Erdafitinib _MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erdafitinib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erdafitinib _MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.160462
RPS12 ribosomal protein S12 0.138725
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.131681
DST dystonin 0.128742
ERRFI1 ERBB receptor feedback inhibitor 1 0.113513
LDHA lactate dehydrogenase A 0.0978909
MT2A metallothionein 2A 0.0945195
EEF2 eukaryotic translation elongation factor 2 0.0887973
RPL12 ribosomal protein L12 0.0728546
RPL26 ribosomal protein L26 0.0674318
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.066367
ENO1 enolase 1, (alpha) 0.0662283
SET SET nuclear proto-oncogene 0.0627369
BIRC3 baculoviral IAP repeat containing 3 0.061416
KLF6 Kruppel-like factor 6 0.0611322
FTH1 ferritin, heavy polypeptide 1 0.0610119
RPS19 ribosomal protein S19 0.0547893
RPL35A ribosomal protein L35a 0.0526543
RPL37A ribosomal protein L37a 0.0518643
TPM3 tropomyosin 3 0.0513719
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0499123
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0498398
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0491263
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0486752
PDIA6 protein disulfide isomerase family A, member 6 0.0475358
HSPA8 heat shock 70kDa protein 8 0.0461394
WWTR1 WW domain containing transcription regulator 1 0.0454269
RPL23 ribosomal protein L23 0.0450466
RPS3 ribosomal protein S3 0.0446116
PGK1 phosphoglycerate kinase 1 0.0431496
RPS2 ribosomal protein S2 0.0428528
MCL1 myeloid cell leukemia 1 0.0424406
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.041296
RPL31 ribosomal protein L31 0.0409424
RPS27 ribosomal protein S27 0.040251
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0401852
MKI67 marker of proliferation Ki-67 0.0397482
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0395803
SQSTM1 sequestosome 1 0.0394783
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0392041
RACK1 receptor for activated C kinase 1 0.0390509
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0381244
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0379621
RPS17 ribosomal protein S17 0.0372771
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0372172
RPS8 ribosomal protein S8 0.0364068
JMJD1C jumonji domain containing 1C 0.0363868
CENPF centromere protein F, 350/400kDa 0.0363706
CALR calreticulin 0.0361737
MYH9 myosin, heavy chain 9, non-muscle 0.0358044
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0353641
NIBAN2 niban apoptosis regulator 2 0.0339896
B2M beta-2-microglobulin 0.0338922
SFTPA2 surfactant protein A2 0.0338613
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0332996
KMT2C lysine (K)-specific methyltransferase 2C 0.032833
USP9X ubiquitin specific peptidase 9, X-linked 0.0326928
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0325314
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0321712
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0319688
ANGPTL4 angiopoietin-like 4 0.0319428
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.031772
NAP1L1 nucleosome assembly protein 1-like 1 0.0317084
SRRM2 serine/arginine repetitive matrix 2 0.0316701
PYGL phosphorylase, glycogen, liver 0.0308082
CXCL8 chemokine (C-X-C motif) ligand 8 0.0308015
APLP2 amyloid beta (A4) precursor-like protein 2 0.0301882
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0294107
RPS4X ribosomal protein S4, X-linked 0.0291852
ESYT2 extended synaptotagmin-like protein 2 0.029045
YEATS2 YEATS domain containing 2 0.028986
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.028961
JUN jun proto-oncogene 0.0289049
RPL30 ribosomal protein L30 0.0286165
EEF1G eukaryotic translation elongation factor 1 gamma 0.0280532
RPLP1 ribosomal protein, large, P1 0.0277467
NAMPT nicotinamide phosphoribosyltransferase 0.0277253
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0275192
FMNL2 formin-like 2 0.0275132
RPL11 ribosomal protein L11 0.0274633
NDRG1 N-myc downstream regulated 1 0.0274072
RPL3 ribosomal protein L3 0.0271647
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0271642
TMED2 transmembrane emp24 domain trafficking protein 2 0.0268473
PCBP2 poly(rC) binding protein 2 0.026708
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0266644
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0257969
EZR ezrin 0.0257623
SPAG9 sperm associated antigen 9 0.0256321
YBX1 Y box binding protein 1 0.025357
GOLGB1 golgin B1 0.0253333
RPL36 ribosomal protein L36 0.0251611
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0246856
GTF2I general transcription factor IIi 0.024674
RAD50 RAD50 homolog (S. cerevisiae) 0.024576
TXNRD1 thioredoxin reductase 1 0.0243165
EGR1 early growth response 1 0.0240434
MORF4L2 mortality factor 4 like 2 0.0239049
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0238224
PRRC2C proline-rich coiled-coil 2C 0.0235995

