Erdafitinib _AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erdafitinib perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erdafitinib _AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MEST mesoderm specific transcript 0.199216
VIM vimentin 0.193269
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.146364
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.140852
TMSB4X thymosin beta 4, X-linked 0.104564
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.102085
PDE4D phosphodiesterase 4D, cAMP-specific 0.0907701
EEF2 eukaryotic translation elongation factor 2 0.0890032
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0841912
RPL23 ribosomal protein L23 0.0835133
SFTPA2 surfactant protein A2 0.0807556
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0737357
RPS12 ribosomal protein S12 0.0730842
ENO1 enolase 1, (alpha) 0.0716246
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0712898
LDHA lactate dehydrogenase A 0.0663596
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0644439
PGK1 phosphoglycerate kinase 1 0.063507
SET SET nuclear proto-oncogene 0.0619725
RPS4X ribosomal protein S4, X-linked 0.0619606
HSPA8 heat shock 70kDa protein 8 0.0599654
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0585561
CALR calreticulin 0.0555565
RPS19 ribosomal protein S19 0.054751
RPL12 ribosomal protein L12 0.0546144
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.051913
RPS8 ribosomal protein S8 0.0505638
RPS6 ribosomal protein S6 0.0504884
TPM3 tropomyosin 3 0.0494478
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0488073
RPS2 ribosomal protein S2 0.0486077
PDIA3 protein disulfide isomerase family A, member 3 0.0474444
RACK1 receptor for activated C kinase 1 0.0460971
ACTG1 actin gamma 1 0.0459861
RPL3 ribosomal protein L3 0.0453675
MACF1 microtubule-actin crosslinking factor 1 0.0452933
THBS1 thrombospondin 1 0.0452713
DDIT4 DNA-damage-inducible transcript 4 0.0450895
ITGAV integrin, alpha V 0.0433493
SFPQ splicing factor proline/glutamine-rich 0.0426346
RPLP0 ribosomal protein, large, P0 0.041695
EXT1 exostosin glycosyltransferase 1 0.0405304
SPTBN1 spectrin, beta, non-erythrocytic 1 0.040426
RPL30 ribosomal protein L30 0.0401497
DSCAM Down syndrome cell adhesion molecule 0.0394702
NAV2 neuron navigator 2 0.0392994
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0391199
XPO1 exportin 1 0.0386959
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0379741
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0377955
COL5A2 collagen, type V, alpha 2 0.0373206
TPI1 triosephosphate isomerase 1 0.0358524
MKI67 marker of proliferation Ki-67 0.0349467
KIF11 kinesin family member 11 0.0349307
ANKRD11 ankyrin repeat domain 11 0.034896
TMED2 transmembrane emp24 domain trafficking protein 2 0.0348332
EZR ezrin 0.0342204
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.0341507
RPL7 ribosomal protein L7 0.0337554
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0335227
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0332333
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0330061
RPS17 ribosomal protein S17 0.0329683
MAML2 mastermind-like 2 (Drosophila) 0.0328357
FNDC3B fibronectin type III domain containing 3B 0.0324201
VEGFA vascular endothelial growth factor A 0.0323015
KAZN kazrin, periplakin interacting protein 0.0320265
PDIA6 protein disulfide isomerase family A, member 6 0.0318031
CCNG2 cyclin G2 0.031749
TMSB10 thymosin beta 10 0.0317248
EEF1G eukaryotic translation elongation factor 1 gamma 0.0316445
SETD2 SET domain containing 2 0.0315642
BCOR BCL6 corepressor 0.0313364
USP9X ubiquitin specific peptidase 9, X-linked 0.031266
RPL37 ribosomal protein L37 0.0305101
ANXA2 annexin A2 0.030345
IPO7 importin 7 0.0301821
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0299851
RPS14 ribosomal protein S14 0.0298309
CHD3 chromodomain helicase DNA binding protein 3 0.029616
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 0.0293723
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0291388
WWOX WW domain containing oxidoreductase 0.0290968
CREBBP CREB binding protein 0.0289894
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.028605
HDLBP high density lipoprotein binding protein 0.0285273
PRELID2 PRELI domain containing 2 0.028513
BRD2 bromodomain containing 2 0.0284988
LMO7 LIM domain 7 0.0283631
ARHGAP5 Rho GTPase activating protein 5 0.028218
B2M beta-2-microglobulin 0.028182
TSHZ2 teashirt zinc finger homeobox 2 0.0280723
RPL8 ribosomal protein L8 0.02802
RPL11 ribosomal protein L11 0.0279749
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 0.0277706
BTN3A3 butyrophilin, subfamily 3, member A3 0.0277572
PDE10A phosphodiesterase 10A 0.0275449
HMGB2 high mobility group box 2 0.0274643
RPS21 ribosomal protein S21 0.0272458
SHROOM3 shroom family member 3 0.0271701

decreased expression

Symbol Name Standardized Value
PRKG1 protein kinase, cGMP-dependent, type I -0.0879494
