| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Erdafitinib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Erdafitinib _A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.16681 |
| VIM | vimentin | 0.128515 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.119471 |
| RRM2 | ribonucleotide reductase M2 | 0.108671 |
| ANXA1 | annexin A1 | 0.0879176 |
| TPI1 | triosephosphate isomerase 1 | 0.0805595 |
| TMSB10 | thymosin beta 10 | 0.0802943 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0751688 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0750794 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0723667 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0704943 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0662285 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0657964 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0609481 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0602852 |
| ENO1 | enolase 1, (alpha) | 0.0583281 |
| CALR | calreticulin | 0.0574121 |
| RPL23 | ribosomal protein L23 | 0.0556594 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0549915 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0535598 |
| RPS12 | ribosomal protein S12 | 0.0533886 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0528694 |
| MKI67 | marker of proliferation Ki-67 | 0.0525601 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0501484 |
| FTL | ferritin, light polypeptide | 0.0498065 |
| LDHA | lactate dehydrogenase A | 0.0495028 |
| AREG | amphiregulin | 0.049276 |
| IPO7 | importin 7 | 0.044007 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0436177 |
| RPS8 | ribosomal protein S8 | 0.0433172 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0430773 |
| TPM3 | tropomyosin 3 | 0.0403461 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0399192 |
| RAD51B | RAD51 paralog B | 0.0392248 |
| YAP1 | Yes-associated protein 1 | 0.0385227 |
| CENPF | centromere protein F, 350/400kDa | 0.0383015 |
| SET | SET nuclear proto-oncogene | 0.0375956 |
| DSPP | dentin sialophosphoprotein | 0.0369924 |
| YBX1 | Y box binding protein 1 | 0.0366702 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 0.0364142 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0358723 |
| RPLP1 | ribosomal protein, large, P1 | 0.0356419 |
| TENM3 | teneurin transmembrane protein 3 | 0.035518 |
| AXIN2 | axin 2 | 0.0353034 |
| WWOX | WW domain containing oxidoreductase | 0.035166 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0349644 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0349182 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0348185 |
| PCDH7 | protocadherin 7 | 0.0343629 |
| RPS19 | ribosomal protein S19 | 0.0332299 |
| PRELID2 | PRELI domain containing 2 | 0.0321732 |
| RPL11 | ribosomal protein L11 | 0.032002 |
| MATR3 | matrin 3 | 0.0319773 |
| MYL12B | myosin, light chain 12B, regulatory | 0.03188 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.0318011 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0315833 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0306553 |
| ASPH | aspartate beta-hydroxylase | 0.0305965 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0305233 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.030433 |
| RPL35A | ribosomal protein L35a | 0.0300561 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0299114 |
| PTMA | prothymosin, alpha | 0.0297818 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.029707 |
| RPS2 | ribosomal protein S2 | 0.0296522 |
| XPO1 | exportin 1 | 0.0294266 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0294253 |
| PGK1 | phosphoglycerate kinase 1 | 0.0292605 |
| RACK1 | receptor for activated C kinase 1 | 0.0289908 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0289743 |
| CEP192 | centrosomal protein 192kDa | 0.028878 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0287574 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0287513 |
| IL6ST | interleukin 6 signal transducer | 0.0285337 |
| RPLP2 | ribosomal protein, large, P2 | 0.0284254 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.028265 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0281399 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0281251 |
| MGAT4C | MGAT4 family, member C | 0.0277815 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0277462 |
| TNPO1 | transportin 1 | 0.0276114 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.0274962 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0274931 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0274579 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0273099 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0271494 |
| RPL7 | ribosomal protein L7 | 0.0271059 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0270255 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0269323 |
| RPL26 | ribosomal protein L26 | 0.0268688 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.026863 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0268578 |
| TPX2 | TPX2, microtubule-associated | 0.0268457 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0268318 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0260926 |
| HLTF | helicase-like transcription factor | 0.02579 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0257181 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | 0.025377 |
