Erdafitinib _HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erdafitinib perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erdafitinib _HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.311659
NDRG1 N-myc downstream regulated 1 0.189832
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.151302
CD44 CD44 molecule (Indian blood group) 0.137387
LDHA lactate dehydrogenase A 0.114001
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0977624
ENO1 enolase 1, (alpha) 0.0960373
CALR calreticulin 0.0889963
MYH9 myosin, heavy chain 9, non-muscle 0.087358
ASPH aspartate beta-hydroxylase 0.0867302
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0755173
MT2A metallothionein 2A 0.0746037
EGFR epidermal growth factor receptor 0.0679479
CDH13 cadherin 13 0.0631751
EEF2 eukaryotic translation elongation factor 2 0.0628801
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.059541
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0487263
EXT1 exostosin glycosyltransferase 1 0.0477798
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0469361
TGFBI transforming growth factor, beta-induced, 68kDa 0.046853
VEGFA vascular endothelial growth factor A 0.0461954
PDIA6 protein disulfide isomerase family A, member 6 0.0445841
DST dystonin 0.044398
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0433109
JARID2 jumonji, AT rich interactive domain 2 0.0421724
NAV1 neuron navigator 1 0.0412504
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0392421
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0373327
EGR1 early growth response 1 0.0370275
DPYSL2 dihydropyrimidinase-like 2 0.0365271
LIMS1 LIM and senescent cell antigen-like domains 1 0.0363411
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0360686
VCAN versican 0.0355695
B2M beta-2-microglobulin 0.0350498
ATXN1 ataxin 1 0.0344473
ZBTB38 zinc finger and BTB domain containing 38 0.0343126
HDAC9 histone deacetylase 9 0.0334309
RPS19 ribosomal protein S19 0.032938
RND3 Rho family GTPase 3 0.0326813
RPS8 ribosomal protein S8 0.0326257
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0318175
GPC6 glypican 6 0.0308403
IFI6 interferon, alpha-inducible protein 6 0.0306142
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0292273
NFE2L1 nuclear factor, erythroid 2-like 1 0.0289263
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0286082
ALCAM activated leukocyte cell adhesion molecule 0.0285304
GOLGB1 golgin B1 0.0283675
CTSB cathepsin B 0.0283202
IL6ST interleukin 6 signal transducer 0.0279089
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0278517
HIPK2 homeodomain interacting protein kinase 2 0.0274907
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0270643
IGFBP7 insulin-like growth factor binding protein 7 0.0265202
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0263191
CALD1 caldesmon 1 0.025901
SAMD9 sterile alpha motif domain containing 9 0.0257015
MBNL1 muscleblind-like splicing regulator 1 0.0256608
F3 coagulation factor III (thromboplastin, tissue factor) 0.0255242
RPL7 ribosomal protein L7 0.0253893
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0250184
KTN1 kinectin 1 (kinesin receptor) 0.0248867
ANO6 anoctamin 6 0.0247595
INHBA inhibin, beta A 0.0246186
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0243315
DOCK7 dedicator of cytokinesis 7 0.0240395
PGK1 phosphoglycerate kinase 1 0.0239291
CRYBG3 beta-gamma crystallin domain containing 3 0.0238257
PSD3 pleckstrin and Sec7 domain containing 3 0.0237627
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0236838
CLTC clathrin, heavy chain (Hc) 0.023333
VIM vimentin 0.023059
PDIA3 protein disulfide isomerase family A, member 3 0.0230327
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0227043
SFTPA2 surfactant protein A2 0.0224648
RPL23 ribosomal protein L23 0.0224431
HSPA8 heat shock 70kDa protein 8 0.0223285
WWTR1 WW domain containing transcription regulator 1 0.0220517
USP9X ubiquitin specific peptidase 9, X-linked 0.0211031
TMSB10 thymosin beta 10 0.0209397
SQSTM1 sequestosome 1 0.0209088
ECE1 endothelin converting enzyme 1 0.0208507
ANXA1 annexin A1 0.0208219
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0206714
NLRP1 NLR family, pyrin domain containing 1 0.0203647
MSN moesin 0.0203265
RPS17 ribosomal protein S17 0.0202278
SRRM2 serine/arginine repetitive matrix 2 0.0197158
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0196723
IPO7 importin 7 0.0195316
RPS12 ribosomal protein S12 0.0195293
MACF1 microtubule-actin crosslinking factor 1 0.019417
GLIS3 GLIS family zinc finger 3 0.0193751
RPL30 ribosomal protein L30 0.0191496
BTBD9 BTB (POZ) domain containing 9 0.0189368
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.018932
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.018838
FNDC3B fibronectin type III domain containing 3B 0.0187484
ARRDC3 arrestin domain containing 3 0.0185008
ISG15 ISG15 ubiquitin-like modifier 0.0183149

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.308592
