| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Erdafitinib perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Erdafitinib _RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.166561 |
| FRMD6 | FERM domain containing 6 | 0.144882 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.140309 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.133739 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.114859 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0996849 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0976571 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0919419 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0881442 |
| ZNF438 | zinc finger protein 438 | 0.0847671 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0833266 |
| ENO1 | enolase 1, (alpha) | 0.0778959 |
| HMGA2 | high mobility group AT-hook 2 | 0.0761051 |
| HDAC9 | histone deacetylase 9 | 0.0751676 |
| SGMS2 | sphingomyelin synthase 2 | 0.0696358 |
| NAV3 | neuron navigator 3 | 0.0685306 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0640462 |
| RPL7 | ribosomal protein L7 | 0.0608402 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.0600611 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0600163 |
| MCL1 | myeloid cell leukemia 1 | 0.0589272 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0587463 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0586822 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0576635 |
| RPS12 | ribosomal protein S12 | 0.0570554 |
| SET | SET nuclear proto-oncogene | 0.0564807 |
| LDHA | lactate dehydrogenase A | 0.0527479 |
| FLNB | filamin B, beta | 0.0526353 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0515246 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0512669 |
| EGR1 | early growth response 1 | 0.0507353 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0491343 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0485927 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0485571 |
| CALR | calreticulin | 0.0481435 |
| RPL30 | ribosomal protein L30 | 0.0464717 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0463823 |
| LAMB3 | laminin, beta 3 | 0.0449141 |
| PGK1 | phosphoglycerate kinase 1 | 0.0432398 |
| RPS4X | ribosomal protein S4, X-linked | 0.0425208 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0422712 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.04134 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0407995 |
| RACK1 | receptor for activated C kinase 1 | 0.0407728 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0403587 |
| RPL23 | ribosomal protein L23 | 0.0402321 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0399604 |
| CORO1C | coronin, actin binding protein, 1C | 0.0393951 |
| RPS8 | ribosomal protein S8 | 0.0393864 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0388328 |
| FRMD4A | FERM domain containing 4A | 0.0385224 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0382651 |
| CANX | calnexin | 0.038237 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0379954 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0360168 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0358045 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.035792 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0353828 |
| RPL7A | ribosomal protein L7a | 0.0353376 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0346965 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0337846 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 0.0335353 |
| NAV2 | neuron navigator 2 | 0.0333971 |
| INTS6 | integrator complex subunit 6 | 0.0333022 |
| JMJD1C | jumonji domain containing 1C | 0.0319312 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0318281 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0317437 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0313867 |
| RPL4 | ribosomal protein L4 | 0.0311741 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0310025 |
| RPL3 | ribosomal protein L3 | 0.0306577 |
| ASPH | aspartate beta-hydroxylase | 0.0306183 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0303604 |
| SFTPA2 | surfactant protein A2 | 0.0300466 |
| EFNB2 | ephrin-B2 | 0.0299358 |
| MKI67 | marker of proliferation Ki-67 | 0.029276 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0287632 |
| RPLP1 | ribosomal protein, large, P1 | 0.0284558 |
| RPL12 | ribosomal protein L12 | 0.0280864 |
| MLEC | malectin | 0.0275836 |
| YBX1 | Y box binding protein 1 | 0.0275228 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0273076 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0272924 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0268886 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0267467 |
| RPS2 | ribosomal protein S2 | 0.0266304 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0263238 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0259729 |
| SP100 | SP100 nuclear antigen | 0.0257994 |
| DST | dystonin | 0.0256702 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0256008 |
| RPS3 | ribosomal protein S3 | 0.0253159 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0251749 |
| TPM3 | tropomyosin 3 | 0.0250281 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0247107 |
| USO1 | USO1 vesicle transport factor | 0.02461 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0243405 |
| SLC38A2 | solute carrier family 38, member 2 | 0.023457 |
| JUN | jun proto-oncogene | 0.0231181 |
| RCOR1 | REST corepressor 1 | 0.0230535 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0610217 |
