarcoma translocation, chromosome 18 -0.23
SYK spleen tyrosine kinase -0.23
GSE1 Gse1 coiled-coil protein -0.23
APOE apolipoprotein E -0.22
C6ORF47 chromosome 6 open reading frame 47 -0.22
BID BH3 interacting domain death agonist -0.22