Erdafitinib _BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erdafitinib perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erdafitinib _BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 0.198168
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.101395
SET SET nuclear proto-oncogene 0.0722464
ENO1 enolase 1, (alpha) 0.0704175
INTS6 integrator complex subunit 6 0.0691772
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0676083
RPL19 ribosomal protein L19 0.0639443
RPS3 ribosomal protein S3 0.0601616
LDHA lactate dehydrogenase A 0.05941
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.057387
RPS12 ribosomal protein S12 0.0510841
EEF2 eukaryotic translation elongation factor 2 0.0504414
FTH1 ferritin, heavy polypeptide 1 0.0495941
STXBP4 syntaxin binding protein 4 0.0473102
NDRG1 N-myc downstream regulated 1 0.0471784
PGK1 phosphoglycerate kinase 1 0.0446226
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0439113
SLFN5 schlafen family member 5 0.0418217
CLTC clathrin, heavy chain (Hc) 0.0414944
MCL1 myeloid cell leukemia 1 0.0411818
LOC112694756 uncharaterized LOC112694756 0.0408436
RPL37A ribosomal protein L37a 0.0404454
TMED2 transmembrane emp24 domain trafficking protein 2 0.040118
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0374371
EXT1 exostosin glycosyltransferase 1 0.0373116
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.035473
PABPC1 poly(A) binding protein, cytoplasmic 1 0.035195
RPL35A ribosomal protein L35a 0.0346932
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) 0.0344836
DSPP dentin sialophosphoprotein 0.0327886
SRRM2 serine/arginine repetitive matrix 2 0.0322661
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0310435
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0301137
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0299216
GOLGB1 golgin B1 0.028958
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.028726
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0282263
LASP1 LIM and SH3 protein 1 0.0279263
RPL12 ribosomal protein L12 0.026958
RPS8 ribosomal protein S8 0.026359
RAB6A RAB6A, member RAS oncogene family 0.0257515
ZNF292 zinc finger protein 292 0.0254682
SP100 SP100 nuclear antigen 0.0253714
ADIPOR2 adiponectin receptor 2 0.0248305
FAM219A family with sequence similarity 219, member A 0.0248281
USP9X ubiquitin specific peptidase 9, X-linked 0.0248124
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0244663
UNC13B unc-13 homolog B (C. elegans) 0.0240999
RPL30 ribosomal protein L30 0.0239896
RPS17 ribosomal protein S17 0.0239836
KRT86 keratin 86, type II 0.0239642
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0239428
ZSWIM6 zinc finger, SWIM-type containing 6 0.0238327
PLSCR2 phospholipid scramblase 2 0.0234836
USO1 USO1 vesicle transport factor 0.0230997
RTN3 reticulon 3 0.0226856
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0226119
ALCAM activated leukocyte cell adhesion molecule 0.0226013
SERINC3 serine incorporator 3 0.0224616
CANX calnexin 0.022404
RPL7A ribosomal protein L7a 0.0223784
HSPA8 heat shock 70kDa protein 8 0.0222441
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0221522
IFI6 interferon, alpha-inducible protein 6 0.0220798
KIF5B kinesin family member 5B 0.0216928
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0216416
RPL9 ribosomal protein L9 0.0216332
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0216151
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0214818
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0213601
RAB7A RAB7A, member RAS oncogene family 0.0213541
KIF1A kinesin family member 1A 0.0213524
GPATCH2L G patch domain containing 2-like 0.021316
PTPRK protein tyrosine phosphatase, receptor type, K 0.0208723
CSDE1 cold shock domain containing E1, RNA-binding 0.0208356
RPL31 ribosomal protein L31 0.0207892
EIF1 eukaryotic translation initiation factor 1 0.0207559
C6ORF62 chromosome 6 open reading frame 62 0.0207393
DYNLL2 dynein, light chain, LC8-type 2 0.0206225
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.020476
BPTF bromodomain PHD finger transcription factor 0.0203487
RPL7 ribosomal protein L7 0.0203307
NAP1L1 nucleosome assembly protein 1-like 1 0.0202778
FTL ferritin, light polypeptide 0.0202088
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0201919
RACK1 receptor for activated C kinase 1 0.0199564
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0197883
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0197267
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0196116
GRHL1 grainyhead-like 1 (Drosophila) 0.0193023
APLP2 amyloid beta (A4) precursor-like protein 2 0.0192948
CDK13 cyclin-dependent kinase 13 0.0191782
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.0189695
RPS2 ribosomal protein S2 0.0188653
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0188207
TRPS1 trichorhinophalangeal syndrome I 0.0187833
EGFR epidermal growth factor receptor 0.018659
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0186015
ZBTB20 zinc finger and BTB domain containing 20 0.0186003
SQSTM1 sequestosome 1 0.0185168

