Erdafitinib _HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erdafitinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erdafitinib _HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.444151
ENO1 enolase 1, (alpha) 0.176491
IGFBP1 insulin-like growth factor binding protein 1 0.164717
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.15542
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.15002
SVIL supervillin 0.136029
SPTBN1 spectrin, beta, non-erythrocytic 1 0.118185
SAMD4A sterile alpha motif domain containing 4A 0.107316
APOB apolipoprotein B 0.105451
DST dystonin 0.096721
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0954401
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0894188
DSPP dentin sialophosphoprotein 0.0872508
MYH9 myosin, heavy chain 9, non-muscle 0.0869204
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0867749
PDIA6 protein disulfide isomerase family A, member 6 0.0837444
LDHA lactate dehydrogenase A 0.0812002
EEF2 eukaryotic translation elongation factor 2 0.0727614
UBC ubiquitin C 0.0719487
ASPH aspartate beta-hydroxylase 0.0703227
FAT1 FAT atypical cadherin 1 0.0653209
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0611933
RPL23 ribosomal protein L23 0.0591243
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0587395
CCL20 chemokine (C-C motif) ligand 20 0.0577971
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0568342
CANX calnexin 0.0564949
MT2A metallothionein 2A 0.0551769
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0527081
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0517257
CALR calreticulin 0.0511823
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0502665
AKAP12 A kinase (PRKA) anchor protein 12 0.0499514
RPS12 ribosomal protein S12 0.0482654
FAM107B family with sequence similarity 107, member B 0.0480923
ATXN1 ataxin 1 0.0480581
APLP2 amyloid beta (A4) precursor-like protein 2 0.0467264
KRT8 keratin 8, type II 0.0461273
CFB complement factor B 0.0460238
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0457769
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0440451
FN1 fibronectin 1 0.0439939
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0430546
RPS27A ribosomal protein S27a 0.0429387
EXT1 exostosin glycosyltransferase 1 0.0417247
RPL3 ribosomal protein L3 0.0414563
ERRFI1 ERBB receptor feedback inhibitor 1 0.0412739
KYNU kynureninase 0.0397204
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0387251
TMSB10 thymosin beta 10 0.0380711
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0369966
JUN jun proto-oncogene 0.0369865
MCL1 myeloid cell leukemia 1 0.0368888
NFE2L1 nuclear factor, erythroid 2-like 1 0.0364178
LPP LIM domain containing preferred translocation partner in lipoma 0.0358309
PDIA3 protein disulfide isomerase family A, member 3 0.0346878
PKM pyruvate kinase, muscle 0.0341266
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0340582
TXNRD1 thioredoxin reductase 1 0.0327048
KRT18 keratin 18, type I 0.0320609
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0317334
CSNK1A1 casein kinase 1, alpha 1 0.0316743
SFTPA2 surfactant protein A2 0.0308921
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0300572
TPM4 tropomyosin 4 0.0299655
ABAT 4-aminobutyrate aminotransferase 0.0297444
CTSB cathepsin B 0.0287512
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0286627
MAP1B microtubule-associated protein 1B 0.0277109
DIAPH1 diaphanous-related formin 1 0.0274262
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0271182
ALPK2 alpha-kinase 2 0.0270914
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0270007
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.0268901
KRT19 keratin 19, type I 0.0266074
ACTN4 actinin, alpha 4 0.0265943
OPTN optineurin 0.0265779
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0265748
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0263807
MRTFA myocardin related transcription factor A 0.0262712
PCBP2 poly(rC) binding protein 2 0.0262051
MACF1 microtubule-actin crosslinking factor 1 0.0258233
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0256833
TMED2 transmembrane emp24 domain trafficking protein 2 0.025659
SRRM2 serine/arginine repetitive matrix 2 0.0256508
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0256238
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0253471
AHNAK AHNAK nucleoprotein 0.0253384
TPM3 tropomyosin 3 0.0253358
PAWR PRKC, apoptosis, WT1, regulator 0.025278
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0250748
FOXP1 forkhead box P1 0.0249458
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0236195
HYOU1 hypoxia up-regulated 1 0.0231747
SET SET nuclear proto-oncogene 0.0229806
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0226998
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0226294
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.022574
PGK1 phosphoglycerate kinase 1 0.0225221
VCL vinculin 0.0224899

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.159222
