| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Erdafitinib perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Erdafitinib _A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0894755 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0872227 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0736766 |
| MT2A | metallothionein 2A | 0.070619 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0645953 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0609926 |
| SMAD3 | SMAD family member 3 | 0.0549473 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0532543 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0488112 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0486521 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0462832 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0447 |
| MT1X | metallothionein 1X | 0.0427372 |
| KYNU | kynureninase | 0.0424867 |
| TXNRD1 | thioredoxin reductase 1 | 0.0421584 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0403646 |
| FAM107B | family with sequence similarity 107, member B | 0.0395099 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.03794 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0378758 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0376326 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0375617 |
| STC1 | stanniocalcin 1 | 0.0358423 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0348672 |
| LDHA | lactate dehydrogenase A | 0.0342796 |
| ASPH | aspartate beta-hydroxylase | 0.0337475 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0328118 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0324767 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0317048 |
| EFNA5 | ephrin-A5 | 0.0303658 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0298927 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0298266 |
| KLF6 | Kruppel-like factor 6 | 0.0294483 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0291363 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.029107 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0281385 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0275292 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.0268452 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0266414 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0260045 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0252829 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0247562 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0246226 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0235884 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0232074 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0231946 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0217995 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0210636 |
| SET | SET nuclear proto-oncogene | 0.0209417 |
| RPL26 | ribosomal protein L26 | 0.0208303 |
| EREG | epiregulin | 0.0205944 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0205022 |
| MYOF | myoferlin | 0.0203887 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0190936 |
| CENPF | centromere protein F, 350/400kDa | 0.0190582 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0186044 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0185824 |
| EZR | ezrin | 0.0183807 |
| ANGPTL4 | angiopoietin-like 4 | 0.0181618 |
| RUNX1 | runt-related transcription factor 1 | 0.0178628 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0176888 |
| MKI67 | marker of proliferation Ki-67 | 0.017651 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0175633 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.017547 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0174156 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0173131 |
| ANXA1 | annexin A1 | 0.017233 |
| SMYD3 | SET and MYND domain containing 3 | 0.0171353 |
| RNF213 | ring finger protein 213 | 0.0170621 |
| DST | dystonin | 0.0169183 |
| RIGI | RNA sensor RIG-I | 0.0169037 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0167675 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0163864 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0162716 |
| GRAMD1B | GRAM domain containing 1B | 0.0153332 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0152206 |
| YBX3 | Y box binding protein 3 | 0.0150094 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0148623 |
| WWOX | WW domain containing oxidoreductase | 0.0148382 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0148374 |
| DOCK4 | dedicator of cytokinesis 4 | 0.014656 |
| ANLN | anillin, actin binding protein | 0.0144118 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0144085 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.014235 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0141426 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0139057 |
| PCNX1 | pecanex 1 | 0.0137806 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0137619 |
| IPO7 | importin 7 | 0.0133517 |
| SLTM | SAFB-like, transcription modulator | 0.0133234 |
| PDE10A | phosphodiesterase 10A | 0.0132695 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0132611 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0132479 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0131465 |
| RPS2 | ribosomal protein S2 | 0.0130568 |
| RTN4 | reticulon 4 | 0.0128328 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | 0.0126802 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0126505 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0126079 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0125915 |
