Erdafitinib _C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erdafitinib perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erdafitinib _C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.168388
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.165509
ENO1 enolase 1, (alpha) 0.159093
SFTPA2 surfactant protein A2 0.131836
LDHA lactate dehydrogenase A 0.119921
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0997635
ASPH aspartate beta-hydroxylase 0.0981572
GPC6 glypican 6 0.0859147
IGFBP5 insulin-like growth factor binding protein 5 0.0769867
EGR1 early growth response 1 0.0760686
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0741953
MACF1 microtubule-actin crosslinking factor 1 0.0731257
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0717518
DST dystonin 0.0714477
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0650713
MYH9 myosin, heavy chain 9, non-muscle 0.064977
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0641905
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0638536
EEF2 eukaryotic translation elongation factor 2 0.0627934
MCL1 myeloid cell leukemia 1 0.0622462
MT2A metallothionein 2A 0.0608871
APLP2 amyloid beta (A4) precursor-like protein 2 0.0601103
SETBP1 SET binding protein 1 0.0568627
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0561689
NAV1 neuron navigator 1 0.0520479
CALR calreticulin 0.051815
FN1 fibronectin 1 0.0514922
LRMDA leucine rich melanocyte differentiation associated 0.0510382
ACTN1 actinin, alpha 1 0.0509598
NDRG1 N-myc downstream regulated 1 0.0507542
ZSWIM6 zinc finger, SWIM-type containing 6 0.0505352
FRMD4A FERM domain containing 4A 0.0502458
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0488537
PGK1 phosphoglycerate kinase 1 0.0472193
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0463601
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0453565
RPS12 ribosomal protein S12 0.0437288
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0435078
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0426786
PKM pyruvate kinase, muscle 0.0419752
B2M beta-2-microglobulin 0.0417264
AKAP9 A kinase (PRKA) anchor protein 9 0.0415132
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0394413
IFI6 interferon, alpha-inducible protein 6 0.0392532
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0390727
CENPF centromere protein F, 350/400kDa 0.0382949
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0381965
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0378954
LEF1 lymphoid enhancer-binding factor 1 0.0369579
LPP LIM domain containing preferred translocation partner in lipoma 0.0368319
ZBTB20 zinc finger and BTB domain containing 20 0.0368153
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0366913
LOC102724023 ES1 protein homolog, mitochondrial 0.0366886
PDIA6 protein disulfide isomerase family A, member 6 0.036538
CEMIP2 cell migration inducing hyaluronidase 2 0.0364651
KTN1 kinectin 1 (kinesin receptor) 0.0358104
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0356586
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0353322
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0349993
SEPTIN9 septin 9 0.0349083
UTRN utrophin 0.034675
EXOC4 exocyst complex component 4 0.0346263
BACE2 beta-site APP-cleaving enzyme 2 0.0342976
TPM3 tropomyosin 3 0.0338657
SMYD3 SET and MYND domain containing 3 0.0337691
BHLHE40 basic helix-loop-helix family, member e40 0.0329293
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0329126
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0326301
SRRM2 serine/arginine repetitive matrix 2 0.0324007
PRELID2 PRELI domain containing 2 0.0323935
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0322798
LGALS3 lectin, galactoside-binding, soluble, 3 0.0317186
JUN jun proto-oncogene 0.031581
OSBPL10 oxysterol binding protein-like 10 0.0314644
CLIC4 chloride intracellular channel 4 0.0312744
ATXN1 ataxin 1 0.0311539
MLEC malectin 0.0308282
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0306102
TLE4 transducin-like enhancer of split 4 0.0305826
SET SET nuclear proto-oncogene 0.0305191
BRD2 bromodomain containing 2 0.0304804
EFNA5 ephrin-A5 0.0296552
CHD9 chromodomain helicase DNA binding protein 9 0.0293877
UBASH3B ubiquitin associated and SH3 domain containing B 0.0291457
ANXA2 annexin A2 0.0291251
TAGLN2 transgelin 2 0.0287493
INTS6 integrator complex subunit 6 0.0285662
ANK2 ankyrin 2, neuronal 0.0285156
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0283876
DOCK4 dedicator of cytokinesis 4 0.0283576
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0280649
NAP1L1 nucleosome assembly protein 1-like 1 0.0275217
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0273906
LGALS1 lectin, galactoside-binding, soluble, 1 0.0273605
USP9X ubiquitin specific peptidase 9, X-linked 0.0272246
MKI67 marker of proliferation Ki-67 0.0272219
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0272117
WNK1 WNK lysine deficient protein kinase 1 0.027131
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0266571
FLNB filamin B, beta 0.0265498

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.09898
