| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Erdafitinib perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Erdafitinib _SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FMN1 | formin 1 | 0.164719 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.142673 |
| SFTPA2 | surfactant protein A2 | 0.125262 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.118941 |
| ENO1 | enolase 1, (alpha) | 0.0925872 |
| DST | dystonin | 0.0830598 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0729678 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0587355 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0550581 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0543838 |
| PGK1 | phosphoglycerate kinase 1 | 0.0513848 |
| LDHA | lactate dehydrogenase A | 0.0494623 |
| RNF213 | ring finger protein 213 | 0.049154 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0480464 |
| ANGPTL4 | angiopoietin-like 4 | 0.0458646 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0456873 |
| CTSB | cathepsin B | 0.0453004 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0446281 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0428359 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0413612 |
| HDAC9 | histone deacetylase 9 | 0.0411236 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0405523 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0403583 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0395962 |
| CD44 | CD44 molecule (Indian blood group) | 0.0391907 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0383964 |
| RUNX1 | runt-related transcription factor 1 | 0.03807 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0373873 |
| FLNA | filamin A, alpha | 0.0371977 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0366328 |
| FRMD4A | FERM domain containing 4A | 0.0364301 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0356683 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0352395 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0351602 |
| B2M | beta-2-microglobulin | 0.0348674 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0348643 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0347879 |
| SET | SET nuclear proto-oncogene | 0.0346774 |
| TPM3 | tropomyosin 3 | 0.0344354 |
| RPS12 | ribosomal protein S12 | 0.0343825 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0338328 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0333356 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.033026 |
| MCL1 | myeloid cell leukemia 1 | 0.0328372 |
| CENPF | centromere protein F, 350/400kDa | 0.0327901 |
| CCND1 | cyclin D1 | 0.0323962 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0318887 |
| NLGN1 | neuroligin 1 | 0.0308089 |
| SP100 | SP100 nuclear antigen | 0.0307901 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0304225 |
| ACTN4 | actinin, alpha 4 | 0.0295871 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0295624 |
| SVIL | supervillin | 0.0291915 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0289909 |
| AMOTL1 | angiomotin like 1 | 0.0289352 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.0289214 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0287748 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0283979 |
| RIGI | RNA sensor RIG-I | 0.0283967 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.028278 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0282337 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.02778 |
| RASAL2 | RAS protein activator like 2 | 0.0276872 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.027643 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.026979 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0261494 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0259547 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0258451 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0258441 |
| IFI44L | interferon-induced protein 44-like | 0.0255808 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0255096 |
| FBXO32 | F-box protein 32 | 0.025503 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0254852 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0254168 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0252833 |
| PLEC | plectin | 0.0251145 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0248227 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0244563 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0243986 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0242635 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0242029 |
| TRIM44 | tripartite motif containing 44 | 0.0238912 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.023891 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.023865 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0238528 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0235867 |
| RAD51B | RAD51 paralog B | 0.0235231 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0234676 |
| PMEL | premelanosome protein | 0.0234542 |
| SEPTIN9 | septin 9 | 0.023383 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0232706 |
| ASPH | aspartate beta-hydroxylase | 0.023239 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0231766 |
| MYO9A | myosin IXA | 0.0231145 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0231081 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0227533 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0224824 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 0.0222905 |
| MKI67 | marker of proliferation Ki-67 | 0.0221213 |
| CHSY3 | chondroitin sulfate synthase 3 | 0.0220867 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.152763 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0717124 |
| VIM | vimentin | -0.0698246 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0655363 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0635796 |
| GOLGA4 | golgin A4 | -0.0585916 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0549364 |
| FN1 | fibronectin 1 | -0.0513085 |
| TENM1 | teneurin transmembrane protein 1 | -0.0505026 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0494848 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0465707 |
| RPS6 | ribosomal protein S6 | -0.0446078 |
| SETD5 | SET domain containing 5 | -0.0443514 |
| MT2A | metallothionein 2A | -0.0442402 |
| FTL | ferritin, light polypeptide | -0.0432519 |
| WDR45B | WD repeat domain 45B | -0.0393232 |
| SBF2 | SET binding factor 2 | -0.0370283 |
| RNF145 | ring finger protein 145 | -0.03666 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0365946 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0359614 |
| POTEF | POTE ankyrin domain family, member F | -0.0352063 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0348002 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0315018 |
| MT1X | metallothionein 1X | -0.0305548 |
| RTN4 | reticulon 4 | -0.0303722 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0303237 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0302259 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0291387 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0289363 |
| BBX | bobby sox homolog (Drosophila) | -0.0282651 |
| HELZ | helicase with zinc finger | -0.0276191 |
| CDK19 | cyclin-dependent kinase 19 | -0.0273877 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.0268741 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0266065 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.026497 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0263449 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0258782 |
| VDAC1 | voltage-dependent anion channel 1 | -0.025821 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0256871 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0256539 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0252571 |
| RBM39 | RNA binding motif protein 39 | -0.0249804 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0249587 |
| SRP54 | signal recognition particle 54kDa | -0.0247847 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0247002 |
| CLEC2D | C-type lectin domain family 2, member D | -0.0243728 |
| MIS18BP1 | MIS18 binding protein 1 | -0.024364 |
| MSN | moesin | -0.0242401 |
| COPA | coatomer protein complex, subunit alpha | -0.0242199 |
| THOC2 | THO complex 2 | -0.0241842 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0236164 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0233486 |
| SEC24A | SEC24 family member A | -0.0229725 |
| DOCK7 | dedicator of cytokinesis 7 | -0.0227719 |
| CCNL1 | cyclin L1 | -0.0221586 |
| NKTR | natural killer cell triggering receptor | -0.0221506 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0221018 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | -0.022069 |
| COG5 | component of oligomeric golgi complex 5 | -0.0212835 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0212655 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0212225 |
| ITGB5 | integrin, beta 5 | -0.0208799 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | -0.0207934 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0205705 |
| ATP11B | ATPase, class VI, type 11B | -0.0202434 |
| NOTCH2 | notch 2 | -0.0201435 |
| NBAS | neuroblastoma amplified sequence | -0.0198012 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0198008 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0196782 |
| ARF4 | ADP-ribosylation factor 4 | -0.0196624 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0196474 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | -0.0194108 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0191599 |
| TMEM87A | transmembrane protein 87A | -0.0191543 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.0191085 |
| FAM13B | family with sequence similarity 13, member B | -0.0189882 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0189866 |
| SRPK2 | SRSF protein kinase 2 | -0.0189342 |
| TFG | TRK-fused gene | -0.0187922 |
| NGLY1 | N-glycanase 1 | -0.0187541 |
| RHEB | Ras homolog enriched in brain | -0.0187062 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0185931 |
| YTHDC1 | YTH domain containing 1 | -0.0184619 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0184558 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | -0.0184511 |
| TMEM263 | transmembrane protein 263 | -0.0183596 |
| FNIP1 | folliculin interacting protein 1 | -0.018253 |
| TCERG1 | transcription elongation regulator 1 | -0.0181213 |
| UBC | ubiquitin C | -0.0180666 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0179103 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.017883 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0178044 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.017715 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0176738 |
| SPAG9 | sperm associated antigen 9 | -0.0175756 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0175714 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0174337 |
| ZNF292 | zinc finger protein 292 | -0.0171466 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0170757 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0170742 |
