| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Erdafitinib perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Erdafitinib _SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.159346 |
| MCL1 | myeloid cell leukemia 1 | 0.117514 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.112808 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.108894 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0899549 |
| NDRG1 | N-myc downstream regulated 1 | 0.0862157 |
| ENO1 | enolase 1, (alpha) | 0.0850003 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0847966 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0687051 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0640807 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0626714 |
| CHGB | chromogranin B | 0.0615622 |
| SET | SET nuclear proto-oncogene | 0.0600189 |
| PDE10A | phosphodiesterase 10A | 0.060009 |
| DST | dystonin | 0.0596345 |
| HMGB3 | high mobility group box 3 | 0.056519 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0551329 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0532478 |
| CPE | carboxypeptidase E | 0.0530558 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0527744 |
| ASPH | aspartate beta-hydroxylase | 0.0494717 |
| RPL7 | ribosomal protein L7 | 0.0488019 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0480303 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.04796 |
| TPM3 | tropomyosin 3 | 0.0474928 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.045942 |
| EFNA5 | ephrin-A5 | 0.0444813 |
| RPL37A | ribosomal protein L37a | 0.0441681 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0431314 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0387955 |
| FAM13A | family with sequence similarity 13, member A | 0.0387734 |
| VGF | VGF nerve growth factor inducible | 0.0386572 |
| FAT1 | FAT atypical cadherin 1 | 0.0382833 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0381055 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0380232 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0379686 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0377374 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.03704 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0367913 |
| PCBP2 | poly(rC) binding protein 2 | 0.0361696 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0361481 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0359208 |
| RPL23 | ribosomal protein L23 | 0.0355937 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0353348 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0352557 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0349196 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0328068 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0327769 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0325938 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0325488 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0324478 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0322482 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0320074 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0317534 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0314971 |
| RPS17 | ribosomal protein S17 | 0.0313575 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0311186 |
| VEGFA | vascular endothelial growth factor A | 0.0305012 |
| SETX | senataxin | 0.0298407 |
| FLNB | filamin B, beta | 0.0297841 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0296061 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0291467 |
| RPS27 | ribosomal protein S27 | 0.0291356 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0288394 |
| MSN | moesin | 0.0288138 |
| RPS3 | ribosomal protein S3 | 0.0285988 |
| RPS6 | ribosomal protein S6 | 0.0285399 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0283444 |
| ST18 | suppression of tumorigenicity 18, zinc finger | 0.0283221 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0278447 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 0.0278002 |
| RPS8 | ribosomal protein S8 | 0.0277255 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0272939 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0272418 |
| SCG2 | secretogranin II | 0.0271741 |
| ZMAT4 | zinc finger, matrin-type 4 | 0.027106 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0270331 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0269295 |
| RPS12 | ribosomal protein S12 | 0.0268781 |
| RPL3 | ribosomal protein L3 | 0.026703 |
| LDHA | lactate dehydrogenase A | 0.0262295 |
| RPL30 | ribosomal protein L30 | 0.0259898 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0257903 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.025774 |
| CALR | calreticulin | 0.0256921 |
| DOCK5 | dedicator of cytokinesis 5 | 0.025472 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0253518 |
| ZFHX3 | zinc finger homeobox 3 | 0.0253357 |
| EZR | ezrin | 0.0251237 |
| SFTPA2 | surfactant protein A2 | 0.0251036 |
| FMNL2 | formin-like 2 | 0.0250129 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0249454 |
| YBX1 | Y box binding protein 1 | 0.0244576 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.024372 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0243229 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0243021 |
| RNASE12 | ribonuclease, RNase A family, 12 (non-active) | 0.0242183 |
| SVIL | supervillin | 0.0241489 |
