Erdafitinib _HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erdafitinib perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erdafitinib _HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.168601
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.159035
MT2A metallothionein 2A 0.153915
NDRG1 N-myc downstream regulated 1 0.134392
ENO1 enolase 1, (alpha) 0.123931
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.107176
LDHA lactate dehydrogenase A 0.0968868
VIM vimentin 0.0900958
RPL12 ribosomal protein L12 0.0892667
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0832506
RPS12 ribosomal protein S12 0.0825216
RPS8 ribosomal protein S8 0.0723848
TIMP1 TIMP metallopeptidase inhibitor 1 0.071738
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0707813
ERRFI1 ERBB receptor feedback inhibitor 1 0.0688403
EIF1 eukaryotic translation initiation factor 1 0.0675523
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0632602
RPLP1 ribosomal protein, large, P1 0.0630742
RPL35A ribosomal protein L35a 0.0599289
EEF2 eukaryotic translation elongation factor 2 0.0587197
STC1 stanniocalcin 1 0.0563514
MCL1 myeloid cell leukemia 1 0.0562168
RPL11 ribosomal protein L11 0.0545943
NAP1L1 nucleosome assembly protein 1-like 1 0.0545637
RPL23 ribosomal protein L23 0.0545313
FTL ferritin, light polypeptide 0.0542815
RPL30 ribosomal protein L30 0.0527668
RACK1 receptor for activated C kinase 1 0.0497986
RPL37A ribosomal protein L37a 0.0497243
CXCL8 chemokine (C-X-C motif) ligand 8 0.0488601
RPS3 ribosomal protein S3 0.0477417
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0475929
COL6A3 collagen, type VI, alpha 3 0.0471957
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0462211
SFTPA2 surfactant protein A2 0.046157
RPL26 ribosomal protein L26 0.0461209
RPS17 ribosomal protein S17 0.0449118
THBS1 thrombospondin 1 0.0436406
RPL7 ribosomal protein L7 0.0433357
HSPA8 heat shock 70kDa protein 8 0.0430419
RPS19 ribosomal protein S19 0.0424622
RPL9 ribosomal protein L9 0.0424234
RPL31 ribosomal protein L31 0.0423417
PDIA6 protein disulfide isomerase family A, member 6 0.0422114
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0413033
TPT1 tumor protein, translationally-controlled 1 0.0408469
RPLP0 ribosomal protein, large, P0 0.0388572
PGK1 phosphoglycerate kinase 1 0.0380344
PKM pyruvate kinase, muscle 0.0376669
ANGPTL4 angiopoietin-like 4 0.0365655
TMEM117 transmembrane protein 117 0.0364363
RPL37 ribosomal protein L37 0.0363351
RPS27A ribosomal protein S27a 0.0362569
RPS20 ribosomal protein S20 0.0355139
LOC112694756 uncharaterized LOC112694756 0.0347253
CD44 CD44 molecule (Indian blood group) 0.0336502
RPS13 ribosomal protein S13 0.0336102
RPS4X ribosomal protein S4, X-linked 0.0336075
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0328717
YBX1 Y box binding protein 1 0.0327664
B2M beta-2-microglobulin 0.0322222
IER3 immediate early response 3 0.0318114
EGR1 early growth response 1 0.031573
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.030855
RPS2 ribosomal protein S2 0.0306204
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0297381
SET SET nuclear proto-oncogene 0.0295053
RPS27 ribosomal protein S27 0.0288875
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0286104
RPL10A ribosomal protein L10a 0.028579
BHLHE40 basic helix-loop-helix family, member e40 0.0276001
PCBP2 poly(rC) binding protein 2 0.0269668
FTH1 ferritin, heavy polypeptide 1 0.0265622
MT1E metallothionein 1E 0.0265491
RPL19 ribosomal protein L19 0.0259101
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0258586
PDE10A phosphodiesterase 10A 0.0258565
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0253684
DDIT4 DNA-damage-inducible transcript 4 0.0253596
SQSTM1 sequestosome 1 0.0250337
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0246029
RPL3 ribosomal protein L3 0.0244268
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0239016
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0238499
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.023571
SRRM2 serine/arginine repetitive matrix 2 0.0232978
RPS25 ribosomal protein S25 0.0232471
CENPF centromere protein F, 350/400kDa 0.0231408
EEF1G eukaryotic translation elongation factor 1 gamma 0.0229376
TMED2 transmembrane emp24 domain trafficking protein 2 0.0228312
RPL15 ribosomal protein L15 0.0227925
RPS16 ribosomal protein S16 0.0224056
INTS6 integrator complex subunit 6 0.0220767
KTN1 kinectin 1 (kinesin receptor) 0.0220548
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0217432
NUP58 nucleoporin 58 0.021688
RPS6 ribosomal protein S6 0.0215319
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0214509
GLRX glutaredoxin (thioltransferase) 0.021053
MYH9 myosin, heavy chain 9, non-muscle 0.020985

decreased expression

Symbol Name Standardized Value