| POTEF | POTE ankyrin domain family, member F | -0.0492855 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0434648 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0430902 |
| PTK2 | protein tyrosine kinase 2 | -0.0424642 |
| CALD1 | caldesmon 1 | -0.0395397 |
| RBM25 | RNA binding motif protein 25 | -0.0341296 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0295598 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0287696 |
| NF1 | neurofibromin 1 | -0.0286729 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0282995 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0282422 |
| SETD5 | SET domain containing 5 | -0.0274093 |
| RPS6 | ribosomal protein S6 | -0.0273337 |
| RTN4 | reticulon 4 | -0.026295 |
| DIAPH3 | diaphanous-related formin 3 | -0.0257751 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0250365 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0243481 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.0236172 |
| USP3 | ubiquitin specific peptidase 3 | -0.0232045 |
| WDR43 | WD repeat domain 43 | -0.0230899 |
| RBM39 | RNA binding motif protein 39 | -0.0228844 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0227595 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0225809 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0223636 |
| SRPK2 | SRSF protein kinase 2 | -0.0222982 |
| PFN1 | profilin 1 | -0.0222422 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0221802 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0214287 |
| SBF2 | SET binding factor 2 | -0.0213865 |
| RPS23 | ribosomal protein S23 | -0.0212156 |
| ACTG1 | actin gamma 1 | -0.0207259 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0207115 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0206147 |
| PARD3 | par-3 family cell polarity regulator | -0.020385 |
| RPS15 | ribosomal protein S15 | -0.0202881 |
| RPS29 | ribosomal protein S29 | -0.0202222 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0195701 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.01929 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.019288 |
| THOC2 | THO complex 2 | -0.0192072 |
| TMEM87A | transmembrane protein 87A | -0.0191881 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0191818 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0190376 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0188306 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0186926 |
| TCF12 | transcription factor 12 | -0.018654 |
| TCERG1 | transcription elongation regulator 1 | -0.0183588 |
| RPL21 | ribosomal protein L21 | -0.0183559 |
| NKTR | natural killer cell triggering receptor | -0.0182346 |
| BBX | bobby sox homolog (Drosophila) | -0.018233 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0181842 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0180634 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0180323 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0178717 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0178425 |
| RAB3IP | RAB3A interacting protein | -0.0177652 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | -0.0176525 |
| RPLP2 | ribosomal protein, large, P2 | -0.0176092 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0173666 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0172964 |
| FOXJ3 | forkhead box J3 | -0.0172822 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0171398 |
| SNX14 | sorting nexin 14 | -0.0169757 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0169417 |
| ZNF292 | zinc finger protein 292 | -0.0167854 |
| BRD4 | bromodomain containing 4 | -0.0166994 |
| NSMAF | neutral sphingomyelinase (N-SMase) activation associated factor | -0.0165724 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0165322 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0165232 |
| RNF145 | ring finger protein 145 | -0.0164654 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0163307 |
| MT2A | metallothionein 2A | -0.0161819 |
| ERBIN | erbb2 interacting protein | -0.0160496 |
| FRS2 | fibroblast growth factor receptor substrate 2 | -0.0157664 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0156924 |
| TENT2 | terminal nucleotidyltransferase 2 | -0.0155134 |
| RPL28 | ribosomal protein L28 | -0.0154754 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0154513 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0153761 |
| RPS10 | ribosomal protein S10 | -0.0152408 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0152029 |
| NEMF | nuclear export mediator factor | -0.015138 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0150973 |
| WDR45B | WD repeat domain 45B | -0.0150371 |
| RPS24 | ribosomal protein S24 | -0.0148777 |
| OLA1 | Obg-like ATPase 1 | -0.0148694 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0148675 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0147324 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | -0.0147123 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.014591 |
| PTMA | prothymosin, alpha | -0.0145741 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0145638 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | -0.0145496 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | -0.0144652 |
| RPL38 | ribosomal protein L38 | -0.0144437 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -0.0144372 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0144103 |
| FUBP3 | far upstream element (FUSE) binding protein 3 | -0.0143799 |
| NUDT3 | nudix (nucleoside diphosphate linked moiety X)-type motif 3 | -0.0143151 |
