Erdafitinib _NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erdafitinib perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erdafitinib _NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.157671
AKAP12 A kinase (PRKA) anchor protein 12 0.108328
CD44 CD44 molecule (Indian blood group) 0.103479
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0943232
ENO1 enolase 1, (alpha) 0.0829954
NDRG1 N-myc downstream regulated 1 0.0796785
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0739989
LDHA lactate dehydrogenase A 0.0727302
LOX lysyl oxidase 0.0652211
PCBP2 poly(rC) binding protein 2 0.0648759
B2M beta-2-microglobulin 0.0589299
DST dystonin 0.0587517
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0581213
SOD2 superoxide dismutase 2, mitochondrial 0.0562524
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0533958
SFTPA2 surfactant protein A2 0.0526813
FTL ferritin, light polypeptide 0.0518674
TMSB10 thymosin beta 10 0.0489172
FTH1 ferritin, heavy polypeptide 1 0.0477642
RPS12 ribosomal protein S12 0.0471013
SMAD3 SMAD family member 3 0.0467938
RPS19 ribosomal protein S19 0.046445
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0455666
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0441653
ANGPTL4 angiopoietin-like 4 0.0433703
ASPH aspartate beta-hydroxylase 0.0433099
EEF2 eukaryotic translation elongation factor 2 0.0431936
NAP1L1 nucleosome assembly protein 1-like 1 0.0426186
MYH9 myosin, heavy chain 9, non-muscle 0.0415567
RPS8 ribosomal protein S8 0.0410348
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0398622
RPLP1 ribosomal protein, large, P1 0.0398161
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0393137
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.039203
APLP2 amyloid beta (A4) precursor-like protein 2 0.0391958
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0387402
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0383931
FN1 fibronectin 1 0.0361525
EIF1 eukaryotic translation initiation factor 1 0.0360359
MAP1B microtubule-associated protein 1B 0.035535
KTN1 kinectin 1 (kinesin receptor) 0.0354651
BIRC3 baculoviral IAP repeat containing 3 0.0351307
MT2A metallothionein 2A 0.0350507
PDIA6 protein disulfide isomerase family A, member 6 0.0342338
RPL23 ribosomal protein L23 0.0333419
ECE1 endothelin converting enzyme 1 0.0333142
PKM pyruvate kinase, muscle 0.0328517
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0321687
PGK1 phosphoglycerate kinase 1 0.0305511
TIMP1 TIMP metallopeptidase inhibitor 1 0.0304007
RPL35A ribosomal protein L35a 0.0300706
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0297806
BHLHE40 basic helix-loop-helix family, member e40 0.0289091
MCL1 myeloid cell leukemia 1 0.0288011
RPS27 ribosomal protein S27 0.0283593
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0283447
S100A10 S100 calcium binding protein A10 0.0283332
PDIA3 protein disulfide isomerase family A, member 3 0.028198
RPL31 ribosomal protein L31 0.0279699
RPL11 ribosomal protein L11 0.0277632
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0274294
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0273544
LOXL2 lysyl oxidase-like 2 0.0271311
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0271298
SRRM2 serine/arginine repetitive matrix 2 0.0271074
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0271032
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0270906
EGR1 early growth response 1 0.0270421
C15ORF48 chromosome 15 open reading frame 48 0.0268299
HMGA1 high mobility group AT-hook 1 0.0263473
CALR calreticulin 0.0262522
FLNB filamin B, beta 0.0262408
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0262063
RPL36 ribosomal protein L36 0.0261141
TMSB4X thymosin beta 4, X-linked 0.0259979
RPS17 ribosomal protein S17 0.0258203
IFI6 interferon, alpha-inducible protein 6 0.0255305
MYO10 myosin X 0.025458
ELL2 elongation factor, RNA polymerase II, 2 0.0252759
TXNRD1 thioredoxin reductase 1 0.0251841
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0244826
CA12 carbonic anhydrase XII 0.0244643
FAM107B family with sequence similarity 107, member B 0.0241559
FAM13A family with sequence similarity 13, member A 0.0240952
SAMD9 sterile alpha motif domain containing 9 0.0236105
RPL37A ribosomal protein L37a 0.0235195
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0235076
CANX calnexin 0.0234769
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0233241
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.023111
OPTN optineurin 0.0230027
ESYT2 extended synaptotagmin-like protein 2 0.0228996
ANXA2 annexin A2 0.0228546
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0226114
RPL7 ribosomal protein L7 0.0223364
RPS6 ribosomal protein S6 0.0219653
ANXA1 annexin A1 0.0219162
RACK1 receptor for activated C kinase 1 0.0215186
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0214143
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0213757

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.108399
SDK1 sidekick cell adhesion molecule 1 -0.0946029
