Erdafitinib _CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erdafitinib perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erdafitinib _CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.178339
IGF2 insulin-like growth factor 2 0.0971865
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0889827
EEF2 eukaryotic translation elongation factor 2 0.0847637
NDRG1 N-myc downstream regulated 1 0.0838953
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0832381
RPL23 ribosomal protein L23 0.082974
EIF1 eukaryotic translation initiation factor 1 0.082231
NALF1 NALCN channel auxiliary factor 1 0.0791917
FMN1 formin 1 0.0787829
SLIT2 slit homolog 2 (Drosophila) 0.0776617
RPS12 ribosomal protein S12 0.0776507
RPL37A ribosomal protein L37a 0.0759984
TRIO trio Rho guanine nucleotide exchange factor 0.0717646
ZSWIM6 zinc finger, SWIM-type containing 6 0.0690862
SET SET nuclear proto-oncogene 0.0674361
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0650267
RPS3 ribosomal protein S3 0.0646962
PDE10A phosphodiesterase 10A 0.0626291
RPL26 ribosomal protein L26 0.0599757
RPL35A ribosomal protein L35a 0.0597896
RACK1 receptor for activated C kinase 1 0.0573599
TLE4 transducin-like enhancer of split 4 0.0542587
RPS19 ribosomal protein S19 0.0523051
RPL7 ribosomal protein L7 0.0522388
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0516915
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0514026
EGR1 early growth response 1 0.0510306
MYH9 myosin, heavy chain 9, non-muscle 0.0506026
BPTF bromodomain PHD finger transcription factor 0.0499642
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0499346
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.049322
LDHA lactate dehydrogenase A 0.0484157
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0483677
KLHL13 kelch-like family member 13 0.048202
B2M beta-2-microglobulin 0.0481711
SFTPA2 surfactant protein A2 0.0475542
FAM107B family with sequence similarity 107, member B 0.0472325
CENPF centromere protein F, 350/400kDa 0.0470899
RPS8 ribosomal protein S8 0.0469277
PGK1 phosphoglycerate kinase 1 0.0468531
FTL ferritin, light polypeptide 0.0450936
MCL1 myeloid cell leukemia 1 0.0449727
RPL19 ribosomal protein L19 0.0445108
THBS1 thrombospondin 1 0.04399
RPS2 ribosomal protein S2 0.0432216
TPI1 triosephosphate isomerase 1 0.042651
RPL7A ribosomal protein L7a 0.0416713
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.041213
COL4A2 collagen, type IV, alpha 2 0.0409992
MAP1B microtubule-associated protein 1B 0.040726
PCBP2 poly(rC) binding protein 2 0.0406956
RPS27A ribosomal protein S27a 0.040426
ASPH aspartate beta-hydroxylase 0.0400451
FERMT2 fermitin family member 2 0.039888
ANTXR1 anthrax toxin receptor 1 0.0398388
DST dystonin 0.0397467
TMSB10 thymosin beta 10 0.0394211
NAP1L1 nucleosome assembly protein 1-like 1 0.0384981
RPS27 ribosomal protein S27 0.0382465
SQSTM1 sequestosome 1 0.0382444
PRRC2C proline-rich coiled-coil 2C 0.0381308
ITGA1 integrin, alpha 1 0.0379948
ENO1 enolase 1, (alpha) 0.0372087
CSDE1 cold shock domain containing E1, RNA-binding 0.036986
APLP2 amyloid beta (A4) precursor-like protein 2 0.0365799
KTN1 kinectin 1 (kinesin receptor) 0.0365259
CSNK1A1 casein kinase 1, alpha 1 0.0365193
TBC1D5 TBC1 domain family, member 5 0.0357585
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0356919
NFE2L1 nuclear factor, erythroid 2-like 1 0.0355346
RAD51B RAD51 paralog B 0.035094
RPS25 ribosomal protein S25 0.035086
RPL3 ribosomal protein L3 0.0350676
RPS17 ribosomal protein S17 0.0347465
RPL36 ribosomal protein L36 0.0342433
NFIB nuclear factor I/B 0.0340479
VCL vinculin 0.0339914
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0339135
RPL37 ribosomal protein L37 0.0336333
RPL30 ribosomal protein L30 0.0332897
DUSP10 dual specificity phosphatase 10 0.0328748
FTH1 ferritin, heavy polypeptide 1 0.0328561
RPS14 ribosomal protein S14 0.0328514
LRP1B low density lipoprotein receptor-related protein 1B 0.032738
PLPP1 phospholipid phosphatase 1 0.0326952
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0325835
EGFR epidermal growth factor receptor 0.0322795
THSD4 thrombospondin, type I, domain containing 4 0.0317431
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0316721
PTPRK protein tyrosine phosphatase, receptor type, K 0.0316565
MKI67 marker of proliferation Ki-67 0.0311624
AOPEP aminopeptidase O (putative) 0.031013
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0307268
DOCK5 dedicator of cytokinesis 5 0.0306952
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0306785
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0306123
SLITRK6 SLIT and NTRK-like family, member 6 0.0306096
S100A9 S100 calcium binding protein A9 0.0305132
HSPA8 heat shock 70kDa protein 8 0.030513

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.112507
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0901315
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0891909