CDH13 cadherin 13 -0.183217
FN1 fibronectin 1 -0.179426
MYO10 myosin X -0.118963
COL6A1 collagen, type VI, alpha 1 -0.115324
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.108451
COL5A1 collagen, type V, alpha 1 -0.105247
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.104023
AHNAK AHNAK nucleoprotein -0.0944836
GLIS3 GLIS family zinc finger 3 -0.0942746
IGF2 insulin-like growth factor 2 -0.090289
COL6A2 collagen, type VI, alpha 2 -0.0859212
NAV1 neuron navigator 1 -0.0850217
VCL vinculin -0.0828789
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0768756
EXT1 exostosin glycosyltransferase 1 -0.0765269
TENM2 teneurin transmembrane protein 2 -0.075319
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0675071
MAML3 mastermind-like 3 (Drosophila) -0.0640917
ZBTB20 zinc finger and BTB domain containing 20 -0.0608554
HMGA2 high mobility group AT-hook 2 -0.0596084
FMN1 formin 1 -0.0591054
RRBP1 ribosome binding protein 1 -0.0588219
FNDC3B fibronectin type III domain containing 3B -0.0578273
PRKCA protein kinase C, alpha -0.0551851
NALF1 NALCN channel auxiliary factor 1 -0.0537107
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0530558
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0529897
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0529165
CLMP CXADR-like membrane protein -0.0525331
COL1A1 collagen, type I, alpha 1 -0.0525107
PTK2 protein tyrosine kinase 2 -0.0492518
ACTG1 actin gamma 1 -0.0475955
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0463435
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0450897
TUBB6 tubulin, beta 6 class V -0.0446104
GRB10 growth factor receptor-bound protein 10 -0.0442074
RAI14 retinoic acid induced 14 -0.0441773
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0440297
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0438131
PRELID2 PRELI domain containing 2 -0.0438015
MAP4 microtubule-associated protein 4 -0.0423534
COL7A1 collagen, type VII, alpha 1 -0.0422715
IGF1R insulin-like growth factor 1 receptor -0.0418794
SBF2 SET binding factor 2 -0.0414493
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.040746
KIAA1549L KIAA1549-like -0.0397783
CUX1 cut-like homeobox 1 -0.0394329
EFNA5 ephrin-A5 -0.0389232
DIAPH2 diaphanous-related formin 2 -0.0388551
MSN moesin -0.0385394
TAS2R14 taste receptor, type 2, member 14 -0.0384494
TMSB10 thymosin beta 10 -0.0382405
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0381574
CCDC91 coiled-coil domain containing 91 -0.0380834
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0376441
RAD51B RAD51 paralog B -0.0369359
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0362664
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.036075
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0357768
TNNC1 troponin C type 1 (slow) -0.0356179
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0349666
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0349315
SDK1 sidekick cell adhesion molecule 1 -0.034906
CDK14 cyclin-dependent kinase 14 -0.0346539
PTPRG protein tyrosine phosphatase, receptor type, G -0.0343852
ATXN1 ataxin 1 -0.0342796
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0340765
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0335464
IGFBP4 insulin-like growth factor binding protein 4 -0.0325726
CALD1 caldesmon 1 -0.0321547
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0317165
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0317129
CAPN2 calpain 2, (m/II) large subunit -0.0317099
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0311904
LIMCH1 LIM and calponin homology domains 1 -0.0309728
DIAPH3 diaphanous-related formin 3 -0.0305481
SH3RF3 SH3 domain containing ring finger 3 -0.030309
SAMD4A sterile alpha motif domain containing 4A -0.0301932
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -0.0298609
MBD5 methyl-CpG binding domain protein 5 -0.0298152
ACTN4 actinin, alpha 4 -0.0297604
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0295275
RIN2 Ras and Rab interactor 2 -0.0294886
TPM1 tropomyosin 1 (alpha) -0.0293985
TRIO trio Rho guanine nucleotide exchange factor -0.0290496
FLNB filamin B, beta -0.0290106
NCOR2 nuclear receptor corepressor 2 -0.0289547
KIRREL3 kin of IRRE like 3 (Drosophila) -0.0287698
P4HB prolyl 4-hydroxylase, beta polypeptide -0.028609
SETD5 SET domain containing 5 -0.0282442
ACTN1 actinin, alpha 1 -0.0277312
ABLIM3 actin binding LIM protein family, member 3 -0.0276043
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0275881
NF1 neurofibromin 1 -0.027511
PLS3 plastin 3 -0.0273454
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0272153
ETV6 ets variant 6 -0.0271106
WDFY2 WD repeat and FYVE domain containing 2 -0.0270932
RTN4 reticulon 4 -0.0266601
DNER delta/notch-like EGF repeat containing -0.0263005