Erdafitinib _C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erdafitinib perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erdafitinib _C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.217062
SLIT2 slit homolog 2 (Drosophila) 0.18495
TENM3 teneurin transmembrane protein 3 0.179892
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.150118
ENO1 enolase 1, (alpha) 0.137417
NEBL nebulette 0.130985
EEF2 eukaryotic translation elongation factor 2 0.130825
ZNF608 zinc finger protein 608 0.130211
SET SET nuclear proto-oncogene 0.0969083
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0951273
LDHA lactate dehydrogenase A 0.095111
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0934999
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0917453
RPS12 ribosomal protein S12 0.0914704
DST dystonin 0.0854307
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0846004
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0832397
ATP11A ATPase, class VI, type 11A 0.0811074
COL5A2 collagen, type V, alpha 2 0.0809681
RPL11 ribosomal protein L11 0.0801481
SRRM2 serine/arginine repetitive matrix 2 0.0754744
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0749448
RPS8 ribosomal protein S8 0.074309
USP9X ubiquitin specific peptidase 9, X-linked 0.0715721
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0660219
PDE4D phosphodiesterase 4D, cAMP-specific 0.064658
KTN1 kinectin 1 (kinesin receptor) 0.064584
CENPF centromere protein F, 350/400kDa 0.0644727
VCL vinculin 0.064441
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0629963
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0600313
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0587423
VMP1 vacuole membrane protein 1 0.0570806
MKI67 marker of proliferation Ki-67 0.0568987
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0565667
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0545765
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0535373
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0523041
WLS wntless Wnt ligand secretion mediator 0.0519801
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0515061
RAD51B RAD51 paralog B 0.0510743
RPL37A ribosomal protein L37a 0.0509852
HSPA8 heat shock 70kDa protein 8 0.049501
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0494234
LOC112694756 uncharaterized LOC112694756 0.0492697
NAP1L1 nucleosome assembly protein 1-like 1 0.0492532
NRDC nardilysin convertase 0.049237
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0470737
BNC2 basonuclin 2 0.0462688
MCTP1 multiple C2 domains, transmembrane 1 0.0459841
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0456455
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0450432
RCC1 regulator of chromosome condensation 1 0.044878
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0447171
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0444701
RPL7 ribosomal protein L7 0.043781
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0434332
PCBP2 poly(rC) binding protein 2 0.0428984
RPL26 ribosomal protein L26 0.0428347
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0423885
RPLP1 ribosomal protein, large, P1 0.0422586
PCNX4 pecanex 4 0.0420174
YBX1 Y box binding protein 1 0.0415896
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0415338
PRICKLE1 prickle homolog 1 (Drosophila) 0.0410572
MLIP muscular LMNA-interacting protein 0.0408244
RPL3 ribosomal protein L3 0.0405999
OSBPL10 oxysterol binding protein-like 10 0.0397838
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0396681
RPS6 ribosomal protein S6 0.0396631
RPL23 ribosomal protein L23 0.0394828
RACK1 receptor for activated C kinase 1 0.0387493
RPL30 ribosomal protein L30 0.0387286
ADGRG6 adhesion G protein-coupled receptor G6 0.0383443
RPS2 ribosomal protein S2 0.0382888
RPL31 ribosomal protein L31 0.037857
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0375497
EXT1 exostosin glycosyltransferase 1 0.0373817
SIK2 salt-inducible kinase 2 0.0372421
EEF1G eukaryotic translation elongation factor 1 gamma 0.0372062
SFPQ splicing factor proline/glutamine-rich 0.0370373
RIGI RNA sensor RIG-I 0.0369236
MCL1 myeloid cell leukemia 1 0.0365094
RPL37 ribosomal protein L37 0.0361488
IPO7 importin 7 0.0361363
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0358507
SIK3 SIK family kinase 3 0.0358204
JUN jun proto-oncogene 0.0351733
RPS17 ribosomal protein S17 0.0346678
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0346111
N4BP2L2 NEDD4 binding protein 2-like 2 0.0344017
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0342974
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0341336
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0334626
SOX5 SRY (sex determining region Y)-box 5 0.0333267
PGK1 phosphoglycerate kinase 1 0.0330628
PDIA3 protein disulfide isomerase family A, member 3 0.033056
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0328126
RPS4X ribosomal protein S4, X-linked 0.0325795
BPTF bromodomain PHD finger transcription factor 0.0325399

decreased expression

Symbol Name Standardized Value
KDM3A lysine (K)-specific demethylase 3A -0.0531713