| RPS27 | ribosomal protein S27 | 0.0252866 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0252336 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.115473 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0640584 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0607606 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0516195 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0486866 |
| MMP12 | matrix metallopeptidase 12 | -0.047085 |
| RASAL2 | RAS protein activator like 2 | -0.046256 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0394661 |
| ACTG1 | actin gamma 1 | -0.0383839 |
| NABP1 | nucleic acid binding protein 1 | -0.0374682 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0363345 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0337112 |
| POTEF | POTE ankyrin domain family, member F | -0.0313141 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0302688 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0288476 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0281673 |
| EHBP1 | EH domain binding protein 1 | -0.0278978 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0276382 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0272419 |
| MYPN | myopalladin | -0.0271234 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0261187 |
| ERBIN | erbb2 interacting protein | -0.0252654 |
| ADIPOR2 | adiponectin receptor 2 | -0.0245231 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0236503 |
| CMIP | c-Maf inducing protein | -0.0227699 |
| AK1 | adenylate kinase 1 | -0.0225162 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0217143 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0212458 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0206972 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.020224 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0195959 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0195393 |
| SETD5 | SET domain containing 5 | -0.0193698 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0183484 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0183365 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0179921 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0178718 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0174048 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0173727 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0173438 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.01716 |
| PRR16 | proline rich 16 | -0.0168731 |
| EGR1 | early growth response 1 | -0.016602 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0165698 |
| PCNX4 | pecanex 4 | -0.0164601 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0163972 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0161022 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0159932 |
| ATF6 | activating transcription factor 6 | -0.0159149 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0158176 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0153235 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0151903 |
| ATN1 | atrophin 1 | -0.0151504 |
| TBCA | tubulin folding cofactor A | -0.014973 |
| BCHE | butyrylcholinesterase | -0.0148453 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.014804 |
| RAB10 | RAB10, member RAS oncogene family | -0.0145967 |
| FBXO11 | F-box protein 11 | -0.0145961 |
| BPTF | bromodomain PHD finger transcription factor | -0.0145503 |
| NBEAL1 | neurobeachin-like 1 | -0.0144908 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0144766 |
| NRXN3 | neurexin 3 | -0.0144035 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0143234 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0142497 |
| NEBL | nebulette | -0.0142313 |
| TGM2 | transglutaminase 2 | -0.0140083 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0139808 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0139373 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0138632 |
| TTC27 | tetratricopeptide repeat domain 27 | -0.0138489 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0138145 |
| SEC24B | SEC24 family member B | -0.0136864 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0136319 |
| RAP1GDS1 | RAP1, GTP-GDP dissociation stimulator 1 | -0.0136154 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | -0.0134898 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0133582 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0132169 |
| CLDN1 | claudin 1 | -0.013157 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.0131475 |
| ZMYM4 | zinc finger, MYM-type 4 | -0.0131468 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0130814 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0130053 |
| SRBD1 | S1 RNA binding domain 1 | -0.0128581 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0128058 |
| ATXN2 | ataxin 2 | -0.0126295 |
| TSPAN5 | tetraspanin 5 | -0.012579 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0125665 |
| PHF14 | PHD finger protein 14 | -0.0125309 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | -0.0124451 |
| SPPL3 | signal peptide peptidase like 3 | -0.012125 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0120707 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0120537 |
| CCN2 | cellular communication network factor 2 | -0.0120095 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0120066 |
| AHRR | aryl-hydrocarbon receptor repressor | -0.0119907 |
| R3HDM2 | R3H domain containing 2 | -0.0119041 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0118864 |
| VPS8 | vacuolar protein sorting 8 homolog (S. cerevisiae) | -0.0118664 |
| FNIP1 | folliculin interacting protein 1 | -0.0118346 |
| RNF13 | ring finger protein 13 | -0.0117279 |
