Erdafitinib _NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erdafitinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erdafitinib _NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.275673
GRAMD1B GRAM domain containing 1B 0.247867
PM20D1 peptidase M20 domain containing 1 0.163662
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0903172
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0856027
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0803098
PDIA6 protein disulfide isomerase family A, member 6 0.0774542
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0730766
TPM3 tropomyosin 3 0.0646721
MYH9 myosin, heavy chain 9, non-muscle 0.0602035
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0598087
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0591602
CALR calreticulin 0.057278
FAM107B family with sequence similarity 107, member B 0.0559293
BASP1 brain abundant, membrane attached signal protein 1 0.0545284
TXNRD1 thioredoxin reductase 1 0.0507175
FGB fibrinogen beta chain 0.0506255
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0497911
TMSB10 thymosin beta 10 0.0491119
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0488429
RPL23 ribosomal protein L23 0.048647
RPS19 ribosomal protein S19 0.0427522
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0422458
TFPI2 tissue factor pathway inhibitor 2 0.0409338
SFTPA2 surfactant protein A2 0.040766
PDE4D phosphodiesterase 4D, cAMP-specific 0.0396413
EEF2 eukaryotic translation elongation factor 2 0.0393209
MCL1 myeloid cell leukemia 1 0.0380435
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0377785
APP amyloid beta (A4) precursor protein 0.0376018
FGG fibrinogen gamma chain 0.0366778
PDE10A phosphodiesterase 10A 0.0349784
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0344988
WWOX WW domain containing oxidoreductase 0.0339225
LDHA lactate dehydrogenase A 0.0329066
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0318925
RPLP1 ribosomal protein, large, P1 0.0307546
ENO1 enolase 1, (alpha) 0.0307174
C15ORF48 chromosome 15 open reading frame 48 0.0305985
SVIL supervillin 0.0304391
CANX calnexin 0.0303112
FGA fibrinogen alpha chain 0.0301541
HSPA8 heat shock 70kDa protein 8 0.0299812
IGF2 insulin-like growth factor 2 0.0289484
RPL7 ribosomal protein L7 0.0289098
EIF1 eukaryotic translation initiation factor 1 0.0287362
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0286091
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0285793
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0285473
FTH1 ferritin, heavy polypeptide 1 0.0278983
HDAC9 histone deacetylase 9 0.0269948
MORF4L2 mortality factor 4 like 2 0.0264453
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0255666
TRA2A transformer 2 alpha homolog (Drosophila) 0.0254473
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.0252571
VIM vimentin 0.0247952
ATP5F1E ATP synthase F1 subunit epsilon 0.0246075
TPI1 triosephosphate isomerase 1 0.0244953
LGALS1 lectin, galactoside-binding, soluble, 1 0.0243825
SOX4 SRY (sex determining region Y)-box 4 0.0242192
RPL32 ribosomal protein L32 0.0239624
OSMR oncostatin M receptor 0.0238902
RPL36 ribosomal protein L36 0.0238869
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.023848
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0237434
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0236856
ANXA1 annexin A1 0.0233362
YBX1 Y box binding protein 1 0.0233341
YBX3 Y box binding protein 3 0.0232448
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0227573
NCOA7 nuclear receptor coactivator 7 0.022694
CFLAR CASP8 and FADD-like apoptosis regulator 0.022686
APLP2 amyloid beta (A4) precursor-like protein 2 0.02262
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0223722
PFDN2 prefoldin subunit 2 0.0223192
LOC102724023 ES1 protein homolog, mitochondrial 0.0223042
KIF5B kinesin family member 5B 0.0222462
RPS21 ribosomal protein S21 0.0218836
ASPH aspartate beta-hydroxylase 0.0213156
RBM39 RNA binding motif protein 39 0.0212473
ERRFI1 ERBB receptor feedback inhibitor 1 0.0210657
TMSB4X thymosin beta 4, X-linked 0.0208983
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0207384
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0207346
SSB Sjogren syndrome antigen B (autoantigen La) 0.0206622
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.020541
SERF2 small EDRK-rich factor 2 0.0203682
MT1X metallothionein 1X 0.0202974
RPS4X ribosomal protein S4, X-linked 0.0202692
B2M beta-2-microglobulin 0.0202654
SIK3 SIK family kinase 3 0.019936
PTMA prothymosin, alpha 0.0198197
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0196839
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0195837
RPS7 ribosomal protein S7 0.0194434
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0193209
PDIA4 protein disulfide isomerase family A, member 4 0.0192843
MACF1 microtubule-actin crosslinking factor 1 0.0191575
MAP1B microtubule-associated protein 1B 0.0190751
MARCHF6 membrane associated ring-CH-type finger 6 0.0187034

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.245784
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.120218