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.041436
WDR45B WD repeat domain 45B -0.0410628
ZNF292 zinc finger protein 292 -0.0326925
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0308824
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0293857
MARCHF6 membrane associated ring-CH-type finger 6 -0.0285125
BRWD3 bromodomain and WD repeat domain containing 3 -0.0283129
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0278139
SLF1 SMC5-SMC6 complex localization factor 1 -0.0264521
KDM5B lysine (K)-specific demethylase 5B -0.0259443
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0258786
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0246472
SSBP2 single-stranded DNA binding protein 2 -0.0244873
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0244784
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0242071
ATRN attractin -0.0234278
RNF145 ring finger protein 145 -0.023331
MYL12B myosin, light chain 12B, regulatory -0.0230892
TM9SF3 transmembrane 9 superfamily member 3 -0.0229772
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0229142
USP3 ubiquitin specific peptidase 3 -0.0228917
RAP1B RAP1B, member of RAS oncogene family -0.0228305
PDS5B PDS5 cohesin associated factor B -0.022602
RNMT RNA (guanine-7-) methyltransferase -0.0225021
PNISR PNN-interacting serine/arginine-rich protein -0.0224625
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0222483
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0221539
QKI QKI, KH domain containing, RNA binding -0.0220603
OGA O-GlcNAcase -0.0217744
NAMPT nicotinamide phosphoribosyltransferase -0.0206288
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha -0.02048
BRWD1 bromodomain and WD repeat domain containing 1 -0.0202281
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0184298
LYPLA1 lysophospholipase I -0.0182105
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.018182
H1-0 H1.0 linker histone -0.017936
RNF130 ring finger protein 130 -0.0177517
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0177159
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0175987
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0173631
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0172456
TMEM263 transmembrane protein 263 -0.0172194
LPIN2 lipin 2 -0.0171253
FOXK2 forkhead box K2 -0.0170848
CD2AP CD2-associated protein -0.0170215
RBM27 RNA binding motif protein 27 -0.0169093
LUC7L LUC7-like (S. cerevisiae) -0.016859
ZC3H15 zinc finger CCCH-type containing 15 -0.0167485
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.016654
ANAPC5 anaphase promoting complex subunit 5 -0.0166048
ZFAND6 zinc finger, AN1-type domain 6 -0.0165996
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0165662
MIMS1 mitochondrial inner membrane scaffold 1 -0.0165385
RHEB Ras homolog enriched in brain -0.0165261
FAM222B family with sequence similarity 222, member B -0.0164442
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0163768
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0163522
TDRP testis development related protein -0.016274
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0162515
PGAP1 post-GPI attachment to proteins 1 -0.016129
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0160793
MIS18BP1 MIS18 binding protein 1 -0.0158398
RTN4 reticulon 4 -0.0158063
ANKRD28 ankyrin repeat domain 28 -0.0157633
SOX2 SRY (sex determining region Y)-box 2 -0.0156496
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0154678
ADAM17 ADAM metallopeptidase domain 17 -0.0151545
SREBF2 sterol regulatory element binding transcription factor 2 -0.0150076
YAF2 YY1 associated factor 2 -0.01496
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0149162
STAU1 staufen double-stranded RNA binding protein 1 -0.0149088
CAMKMT calmodulin-lysine N-methyltransferase -0.0148832
ANXA2 annexin A2 -0.0148293
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0146029
HILPDA hypoxia inducible lipid droplet-associated -0.0145904
XPO4 exportin 4 -0.0144779
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0144581
POM121 POM121 transmembrane nucleoporin -0.0144315
PTBP2 polypyrimidine tract binding protein 2 -0.0144254
ORC4 origin recognition complex, subunit 4 -0.0144136
SRPK2 SRSF protein kinase 2 -0.0143625
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 -0.0143297
KDM6A lysine (K)-specific demethylase 6A -0.0142976
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.0142967
CTTNBP2NL CTTNBP2 N-terminal like -0.0141831
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 -0.0140919
CDCA2 cell division cycle associated 2 -0.0140113
MEF2A myocyte enhancer factor 2A -0.0138723
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0138541
ARB2A ARB2 cotranscriptional regulator A -0.0138326
CSNK1E casein kinase 1, epsilon -0.0138104
CSNK1G3 casein kinase 1, gamma 3 -0.0137823
TMEM87A transmembrane protein 87A -0.0137171
RBM39 RNA binding motif protein 39 -0.0137012
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B -0.0136421
CCNL1 cyclin L1 -0.013611
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0135917
LMAN1 lectin, mannose-binding, 1 -0.0135739
LCORL ligand dependent nuclear receptor corepressor-like -0.013541