| SFTPA2 | surfactant protein A2 | 0.0125745 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.138567 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.130551 |
| ACTG1 | actin gamma 1 | -0.0978485 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0859049 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0773619 |
| RPS6 | ribosomal protein S6 | -0.0725685 |
| FTL | ferritin, light polypeptide | -0.0657277 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0637343 |
| KRT81 | keratin 81, type II | -0.0588679 |
| VIM | vimentin | -0.0556527 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0556453 |
| PTMA | prothymosin, alpha | -0.0509055 |
| NDRG1 | N-myc downstream regulated 1 | -0.0444858 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0442978 |
| RPS16 | ribosomal protein S16 | -0.0418071 |
| POTEF | POTE ankyrin domain family, member F | -0.039177 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0377699 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0376076 |
| RPS23 | ribosomal protein S23 | -0.0375069 |
| RPS29 | ribosomal protein S29 | -0.0367475 |
| PKM | pyruvate kinase, muscle | -0.0354336 |
| S100A6 | S100 calcium binding protein A6 | -0.0333847 |
| RPS13 | ribosomal protein S13 | -0.0332628 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0330207 |
| PARD3 | par-3 family cell polarity regulator | -0.032535 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0315369 |
| RPL35A | ribosomal protein L35a | -0.0312439 |
| COPA | coatomer protein complex, subunit alpha | -0.0310169 |
| RPL37A | ribosomal protein L37a | -0.0309138 |
| RPL28 | ribosomal protein L28 | -0.0304639 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0296853 |
| WASF2 | WAS protein family, member 2 | -0.0294849 |
| RPL31 | ribosomal protein L31 | -0.0286902 |
| S100A10 | S100 calcium binding protein A10 | -0.0284291 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0283029 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0280787 |
| RPS27A | ribosomal protein S27a | -0.0280773 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0279534 |
| RPS11 | ribosomal protein S11 | -0.0270736 |
| SP100 | SP100 nuclear antigen | -0.0267464 |
| VCL | vinculin | -0.0260999 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0260832 |
| AUTS2 | autism susceptibility candidate 2 | -0.0260742 |
| RPS24 | ribosomal protein S24 | -0.0259349 |
| SETD5 | SET domain containing 5 | -0.0259115 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0258457 |
| RPS19 | ribosomal protein S19 | -0.0258264 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0254119 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0247281 |
| GOLGB1 | golgin B1 | -0.0245047 |
| INTS6 | integrator complex subunit 6 | -0.0243543 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0241922 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0240324 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0236058 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0235945 |
| GOLGA4 | golgin A4 | -0.0235496 |
| UBC | ubiquitin C | -0.0232429 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0231177 |
| PALLD | palladin, cytoskeletal associated protein | -0.0230463 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0229399 |
| TNS3 | tensin 3 | -0.0227158 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0227041 |
| HLA-B | major histocompatibility complex, class I, B | -0.0226235 |
| RPL38 | ribosomal protein L38 | -0.0225654 |
| LTBP4 | latent transforming growth factor beta binding protein 4 | -0.022248 |
| PFN1 | profilin 1 | -0.0218055 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0213318 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0212814 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0212064 |
| TPM4 | tropomyosin 4 | -0.0208225 |
| RPLP2 | ribosomal protein, large, P2 | -0.0200157 |
| RPL13A | ribosomal protein L13a | -0.019947 |
| HM13 | histocompatibility (minor) 13 | -0.0199182 |
| FBXO11 | F-box protein 11 | -0.019821 |
| RCOR1 | REST corepressor 1 | -0.019574 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0193335 |
| DSTN | destrin (actin depolymerizing factor) | -0.0192601 |
| NLK | nemo-like kinase | -0.0190928 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0183289 |
| UPP1 | uridine phosphorylase 1 | -0.0181621 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.0181085 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0179812 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0179243 |
| CUX1 | cut-like homeobox 1 | -0.0176559 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0175882 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0175661 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0173594 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0172474 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.0172016 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0171189 |
| RPL8 | ribosomal protein L8 | -0.0170891 |
| HIP1 | huntingtin interacting protein 1 | -0.0169613 |
| HDGF | hepatoma-derived growth factor | -0.0168271 |
| USP47 | ubiquitin specific peptidase 47 | -0.016758 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0166898 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0165127 |
| ST6GAL2 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 | -0.0164856 |
| AADAC | arylacetamide deacetylase | -0.0163291 |
| RPS27L | ribosomal protein S27-like | -0.0163195 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0160841 |