FBF1 Fas (TNFRSF6) binding factor 1 -0.112108
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0892298
EHBP1 EH domain binding protein 1 -0.0698109
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0677904
MAML2 mastermind-like 2 (Drosophila) -0.0673453
DLC1 DLC1 Rho GTPase activating protein -0.066661
TPT1 tumor protein, translationally-controlled 1 -0.0647992
EML4 echinoderm microtubule associated protein like 4 -0.0596792
CP ceruloplasmin (ferroxidase) -0.0544952
PTCHD4 patched domain containing 4 -0.0526783
GNAS GNAS complex locus -0.052556
A2M alpha-2-macroglobulin -0.0523718
AHSG alpha-2-HS-glycoprotein -0.0509347
APOA2 apolipoprotein A-II -0.0508676
TMEM123 transmembrane protein 123 -0.0456644
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0452664
TM4SF1 transmembrane 4 L six family member 1 -0.0405422
TRIM26 tripartite motif containing 26 -0.0387389
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0383689
PTBP3 polypyrimidine tract binding protein 3 -0.0340692
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0338386
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0336109
GMDS GDP-mannose 4,6-dehydratase -0.0324349
NKD1 naked cuticle homolog 1 (Drosophila) -0.0307121
EPAS1 endothelial PAS domain protein 1 -0.0295603
APOA1 apolipoprotein A-I -0.029492
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.0288756
RPL35A ribosomal protein L35a -0.0285727
FMNL2 formin-like 2 -0.0280443
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0280246
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0276102
NPR2 natriuretic peptide receptor 2 -0.0267369
RPL11 ribosomal protein L11 -0.0260092
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0260078
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.024882
NHSL1 NHS-like 1 -0.0244367
ITGA1 integrin, alpha 1 -0.0240644
MALT1 MALT1 paracaspase -0.0240369
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0239756
FNDC3B fibronectin type III domain containing 3B -0.0236625
RAI14 retinoic acid induced 14 -0.0235642
DOK6 docking protein 6 -0.023344
GK glycerol kinase -0.0233235
FRMD5 FERM domain containing 5 -0.0232693
APOH apolipoprotein H (beta-2-glycoprotein I) -0.0232054
WDR45B WD repeat domain 45B -0.0224313
FTL ferritin, light polypeptide -0.0222865
GDF15 growth differentiation factor 15 -0.0222235
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0222113
GPC3 glypican 3 -0.0217951
PKP4 plakophilin 4 -0.0215674
SELENOP selenoprotein P -0.0215654
NSUN6 NOP2/Sun domain family, member 6 -0.021428
RBM39 RNA binding motif protein 39 -0.0211227
SETD5 SET domain containing 5 -0.021086
PTPRM protein tyrosine phosphatase, receptor type, M -0.0208974
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0208133
ATP10A ATPase, class V, type 10A -0.0206775
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0202354
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0201652
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0200335
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0197034
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 -0.0196727
WSB1 WD repeat and SOCS box containing 1 -0.0195222
RYBP RING1 and YY1 binding protein -0.0191258
PTPRK protein tyrosine phosphatase, receptor type, K -0.0189421
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0186614
SCARB1 scavenger receptor class B, member 1 -0.0186294
SYN3 synapsin III -0.0183269
ZFAND3 zinc finger, AN1-type domain 3 -0.0180788
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0179087
CAMTA1 calmodulin binding transcription activator 1 -0.0178928
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0178289
ZSWIM5 zinc finger, SWIM-type containing 5 -0.0177854
GCC2 GRIP and coiled-coil domain containing 2 -0.0174417
DNAH17 dynein, axonemal, heavy chain 17 -0.0173038
SESTD1 SEC14 and spectrin domains 1 -0.0171543
IER3 immediate early response 3 -0.016894
TAS2R14 taste receptor, type 2, member 14 -0.0166699
PPARG peroxisome proliferator-activated receptor gamma -0.0165209
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0165087
DOCK5 dedicator of cytokinesis 5 -0.016315
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -0.016313
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0162743
PARD3 par-3 family cell polarity regulator -0.0161902
MEMO1 mediator of cell motility 1 -0.0161664
FBXO11 F-box protein 11 -0.0160802
RPL27A ribosomal protein L27a -0.0159353
NCOA7 nuclear receptor coactivator 7 -0.0159241
USP3 ubiquitin specific peptidase 3 -0.0157224
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -0.015702
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0155553
AUH AU RNA binding protein/enoyl-CoA hydratase -0.015553
RBM25 RNA binding motif protein 25 -0.0154157
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0154147
ARID3A AT rich interactive domain 3A (BRIGHT-like) -0.0153989
AGXT alanine-glyoxylate aminotransferase -0.0153749
NIPBL Nipped-B homolog (Drosophila) -0.0153735
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0153446