COL1A1 collagen, type I, alpha 1 -0.126322
IGFBP3 insulin-like growth factor binding protein 3 -0.116552
FN1 fibronectin 1 -0.109613
ATP13A3 ATPase type 13A3 -0.0737391
TRIO trio Rho guanine nucleotide exchange factor -0.0635467
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0604724
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0578156
IER3 immediate early response 3 -0.054982
ZFAND3 zinc finger, AN1-type domain 3 -0.0540734
NAMPT nicotinamide phosphoribosyltransferase -0.0537468
PTMA prothymosin, alpha -0.0497621
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0488062
SPAG9 sperm associated antigen 9 -0.046347
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0449392
ZNF292 zinc finger protein 292 -0.0414683
USP3 ubiquitin specific peptidase 3 -0.0405682
QKI QKI, KH domain containing, RNA binding -0.0405644
RASA2 RAS p21 protein activator 2 -0.0402646
ANKRD11 ankyrin repeat domain 11 -0.0401004
COL1A2 collagen, type I, alpha 2 -0.0368462
SQLE squalene epoxidase -0.0342719
ICAM1 intercellular adhesion molecule 1 -0.0340938
RHEB Ras homolog enriched in brain -0.0335547
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0331261
SETD5 SET domain containing 5 -0.0327665
TPM4 tropomyosin 4 -0.0318814
KMT2E lysine (K)-specific methyltransferase 2E -0.0312079
RAD21 RAD21 homolog (S. pombe) -0.0307125
ANXA2 annexin A2 -0.0304577
PRRC1 proline-rich coiled-coil 1 -0.0298955
POSTN periostin, osteoblast specific factor -0.0284878
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0282162
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0279988
LMAN1 lectin, mannose-binding, 1 -0.0274456
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0270219
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0268374
WSB1 WD repeat and SOCS box containing 1 -0.0266447
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0265092
TM4SF1 transmembrane 4 L six family member 1 -0.0263342
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0256943
MAP4 microtubule-associated protein 4 -0.0254751
RBM39 RNA binding motif protein 39 -0.0252607
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0249947
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0238787
CAVIN1 caveolae associated protein 1 -0.0238487
RYK receptor-like tyrosine kinase -0.0235349
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0232197
FOXJ3 forkhead box J3 -0.0226489
BZW1 basic leucine zipper and W2 domains 1 -0.0219248
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0218985
TMEM263 transmembrane protein 263 -0.0212552
SRGN serglycin -0.0210519
WASF2 WAS protein family, member 2 -0.0209361
GNAS GNAS complex locus -0.0209231
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0208968
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0208938
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0207505
TSC22D2 TSC22 domain family, member 2 -0.0204107
OGA O-GlcNAcase -0.0203902
RAB1A RAB1A, member RAS oncogene family -0.0203575
NPEPPS aminopeptidase puromycin sensitive -0.020244
PXDN peroxidasin -0.0202321
WAC WW domain containing adaptor with coiled-coil -0.0197778
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0196654
RLF rearranged L-myc fusion -0.0196386
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0195206
KMT2A lysine (K)-specific methyltransferase 2A -0.0194667
MT1X metallothionein 1X -0.0194309
RTN4 reticulon 4 -0.0193037
GRID1 glutamate receptor, ionotropic, delta 1 -0.0192172
CAMTA1 calmodulin binding transcription activator 1 -0.0191151
OSBPL9 oxysterol binding protein-like 9 -0.0190732
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0190574
AHNAK AHNAK nucleoprotein -0.0189577
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0188876
TFG TRK-fused gene -0.018808
NDFIP1 Nedd4 family interacting protein 1 -0.0187622
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0186926
BHLHE40 basic helix-loop-helix family, member e40 -0.0185793
MED13L mediator complex subunit 13-like -0.0184667
SRSF11 serine/arginine-rich splicing factor 11 -0.0184665
LOXL2 lysyl oxidase-like 2 -0.0184639
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0184153
THY1 Thy-1 cell surface antigen -0.0182531
RAB8B RAB8B, member RAS oncogene family -0.0181747
WTAP Wilms tumor 1 associated protein -0.0180321
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0180109
GRB10 growth factor receptor-bound protein 10 -0.01799
AFAP1 actin filament associated protein 1 -0.0175907
FNBP1L formin binding protein 1-like -0.0175864
ANKRD10 ankyrin repeat domain 10 -0.0173489
HMGB2 high mobility group box 2 -0.0172822
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0172737
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0172715
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0172116
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0170445
ECT2 epithelial cell transforming 2 -0.0170364
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0168472
KDM5B lysine (K)-specific demethylase 5B -0.0168164