NRG1 neuregulin 1 -0.06944
IGFBP3 insulin-like growth factor binding protein 3 -0.0579164
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0570538
MTSS1 metastasis suppressor 1 -0.056061
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0543303
CDH13 cadherin 13 -0.0519578
FAM20C family with sequence similarity 20, member C -0.0487468
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0458144
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0416936
DNER delta/notch-like EGF repeat containing -0.0404832
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0383209
GLCCI1 glucocorticoid induced 1 -0.0380542
DPYD dihydropyrimidine dehydrogenase -0.0357446
TFPI2 tissue factor pathway inhibitor 2 -0.0355142
RBM39 RNA binding motif protein 39 -0.0353654
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0353015
AKAP13 A kinase (PRKA) anchor protein 13 -0.0324771
OSMR oncostatin M receptor -0.0321899
USP34 ubiquitin specific peptidase 34 -0.031724
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0299083
MSRB3 methionine sulfoxide reductase B3 -0.0286668
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0276455
PID1 phosphotyrosine interaction domain containing 1 -0.0275539
NPAS2 neuronal PAS domain protein 2 -0.0268429
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0256288
ZNF804A zinc finger protein 804A -0.0251639
CXCL8 chemokine (C-X-C motif) ligand 8 -0.024503
CDK14 cyclin-dependent kinase 14 -0.0235729
NUMB numb homolog (Drosophila) -0.0230446
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0230403
TAS2R14 taste receptor, type 2, member 14 -0.0216205
VRK2 vaccinia related kinase 2 -0.0215376
MECOM MDS1 and EVI1 complex locus -0.0212945
PSD3 pleckstrin and Sec7 domain containing 3 -0.0211675
ANTXR2 anthrax toxin receptor 2 -0.0211481
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.020562
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0204895
NHSL1 NHS-like 1 -0.0203907
ZC3H12C zinc finger CCCH-type containing 12C -0.0202632
EFCAB13 EF-hand calcium binding domain 13 -0.0202392
PRRX1 paired related homeobox 1 -0.0202357
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0202337
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0200181
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0199249
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.019908
TRIO trio Rho guanine nucleotide exchange factor -0.019765
TRPS1 trichorhinophalangeal syndrome I -0.019537
EFNA5 ephrin-A5 -0.0192021
CEMIP cell migration inducing protein, hyaluronan binding -0.019144
GREB1L growth regulation by estrogen in breast cancer-like -0.019048
TM4SF1 transmembrane 4 L six family member 1 -0.0189563
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0188793
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0187849
BTBD9 BTB (POZ) domain containing 9 -0.0185587
TMEM263 transmembrane protein 263 -0.0183101
DENND4A DENN/MADD domain containing 4A -0.0182462
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0181427
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0180942
NLK nemo-like kinase -0.0180228
RAB1A RAB1A, member RAS oncogene family -0.0179551
ATG7 autophagy related 7 -0.0177031
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0176607
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0176087
GPC6 glypican 6 -0.0175536
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0174031
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0173852
CLMP CXADR-like membrane protein -0.0173593
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.017318
NAV3 neuron navigator 3 -0.017304
GLIS3 GLIS family zinc finger 3 -0.0172603
NRP1 neuropilin 1 -0.0170219
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0169737
DOCK5 dedicator of cytokinesis 5 -0.0169642
MEF2A myocyte enhancer factor 2A -0.0169101
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 -0.0167428
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0166793
STC1 stanniocalcin 1 -0.0166615
IL1B interleukin 1, beta -0.0166348
NF1 neurofibromin 1 -0.0165608
MRPS6 mitochondrial ribosomal protein S6 -0.0165591
OXR1 oxidation resistance 1 -0.0165564
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0165104
FBN1 fibrillin 1 -0.0162191
CP ceruloplasmin (ferroxidase) -0.0161994
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0161781
NAMPT nicotinamide phosphoribosyltransferase -0.0159802
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0159553
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0159027
TMTC1 transmembrane and tetratricopeptide repeat containing 1 -0.0158651
DLG1 discs, large homolog 1 (Drosophila) -0.0158196
SEC31A SEC31 homolog A (S. cerevisiae) -0.0157992
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0157741
PCNX4 pecanex 4 -0.0156582
ZFAND3 zinc finger, AN1-type domain 3 -0.0156522
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0155809
ANXA10 annexin A10 -0.0153263
TTC28 tetratricopeptide repeat domain 28 -0.015299
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0152785