| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Erdafitinib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Erdafitinib _NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.267151 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.223753 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.218759 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.157859 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.147139 |
| EGFR | epidermal growth factor receptor | 0.123075 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.105186 |
| LAMB3 | laminin, beta 3 | 0.10416 |
| MCL1 | myeloid cell leukemia 1 | 0.0997599 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0980782 |
| KRT17 | keratin 17, type I | 0.0969874 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0962676 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0929975 |
| RPL23 | ribosomal protein L23 | 0.0901374 |
| RPL12 | ribosomal protein L12 | 0.0900921 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0891657 |
| RPS6 | ribosomal protein S6 | 0.0891125 |
| STC1 | stanniocalcin 1 | 0.0866069 |
| MEST | mesoderm specific transcript | 0.0768204 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0763281 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0748237 |
| SVIL | supervillin | 0.0734754 |
| EZR | ezrin | 0.0661316 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0619496 |
| RPLP1 | ribosomal protein, large, P1 | 0.0606397 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0604773 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0597348 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0575644 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0574714 |
| CA12 | carbonic anhydrase XII | 0.0566217 |
| RUNX1 | runt-related transcription factor 1 | 0.0566085 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0559262 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0558356 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0549017 |
| CMIP | c-Maf inducing protein | 0.0546237 |
| RPL35A | ribosomal protein L35a | 0.0540672 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0535156 |
| RPS12 | ribosomal protein S12 | 0.0524586 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0509931 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0493613 |
| PRKCA | protein kinase C, alpha | 0.0486632 |
| EXT1 | exostosin glycosyltransferase 1 | 0.048354 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0481038 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0479357 |
| INTS6 | integrator complex subunit 6 | 0.0478011 |
| FAM13A | family with sequence similarity 13, member A | 0.0477131 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0463283 |
| ACTG1 | actin gamma 1 | 0.0457547 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0455234 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0452964 |
| RPS8 | ribosomal protein S8 | 0.0443084 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0442714 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0439816 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0437387 |
| MYO1E | myosin IE | 0.0436815 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0409886 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0408742 |
| PKM | pyruvate kinase, muscle | 0.0408271 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.039017 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.038787 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0362607 |
| LMO7 | LIM domain 7 | 0.0358243 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0358186 |
| DSPP | dentin sialophosphoprotein | 0.0356079 |
| VIM | vimentin | 0.034773 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0320743 |
| SBF2 | SET binding factor 2 | 0.032029 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0310335 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0310102 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0309706 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0301028 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0299985 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0299342 |
| RPL19 | ribosomal protein L19 | 0.0292639 |
| JMJD1C | jumonji domain containing 1C | 0.0268735 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0265516 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0264636 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0257158 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0255077 |
| SMAD3 | SMAD family member 3 | 0.0237456 |
| USP34 | ubiquitin specific peptidase 34 | 0.0210213 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0203509 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0200773 |
| RPL4 | ribosomal protein L4 | 0.0199063 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0197183 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0183046 |
| RACK1 | receptor for activated C kinase 1 | 0.0173342 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0159028 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0158179 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0157338 |
| RAD51B | RAD51 paralog B | 0.0156362 |
| EFNA5 | ephrin-A5 | 0.0152583 |
| MT2A | metallothionein 2A | 0.0151356 |
| FMNL2 | formin-like 2 | 0.0145603 |
| RPL11 | ribosomal protein L11 | 0.0127101 |
| RPL34 | ribosomal protein L34 | 0.0119403 |
| NDRG1 | N-myc downstream regulated 1 | 0.0112861 |
| RPL37A | ribosomal protein L37a | 0.0105072 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.00998016 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.00949716 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.164923 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.152412 |
| AHNAK | AHNAK nucleoprotein | -0.116654 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.11201 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.105038 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.097003 |
| PTMA | prothymosin, alpha | -0.0902603 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0886131 |
| ANXA2 | annexin A2 | -0.0812828 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0788278 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.077377 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0755269 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0742345 |
| AUTS2 | autism susceptibility candidate 2 | -0.0711016 |
| FN1 | fibronectin 1 | -0.0700538 |
| FOXO3 | forkhead box O3 | -0.0678522 |
| UBC | ubiquitin C | -0.0642793 |
| ASPH | aspartate beta-hydroxylase | -0.061875 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0614541 |
| CD2AP | CD2-associated protein | -0.0614408 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0608628 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0603295 |
| SMYD3 | SET and MYND domain containing 3 | -0.0599963 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0593756 |
| USP53 | ubiquitin specific peptidase 53 | -0.0581607 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0580582 |
| WDR45B | WD repeat domain 45B | -0.0561143 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0555697 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0555684 |
| SYT1 | synaptotagmin I | -0.0551496 |
| RORA | RAR-related orphan receptor A | -0.055081 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0540679 |
| OGA | O-GlcNAcase | -0.0535836 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0530598 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0516424 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0509764 |
| H3-3B | H3.3 histone B | -0.0483212 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0478849 |
| MAPK6 | mitogen-activated protein kinase 6 | -0.0477283 |
| SQSTM1 | sequestosome 1 | -0.0474081 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0473478 |
| PERP | PERP, TP53 apoptosis effector | -0.0468969 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.04679 |
| KIAA1217 | KIAA1217 | -0.045543 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0446474 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0438772 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0433766 |
| CLASP1 | cytoplasmic linker associated protein 1 | -0.0425143 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0420697 |
| DSG2 | desmoglein 2 | -0.0413302 |
| DENND1A | DENN/MADD domain containing 1A | -0.0413302 |
| RPL26 | ribosomal protein L26 | -0.0410539 |
| PRELID2 | PRELI domain containing 2 | -0.0392769 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0391101 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0377966 |
| NF1 | neurofibromin 1 | -0.0375392 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.0373751 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0371997 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0363577 |
| RIGI | RNA sensor RIG-I | -0.03561 |
| ADM | adrenomedullin | -0.0354634 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0354167 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0354006 |
| SETD5 | SET domain containing 5 | -0.0353949 |
| PGK1 | phosphoglycerate kinase 1 | -0.0352281 |
| TMEM41B | transmembrane protein 41B | -0.0352043 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0350829 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0347477 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0346717 |
| PDE10A | phosphodiesterase 10A | -0.0343994 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.033956 |
| CEP350 | centrosomal protein 350kDa | -0.0335636 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0334743 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0334087 |
| SEC24D | SEC24 family member D | -0.0323983 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.032043 |
| MYOF | myoferlin | -0.0318819 |
| RPL5 | ribosomal protein L5 | -0.0314411 |
| NUMB | numb homolog (Drosophila) | -0.0312903 |
| IER3 | immediate early response 3 | -0.0307619 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0301369 |
| PHF21A | PHD finger protein 21A | -0.0298193 |
| TANK | TRAF family member-associated NFKB activator | -0.0297445 |
| CANX | calnexin | -0.029682 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0292413 |
| WASF2 | WAS protein family, member 2 | -0.0291986 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0281987 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0281315 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0272666 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0269649 |
| ARRDC3 | arrestin domain containing 3 | -0.0268491 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0265994 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.026558 |
| RBM39 | RNA binding motif protein 39 | -0.0254794 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0248134 |
| VMP1 | vacuole membrane protein 1 | -0.0242455 |
| B2M | beta-2-microglobulin | -0.0241725 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0239978 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0239631 |
| CCNI | cyclin I | -0.0238003 |
