Erdafitinib _NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erdafitinib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erdafitinib _NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.160549
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.156964
EEF2 eukaryotic translation elongation factor 2 0.1236
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.12281
LDHA lactate dehydrogenase A 0.121213
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.115778
MCL1 myeloid cell leukemia 1 0.0939557
GRAMD1B GRAM domain containing 1B 0.093904
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0895906
RPS12 ribosomal protein S12 0.0893612
ASPH aspartate beta-hydroxylase 0.0860696
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.084033
CXCL8 chemokine (C-X-C motif) ligand 8 0.0756937
TXNRD1 thioredoxin reductase 1 0.0703835
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0692746
NAP1L1 nucleosome assembly protein 1-like 1 0.068638
PABPC1 poly(A) binding protein, cytoplasmic 1 0.067743
ENO1 enolase 1, (alpha) 0.0653743
TPM3 tropomyosin 3 0.0650515
PCBP2 poly(rC) binding protein 2 0.0649508
SET SET nuclear proto-oncogene 0.062357
ESYT2 extended synaptotagmin-like protein 2 0.0614974
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0612111
RPS4X ribosomal protein S4, X-linked 0.0598014
RPL23 ribosomal protein L23 0.0572686
CENPF centromere protein F, 350/400kDa 0.0569391
NAMPT nicotinamide phosphoribosyltransferase 0.0563327
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0542778
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0528324
HSPA8 heat shock 70kDa protein 8 0.0514985
PDIA6 protein disulfide isomerase family A, member 6 0.0509921
GDA guanine deaminase 0.0508362
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0500529
RPS2 ribosomal protein S2 0.0480002
RPL3 ribosomal protein L3 0.0479613
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0479064
NDRG1 N-myc downstream regulated 1 0.047551
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0474168
SFTPA2 surfactant protein A2 0.04651
TRIO trio Rho guanine nucleotide exchange factor 0.0456234
MKI67 marker of proliferation Ki-67 0.0452044
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0441537
CD109 CD109 molecule 0.0433237
EZR ezrin 0.0432444
RPS27 ribosomal protein S27 0.0416182
MYH9 myosin, heavy chain 9, non-muscle 0.0411719
RPS17 ribosomal protein S17 0.0409563
RPL26 ribosomal protein L26 0.0400661
DST dystonin 0.0390905
SAMD4A sterile alpha motif domain containing 4A 0.0388511
ANXA1 annexin A1 0.038793
PGK1 phosphoglycerate kinase 1 0.0384523
PRRC2C proline-rich coiled-coil 2C 0.0381374
YBX1 Y box binding protein 1 0.038015
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0379808
EIF1 eukaryotic translation initiation factor 1 0.0363058
KYNU kynureninase 0.0358213
RPL7 ribosomal protein L7 0.0353611
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0344272
RACK1 receptor for activated C kinase 1 0.0340689
RPL30 ribosomal protein L30 0.0334844
SRRM2 serine/arginine repetitive matrix 2 0.0329571
MORF4L2 mortality factor 4 like 2 0.0326451
FTL ferritin, light polypeptide 0.0326076
USP9X ubiquitin specific peptidase 9, X-linked 0.0325598
RPL37A ribosomal protein L37a 0.0320245
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0318077
FLNB filamin B, beta 0.0311285
RPL12 ribosomal protein L12 0.03101
KTN1 kinectin 1 (kinesin receptor) 0.0308142
MT2A metallothionein 2A 0.0307069
RPS19 ribosomal protein S19 0.0306929
IPO7 importin 7 0.0304307
ELL2 elongation factor, RNA polymerase II, 2 0.0300605
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0296427
DDIT4 DNA-damage-inducible transcript 4 0.0291685
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0291377
RPS8 ribosomal protein S8 0.0290467
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.028785
COL8A1 collagen, type VIII, alpha 1 0.0286711
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0286649
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0282856
RPL31 ribosomal protein L31 0.0280325
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0274306
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0273592
SERBP1 SERPINE1 mRNA binding protein 1 0.0270051
MYOF myoferlin 0.0268571
ERRFI1 ERBB receptor feedback inhibitor 1 0.0266051
CALR calreticulin 0.0263559
TGFBR1 transforming growth factor, beta receptor 1 0.0259658
EEF1G eukaryotic translation elongation factor 1 gamma 0.02593
APLP2 amyloid beta (A4) precursor-like protein 2 0.0259203
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.025301
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0252701
MATR3 matrin 3 0.0249422
RPS3 ribosomal protein S3 0.0248961
ENAH enabled homolog (Drosophila) 0.0246756
CHD1 chromodomain helicase DNA binding protein 1 0.0245205
KRT19 keratin 19, type I 0.0244406
SMC1A structural maintenance of chromosomes 1A 0.0244266

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.287586
PDE4D phosphodiesterase 4D, cAMP-specific -0.231853
