Erdafitinib _SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erdafitinib perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erdafitinib _SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LDHA lactate dehydrogenase A 0.13125
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.130086
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.106985
BIRC3 baculoviral IAP repeat containing 3 0.0844331
SQSTM1 sequestosome 1 0.0800738
LOC112694756 uncharaterized LOC112694756 0.0710405
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0686092
VIM vimentin 0.0609143
ENO1 enolase 1, (alpha) 0.0553586
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0538876
MACF1 microtubule-actin crosslinking factor 1 0.0526639
EIF1 eukaryotic translation initiation factor 1 0.0515457
ASPH aspartate beta-hydroxylase 0.0475257
DST dystonin 0.0467155
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0437524
CD44 CD44 molecule (Indian blood group) 0.0418731
SET SET nuclear proto-oncogene 0.0412071
NAP1L1 nucleosome assembly protein 1-like 1 0.0397112
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0380858
DSCAM Down syndrome cell adhesion molecule 0.0370376
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0366831
RPS12 ribosomal protein S12 0.0363588
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.036048
SMAD3 SMAD family member 3 0.0350486
PGK1 phosphoglycerate kinase 1 0.0348014
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0347669
TXNRD1 thioredoxin reductase 1 0.0335834
FNDC3B fibronectin type III domain containing 3B 0.0335111
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.032711
WNK1 WNK lysine deficient protein kinase 1 0.0325166
ZNF292 zinc finger protein 292 0.0323988
RPL9 ribosomal protein L9 0.0311726
RORA RAR-related orphan receptor A 0.0311005
RDX radixin 0.0307169
KTN1 kinectin 1 (kinesin receptor) 0.0306424
ITCH itchy E3 ubiquitin protein ligase 0.0306209
RPL23 ribosomal protein L23 0.0297676
ERRFI1 ERBB receptor feedback inhibitor 1 0.0297344
JMJD1C jumonji domain containing 1C 0.0293068
TXNIP thioredoxin interacting protein 0.0287114
IPO7 importin 7 0.02868
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0285877
ANGPTL4 angiopoietin-like 4 0.0284007
RACK1 receptor for activated C kinase 1 0.0283722
PKM pyruvate kinase, muscle 0.0279687
MATR3 matrin 3 0.0277855
MBNL2 muscleblind-like splicing regulator 2 0.0277584
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0274482
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0273667
RIOK3 RIO kinase 3 0.0271758
HSPA8 heat shock 70kDa protein 8 0.0269944
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0268943
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0265949
ESYT2 extended synaptotagmin-like protein 2 0.0263659
NDRG1 N-myc downstream regulated 1 0.0260437
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0259232
GOLGB1 golgin B1 0.025678
YBX3 Y box binding protein 3 0.025115
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0247852
ANXA2 annexin A2 0.0244296
KIF5B kinesin family member 5B 0.0243669
MYH9 myosin, heavy chain 9, non-muscle 0.0241788
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0230451
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0228171
RTN4 reticulon 4 0.022777
CSNK1A1 casein kinase 1, alpha 1 0.0227389
RPL37A ribosomal protein L37a 0.0227026
ANXA1 annexin A1 0.0226153
PNISR PNN-interacting serine/arginine-rich protein 0.0225505
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.022502
CALR calreticulin 0.0222226
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0221074
TPI1 triosephosphate isomerase 1 0.0220623
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0219988
GSK3B glycogen synthase kinase 3 beta 0.0218159
TTC1 tetratricopeptide repeat domain 1 0.021644
FMNL2 formin-like 2 0.0215031
SEPTIN2 septin 2 0.0213408
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0212457
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0208566
AKAP13 A kinase (PRKA) anchor protein 13 0.020831
TNIP1 TNFAIP3 interacting protein 1 0.0207864
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0204369
EZR ezrin 0.0203567
SLC38A2 solute carrier family 38, member 2 0.0202725
RPS17 ribosomal protein S17 0.0202685
TTC3 tetratricopeptide repeat domain 3 0.0200889
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0200647
RUNX1 runt-related transcription factor 1 0.0198911
RSF1 remodeling and spacing factor 1 0.0198773
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.01977
MYOF myoferlin 0.0196393
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0196337
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0196008
CDCP1 CUB domain containing protein 1 0.0195881
SRRM2 serine/arginine repetitive matrix 2 0.0195076
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0195057
ELL2 elongation factor, RNA polymerase II, 2 0.019501
DPYD dihydropyrimidine dehydrogenase 0.0194192
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0193594

decreased expression

Symbol Name Standardized Value
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.051121
