| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Erdafitinib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Erdafitinib _NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.199121 |
| ASPH | aspartate beta-hydroxylase | 0.114716 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0918384 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0917791 |
| LDHA | lactate dehydrogenase A | 0.0900395 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.083524 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0796763 |
| ENO1 | enolase 1, (alpha) | 0.079127 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.075333 |
| GRAMD1B | GRAM domain containing 1B | 0.0694285 |
| MCL1 | myeloid cell leukemia 1 | 0.0685618 |
| NDRG1 | N-myc downstream regulated 1 | 0.0597076 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0573207 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0567782 |
| SLTM | SAFB-like, transcription modulator | 0.0551687 |
| LMO7 | LIM domain 7 | 0.0540159 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0538304 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0530459 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0521846 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0508924 |
| FAM13A | family with sequence similarity 13, member A | 0.0497671 |
| KRT18 | keratin 18, type I | 0.0482124 |
| PKM | pyruvate kinase, muscle | 0.0475941 |
| TMSB10 | thymosin beta 10 | 0.0469073 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0459383 |
| INTS6 | integrator complex subunit 6 | 0.0454103 |
| PTMA | prothymosin, alpha | 0.0447645 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0429816 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.041833 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0417649 |
| DSPP | dentin sialophosphoprotein | 0.0416917 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0407342 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.040511 |
| S100A10 | S100 calcium binding protein A10 | 0.0389233 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0389108 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0385521 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0374907 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0359855 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0359469 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0352529 |
| SMAD3 | SMAD family member 3 | 0.0349767 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0347998 |
| RPS12 | ribosomal protein S12 | 0.0346562 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0346365 |
| MYOF | myoferlin | 0.0340532 |
| STC1 | stanniocalcin 1 | 0.0338693 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0333816 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0321012 |
| ANXA2 | annexin A2 | 0.0315932 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0315409 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0311099 |
| SCEL | sciellin | 0.0304287 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0295546 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0293292 |
| SPAG9 | sperm associated antigen 9 | 0.0285835 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0285359 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0280715 |
| CAV2 | caveolin 2 | 0.0279107 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0272489 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0272137 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.02709 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0269604 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0268254 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0265567 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0260071 |
| MYO1E | myosin IE | 0.025875 |
| PGK1 | phosphoglycerate kinase 1 | 0.0256401 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0255953 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0254496 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0253823 |
| FTL | ferritin, light polypeptide | 0.0253694 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0250991 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0249996 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0245977 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0244673 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0244662 |
| ARRDC3 | arrestin domain containing 3 | 0.0240958 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.023924 |
| ANXA1 | annexin A1 | 0.0238523 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0238355 |
| ACTG1 | actin gamma 1 | 0.0236483 |
| KRT7 | keratin 7, type II | 0.0236443 |
| CSTB | cystatin B (stefin B) | 0.0236356 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0233163 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0231825 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0229624 |
| CPE | carboxypeptidase E | 0.0229544 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.022937 |
| RNF213 | ring finger protein 213 | 0.0228392 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0227755 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0224986 |
| HOMER1 | homer scaffolding protein 1 | 0.0223319 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0221323 |
| EFNA5 | ephrin-A5 | 0.0216749 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0214575 |
| MORF4L2 | mortality factor 4 like 2 | 0.0213553 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0209861 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0209653 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0207214 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0206305 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.046158 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0249243 |
