Erdafitinib _A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erdafitinib perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erdafitinib _A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.130967
CD44 CD44 molecule (Indian blood group) 0.0737098
FRMD4A FERM domain containing 4A 0.0668781
MYH9 myosin, heavy chain 9, non-muscle 0.0579995
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0474711
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0448901
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0442474
PDIA6 protein disulfide isomerase family A, member 6 0.0425069
TPM3 tropomyosin 3 0.0422052
RND3 Rho family GTPase 3 0.0419132
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0405996
LDHA lactate dehydrogenase A 0.0381749
SOD2 superoxide dismutase 2, mitochondrial 0.0377358
RAI14 retinoic acid induced 14 0.0376765
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0347533
SFTPA2 surfactant protein A2 0.0319036
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0310137
KYNU kynureninase 0.0307177
DST dystonin 0.029884
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0296692
FAT1 FAT atypical cadherin 1 0.0294147
EXT1 exostosin glycosyltransferase 1 0.0285194
RIGI RNA sensor RIG-I 0.0282692
NAV2 neuron navigator 2 0.0281253
ZSWIM6 zinc finger, SWIM-type containing 6 0.0278635
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0277309
MX1 MX dynamin-like GTPase 1 0.0263593
TMED2 transmembrane emp24 domain trafficking protein 2 0.025184
RNF213 ring finger protein 213 0.02496
NFE2L1 nuclear factor, erythroid 2-like 1 0.0244978
ANXA1 annexin A1 0.0239047
EHBP1 EH domain binding protein 1 0.0238126
CREB5 cAMP responsive element binding protein 5 0.0236496
SET SET nuclear proto-oncogene 0.0231627
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0230429
TRIO trio Rho guanine nucleotide exchange factor 0.0221067
EFNA5 ephrin-A5 0.0221048
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0220523
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0215175
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0214237
MCL1 myeloid cell leukemia 1 0.0213856
TLN1 talin 1 0.0211425
GOLGB1 golgin B1 0.0211417
EGFR epidermal growth factor receptor 0.0211056
FNDC3B fibronectin type III domain containing 3B 0.0210916
HDAC9 histone deacetylase 9 0.0208579
MKI67 marker of proliferation Ki-67 0.0202647
PDLIM5 PDZ and LIM domain 5 0.0201277
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.019308
SP100 SP100 nuclear antigen 0.0192652
GPC6 glypican 6 0.0191889
IFI44L interferon-induced protein 44-like 0.0186545
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0184551
LPP LIM domain containing preferred translocation partner in lipoma 0.0182982
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0181312
PLIN2 perilipin 2 0.0176501
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0175587
PDIA3 protein disulfide isomerase family A, member 3 0.0173249
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.017293
SMAD3 SMAD family member 3 0.0170288
MACF1 microtubule-actin crosslinking factor 1 0.0169968
SAMD9 sterile alpha motif domain containing 9 0.0169089
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0168428
GLIS3 GLIS family zinc finger 3 0.0167886
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0166598
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0164931
CSNK1A1 casein kinase 1, alpha 1 0.0164587
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0163189
CANX calnexin 0.0162686
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0162033
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0161747
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.0161647
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0160833
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0158615
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0158258
PLK2 polo-like kinase 2 0.0155416
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.015442
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0154195
INTS6 integrator complex subunit 6 0.0153681
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.015169
SETX senataxin 0.015081
KIRREL3 kin of IRRE like 3 (Drosophila) 0.0149722
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0148913
ERRFI1 ERBB receptor feedback inhibitor 1 0.0147447
MLEC malectin 0.0147336
DOCK5 dedicator of cytokinesis 5 0.0146973
SCARB2 scavenger receptor class B, member 2 0.0145961
SRRM2 serine/arginine repetitive matrix 2 0.0145857
EXOC4 exocyst complex component 4 0.0145852
ANO6 anoctamin 6 0.0145035
PDE4D phosphodiesterase 4D, cAMP-specific 0.0144767
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0144327
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0142936
MYOF myoferlin 0.0142066
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.013901
