| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Erdafitinib perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Erdafitinib _J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.214161 |
| MT2A | metallothionein 2A | 0.179736 |
| NDRG1 | N-myc downstream regulated 1 | 0.148653 |
| ENO1 | enolase 1, (alpha) | 0.141169 |
| FTL | ferritin, light polypeptide | 0.129647 |
| LDHA | lactate dehydrogenase A | 0.108867 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0953292 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0947323 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0815214 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0787791 |
| RPL35A | ribosomal protein L35a | 0.0755112 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.070324 |
| INTS6 | integrator complex subunit 6 | 0.0698998 |
| SET | SET nuclear proto-oncogene | 0.0638731 |
| DST | dystonin | 0.0630909 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0607478 |
| RPS3 | ribosomal protein S3 | 0.0570729 |
| ANXA1 | annexin A1 | 0.0539672 |
| PGK1 | phosphoglycerate kinase 1 | 0.0535026 |
| FLNB | filamin B, beta | 0.0531212 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0522989 |
| RPS12 | ribosomal protein S12 | 0.0504313 |
| JUN | jun proto-oncogene | 0.0488743 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0481611 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0478257 |
| VIM | vimentin | 0.0472556 |
| RPS8 | ribosomal protein S8 | 0.0466221 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.045925 |
| RND3 | Rho family GTPase 3 | 0.0458569 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0449795 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0443923 |
| DTNA | dystrobrevin, alpha | 0.0432093 |
| RPL26 | ribosomal protein L26 | 0.0431164 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0420752 |
| RPL23 | ribosomal protein L23 | 0.0418516 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0418038 |
| MKI67 | marker of proliferation Ki-67 | 0.0415187 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0404486 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0395321 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0392842 |
| RPLP1 | ribosomal protein, large, P1 | 0.0387557 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0367817 |
| PLIN2 | perilipin 2 | 0.0364622 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0359469 |
| RAI14 | retinoic acid induced 14 | 0.0355285 |
| RPL30 | ribosomal protein L30 | 0.0353221 |
| RACK1 | receptor for activated C kinase 1 | 0.0352265 |
| RPL12 | ribosomal protein L12 | 0.0349395 |
| PHACTR1 | phosphatase and actin regulator 1 | 0.0347437 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0339694 |
| MORF4L2 | mortality factor 4 like 2 | 0.0339551 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0331744 |
| YBX1 | Y box binding protein 1 | 0.0327053 |
| ANXA2 | annexin A2 | 0.0323649 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0318703 |
| EGFR | epidermal growth factor receptor | 0.0318371 |
| RPL11 | ribosomal protein L11 | 0.0316354 |
| RUNX1 | runt-related transcription factor 1 | 0.0314661 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0313921 |
| TLE4 | transducin-like enhancer of split 4 | 0.0313792 |
| ASPH | aspartate beta-hydroxylase | 0.0312922 |
| RPL7 | ribosomal protein L7 | 0.031208 |
| RPS17 | ribosomal protein S17 | 0.030772 |
| RPL31 | ribosomal protein L31 | 0.0302101 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0301023 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0300015 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0299154 |
| FAM107B | family with sequence similarity 107, member B | 0.0297803 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0295652 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0294351 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0294219 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0293728 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0292984 |
| MCL1 | myeloid cell leukemia 1 | 0.0291773 |
| RPS20 | ribosomal protein S20 | 0.0291304 |
| TPM3 | tropomyosin 3 | 0.0286316 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0285356 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0285143 |
| RPL37 | ribosomal protein L37 | 0.0281905 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0278283 |
| CAVIN1 | caveolae associated protein 1 | 0.027614 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.027603 |
| SFTPA2 | surfactant protein A2 | 0.0274277 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0271935 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0266391 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0265522 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0265268 |
| HLA-E | major histocompatibility complex, class I, E | 0.0263527 |
| PKM | pyruvate kinase, muscle | 0.0260902 |
| PODXL | podocalyxin-like | 0.0258592 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0252883 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0247924 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0247063 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0247041 |
| S100A10 | S100 calcium binding protein A10 | 0.0246093 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0243013 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0242851 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0242214 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0242074 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0241798 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.11514 |
