Erdafitinib _Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erdafitinib perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erdafitinib _Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.150943
LAMB3 laminin, beta 3 0.143858
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.122006
RPL23 ribosomal protein L23 0.114737
TPT1 tumor protein, translationally-controlled 1 0.110439
RPS8 ribosomal protein S8 0.106372
RPL35A ribosomal protein L35a 0.104944
RPS12 ribosomal protein S12 0.103919
RPL37A ribosomal protein L37a 0.0940581
RPS3 ribosomal protein S3 0.0940428
ACTG1 actin gamma 1 0.0889591
LDHA lactate dehydrogenase A 0.087269
LMO7 LIM domain 7 0.0804672
RPLP1 ribosomal protein, large, P1 0.076315
RACK1 receptor for activated C kinase 1 0.0754537
EIF1 eukaryotic translation initiation factor 1 0.0751822
INTS6 integrator complex subunit 6 0.0739907
ZSWIM6 zinc finger, SWIM-type containing 6 0.0738894
RPS27A ribosomal protein S27a 0.0715618
RPL12 ribosomal protein L12 0.0713108
RPL31 ribosomal protein L31 0.070528
RPS19 ribosomal protein S19 0.0691355
MYO5B myosin VB 0.0654106
SMAD3 SMAD family member 3 0.0634162
LAMC2 laminin, gamma 2 0.0631625
KRT18 keratin 18, type I 0.0624542
RPS17 ribosomal protein S17 0.0624502
SVIL supervillin 0.0620285
EEF2 eukaryotic translation elongation factor 2 0.0619633
B2M beta-2-microglobulin 0.0617719
RPL37 ribosomal protein L37 0.0611744
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0609595
SQSTM1 sequestosome 1 0.0603622
RPS13 ribosomal protein S13 0.0603598
MACF1 microtubule-actin crosslinking factor 1 0.0596647
RPL30 ribosomal protein L30 0.0595577
IFI27 interferon, alpha-inducible protein 27 0.0594512
DSPP dentin sialophosphoprotein 0.0567124
KRT19 keratin 19, type I 0.056211
ENO1 enolase 1, (alpha) 0.0561912
RPS6 ribosomal protein S6 0.0557601
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0556646
RPS27 ribosomal protein S27 0.055102
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0545555
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0540177
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.053681
SH3KBP1 SH3-domain kinase binding protein 1 0.052854
RPL19 ribosomal protein L19 0.052619
ZBTB20 zinc finger and BTB domain containing 20 0.0523209
RPL26 ribosomal protein L26 0.0518209
LPP LIM domain containing preferred translocation partner in lipoma 0.0517848
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0507002
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0498167
RPL11 ribosomal protein L11 0.0494843
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0493224
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0482955
TMSB4X thymosin beta 4, X-linked 0.0479671
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0471936
HLA-B major histocompatibility complex, class I, B 0.0471933
ETV6 ets variant 6 0.0471666
CD44 CD44 molecule (Indian blood group) 0.0455249
RPS29 ribosomal protein S29 0.0454881
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0454494
RPL34 ribosomal protein L34 0.0453307
LOC102724023 ES1 protein homolog, mitochondrial 0.0450844
HDAC9 histone deacetylase 9 0.0449454
BRD2 bromodomain containing 2 0.0443863
GOLGB1 golgin B1 0.0442489
SP100 SP100 nuclear antigen 0.0439667
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0434976
SET SET nuclear proto-oncogene 0.0434316
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0434198
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0430019
EGFR epidermal growth factor receptor 0.042406
MYH9 myosin, heavy chain 9, non-muscle 0.0415061
MYO1E myosin IE 0.0412422
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0412362
RPL7 ribosomal protein L7 0.0408208
RPL9 ribosomal protein L9 0.0404695
CSNK1A1 casein kinase 1, alpha 1 0.0400738
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0397843
PLSCR1 phospholipid scramblase 1 0.0396472
RPL10A ribosomal protein L10a 0.0391573
RPL36 ribosomal protein L36 0.038957
EXT1 exostosin glycosyltransferase 1 0.0385301
RPS14 ribosomal protein S14 0.0379218
RPL7A ribosomal protein L7a 0.037728
RPL27 ribosomal protein L27 0.0371706
ARHGAP5 Rho GTPase activating protein 5 0.0366122
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0361356
HSPA8 heat shock 70kDa protein 8 0.0359907
TJP1 tight junction protein 1 0.0358777
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.035607
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0350037
RPS4X ribosomal protein S4, X-linked 0.0345778
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0345708
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0345572
RNF213 ring finger protein 213 0.0344823
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0343836
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0343603

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.165915
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0931592
