Erdafitinib _NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erdafitinib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

76 genes differentially expressed following the Erdafitinib _NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.284552
NDRG1 N-myc downstream regulated 1 0.173198
LDHA lactate dehydrogenase A 0.130884
EEF2 eukaryotic translation elongation factor 2 0.122445
ENO1 enolase 1, (alpha) 0.120758
SPTBN1 spectrin, beta, non-erythrocytic 1 0.108207
TMSB10 thymosin beta 10 0.104468
P4HB prolyl 4-hydroxylase, beta polypeptide 0.101028
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0935507
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0908372
RPL35A ribosomal protein L35a 0.085747
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0794937
RPS8 ribosomal protein S8 0.0782605
PTMA prothymosin, alpha 0.0750204
ANXA2 annexin A2 0.0686413
RUNX1 runt-related transcription factor 1 0.0668087
VCL vinculin 0.0667426
MACF1 microtubule-actin crosslinking factor 1 0.0621893
EXT1 exostosin glycosyltransferase 1 0.0620345
RPS12 ribosomal protein S12 0.058206
TTC3 tetratricopeptide repeat domain 3 0.056625
LMO7 LIM domain 7 0.0554285
TXNRD1 thioredoxin reductase 1 0.0525419
PGK1 phosphoglycerate kinase 1 0.0514902
HMGA1 high mobility group AT-hook 1 0.0483054
AKAP12 A kinase (PRKA) anchor protein 12 0.047661
MCL1 myeloid cell leukemia 1 0.0418435
ANO6 anoctamin 6 0.0403739
FAT1 FAT atypical cadherin 1 0.0401745
FNDC3B fibronectin type III domain containing 3B 0.0348005
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.034492
PRKCA protein kinase C, alpha 0.0321682
ATXN1 ataxin 1 0.0247279
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0161894
VIM vimentin 0.0130309
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0112425

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.496271
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.114886
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.107761
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.107235
PARD3 par-3 family cell polarity regulator -0.104396
PDLIM5 PDZ and LIM domain 5 -0.102118
PSD3 pleckstrin and Sec7 domain containing 3 -0.0984256
THSD4 thrombospondin, type I, domain containing 4 -0.0928708
KMT2C lysine (K)-specific methyltransferase 2C -0.0903479
CDH13 cadherin 13 -0.0884067
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0872261
PDE10A phosphodiesterase 10A -0.0871461
APP amyloid beta (A4) precursor protein -0.0804019
RORA RAR-related orphan receptor A -0.0786068
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.07395
TCF12 transcription factor 12 -0.071672
DOCK4 dedicator of cytokinesis 4 -0.0700663
FNDC3A fibronectin type III domain containing 3A -0.0688781
GRB10 growth factor receptor-bound protein 10 -0.0682965
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0632421
PTPRM protein tyrosine phosphatase, receptor type, M -0.0595308
EFNA5 ephrin-A5 -0.0563468
SAMD4A sterile alpha motif domain containing 4A -0.0551466
FN1 fibronectin 1 -0.0491501
SETD5 SET domain containing 5 -0.038804
ASPH aspartate beta-hydroxylase -0.0368619
SMYD3 SET and MYND domain containing 3 -0.0352925
MYO1E myosin IE -0.0337496
BBX bobby sox homolog (Drosophila) -0.0331951
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0319346
EGFR epidermal growth factor receptor -0.0317159
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0230505
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0215081
NKD1 naked cuticle homolog 1 (Drosophila) -0.0167626
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0141836
DST dystonin -0.0125508
GPC6 glypican 6 -0.0105188
SLTM SAFB-like, transcription modulator -0.00824871
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.00634406
PRRC2C proline-rich coiled-coil 2C -0.00140706