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.17471
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.151316
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.108956
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.105543
CDH13 cadherin 13 -0.0899879
TPT1 tumor protein, translationally-controlled 1 -0.0771598
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0737342
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.071966
NALF1 NALCN channel auxiliary factor 1 -0.0712475
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0674282
PSD3 pleckstrin and Sec7 domain containing 3 -0.0589233
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0583113
TM4SF1 transmembrane 4 L six family member 1 -0.0571821
PTMA prothymosin, alpha -0.0544978
STC1 stanniocalcin 1 -0.0535588
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0510944
RPS24 ribosomal protein S24 -0.0489335
PCBP3 poly(rC) binding protein 3 -0.047106
HLA-B major histocompatibility complex, class I, B -0.0467787
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0463778
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0372574
TFPI2 tissue factor pathway inhibitor 2 -0.0372428
COL5A2 collagen, type V, alpha 2 -0.0365545
VCL vinculin -0.0356566
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0355257
AUTS2 autism susceptibility candidate 2 -0.0352673
TMSB10 thymosin beta 10 -0.0349211
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0346534
NCKAP5 NCK-associated protein 5 -0.0346249
PTPRM protein tyrosine phosphatase, receptor type, M -0.0343255
P3H2 prolyl 3-hydroxylase 2 -0.0322308
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0319837
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.031927
RPS6 ribosomal protein S6 -0.0318487
SOX4 SRY (sex determining region Y)-box 4 -0.0315492
IGFBP3 insulin-like growth factor binding protein 3 -0.0307568
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0307201
CUX1 cut-like homeobox 1 -0.0296814
GNAS GNAS complex locus -0.0295378
WARS1 tryptophanyl-tRNA synthetase 1 -0.0285239
LSAMP limbic system-associated membrane protein -0.0283568
INHBA inhibin, beta A -0.0280225
ADGRD1 adhesion G protein-coupled receptor D1 -0.0278478
WSB1 WD repeat and SOCS box containing 1 -0.0277094
TENM3 teneurin transmembrane protein 3 -0.0275766
CHL1 cell adhesion molecule L1-like -0.0269262
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.026744
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0264647
STEAP1B STEAP family member 1B -0.0263633
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0252809
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0250588
BCAS3 breast carcinoma amplified sequence 3 -0.0249492
VIM vimentin -0.0247394
ESM1 endothelial cell-specific molecule 1 -0.0244498
S100A6 S100 calcium binding protein A6 -0.0241993
SMYD3 SET and MYND domain containing 3 -0.0241953
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0236435
PCDH15 protocadherin-related 15 -0.0234121
BZW1 basic leucine zipper and W2 domains 1 -0.0233768
SRGN serglycin -0.0216589
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0215806
AGR2 anterior gradient 2 -0.021427
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.021336
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0212107
TTC28 tetratricopeptide repeat domain 28 -0.0210602
KIAA0825 KIAA0825 -0.02066
FNDC3B fibronectin type III domain containing 3B -0.0206583
NRCAM neuronal cell adhesion molecule -0.0206329
RTN1 reticulon 1 -0.020612
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0205586
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0202841
SLC16A6 solute carrier family 16, member 6 -0.0200787
SLC38A2 solute carrier family 38, member 2 -0.0199683
NT5C2 5'-nucleotidase, cytosolic II -0.0198653
UNC5D unc-5 homolog D (C. elegans) -0.0196521
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.0194663
MAML3 mastermind-like 3 (Drosophila) -0.0190898
RPL38 ribosomal protein L38 -0.0190759
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0187632
DENND1A DENN/MADD domain containing 1A -0.018535
DOCK5 dedicator of cytokinesis 5 -0.0185227
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0184532
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0183129
SOX6 SRY (sex determining region Y)-box 6 -0.0177343
AHNAK AHNAK nucleoprotein -0.0176774
LAMB1 laminin, beta 1 -0.0175161
NCOA7 nuclear receptor coactivator 7 -0.0174019
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0174017
THSD4 thrombospondin, type I, domain containing 4 -0.0173718
DNER delta/notch-like EGF repeat containing -0.0172947
ACTG1 actin gamma 1 -0.0171068
ZMYND8 zinc finger, MYND-type containing 8 -0.0169486
SSBP2 single-stranded DNA binding protein 2 -0.0168094
RPL6 ribosomal protein L6 -0.0166073
IFIH1 interferon induced with helicase C domain 1 -0.0165161
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 -0.0162902
TPM4 tropomyosin 4 -0.0162687
SCN3A sodium channel, voltage gated, type III alpha subunit -0.016237