Erdafitinib _Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erdafitinib perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erdafitinib _Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.0929536
LDHA lactate dehydrogenase A 0.090735
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.085202
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0804653
RPS12 ribosomal protein S12 0.0791506
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0753911
ENO1 enolase 1, (alpha) 0.0728879
MTSS1 metastasis suppressor 1 0.0700422
MEF2A myocyte enhancer factor 2A 0.0670714
FTH1 ferritin, heavy polypeptide 1 0.0663628
MYH9 myosin, heavy chain 9, non-muscle 0.0634441
B2M beta-2-microglobulin 0.0616357
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0568671
MSN moesin 0.0566745
APLP2 amyloid beta (A4) precursor-like protein 2 0.0550128
RPS8 ribosomal protein S8 0.0514894
TPM3 tropomyosin 3 0.0476312
PDE4D phosphodiesterase 4D, cAMP-specific 0.0473466
ANXA1 annexin A1 0.0453707
IFI6 interferon, alpha-inducible protein 6 0.0448433
SLK STE20-like kinase 0.0447365
TGM2 transglutaminase 2 0.0433699
CD44 CD44 molecule (Indian blood group) 0.0432247
FNDC3B fibronectin type III domain containing 3B 0.042744
DOK5 docking protein 5 0.0412176
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0407947
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0407433
KIAA1217 KIAA1217 0.0399172
MCL1 myeloid cell leukemia 1 0.0394248
DST dystonin 0.0380003
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.037451
SIK3 SIK family kinase 3 0.0374349
SET SET nuclear proto-oncogene 0.0367207
MBNL1 muscleblind-like splicing regulator 1 0.0364582
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0361587
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0361145
MT2A metallothionein 2A 0.035447
RPL37 ribosomal protein L37 0.0350427
RPS2 ribosomal protein S2 0.0348473
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0347827
IFI44L interferon-induced protein 44-like 0.0347152
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0339454
SMAD3 SMAD family member 3 0.0338563
IFITM1 interferon induced transmembrane protein 1 0.0336583
ASPH aspartate beta-hydroxylase 0.0334559
FTL ferritin, light polypeptide 0.0330507
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0329506
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0324825
EEF2 eukaryotic translation elongation factor 2 0.0323717
RPL3 ribosomal protein L3 0.0321932
JAG1 jagged 1 0.0317712
ZSWIM6 zinc finger, SWIM-type containing 6 0.0317364
RND3 Rho family GTPase 3 0.0316901
HSPA8 heat shock 70kDa protein 8 0.0312881
PCDH1 protocadherin 1 0.0310946
DIAPH1 diaphanous-related formin 1 0.0310481
RPS17 ribosomal protein S17 0.030704
RPL37A ribosomal protein L37a 0.0306092
YBX1 Y box binding protein 1 0.0303483
SRRM2 serine/arginine repetitive matrix 2 0.0302405
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0300934
CSTB cystatin B (stefin B) 0.0300168
MT1E metallothionein 1E 0.0299837
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0295537
ANGPTL4 angiopoietin-like 4 0.0286536
RPS3 ribosomal protein S3 0.028553
RAI14 retinoic acid induced 14 0.0283972
KLF5 Kruppel-like factor 5 (intestinal) 0.0283606
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0280474
RPL26 ribosomal protein L26 0.0280465
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0280306
ESYT2 extended synaptotagmin-like protein 2 0.0280012
MBNL2 muscleblind-like splicing regulator 2 0.0275707
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0275228
ERRFI1 ERBB receptor feedback inhibitor 1 0.0271578
MKI67 marker of proliferation Ki-67 0.0268019
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0265993
RPS27 ribosomal protein S27 0.0265941
BHLHE40 basic helix-loop-helix family, member e40 0.0264457
ARRDC3 arrestin domain containing 3 0.0264084
CLU clusterin 0.026038
SFTPA2 surfactant protein A2 0.0259254
CSNK1A1 casein kinase 1, alpha 1 0.0258856
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0258302
MRPS6 mitochondrial ribosomal protein S6 0.0255254
PLS3 plastin 3 0.025497
ARHGAP21 Rho GTPase activating protein 21 0.0254633
IFI27 interferon, alpha-inducible protein 27 0.024973
SFPQ splicing factor proline/glutamine-rich 0.0249254
TBC1D5 TBC1 domain family, member 5 0.024803
SAMD9 sterile alpha motif domain containing 9 0.0246365
PEAK1 pseudopodium-enriched atypical kinase 1 0.0239533
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0239433
MACF1 microtubule-actin crosslinking factor 1 0.0235236
VEGFA vascular endothelial growth factor A 0.0233676
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0230835
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0230444
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0229053
KTN1 kinectin 1 (kinesin receptor) 0.0227085
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0225773

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.229211