TPK1 thiamin pyrophosphokinase 1 -0.0854518
COL1A2 collagen, type I, alpha 2 -0.0752766
MEOX2 mesenchyme homeobox 2 -0.0622998
RANBP17 RAN binding protein 17 -0.0601875
ZEB1 zinc finger E-box binding homeobox 1 -0.0517045
SSBP2 single-stranded DNA binding protein 2 -0.0503502
ZNF292 zinc finger protein 292 -0.048537
NFIB nuclear factor I/B -0.0474534
NCOA1 nuclear receptor coactivator 1 -0.0468479
AK1 adenylate kinase 1 -0.0462707
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0460914
NFIA nuclear factor I/A -0.0444479
KDM5B lysine (K)-specific demethylase 5B -0.0415035
MED13L mediator complex subunit 13-like -0.0407972
CADM2 cell adhesion molecule 2 -0.039765
NIPBL Nipped-B homolog (Drosophila) -0.0378166
OGA O-GlcNAcase -0.0375276
PHIP pleckstrin homology domain interacting protein -0.0374428
TCF12 transcription factor 12 -0.0374237
LPP LIM domain containing preferred translocation partner in lipoma -0.0363009
DOCK3 dedicator of cytokinesis 3 -0.0362094
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 -0.0359924
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0354042
RHEB Ras homolog enriched in brain -0.0352807
BMPR1A bone morphogenetic protein receptor, type IA -0.0349648
POU2F1 POU class 2 homeobox 1 -0.0338064
SOBP sine oculis binding protein homolog (Drosophila) -0.0329295
AKAP9 A kinase (PRKA) anchor protein 9 -0.0325698
NCOR2 nuclear receptor corepressor 2 -0.03215
FNDC3A fibronectin type III domain containing 3A -0.0318605
KMT2A lysine (K)-specific methyltransferase 2A -0.0318299
SCAPER S-phase cyclin A-associated protein in the ER -0.0307597
GPHN gephyrin -0.0300673
MIS18BP1 MIS18 binding protein 1 -0.0299774
PAXBP1 PAX3 and PAX7 binding protein 1 -0.0299649
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.029892
NBEAL1 neurobeachin-like 1 -0.0297642
SRPK2 SRSF protein kinase 2 -0.0297036
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0292246
PRTG protogenin -0.0291471
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0289604
WSB1 WD repeat and SOCS box containing 1 -0.0289087
KMT2E lysine (K)-specific methyltransferase 2E -0.0287906
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0285547
TRERF1 transcriptional regulating factor 1 -0.028439
PDS5B PDS5 cohesin associated factor B -0.0283426
TNRC6B trinucleotide repeat containing 6B -0.0282695
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0281637
PARD3 par-3 family cell polarity regulator -0.0281269
PHF3 PHD finger protein 3 -0.0275299
TTC28 tetratricopeptide repeat domain 28 -0.0275097
UBTD2 ubiquitin domain containing 2 -0.0274816
ZBTB20 zinc finger and BTB domain containing 20 -0.027258
PDGFC platelet derived growth factor C -0.0271467
DENND5B DENN/MADD domain containing 5B -0.0271244
TET1 tet methylcytosine dioxygenase 1 -0.0270729
MEF2A myocyte enhancer factor 2A -0.0268332
NBEA neurobeachin -0.0265611
EVI5 ecotropic viral integration site 5 -0.0262167
RNF145 ring finger protein 145 -0.026098
VDAC1 voltage-dependent anion channel 1 -0.0259555
ZNF451 zinc finger protein 451 -0.0258786
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0257904
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0256471
PTEN phosphatase and tensin homolog -0.0256155
DEPDC1B DEP domain containing 1B -0.025599
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0255204
SMC4 structural maintenance of chromosomes 4 -0.0254969
MIPOL1 mirror-image polydactyly 1 -0.0254636
FNBP4 formin binding protein 4 -0.0254385
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0253965
FBXL7 F-box and leucine-rich repeat protein 7 -0.0249114
PNISR PNN-interacting serine/arginine-rich protein -0.0249037
ARID4B AT rich interactive domain 4B (RBP1-like) -0.024871
MARCHF6 membrane associated ring-CH-type finger 6 -0.0248548
RBM25 RNA binding motif protein 25 -0.0247917
CCNY cyclin Y -0.0243965
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0242694
FCHSD2 FCH and double SH3 domains 2 -0.0242393
MON2 MON2 homolog (S. cerevisiae) -0.0242336
SEPTIN11 septin 11 -0.0240186
RBM33 RNA binding motif protein 33 -0.0239951
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 -0.02397
HBP1 HMG-box transcription factor 1 -0.0238007
IFRD1 interferon-related developmental regulator 1 -0.0236695
ERBIN erbb2 interacting protein -0.0231807
ZNF827 zinc finger protein 827 -0.0230839
ZFX zinc finger protein, X-linked -0.023019
DDHD1 DDHD domain containing 1 -0.0229087
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0228674
SQSTM1 sequestosome 1 -0.0228048
ACBD6 acyl-CoA binding domain containing 6 -0.0227742
MMS22L MMS22-like, DNA repair protein -0.0225885
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 -0.0225284
RBM39 RNA binding motif protein 39 -0.0225255
ABI2 abl-interactor 2 -0.0223391
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.022219
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0219808
KDM4B lysine (K)-specific demethylase 4B -0.0218294