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0138245
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0137803
ITM2B integral membrane protein 2B 0.0136146
MAP1B microtubule-associated protein 1B 0.0135792
COL4A2 collagen, type IV, alpha 2 0.0135498

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.109893
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.10313
RPS6 ribosomal protein S6 -0.0762326
TMSB10 thymosin beta 10 -0.0758747
PTMA prothymosin, alpha -0.0613968
HSPB1 heat shock 27kDa protein 1 -0.0602964
POTEF POTE ankyrin domain family, member F -0.0587468
TPT1 tumor protein, translationally-controlled 1 -0.0585126
HLA-B major histocompatibility complex, class I, B -0.0522896
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0497088
RPLP2 ribosomal protein, large, P2 -0.0472432
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0423833
VIM vimentin -0.0417927
RPS24 ribosomal protein S24 -0.0374194
RPL35A ribosomal protein L35a -0.0366749
RPL28 ribosomal protein L28 -0.0364569
RPLP1 ribosomal protein, large, P1 -0.03611
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0355755
EIF1 eukaryotic translation initiation factor 1 -0.0339139
G0S2 G0/G1 switch 2 -0.0338844
RPS8 ribosomal protein S8 -0.0308994
RPL19 ribosomal protein L19 -0.0300531
CTSD cathepsin D -0.0283568
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0280706
RPS5 ribosomal protein S5 -0.0280179
CSF1 colony stimulating factor 1 (macrophage) -0.0279946
RPS19 ribosomal protein S19 -0.0276164
RHEB Ras homolog enriched in brain -0.0274354
PFN1 profilin 1 -0.0259604
RPS23 ribosomal protein S23 -0.0258581
MTDH metadherin -0.0252225
RPL34 ribosomal protein L34 -0.0252129
ACTG1 actin gamma 1 -0.0249227
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0239026
RAB1A RAB1A, member RAS oncogene family -0.0238113
LITAF lipopolysaccharide-induced TNF factor -0.0231016
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0230001
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0229451
RPS16 ribosomal protein S16 -0.0226593
RPL8 ribosomal protein L8 -0.0223
RPL9 ribosomal protein L9 -0.02226
HMGB1 high mobility group box 1 -0.0219666
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0219222
CAVIN1 caveolae associated protein 1 -0.0218978
RPS21 ribosomal protein S21 -0.0218808
RPL31 ribosomal protein L31 -0.0214364
UBC ubiquitin C -0.0214092
RPS11 ribosomal protein S11 -0.0213961
H3-3B H3.3 histone B -0.0211626
PTBP3 polypyrimidine tract binding protein 3 -0.0210734
RPS13 ribosomal protein S13 -0.0210623
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0206433
RPL38 ribosomal protein L38 -0.0204856
GNAS GNAS complex locus -0.0204604
RTN4 reticulon 4 -0.0204263
ADM adrenomedullin -0.0203431
ANKRD33B ankyrin repeat domain 33B -0.0202155
PRRC2C proline-rich coiled-coil 2C -0.0201877
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0199934
MT2A metallothionein 2A -0.0199632
RPS15 ribosomal protein S15 -0.0198468
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0197051
LMNA lamin A/C -0.0196801
RBM39 RNA binding motif protein 39 -0.0195265
CELF1 CUGBP, Elav-like family member 1 -0.01915
RRBP1 ribosome binding protein 1 -0.0191
RPLP0 ribosomal protein, large, P0 -0.0190897
CD70 CD70 molecule -0.019072
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 -0.0190057
RPS27A ribosomal protein S27a -0.0189551
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0188158
CCL2 chemokine (C-C motif) ligand 2 -0.0186648
RPL36A ribosomal protein L36a -0.0185296
GDF15 growth differentiation factor 15 -0.018526
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0184778
RPL23 ribosomal protein L23 -0.0183823
RPL5 ribosomal protein L5 -0.0183138
MARCHF6 membrane associated ring-CH-type finger 6 -0.0180076
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0179917
RPS25 ribosomal protein S25 -0.0178638
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0177682
RPL36 ribosomal protein L36 -0.0176889
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0174556
GOLGA4 golgin A4 -0.0173316
GARS1 glycyl-tRNA synthetase 1 -0.0172556
DENND2B DENN domain containing 2B -0.0171569
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0169742
RPS14 ribosomal protein S14 -0.0168911
TMEM263 transmembrane protein 263 -0.0168793
SERF2 small EDRK-rich factor 2 -0.0168525
UGCG UDP-glucose ceramide glucosyltransferase -0.0168103
RPL37A ribosomal protein L37a -0.0167868
ICAM1 intercellular adhesion molecule 1 -0.0167535
ACBD3 acyl-CoA binding domain containing 3 -0.0167076
RPL7A ribosomal protein L7a -0.0165676
RPS29 ribosomal protein S29 -0.0165353
RPL27A ribosomal protein L27a -0.0157844
IRS2 insulin receptor substrate 2 -0.0157641
SRSF11 serine/arginine-rich splicing factor 11 -0.0154211
NOP58 NOP58 ribonucleoprotein -0.0154178