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.364823
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.13751
PTMA prothymosin, alpha -0.125964
TM4SF1 transmembrane 4 L six family member 1 -0.112651
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0988991
VIM vimentin -0.0894868
POTEF POTE ankyrin domain family, member F -0.0823304
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0800598
CADM2 cell adhesion molecule 2 -0.079858
SRGN serglycin -0.0747981
DLG1 discs, large homolog 1 (Drosophila) -0.0720497
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0657902
CD44 CD44 molecule (Indian blood group) -0.0642871
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0639784
EHBP1 EH domain binding protein 1 -0.0595226
ACTG1 actin gamma 1 -0.0584029
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0573952
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0572536
SLC38A2 solute carrier family 38, member 2 -0.0518614
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0496151
TP63 tumor protein p63 -0.049481
EPHA4 EPH receptor A4 -0.0476152
TNS3 tensin 3 -0.0422302
WDR45B WD repeat domain 45B -0.0415184
FBXO11 F-box protein 11 -0.0413295
VCL vinculin -0.0394804
CSMD3 CUB and Sushi multiple domains 3 -0.0386943
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.038151
DOCK11 dedicator of cytokinesis 11 -0.0380781
TMEM123 transmembrane protein 123 -0.0379355
AHNAK AHNAK nucleoprotein -0.0371979
WARS1 tryptophanyl-tRNA synthetase 1 -0.0370889
ZNF217 zinc finger protein 217 -0.0369639
RPS6 ribosomal protein S6 -0.036083
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0353709
CAPN2 calpain 2, (m/II) large subunit -0.0353484
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.034815
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.034722
RPS24 ribosomal protein S24 -0.0344519
PSD3 pleckstrin and Sec7 domain containing 3 -0.0338461
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0336519
WASF2 WAS protein family, member 2 -0.0331985
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.032816
CLIP2 CAP-GLY domain containing linker protein 2 -0.0327258
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.032519
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0323231
FUS FUS RNA binding protein -0.0316564
WSB1 WD repeat and SOCS box containing 1 -0.0311575
TSC22D1 TSC22 domain family, member 1 -0.0310131
EFNA5 ephrin-A5 -0.0302927
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0296581
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0294703
CAVIN1 caveolae associated protein 1 -0.0276274
TP53 tumor protein p53 -0.0274836
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0274689
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0272845
CUX1 cut-like homeobox 1 -0.0265362
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0262781
DENND1A DENN/MADD domain containing 1A -0.0259647
ANKRD11 ankyrin repeat domain 11 -0.0258669
GCLM glutamate-cysteine ligase, modifier subunit -0.0257602
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0257458
RASAL2 RAS protein activator like 2 -0.0256195
LOXL2 lysyl oxidase-like 2 -0.0251361
SLC39A10 solute carrier family 39 (zinc transporter), member 10 -0.0249218
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0246219
COL5A2 collagen, type V, alpha 2 -0.0239316
TUBB6 tubulin, beta 6 class V -0.0237907
RAI1 retinoic acid induced 1 -0.0235376
VDAC1 voltage-dependent anion channel 1 -0.0230235
MYO10 myosin X -0.0224338
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0220403
STK17A serine/threonine kinase 17a -0.0220324
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.0219096
TAPBP TAP binding protein (tapasin) -0.0215837
EXOC4 exocyst complex component 4 -0.0215639
PNISR PNN-interacting serine/arginine-rich protein -0.02154
RTN3 reticulon 3 -0.0213369
DPYD dihydropyrimidine dehydrogenase -0.0213329
RBM25 RNA binding motif protein 25 -0.0212775
RAB27B RAB27B, member RAS oncogene family -0.0209125
ANKRD12 ankyrin repeat domain 12 -0.0205749
SBF2 SET binding factor 2 -0.0204316
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -0.0202678
TUBB tubulin, beta class I -0.020144
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0200067
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0199684
GSK3B glycogen synthase kinase 3 beta -0.0198375
GLG1 golgi glycoprotein 1 -0.0197753
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -0.0196423
BRD4 bromodomain containing 4 -0.0195744
RPL38 ribosomal protein L38 -0.0193945
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0191721
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0191005
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0190001
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0189902
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0188568
MBD5 methyl-CpG binding domain protein 5 -0.0187992
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0184508
POM121C POM121 transmembrane nucleoporin C -0.0183291