POTEF POTE ankyrin domain family, member F -0.0916566
CMIP c-Maf inducing protein -0.0839242
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0799003
DOCK4 dedicator of cytokinesis 4 -0.0761674
FTL ferritin, light polypeptide -0.0707093
IGFBP3 insulin-like growth factor binding protein 3 -0.0689034
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0677712
ACTG1 actin gamma 1 -0.0677065
AKAP12 A kinase (PRKA) anchor protein 12 -0.0586237
SAMD4A sterile alpha motif domain containing 4A -0.0580159
ERBIN erbb2 interacting protein -0.056389
EGFR epidermal growth factor receptor -0.0557664
TRIO trio Rho guanine nucleotide exchange factor -0.0549441
FMNL2 formin-like 2 -0.0498597
USP34 ubiquitin specific peptidase 34 -0.0469754
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0395539
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0395135
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0390363
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0365624
SNX14 sorting nexin 14 -0.0352958
TM4SF1 transmembrane 4 L six family member 1 -0.035117
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0341916
RASAL2 RAS protein activator like 2 -0.034071
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0336016
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.033341
PTPRM protein tyrosine phosphatase, receptor type, M -0.0323905
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0318086
BIRC6 baculoviral IAP repeat containing 6 -0.0317022
NRG1 neuregulin 1 -0.0311564
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0307432
PKM pyruvate kinase, muscle -0.0304613
NF1 neurofibromin 1 -0.0302939
FLNB filamin B, beta -0.0292263
BABAM2 BRISC and BRCA1 A complex member 2 -0.0289885
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0289651
PTK2 protein tyrosine kinase 2 -0.0286131
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0278473
SBF2 SET binding factor 2 -0.0277052
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0275176
KTN1 kinectin 1 (kinesin receptor) -0.0270191
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0268265
HMOX1 heme oxygenase 1 -0.0265507
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.026052
PYGL phosphorylase, glycogen, liver -0.0257464
CFDP1 craniofacial development protein 1 -0.0256621
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) -0.0249391
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0239793
SPDYA speedy/RINGO cell cycle regulator family member A -0.0236411
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0225655
NIPBL Nipped-B homolog (Drosophila) -0.0225574
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0223121
NLK nemo-like kinase -0.0223008
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0222293
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0220122
COG5 component of oligomeric golgi complex 5 -0.0219081
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.021702
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0210067
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.020675
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0204151
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0202739
AK1 adenylate kinase 1 -0.0198921
ARHGAP29 Rho GTPase activating protein 29 -0.0196553
HLA-A major histocompatibility complex, class I, A -0.0195923
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0191749
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0190056
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0188249
EHBP1 EH domain binding protein 1 -0.0187026
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0186581
NUMB numb homolog (Drosophila) -0.0185135
FBXO11 F-box protein 11 -0.0184667
MBNL1 muscleblind-like splicing regulator 1 -0.0184458
CTBP2 C-terminal binding protein 2 -0.0183203
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0182614
SPIDR scaffolding protein involved in DNA repair -0.0182166
BRWD1 bromodomain and WD repeat domain containing 1 -0.0181264
DYM dymeclin -0.0181097
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.018096
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.01803
EXOC6B exocyst complex component 6B -0.0179379
ATXN10 ataxin 10 -0.0178334
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.017789
GLIS3 GLIS family zinc finger 3 -0.017471
SETD5 SET domain containing 5 -0.0172279
MAP7 microtubule-associated protein 7 -0.0171991
CCDC91 coiled-coil domain containing 91 -0.0171629
NBEAL1 neurobeachin-like 1 -0.0171428
LPP LIM domain containing preferred translocation partner in lipoma -0.0169894
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0168635
TNRC6B trinucleotide repeat containing 6B -0.0168124
FAF1 Fas (TNFRSF6) associated factor 1 -0.0166599
PICALM phosphatidylinositol binding clathrin assembly protein -0.0165282
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0164814
SCFD1 sec1 family domain containing 1 -0.0164662
DENND1A DENN/MADD domain containing 1A -0.016341
KCMF1 potassium channel modulatory factor 1 -0.0163068
MAP2K5 mitogen-activated protein kinase kinase 5 -0.0160582
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0160324
RCC1 regulator of chromosome condensation 1 -0.0160026