NAMPT nicotinamide phosphoribosyltransferase -0.0820287
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0810297
WSB1 WD repeat and SOCS box containing 1 -0.059464
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0557019
IFI16 interferon, gamma-inducible protein 16 -0.052684
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0524087
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0486516
RNF145 ring finger protein 145 -0.0483965
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0466417
CHSY1 chondroitin sulfate synthase 1 -0.0451951
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.04474
RHEB Ras homolog enriched in brain -0.0435576
FOXJ3 forkhead box J3 -0.0415042
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0411359
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0398649
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0388984
TMEM123 transmembrane protein 123 -0.0379842
WDR45B WD repeat domain 45B -0.0370667
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0369388
OGA O-GlcNAcase -0.0343081
ZNF292 zinc finger protein 292 -0.0341236
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.03397
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0336946
IER3 immediate early response 3 -0.0329367
CDC73 cell division cycle 73 -0.0327823
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0311602
HILPDA hypoxia inducible lipid droplet-associated -0.0310077
GDF15 growth differentiation factor 15 -0.0297192
FAM162A family with sequence similarity 162, member A -0.029138
CD109 CD109 molecule -0.0277491
USP3 ubiquitin specific peptidase 3 -0.0277281
SCFD2 sec1 family domain containing 2 -0.0267722
KMT2E lysine (K)-specific methyltransferase 2E -0.0257529
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0240929
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0240419
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0237887
RBM39 RNA binding motif protein 39 -0.0237541
SSBP2 single-stranded DNA binding protein 2 -0.0236977
RHOA ras homolog family member A -0.0231361
HBP1 HMG-box transcription factor 1 -0.0231271
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0226184
PTMA prothymosin, alpha -0.0224462
ZC3H7A zinc finger CCCH-type containing 7A -0.0222039
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0220952
NPEPPS aminopeptidase puromycin sensitive -0.0219725
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0218954
PTPRD protein tyrosine phosphatase, receptor type, D -0.0217595
TNNC1 troponin C type 1 (slow) -0.0216043
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0215044
PXMP2 peroxisomal membrane protein 2, 22kDa -0.0214617
RNF24 ring finger protein 24 -0.0213924
TMEM263 transmembrane protein 263 -0.0212258
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0212005
INSIG2 insulin induced gene 2 -0.0208829
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0207406
MEF2A myocyte enhancer factor 2A -0.0205012
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0203128
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0202558
PHF21A PHD finger protein 21A -0.0200855
POM121 POM121 transmembrane nucleoporin -0.020061
RBM33 RNA binding motif protein 33 -0.0198625
TRIM2 tripartite motif containing 2 -0.0198191
GHR growth hormone receptor -0.0196743
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0193371
COL19A1 collagen, type XIX, alpha 1 -0.0191708
ZMYND8 zinc finger, MYND-type containing 8 -0.018882
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0188594
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0185056
PNISR PNN-interacting serine/arginine-rich protein -0.018233
MT1X metallothionein 1X -0.0179971
PTK2 protein tyrosine kinase 2 -0.0179386
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0178659
NOP58 NOP58 ribonucleoprotein -0.0176381
FIP1L1 factor interacting with PAPOLA and CPSF1 -0.0176194
SEC24B SEC24 family member B -0.0175352
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0173702
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 -0.0171712
PI15 peptidase inhibitor 15 -0.0170729
GARS1 glycyl-tRNA synthetase 1 -0.016939
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0168721
PRRC1 proline-rich coiled-coil 1 -0.0168505
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0166577
NDFIP1 Nedd4 family interacting protein 1 -0.0166266
RPS24 ribosomal protein S24 -0.0166129
CDK19 cyclin-dependent kinase 19 -0.0166044
SMAP2 small ArfGAP2 -0.0165367
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0164232
MTF2 metal response element binding transcription factor 2 -0.0162334
MIMS1 mitochondrial inner membrane scaffold 1 -0.016123
GPNMB glycoprotein (transmembrane) nmb -0.0155444
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0154943
ANAPC5 anaphase promoting complex subunit 5 -0.0154471
CALD1 caldesmon 1 -0.0153655
SRPK2 SRSF protein kinase 2 -0.0153089
NPR2 natriuretic peptide receptor 2 -0.015224
PYGB phosphorylase, glycogen; brain -0.0150849
ODR4 odr-4 GPCR localization factor homolog -0.0150076
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 -0.0149174
BMPR1A bone morphogenetic protein receptor, type IA -0.0148627