| NRDC | nardilysin convertase | 0.0238304 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0237447 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.0977647 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | -0.063435 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0625125 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0587501 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0529405 |
| SNTG1 | syntrophin, gamma 1 | -0.048917 |
| PEG10 | paternally expressed 10 | -0.0487182 |
| GPC5 | glypican 5 | -0.0449236 |
| CALCA | calcitonin-related polypeptide alpha | -0.044507 |
| GNAS | GNAS complex locus | -0.0424766 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0401099 |
| FOXC1 | forkhead box C1 | -0.039501 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0386196 |
| AGBL4 | ATP/GTP binding protein-like 4 | -0.0384325 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0381027 |
| H1-0 | H1.0 linker histone | -0.0379646 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0379159 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0360865 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.0337404 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0332859 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0326873 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0323897 |
| RIT2 | Ras-like without CAAX 2 | -0.0318768 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0314269 |
| WDR45B | WD repeat domain 45B | -0.0310791 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0308596 |
| DEK | DEK proto-oncogene | -0.0306391 |
| ESRRG | estrogen-related receptor gamma | -0.0296864 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.029604 |
| DGKB | diacylglycerol kinase, beta 90kDa | -0.0294026 |
| PCDH9 | protocadherin 9 | -0.0284593 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0283121 |
| NIPSNAP2 | nipsnap homolog 2 | -0.0264039 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.025514 |
| TUBB | tubulin, beta class I | -0.0250267 |
| SSR2 | signal sequence receptor, beta (translocon-associated protein beta) | -0.0249315 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0248053 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0245772 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0239014 |
| HMGB1 | high mobility group box 1 | -0.0238109 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0234989 |
| KBTBD2 | kelch repeat and BTB (POZ) domain containing 2 | -0.0227827 |
| PRKD1 | protein kinase D1 | -0.0227542 |
| MKI67 | marker of proliferation Ki-67 | -0.022626 |
| THOC2 | THO complex 2 | -0.0225591 |
| RPS21 | ribosomal protein S21 | -0.0225055 |
| KCTD8 | potassium channel tetramerization domain containing 8 | -0.022154 |
| NSD3 | nuclear receptor binding SET domain protein 3 | -0.0221177 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0221176 |
| TMSB4X | thymosin beta 4, X-linked | -0.0220342 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0216222 |
| PTCHD4 | patched domain containing 4 | -0.0210681 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0208429 |
| RBM25 | RNA binding motif protein 25 | -0.0207146 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0207121 |
| CADM1 | cell adhesion molecule 1 | -0.0204032 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0203927 |
| NRN1 | neuritin 1 | -0.0202429 |
| TUBA1B | tubulin, alpha 1b | -0.0201455 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0200196 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | -0.0199395 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0198024 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0197374 |
| RPL38 | ribosomal protein L38 | -0.0197017 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0195957 |
| STRBP | spermatid perinuclear RNA binding protein | -0.0194344 |
| ZCCHC2 | zinc finger, CCHC domain containing 2 | -0.0192815 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0192124 |
| XPO7 | exportin 7 | -0.019202 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.019191 |
| NF1 | neurofibromin 1 | -0.0191833 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0191353 |
| ACTG1 | actin gamma 1 | -0.019128 |
| C5ORF22 | chromosome 5 open reading frame 22 | -0.0190862 |
| GAS2L3 | growth arrest-specific 2 like 3 | -0.0189795 |
| LAPTM4B | lysosomal protein transmembrane 4 beta | -0.0188843 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0187391 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0186562 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0186456 |
| ZFR | zinc finger RNA binding protein | -0.018497 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0180586 |
| RPL6 | ribosomal protein L6 | -0.0180009 |
| CD99L2 | CD99 molecule-like 2 | -0.0178695 |
| NFIA | nuclear factor I/A | -0.0178691 |
| FAM162A | family with sequence similarity 162, member A | -0.017757 |
| CEP95 | centrosomal protein 95kDa | -0.0177554 |
| KNL1 | kinetochore scaffold 1 | -0.0177443 |
| ECT2 | epithelial cell transforming 2 | -0.0177217 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0177042 |
| H3-3B | H3.3 histone B | -0.0176084 |
| MT1X | metallothionein 1X | -0.0175492 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0175189 |
| ZNF804A | zinc finger protein 804A | -0.0175175 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0174171 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0173685 |
| RRBP1 | ribosome binding protein 1 | -0.0172196 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.017194 |
| SMYD3 | SET and MYND domain containing 3 | -0.0170679 |
| KANTR | KDM5C adjacent non-coding transcript | -0.0170515 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0170102 |
