| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Erdafitinib perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Erdafitinib _HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.230834 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.143377 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.121808 |
| ENO1 | enolase 1, (alpha) | 0.114881 |
| LDHA | lactate dehydrogenase A | 0.113636 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.110479 |
| SET | SET nuclear proto-oncogene | 0.103576 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0999503 |
| SMAD3 | SMAD family member 3 | 0.0922241 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0916222 |
| RPS12 | ribosomal protein S12 | 0.0774898 |
| ASPH | aspartate beta-hydroxylase | 0.0758711 |
| MKI67 | marker of proliferation Ki-67 | 0.0721185 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0631017 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0622678 |
| B2M | beta-2-microglobulin | 0.0612072 |
| TPM3 | tropomyosin 3 | 0.0578132 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0572903 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0564949 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0556921 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0543964 |
| PAX8 | paired box 8 | 0.0537075 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0523352 |
| APP | amyloid beta (A4) precursor protein | 0.0515314 |
| MACROD2 | MACRO domain containing 2 | 0.0504472 |
| MT2A | metallothionein 2A | 0.0503916 |
| RPL3 | ribosomal protein L3 | 0.0499305 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0491041 |
| SCRN1 | secernin 1 | 0.0480757 |
| SFTPA2 | surfactant protein A2 | 0.0476255 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0471932 |
| ITGB8 | integrin, beta 8 | 0.047057 |
| ANXA1 | annexin A1 | 0.0466955 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0466064 |
| RPL23 | ribosomal protein L23 | 0.0463348 |
| TXNRD1 | thioredoxin reductase 1 | 0.0457099 |
| RPS2 | ribosomal protein S2 | 0.0449444 |
| FLNA | filamin A, alpha | 0.04435 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0442211 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0441746 |
| SLTM | SAFB-like, transcription modulator | 0.043858 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0432457 |
| ACTN4 | actinin, alpha 4 | 0.0423846 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0417875 |
| PCBP2 | poly(rC) binding protein 2 | 0.0415831 |
| SVIL | supervillin | 0.0410768 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0410081 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0405223 |
| PRELID2 | PRELI domain containing 2 | 0.0397685 |
| YBX1 | Y box binding protein 1 | 0.0396799 |
| DIAPH1 | diaphanous-related formin 1 | 0.0395414 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.039224 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0391679 |
| CENPF | centromere protein F, 350/400kDa | 0.0389834 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0384866 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0383932 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0382124 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0381918 |
| RPL7 | ribosomal protein L7 | 0.0381679 |
| ANXA11 | annexin A11 | 0.0377893 |
| RPS19 | ribosomal protein S19 | 0.0371033 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0370473 |
| DSPP | dentin sialophosphoprotein | 0.0364819 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0359141 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0352603 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0351988 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0351914 |
| ECT2 | epithelial cell transforming 2 | 0.0345956 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0344443 |
| RPS4X | ribosomal protein S4, X-linked | 0.0339276 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0338253 |
| RPS3 | ribosomal protein S3 | 0.0332348 |
| RPL26 | ribosomal protein L26 | 0.0329843 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0325914 |
| RPL11 | ribosomal protein L11 | 0.0323701 |
| FAT1 | FAT atypical cadherin 1 | 0.0320236 |
| IPO7 | importin 7 | 0.0316957 |
| LAMC2 | laminin, gamma 2 | 0.0315852 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0307093 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0302811 |
| RPS17 | ribosomal protein S17 | 0.0296246 |
| ANLN | anillin, actin binding protein | 0.0294971 |
| RPL12 | ribosomal protein L12 | 0.0294832 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0294355 |
| ANXA3 | annexin A3 | 0.0293846 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0292064 |
| RPL30 | ribosomal protein L30 | 0.0292021 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0289881 |
| RND3 | Rho family GTPase 3 | 0.028808 |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 0.0286714 |
| TPI1 | triosephosphate isomerase 1 | 0.0285412 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0281966 |
| RUNX1 | runt-related transcription factor 1 | 0.0281459 |
| RPL35A | ribosomal protein L35a | 0.0278647 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0277485 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0276943 |
| PKM | pyruvate kinase, muscle | 0.0276844 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0268222 |