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0792659
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0749461
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0731746
LPIN1 lipin 1 -0.052756
LSAMP limbic system-associated membrane protein -0.0526403
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0483911
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0467844
WDR45B WD repeat domain 45B -0.0465271
SYT1 synaptotagmin I -0.0438415
ATRNL1 attractin-like 1 -0.0422909
AHR aryl hydrocarbon receptor -0.0421699
RPTOR regulatory associated protein of MTOR, complex 1 -0.0417704
SEC31A SEC31 homolog A (S. cerevisiae) -0.0400331
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0392967
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.038038
DTNA dystrobrevin, alpha -0.0372975
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0371751
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0368931
DPH6 diphthamine biosynthesis 6 -0.0368607
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0367269
HELZ helicase with zinc finger -0.0365688
TENT5A terminal nucleotidyltransferase 5A -0.0356594
LIMCH1 LIM and calponin homology domains 1 -0.0350003
PTK2 protein tyrosine kinase 2 -0.0343021
MSI2 musashi RNA-binding protein 2 -0.0337423
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0334778
FBXL20 F-box and leucine-rich repeat protein 20 -0.032879
SETD5 SET domain containing 5 -0.0318401
IGF1R insulin-like growth factor 1 receptor -0.0313663
CALD1 caldesmon 1 -0.0305875
HAND2 heart and neural crest derivatives expressed 2 -0.0302987
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0301684
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0291108
AUTS2 autism susceptibility candidate 2 -0.0288083
ACTG1 actin gamma 1 -0.0287436
PRKG1 protein kinase, cGMP-dependent, type I -0.0279976
SEPTIN2 septin 2 -0.0277345
RPS24 ribosomal protein S24 -0.0272187
ZNF804A zinc finger protein 804A -0.0268998
ZNF124 zinc finger protein 124 -0.0265614
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0264695
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0263239
ZMYM2 zinc finger, MYM-type 2 -0.0261289
NBEA neurobeachin -0.0261263
ANKRD17 ankyrin repeat domain 17 -0.0253926
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0249929
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0249576
FNDC3B fibronectin type III domain containing 3B -0.0247448
HIP1 huntingtin interacting protein 1 -0.0247072
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0245969
GPC6 glypican 6 -0.024213
MDM4 MDM4, p53 regulator -0.0241893
LCORL ligand dependent nuclear receptor corepressor-like -0.0241829
GOSR1 golgi SNAP receptor complex member 1 -0.0240461
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0239088
COL18A1 collagen, type XVIII, alpha 1 -0.0238898
SF3B3 splicing factor 3b, subunit 3, 130kDa -0.023877
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0237683
CFDP1 craniofacial development protein 1 -0.0235768
CCNI cyclin I -0.023376
RANBP17 RAN binding protein 17 -0.0230311
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0229723
TCERG1 transcription elongation regulator 1 -0.0229414
IARS1 isoleucyl-tRNA synthetase 1 -0.0229204
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0228674
ACBD6 acyl-CoA binding domain containing 6 -0.0227272
SNX13 sorting nexin 13 -0.0226156
PIBF1 progesterone immunomodulatory binding factor 1 -0.0225741
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0225084
FNBP1 formin binding protein 1 -0.0224544
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0222796
YEATS2 YEATS domain containing 2 -0.0218533
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0216515
WSB1 WD repeat and SOCS box containing 1 -0.021651
FKBP10 FK506 binding protein 10, 65 kDa -0.0216024
SLC39A10 solute carrier family 39 (zinc transporter), member 10 -0.0214122
ANKRD28 ankyrin repeat domain 28 -0.0213293
BZW1 basic leucine zipper and W2 domains 1 -0.0211316
PLCB4 phospholipase C, beta 4 -0.0210229
TFB1M transcription factor B1, mitochondrial -0.0209854
PCNX4 pecanex 4 -0.0209651
MCPH1 microcephalin 1 -0.0209416
H3-3B H3.3 histone B -0.0206641
DLC1 DLC1 Rho GTPase activating protein -0.0206436
TNRC6B trinucleotide repeat containing 6B -0.0205289
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0204367
ATM ATM serine/threonine kinase -0.020298
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0200104
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0199424
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0199312
ATXN2 ataxin 2 -0.0197123
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0196811
COPB1 coatomer protein complex, subunit beta 1 -0.0196591
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0196428
NSD3 nuclear receptor binding SET domain protein 3 -0.0194125
CDC27 cell division cycle 27 -0.0191687
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0190586