DLG1 discs, large homolog 1 (Drosophila) -0.0668776
TSC22D2 TSC22 domain family, member 2 -0.0625445
FAM3C family with sequence similarity 3, member C -0.0546537
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0493565
FOSL1 FOS-like antigen 1 -0.0474931
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0468197
ANLN anillin, actin binding protein -0.0457627
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0453674
TMEM123 transmembrane protein 123 -0.042444
LY6E lymphocyte antigen 6 complex, locus E -0.0395958
NPEPPS aminopeptidase puromycin sensitive -0.0393025
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0392202
ECT2 epithelial cell transforming 2 -0.0363998
PTBP3 polypyrimidine tract binding protein 3 -0.0363634
CCNL1 cyclin L1 -0.0342785
WDR45B WD repeat domain 45B -0.0338541
TFG TRK-fused gene -0.0338277
SMC4 structural maintenance of chromosomes 4 -0.0327952
TM4SF1 transmembrane 4 L six family member 1 -0.0315912
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0307866
DIAPH3 diaphanous-related formin 3 -0.0302733
ITCH itchy E3 ubiquitin protein ligase -0.0301965
GOLGA4 golgin A4 -0.0297847
ARHGAP29 Rho GTPase activating protein 29 -0.0290208
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0283815
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0281582
NT5C2 5'-nucleotidase, cytosolic II -0.0276767
CD2AP CD2-associated protein -0.0264461
RLF rearranged L-myc fusion -0.0262757
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0257649
CD47 CD47 molecule -0.0256636
CDCP1 CUB domain containing protein 1 -0.0251234
CENPF centromere protein F, 350/400kDa -0.0250381
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0249134
RTN4 reticulon 4 -0.0248178
PICALM phosphatidylinositol binding clathrin assembly protein -0.0245565
NAMPT nicotinamide phosphoribosyltransferase -0.024133
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0239868
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0237639
SETD5 SET domain containing 5 -0.0231811
PDE8A phosphodiesterase 8A -0.0229404
USP3 ubiquitin specific peptidase 3 -0.0223267
CCNY cyclin Y -0.0219291
OSBPL3 oxysterol binding protein-like 3 -0.0218383
ESRP1 epithelial splicing regulatory protein 1 -0.0217087
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0216683
ATP11B ATPase, class VI, type 11B -0.021582
EZR ezrin -0.0213501
UGCG UDP-glucose ceramide glucosyltransferase -0.0210633
WSB1 WD repeat and SOCS box containing 1 -0.0209292
RBM39 RNA binding motif protein 39 -0.0207582
GRID1 glutamate receptor, ionotropic, delta 1 -0.0207071
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0206118
STRN3 striatin, calmodulin binding protein 3 -0.0204748
MIS18BP1 MIS18 binding protein 1 -0.0204671
ARF4 ADP-ribosylation factor 4 -0.0204118
RNF145 ring finger protein 145 -0.0203651
XPO1 exportin 1 -0.0196534
SLMAP sarcolemma associated protein -0.0194037
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0190737
PIAS1 protein inhibitor of activated STAT, 1 -0.0188375
PTMA prothymosin, alpha -0.0186308
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0186239
TGM2 transglutaminase 2 -0.0185509
SUCO SUN domain containing ossification factor -0.0184185
UBE2H ubiquitin-conjugating enzyme E2H -0.0180363
RYK receptor-like tyrosine kinase -0.0180182
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.01788
FOXJ3 forkhead box J3 -0.017767
ACBD3 acyl-CoA binding domain containing 3 -0.0176276
ADAM9 ADAM metallopeptidase domain 9 -0.0174799
ITGB4 integrin, beta 4 -0.0170272
PLAT plasminogen activator, tissue -0.0168607
PRR11 proline rich 11 -0.0166628
COPB1 coatomer protein complex, subunit beta 1 -0.0165413
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0165278
OGA O-GlcNAcase -0.0164393
TENT2 terminal nucleotidyltransferase 2 -0.0163911
TAPBP TAP binding protein (tapasin) -0.0163684
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0163562
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0160248
C6ORF132 chromosome 6 open reading frame 132 -0.0159491
TRA2A transformer 2 alpha homolog (Drosophila) -0.0159401
ATP13A3 ATPase type 13A3 -0.0158396
ADGRG6 adhesion G protein-coupled receptor G6 -0.0158334
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0158289
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0158178
BRWD1 bromodomain and WD repeat domain containing 1 -0.0157284
KDM6A lysine (K)-specific demethylase 6A -0.0156492
MTF2 metal response element binding transcription factor 2 -0.0155726
RBM25 RNA binding motif protein 25 -0.015397
ECD ecdysoneless homolog (Drosophila) -0.015215
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha -0.0151867
TPX2 TPX2, microtubule-associated -0.0151558
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0151224
ATN1 atrophin 1 -0.0149837
PDCD10 programmed cell death 10 -0.0149378
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0148554