Erdafitinib _NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erdafitinib perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erdafitinib _NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL11A1 collagen, type XI, alpha 1 0.132195
COL5A2 collagen, type V, alpha 2 0.0886214
CADM2 cell adhesion molecule 2 0.0848824
VIM vimentin 0.0791727
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0731725
RPS12 ribosomal protein S12 0.0694427
LDHA lactate dehydrogenase A 0.063727
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0625917
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0622386
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0587421
DST dystonin 0.0509461
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0497441
ENO1 enolase 1, (alpha) 0.0466811
RPL23 ribosomal protein L23 0.0461865
PDE4D phosphodiesterase 4D, cAMP-specific 0.0459404
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0445186
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0431499
EEF2 eukaryotic translation elongation factor 2 0.0406645
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0399837
TRIO trio Rho guanine nucleotide exchange factor 0.038901
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0383796
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.038244
ITGAV integrin, alpha V 0.038179
KTN1 kinectin 1 (kinesin receptor) 0.0379665
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.037734
B2M beta-2-microglobulin 0.037201
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0365668
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0361626
HMGA2 high mobility group AT-hook 2 0.0356691
RPL31 ribosomal protein L31 0.0305169
NAP1L1 nucleosome assembly protein 1-like 1 0.0300227
MCL1 myeloid cell leukemia 1 0.0298843
NDRG1 N-myc downstream regulated 1 0.0297385
RPL11 ribosomal protein L11 0.0288851
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.028799
ASPH aspartate beta-hydroxylase 0.0287102
RIGI RNA sensor RIG-I 0.0284004
COL3A1 collagen, type III, alpha 1 0.0283869
SLC38A2 solute carrier family 38, member 2 0.0282427
PABPC1 poly(A) binding protein, cytoplasmic 1 0.027789
FN1 fibronectin 1 0.0277245
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0276978
ADGRL2 adhesion G protein-coupled receptor L2 0.0276076
TENM3 teneurin transmembrane protein 3 0.0275452
RPL37A ribosomal protein L37a 0.0267109
MYH9 myosin, heavy chain 9, non-muscle 0.0265513
TTC3 tetratricopeptide repeat domain 3 0.0262146
PGK1 phosphoglycerate kinase 1 0.0254769
SRRM2 serine/arginine repetitive matrix 2 0.0253587
CANX calnexin 0.0252939
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0252788
RPL26 ribosomal protein L26 0.0246475
MKI67 marker of proliferation Ki-67 0.0242666
FNDC3A fibronectin type III domain containing 3A 0.0242081
RPL37 ribosomal protein L37 0.0241355
EIF1 eukaryotic translation initiation factor 1 0.0232939
TMSB10 thymosin beta 10 0.0232842
PDIA6 protein disulfide isomerase family A, member 6 0.0232794
ARHGAP5 Rho GTPase activating protein 5 0.0229276
RPS8 ribosomal protein S8 0.0226461
RPL12 ribosomal protein L12 0.0224769
IFIH1 interferon induced with helicase C domain 1 0.0224081
FTL ferritin, light polypeptide 0.0219436
RPL35A ribosomal protein L35a 0.021926
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0217464
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0216732
CDK6 cyclin-dependent kinase 6 0.0214901
EEF1G eukaryotic translation elongation factor 1 gamma 0.0211628
RPL19 ribosomal protein L19 0.020804
ANXA1 annexin A1 0.020667
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.020628
DDIT4 DNA-damage-inducible transcript 4 0.0202742
TPM3 tropomyosin 3 0.0201611
RPL7 ribosomal protein L7 0.0199594
SET SET nuclear proto-oncogene 0.0198335
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.019711
ADGRV1 adhesion G protein-coupled receptor V1 0.0196511
USP34 ubiquitin specific peptidase 34 0.0193078
GREB1L growth regulation by estrogen in breast cancer-like 0.019133
SFTPA2 surfactant protein A2 0.0190743
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0186087
RAD51B RAD51 paralog B 0.0185461
ZSWIM6 zinc finger, SWIM-type containing 6 0.0184369
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0183745
RACK1 receptor for activated C kinase 1 0.0183345
EXT1 exostosin glycosyltransferase 1 0.0179823
SLC35F5 solute carrier family 35, member F5 0.0179196
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.01783
RPS2 ribosomal protein S2 0.0177675
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0177594
RPS6 ribosomal protein S6 0.0177052
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0175173
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0173218
RPL30 ribosomal protein L30 0.0167439
RPS17 ribosomal protein S17 0.0167346
CALR calreticulin 0.0167094
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0166517
BIRC3 baculoviral IAP repeat containing 3 0.0164888
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0164877
RPS3 ribosomal protein S3 0.0164689

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0515108
NTM neurotrimin -0.0480246