| RPS27 | ribosomal protein S27 | 0.0267466 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0267097 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.295208 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.230057 |
| AHNAK | AHNAK nucleoprotein | -0.119457 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0954488 |
| ACTG1 | actin gamma 1 | -0.0918226 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0873289 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.083199 |
| CCND1 | cyclin D1 | -0.0792009 |
| PTMA | prothymosin, alpha | -0.057723 |
| WDR45B | WD repeat domain 45B | -0.0497564 |
| RPS6 | ribosomal protein S6 | -0.0465644 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0404903 |
| HMGA1 | high mobility group AT-hook 1 | -0.0387275 |
| RPS24 | ribosomal protein S24 | -0.0385324 |
| TPM4 | tropomyosin 4 | -0.0380966 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0375617 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0362872 |
| TMSB10 | thymosin beta 10 | -0.0353016 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0349768 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0347306 |
| NF1 | neurofibromin 1 | -0.0346482 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0345814 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0338096 |
| CDCP1 | CUB domain containing protein 1 | -0.0330862 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0326077 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0324938 |
| KRT7 | keratin 7, type II | -0.0322472 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0321041 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0304836 |
| ANXA2 | annexin A2 | -0.0304013 |
| RTN3 | reticulon 3 | -0.0293157 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.0292415 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0292207 |
| TUBB | tubulin, beta class I | -0.029151 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0279272 |
| H1-0 | H1.0 linker histone | -0.0278068 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0277439 |
| VCAN | versican | -0.0276263 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0271301 |
| MAP4 | microtubule-associated protein 4 | -0.0268006 |
| ZNF609 | zinc finger protein 609 | -0.026525 |
| CD2AP | CD2-associated protein | -0.0256269 |
| SEC24D | SEC24 family member D | -0.0252628 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0251293 |
| ATG7 | autophagy related 7 | -0.0245508 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0241163 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0238979 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.023756 |
| TUBA1B | tubulin, alpha 1b | -0.0232882 |
| RPL38 | ribosomal protein L38 | -0.0231554 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0228697 |
| CLDN1 | claudin 1 | -0.0226453 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0224929 |
| IER3 | immediate early response 3 | -0.0224419 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0222282 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0221709 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0212742 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0208116 |
| WASF2 | WAS protein family, member 2 | -0.0205833 |
| MTDH | metadherin | -0.0205111 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0204469 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | -0.0202951 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | -0.020209 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0201851 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0201646 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0199973 |
| GPATCH8 | G patch domain containing 8 | -0.0199236 |
| SBF2 | SET binding factor 2 | -0.0197804 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0197246 |
| FUS | FUS RNA binding protein | -0.019261 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0192268 |
| SETD5 | SET domain containing 5 | -0.0192055 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0191971 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0191563 |
| EMP1 | epithelial membrane protein 1 | -0.0191504 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0189067 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0189005 |
| LASP1 | LIM and SH3 protein 1 | -0.0185866 |
| RPS15 | ribosomal protein S15 | -0.0185183 |
| HDLBP | high density lipoprotein binding protein | -0.0184273 |
| HM13 | histocompatibility (minor) 13 | -0.0183947 |
| RPL6 | ribosomal protein L6 | -0.0181878 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0181317 |
| KRT19 | keratin 19, type I | -0.0179362 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0179311 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0179308 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.0177923 |
| RPL34 | ribosomal protein L34 | -0.0177829 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0176638 |
| CCNI | cyclin I | -0.0176574 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.017636 |
| S100A6 | S100 calcium binding protein A6 | -0.01763 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0174852 |
| DPP4 | dipeptidyl-peptidase 4 | -0.0173536 |
| LARP1B | La ribonucleoprotein domain family, member 1B | -0.0172682 |
| ENOSF1 | enolase superfamily member 1 | -0.0172251 |
| ZMYM4 | zinc finger, MYM-type 4 | -0.0171727 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0171401 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0170981 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0170731 |