TPT1 tumor protein, translationally-controlled 1 -0.0423505
OASL 2'-5'-oligoadenylate synthetase-like -0.0379706
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0337043
POTEF POTE ankyrin domain family, member F -0.0303612
PTMA prothymosin, alpha -0.0282309
HMGA2 high mobility group AT-hook 2 -0.0268581
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0263684
THSD4 thrombospondin, type I, domain containing 4 -0.0256518
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0245688
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -0.0243269
SCFD1 sec1 family domain containing 1 -0.024072
DNER delta/notch-like EGF repeat containing -0.0239704
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0228239
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0226726
DLG1 discs, large homolog 1 (Drosophila) -0.0225031
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0224908
AOPEP aminopeptidase O (putative) -0.0222468
FOXO3 forkhead box O3 -0.0211362
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0209186
SRPK2 SRSF protein kinase 2 -0.0208045
BTBD9 BTB (POZ) domain containing 9 -0.0197265
SH3KBP1 SH3-domain kinase binding protein 1 -0.0197176
TMEM181 transmembrane protein 181 -0.0196964
ARMH4 armadillo like helical domain containing 4 -0.0194628
MBD5 methyl-CpG binding domain protein 5 -0.0187721
SETD5 SET domain containing 5 -0.0187309
ATM ATM serine/threonine kinase -0.0186103
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0180575
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0180418
POM121C POM121 transmembrane nucleoporin C -0.017552
IFI44 interferon-induced protein 44 -0.0173952
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0173695
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0171208
ANKMY1 ankyrin repeat and MYND domain containing 1 -0.0170118
E2F3 E2F transcription factor 3 -0.0168715
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0168353
GOLGA3 golgin A3 -0.0166923
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0166876
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0165803
CAMTA1 calmodulin binding transcription activator 1 -0.0164355
VCL vinculin -0.0163574
CHSY1 chondroitin sulfate synthase 1 -0.0162475
FCHSD2 FCH and double SH3 domains 2 -0.016118
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0160451
NUP188 nucleoporin 188kDa -0.0159598
PTK2 protein tyrosine kinase 2 -0.015914
XBP1 X-box binding protein 1 -0.0159011
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -0.015871
RMDN1 regulator of microtubule dynamics 1 -0.0156238
RAI14 retinoic acid induced 14 -0.0155916
RCOR1 REST corepressor 1 -0.0155001
PRH1 proline-rich protein HaeIII subfamily 1 -0.0154818
ETV6 ets variant 6 -0.0154022
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor -0.015088
UBA1 ubiquitin-like modifier activating enzyme 1 -0.0150419
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0149469
JAZF1 JAZF zinc finger 1 -0.014918
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0148881
ATP10D ATPase, class V, type 10D -0.0148357
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta -0.0148291
CD2AP CD2-associated protein -0.0148019
ENO2 enolase 2 (gamma, neuronal) -0.0147872
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0147318
SERINC3 serine incorporator 3 -0.014573
SNX14 sorting nexin 14 -0.0144806
CDC73 cell division cycle 73 -0.014403
ANKRD13C ankyrin repeat domain 13C -0.0143102
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0142888
CNKSR3 CNKSR family member 3 -0.0142569
LARP1 La ribonucleoprotein domain family, member 1 -0.0141982
HM13 histocompatibility (minor) 13 -0.0141291
ANKRD11 ankyrin repeat domain 11 -0.0141002
LYRM4 LYR motif containing 4 -0.0139443
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0139341
NPEPPS aminopeptidase puromycin sensitive -0.0139064
LRRC49 leucine rich repeat containing 49 -0.0138705
PRRC2B proline-rich coiled-coil 2B -0.0138526
TRAF3 TNF receptor-associated factor 3 -0.0138429
KDM5C lysine (K)-specific demethylase 5C -0.0138396
R3HDM1 R3H domain containing 1 -0.0138156
PLXNA3 plexin A3 -0.0137606
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -0.0137154
NOL7 nucleolar protein 7, 27kDa -0.0137072
BICRAL BICRA like chromatin remodeling complex associated protein -0.0136394
FAF1 Fas (TNFRSF6) associated factor 1 -0.0136085
KLHL7 kelch-like family member 7 -0.0135823
SMC6 structural maintenance of chromosomes 6 -0.0135479
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0133855
PARD3 par-3 family cell polarity regulator -0.0133715
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0133713
ABHD3 abhydrolase domain containing 3 -0.0132707
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0131017
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0130436
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 -0.0129823
PANX1 pannexin 1 -0.0129668
NEMF nuclear export mediator factor -0.0128982
JAK1 Janus kinase 1 -0.0128433
TAOK3 TAO kinase 3 -0.0128223
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.012734