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0355589
GPC3 glypican 3 -0.0328052
TSC22D2 TSC22 domain family, member 2 -0.0290937
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0279426
MRPS30 mitochondrial ribosomal protein S30 -0.0234658
RFPL4B ret finger protein-like 4B -0.0209117
POTEF POTE ankyrin domain family, member F -0.0203893
MTF2 metal response element binding transcription factor 2 -0.0194423
RBM39 RNA binding motif protein 39 -0.0190801
THOC2 THO complex 2 -0.0190366
ANKRD33B ankyrin repeat domain 33B -0.019014
STRN3 striatin, calmodulin binding protein 3 -0.0185442
PEG10 paternally expressed 10 -0.0183092
RHEB Ras homolog enriched in brain -0.0178463
BTG3 BTG family, member 3 -0.0175774
ZFAND3 zinc finger, AN1-type domain 3 -0.0173492
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0168987
ELF2 E74-like factor 2 (ets domain transcription factor) -0.016728
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0163989
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0161113
NOP58 NOP58 ribonucleoprotein -0.0160281
PLPP1 phospholipid phosphatase 1 -0.0151604
CXADR coxsackie virus and adenovirus receptor -0.0151573
MAP4 microtubule-associated protein 4 -0.0149195
GARS1 glycyl-tRNA synthetase 1 -0.0144901
USP3 ubiquitin specific peptidase 3 -0.014345
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0141694
EMP1 epithelial membrane protein 1 -0.0141193
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0141071
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0140876
PHIP pleckstrin homology domain interacting protein -0.0140834
COTL1 coactosin-like F-actin binding protein 1 -0.0139695
TENM2 teneurin transmembrane protein 2 -0.013809
TMEM64 transmembrane protein 64 -0.013425
KIF13A kinesin family member 13A -0.0133599
KDM5B lysine (K)-specific demethylase 5B -0.0133056
ZNF385D zinc finger protein 385D -0.0133041
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0131822
RAI1 retinoic acid induced 1 -0.0129999
WASF2 WAS protein family, member 2 -0.012862
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0125513
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 -0.0125195
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0124578
LRRC4C leucine rich repeat containing 4C -0.0123541
TCEA1 transcription elongation factor A (SII), 1 -0.0123366
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0122519
TOX thymocyte selection-associated high mobility group box -0.0121347
PPP4R1 protein phosphatase 4, regulatory subunit 1 -0.0120398
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0119588
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.0118124
CECR2 cat eye syndrome chromosome region, candidate 2 -0.0117273
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.0117125
PUM1 pumilio RNA-binding family member 1 -0.0116921
PRKD1 protein kinase D1 -0.0116508
PSPC1 paraspeckle component 1 -0.0116493
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0116293
CNRIP1 cannabinoid receptor interacting protein 1 -0.0116085
CALCR calcitonin receptor -0.0114844
MIB1 mindbomb E3 ubiquitin protein ligase 1 -0.0114754
PDS5A PDS5 cohesin associated factor A -0.0112438
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0111925
RPL6 ribosomal protein L6 -0.010878
NEMF nuclear export mediator factor -0.0108433
APP amyloid beta (A4) precursor protein -0.0108288
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.010734
DPPA4 developmental pluripotency associated 4 -0.0107008
POU3F2 POU class 3 homeobox 2 -0.0106748
ACTG1 actin gamma 1 -0.0106689
BRMS1L breast cancer metastasis-suppressor 1-like -0.0106229
PRR11 proline rich 11 -0.0106115
ADNP activity-dependent neuroprotector homeobox -0.0105759
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0105296
CRY1 cryptochrome circadian clock 1 -0.0104993
C1ORF21 chromosome 1 open reading frame 21 -0.0104154
ECT2 epithelial cell transforming 2 -0.0103369
CAMTA1 calmodulin binding transcription activator 1 -0.0103037
URI1 URI1, prefoldin-like chaperone -0.010194
ANK2 ankyrin 2, neuronal -0.0101854
CCN2 cellular communication network factor 2 -0.0101629
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B -0.0100992
FBXO9 F-box protein 9 -0.0100438
RHOH ras homolog family member H -0.0100185
LYPLA1 lysophospholipase I -0.00996843
SPPL3 signal peptide peptidase like 3 -0.00992224
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.00979726
TP53BP2 tumor protein p53 binding protein 2 -0.00979592
TMEM87A transmembrane protein 87A -0.00978812
CHD1 chromodomain helicase DNA binding protein 1 -0.00977507
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -0.00975338
ARL13B ADP-ribosylation factor-like 13B -0.00969014
KDM3A lysine (K)-specific demethylase 3A -0.00958205
YARS1 tyrosyl-tRNA synthetase 1 -0.00954637
GRM1 glutamate receptor, metabotropic 1 -0.00953397
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.00949609
RPF2 ribosome production factor 2 homolog (S. cerevisiae) -0.00937562
RLF rearranged L-myc fusion -0.0093482
USP53 ubiquitin specific peptidase 53 -0.00930887
TBCB tubulin folding cofactor B -0.00928441