decreased expression

Symbol Name Standardized Value
ZMYND8 zinc finger, MYND-type containing 8 -0.122034
ACACA acetyl-CoA carboxylase alpha -0.0944784
VMP1 vacuole membrane protein 1 -0.088456
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0881254
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0566693
CCND1 cyclin D1 -0.0493131
PTMA prothymosin, alpha -0.0441635
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.043857
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -0.043582
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0429453
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0429316
SRCIN1 SRC kinase signaling inhibitor 1 -0.0399139
THSD4 thrombospondin, type I, domain containing 4 -0.0383444
NAMPT nicotinamide phosphoribosyltransferase -0.0381259
TSC22D2 TSC22 domain family, member 2 -0.0358022
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0353238
OSMR oncostatin M receptor -0.0347369
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0336166
PBX1 pre-B-cell leukemia homeobox 1 -0.0322783
S100A8 S100 calcium binding protein A8 -0.0322613
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0321945
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0321253
POTEF POTE ankyrin domain family, member F -0.0297819
LY6E lymphocyte antigen 6 complex, locus E -0.0296238
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.029153
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0278499
AHNAK AHNAK nucleoprotein -0.0277127
RBM25 RNA binding motif protein 25 -0.027509
KIAA1217 KIAA1217 -0.0272349
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0271371
BCAS1 breast carcinoma amplified sequence 1 -0.0264376
GMDS GDP-mannose 4,6-dehydratase -0.0262799
DOCK5 dedicator of cytokinesis 5 -0.0261426
ANKRD36C ankyrin repeat domain 36C -0.0251774
TMEM165 transmembrane protein 165 -0.0242324
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0238976
ITCH itchy E3 ubiquitin protein ligase -0.0238603
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0235806
SREBF2 sterol regulatory element binding transcription factor 2 -0.0235556
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0233435
S100A9 S100 calcium binding protein A9 -0.0233427
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0233012
NTN4 netrin 4 -0.0230591
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0226093
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0225554
TPD52 tumor protein D52 -0.0225098
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0222816
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0222581
APP amyloid beta (A4) precursor protein -0.0220397
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0219965
PDLIM5 PDZ and LIM domain 5 -0.0219386
ABHD17C abhydrolase domain containing 17C -0.0217511
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0216577
MYOF myoferlin -0.0214578
DYNLRB1 dynein, light chain, roadblock-type 1 -0.0214216
KRT7 keratin 7, type II -0.0210987
NT5C2 5'-nucleotidase, cytosolic II -0.0209247
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0209113
CCNI cyclin I -0.0207385
GRB7 growth factor receptor-bound protein 7 -0.0205623
MDK midkine (neurite growth-promoting factor 2) -0.0204391
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -0.0203037
NRIP1 nuclear receptor interacting protein 1 -0.0202091
MYL12B myosin, light chain 12B, regulatory -0.0201574
WSB1 WD repeat and SOCS box containing 1 -0.0199703
ELL2 elongation factor, RNA polymerase II, 2 -0.0197009
PLSCR1 phospholipid scramblase 1 -0.0196666
LDLR low density lipoprotein receptor -0.0195296
WWC1 WW and C2 domain containing 1 -0.0194838
CAB39 calcium binding protein 39 -0.0193978
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0192231
GSE1 Gse1 coiled-coil protein -0.0191941
TMC5 transmembrane channel-like 5 -0.0191877
KAZN kazrin, periplakin interacting protein -0.0189592
TOM1L1 target of myb1 (chicken)-like 1 -0.0188296
PRR11 proline rich 11 -0.0187288
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0185412
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.0183613
STAU1 staufen double-stranded RNA binding protein 1 -0.0182614
ACTG1 actin gamma 1 -0.0179798
ARHGAP29 Rho GTPase activating protein 29 -0.0179693
MYO1B myosin IB -0.0177622
SHROOM3 shroom family member 3 -0.0177376
S100A14 S100 calcium binding protein A14 -0.0177364
FADS2 fatty acid desaturase 2 -0.0176701
BCAR3 breast cancer anti-estrogen resistance 3 -0.0173239
PTK2 protein tyrosine kinase 2 -0.0172681
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0171866
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.0170752
CBX3 chromobox homolog 3 -0.0170352
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0169666
WDR45B WD repeat domain 45B -0.0169173
TENM2 teneurin transmembrane protein 2 -0.0167609
SRPK2 SRSF protein kinase 2 -0.0167222
ADAM9 ADAM metallopeptidase domain 9 -0.0163274
KLF6 Kruppel-like factor 6 -0.0162982
DENND1B DENN/MADD domain containing 1B -0.0162297
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0159758
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.01597
SDC4 syndecan 4 -0.0159126