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.170792
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.139596
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.132347
AHNAK AHNAK nucleoprotein -0.121405
FLNB filamin B, beta -0.116766
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.108875
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0996798
PTMA prothymosin, alpha -0.0902309
DPYD dihydropyrimidine dehydrogenase -0.0895495
TMSB10 thymosin beta 10 -0.0793272
RBM39 RNA binding motif protein 39 -0.0771421
EMP1 epithelial membrane protein 1 -0.0765631
SULF1 sulfatase 1 -0.074965
HM13 histocompatibility (minor) 13 -0.0619551
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0584502
NAMPT nicotinamide phosphoribosyltransferase -0.0578499
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0571462
LMNA lamin A/C -0.0571019
ABI3BP ABI family, member 3 (NESH) binding protein -0.0554018
GNAS GNAS complex locus -0.0552423
MECOM MDS1 and EVI1 complex locus -0.0549378
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0519151
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0504037
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0482128
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0475449
KRT17 keratin 17, type I -0.0474581
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0466165
WASF2 WAS protein family, member 2 -0.0465588
DLG1 discs, large homolog 1 (Drosophila) -0.0464749
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0459757
GARS1 glycyl-tRNA synthetase 1 -0.0445233
RPS21 ribosomal protein S21 -0.0438695
ANO1 anoctamin 1, calcium activated chloride channel -0.0431441
HDLBP high density lipoprotein binding protein -0.0429227
CANX calnexin -0.0428071
CALU calumenin -0.0417163
IARS1 isoleucyl-tRNA synthetase 1 -0.0414315
CAVIN1 caveolae associated protein 1 -0.0409684
ALCAM activated leukocyte cell adhesion molecule -0.0391503
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0389602
TRIO trio Rho guanine nucleotide exchange factor -0.0385884
KDM3A lysine (K)-specific demethylase 3A -0.0370282
GOLGA4 golgin A4 -0.0362534
H1-0 H1.0 linker histone -0.0357708
COPB1 coatomer protein complex, subunit beta 1 -0.0353044
ITSN1 intersectin 1 (SH3 domain protein) -0.0350712
C4BPB complement component 4 binding protein, beta -0.0347972
SEC31A SEC31 homolog A (S. cerevisiae) -0.0347357
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0341297
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0337281
DOCK5 dedicator of cytokinesis 5 -0.0335701
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.033553
PLAT plasminogen activator, tissue -0.0334173
LMAN1 lectin, mannose-binding, 1 -0.0334104
NT5C2 5'-nucleotidase, cytosolic II -0.0323995
SQLE squalene epoxidase -0.032217
ITCH itchy E3 ubiquitin protein ligase -0.0320316
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0316994
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0316345
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0314737
TMEM263 transmembrane protein 263 -0.0312889
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0309601
TMSB4X thymosin beta 4, X-linked -0.0308675
TTC3 tetratricopeptide repeat domain 3 -0.0306893
IGF2 insulin-like growth factor 2 -0.030672
RRBP1 ribosome binding protein 1 -0.0304996
EXOC6B exocyst complex component 6B -0.0304986
ANKRD33B ankyrin repeat domain 33B -0.030222
SLC35F3 solute carrier family 35, member F3 -0.0299188
CD99 CD99 molecule -0.0296791
ITGA6 integrin, alpha 6 -0.02952
NPEPPS aminopeptidase puromycin sensitive -0.0294009
FSCN1 fascin actin-bundling protein 1 -0.0291019
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0288881
BCL2L1 BCL2-like 1 -0.028256
WSB1 WD repeat and SOCS box containing 1 -0.0281113
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0278849
VDAC1 voltage-dependent anion channel 1 -0.0277618
ZMYND8 zinc finger, MYND-type containing 8 -0.027727
OGA O-GlcNAcase -0.027635
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0275363
CAPN2 calpain 2, (m/II) large subunit -0.0273146
ARHGAP29 Rho GTPase activating protein 29 -0.0271785
ZEB1 zinc finger E-box binding homeobox 1 -0.0270902
RPS24 ribosomal protein S24 -0.0270488
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0267152
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0266653
MON2 MON2 homolog (S. cerevisiae) -0.0266394
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0265011
PALLD palladin, cytoskeletal associated protein -0.0263777
BLCAP bladder cancer associated protein -0.0262942
ERAP2 endoplasmic reticulum aminopeptidase 2 -0.0262702
THBD thrombomodulin -0.0261233
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0258901
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.025529
S100A10 S100 calcium binding protein A10 -0.0254445
S100A4 S100 calcium binding protein A4 -0.0252488
STAU1 staufen double-stranded RNA binding protein 1 -0.0252405
FOXO1 forkhead box O1 -0.0250383