| HLA-B | major histocompatibility complex, class I, B | -0.088936 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0695162 |
| POTEF | POTE ankyrin domain family, member F | -0.0680623 |
| MT1X | metallothionein 1X | -0.0656713 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0534649 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0485575 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0467565 |
| DEK | DEK proto-oncogene | -0.0464516 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0429778 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0417572 |
| POSTN | periostin, osteoblast specific factor | -0.0379985 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0358194 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.033179 |
| OSMR | oncostatin M receptor | -0.0330593 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0327339 |
| ERBIN | erbb2 interacting protein | -0.0319799 |
| SULF1 | sulfatase 1 | -0.0312747 |
| PLCB4 | phospholipase C, beta 4 | -0.0310064 |
| CTSD | cathepsin D | -0.0298261 |
| ARF4 | ADP-ribosylation factor 4 | -0.0284824 |
| KRT7 | keratin 7, type II | -0.027776 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0276939 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0258714 |
| NUP153 | nucleoporin 153kDa | -0.0256542 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0252104 |
| SLC12A8 | solute carrier family 12, member 8 | -0.0245209 |
| NKTR | natural killer cell triggering receptor | -0.0244112 |
| PFN1 | profilin 1 | -0.0241991 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.0238365 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0236441 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0227028 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0221211 |
| CCND1 | cyclin D1 | -0.0221167 |
| SEC22B | SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) | -0.0217878 |
| TCERG1 | transcription elongation regulator 1 | -0.0216817 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.021643 |
| MAP1B | microtubule-associated protein 1B | -0.0215807 |
| NEK7 | NIMA-related kinase 7 | -0.0214965 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0214417 |
| TUBA1B | tubulin, alpha 1b | -0.0214177 |
| GOLT1B | golgi transport 1B | -0.0213843 |
| ATP13A3 | ATPase type 13A3 | -0.0211737 |
| SMC5 | structural maintenance of chromosomes 5 | -0.021049 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0208929 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0206596 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0203237 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0203056 |
| SETD5 | SET domain containing 5 | -0.020285 |
| CLTC | clathrin, heavy chain (Hc) | -0.0202001 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0200476 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0198019 |
| ZNF804A | zinc finger protein 804A | -0.0193851 |
| NUP214 | nucleoporin 214kDa | -0.018867 |
| RBM25 | RNA binding motif protein 25 | -0.0186881 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0185605 |
| H1-4 | H1.4 linker histone, cluster member | -0.0183956 |
| AXL | AXL receptor tyrosine kinase | -0.0183738 |
| COPA | coatomer protein complex, subunit alpha | -0.0182394 |
| TMEM41B | transmembrane protein 41B | -0.0182189 |
| CCDC80 | coiled-coil domain containing 80 | -0.0181166 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0180436 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.017854 |
| TPM1 | tropomyosin 1 (alpha) | -0.0177561 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0176406 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0172164 |
| CCBE1 | collagen and calcium binding EGF domains 1 | -0.0170469 |
| VPS53 | vacuolar protein sorting 53 homolog (S. cerevisiae) | -0.0170122 |
| SCFD2 | sec1 family domain containing 2 | -0.0170088 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0168713 |
| ZXDC | ZXD family zinc finger C | -0.0163576 |
| BTBD10 | BTB (POZ) domain containing 10 | -0.0163001 |
| TMEM263 | transmembrane protein 263 | -0.0161913 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0161709 |
| TMEM87A | transmembrane protein 87A | -0.0161531 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.016069 |
| GPR107 | G protein-coupled receptor 107 | -0.015843 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0158337 |
| CDK17 | cyclin-dependent kinase 17 | -0.0158302 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0158107 |
| NPPB | natriuretic peptide B | -0.015785 |
| SBF2 | SET binding factor 2 | -0.0157736 |
| GORASP2 | golgi reassembly stacking protein 2, 55kDa | -0.0157727 |
| LATS2 | large tumor suppressor kinase 2 | -0.0155698 |
| VMP1 | vacuole membrane protein 1 | -0.0154938 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0154467 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0153796 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.015362 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0153123 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.0151972 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0149629 |
| CALU | calumenin | -0.0148559 |
| SH3RF1 | SH3 domain containing ring finger 1 | -0.0147397 |
| BPNT2 | 3'(2'), 5'-bisphosphate nucleotidase 2 | -0.0145884 |
| SLC9A8 | solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 | -0.014564 |
| GOLGA4 | golgin A4 | -0.014564 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0145547 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0144989 |
| FOSL1 | FOS-like antigen 1 | -0.0144904 |
| FAR1 | fatty acyl CoA reductase 1 | -0.0144754 |