| MT1X | metallothionein 1X | -0.0206995 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0191034 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0183604 |
| MKI67 | marker of proliferation Ki-67 | -0.0161376 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0160657 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0157124 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0149928 |
| OSMR | oncostatin M receptor | -0.0146156 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0141154 |
| TMEM165 | transmembrane protein 165 | -0.0133941 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0126516 |
| RTN4 | reticulon 4 | -0.0125762 |
| RPS24 | ribosomal protein S24 | -0.0125187 |
| WDR26 | WD repeat domain 26 | -0.0124029 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0119675 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0107909 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0104379 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | -0.0102817 |
| KIAA1328 | KIAA1328 | -0.0102358 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0101443 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0100752 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0100628 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.00987605 |
| CES1 | carboxylesterase 1 | -0.00962126 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | -0.00957298 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.00946855 |
| FOSL1 | FOS-like antigen 1 | -0.00934517 |
| HM13 | histocompatibility (minor) 13 | -0.00919407 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | -0.00909275 |
| SGO2 | shugoshin 2 | -0.00908868 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.00897157 |
| MGAT4C | MGAT4 family, member C | -0.00887622 |
| RAP2B | RAP2B, member of RAS oncogene family | -0.00883566 |
| SYAP1 | synapse associated protein 1 | -0.00876394 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0086883 |
| PATJ | PATJ crumbs cell polarity complex component | -0.00857756 |
| CCNL1 | cyclin L1 | -0.00854909 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.00843323 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.00839296 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.00831356 |
| ECD | ecdysoneless homolog (Drosophila) | -0.00826318 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0081833 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | -0.008179 |
| KDM5A | lysine (K)-specific demethylase 5A | -0.00817464 |
| ZXDC | ZXD family zinc finger C | -0.00815933 |
| METTL15 | methyltransferase like 15 | -0.00809716 |
| RBM25 | RNA binding motif protein 25 | -0.0080335 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | -0.00798728 |
| TMEM39A | transmembrane protein 39A | -0.0078234 |
| TCF25 | transcription factor 25 (basic helix-loop-helix) | -0.00778319 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.00774824 |
| POU2F1 | POU class 2 homeobox 1 | -0.00772353 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.00766429 |
| PPP6R2 | protein phosphatase 6, regulatory subunit 2 | -0.00748115 |
| PRELID2 | PRELI domain containing 2 | -0.00746005 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.00734642 |
| GORASP2 | golgi reassembly stacking protein 2, 55kDa | -0.0073118 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0072097 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.00719467 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | -0.00701798 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.00701394 |
| SMC4 | structural maintenance of chromosomes 4 | -0.00699611 |
| FRY | furry homolog (Drosophila) | -0.00692341 |
| STAT2 | signal transducer and activator of transcription 2, 113kDa | -0.00688153 |
| FBXO33 | F-box protein 33 | -0.00666185 |
| DCUN1D3 | DCN1, defective in cullin neddylation 1, domain containing 3 | -0.00664336 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | -0.0065539 |
| KLHL20 | kelch-like family member 20 | -0.00651365 |
| CCNI | cyclin I | -0.00648838 |
| RAB28 | RAB28, member RAS oncogene family | -0.00647952 |
| DDX50 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 | -0.00647816 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.00647166 |
| AMN1 | antagonist of mitotic exit network 1 homolog (S. cerevisiae) | -0.00642555 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.00637753 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | -0.00634371 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.00634123 |
| TMEM263 | transmembrane protein 263 | -0.0063144 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.00629344 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.00620701 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.00618667 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.00613162 |
| UBE4A | ubiquitination factor E4A | -0.00608067 |
| SEC23B | Sec23 homolog B (S. cerevisiae) | -0.0060723 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.00607024 |
| GAK | cyclin G associated kinase | -0.00596916 |
| GPATCH2L | G patch domain containing 2-like | -0.00590678 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.00590514 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.00585344 |
| CFDP1 | craniofacial development protein 1 | -0.00577644 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.00575304 |
| HMGN5 | high mobility group nucleosome binding domain 5 | -0.00573158 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | -0.00571949 |
| NDE1 | nudE neurodevelopment protein 1 | -0.00567315 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0056646 |
| KLHL28 | kelch-like family member 28 | -0.00565431 |
| ZC3H15 | zinc finger CCCH-type containing 15 | -0.00562762 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.00562284 |
| FBXO34 | F-box protein 34 | -0.00557311 |
