Erdafitinib _SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erdafitinib perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erdafitinib _SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.227101
RPS12 ribosomal protein S12 0.118474
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.114059
RPL35A ribosomal protein L35a 0.111808
NCEH1 neutral cholesterol ester hydrolase 1 0.109632
LDHA lactate dehydrogenase A 0.101881
KRT18 keratin 18, type I 0.0882122
RPL12 ribosomal protein L12 0.0857407
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0848917
RPS3 ribosomal protein S3 0.0821798
RPL37A ribosomal protein L37a 0.0813328
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0792943
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0773525
RPLP1 ribosomal protein, large, P1 0.0746441
B2M beta-2-microglobulin 0.0742728
EIF1 eukaryotic translation initiation factor 1 0.0733001
EPCAM epithelial cell adhesion molecule 0.0725563
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0696389
DSPP dentin sialophosphoprotein 0.0679611
APLP2 amyloid beta (A4) precursor-like protein 2 0.0673879
SET SET nuclear proto-oncogene 0.0666617
RPL23 ribosomal protein L23 0.066509
RPL31 ribosomal protein L31 0.0662135
TMSB10 thymosin beta 10 0.0643611
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0641303
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0637262
SRRM2 serine/arginine repetitive matrix 2 0.0631635
RPS19 ribosomal protein S19 0.0626435
RPS17 ribosomal protein S17 0.0612423
EEF2 eukaryotic translation elongation factor 2 0.060851
RPS8 ribosomal protein S8 0.0596046
RPS6 ribosomal protein S6 0.0572554
MKI67 marker of proliferation Ki-67 0.0571245
RPS13 ribosomal protein S13 0.0570444
EGR1 early growth response 1 0.0541215
FTH1 ferritin, heavy polypeptide 1 0.0539766
RPS27A ribosomal protein S27a 0.0525405
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.050924
PGK1 phosphoglycerate kinase 1 0.0507363
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0504556
RPL11 ribosomal protein L11 0.0481271
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0474132
LOC102724023 ES1 protein homolog, mitochondrial 0.0470291
EEF1G eukaryotic translation elongation factor 1 gamma 0.0469698
KTN1 kinectin 1 (kinesin receptor) 0.046829
RPL26 ribosomal protein L26 0.0466139
RACK1 receptor for activated C kinase 1 0.0465155
RPL30 ribosomal protein L30 0.0464597
RPL37 ribosomal protein L37 0.0461779
STAT1 signal transducer and activator of transcription 1, 91kDa 0.046161
RPL7A ribosomal protein L7a 0.0457528
ZSWIM6 zinc finger, SWIM-type containing 6 0.0457478
RPL19 ribosomal protein L19 0.0453179
PTMA prothymosin, alpha 0.0449657
RPLP2 ribosomal protein, large, P2 0.0448142
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0442886
MLEC malectin 0.0436489
RPL13A ribosomal protein L13a 0.0432178
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0431353
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0429801
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0423303
RPL36 ribosomal protein L36 0.0422612
LOC112694756 uncharaterized LOC112694756 0.0419381
EZR ezrin 0.0414538
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0410999
RPL18 ribosomal protein L18 0.0409966
RPS2 ribosomal protein S2 0.0408909
SFTPA2 surfactant protein A2 0.0408787
S100A9 S100 calcium binding protein A9 0.0408786
SMAD3 SMAD family member 3 0.0406852
RPS21 ribosomal protein S21 0.040531
IFITM1 interferon induced transmembrane protein 1 0.0405016
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.04037
ANXA2 annexin A2 0.039917
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0398012
HLA-A major histocompatibility complex, class I, A 0.0394205
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0393656
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0391424
HSPA8 heat shock 70kDa protein 8 0.0390881
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0390044
NDRG1 N-myc downstream regulated 1 0.0390005
BPTF bromodomain PHD finger transcription factor 0.0386914
MYO1E myosin IE 0.0386879
ENO1 enolase 1, (alpha) 0.0384213
GOLGB1 golgin B1 0.0383244
ANKHD1 ankyrin repeat and KH domain containing 1 0.0382826
PKM pyruvate kinase, muscle 0.0378739
RPS27 ribosomal protein S27 0.0372224
CSNK1A1 casein kinase 1, alpha 1 0.0366897
RPS14 ribosomal protein S14 0.0364716
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.036368
RPL28 ribosomal protein L28 0.0359415
NEBL nebulette 0.0350246
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0349097
PRRC2C proline-rich coiled-coil 2C 0.0345968
KRT19 keratin 19, type I 0.0345154
ZBTB38 zinc finger and BTB domain containing 38 0.0339487
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0339233
GOLGA4 golgin A4 0.0337778
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0336863

decreased expression

Symbol Name Standardized Value
SDK1 sidekick cell adhesion molecule 1 -0.0400427
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0316238
USP3 ubiquitin specific peptidase 3 -0.0227967
TMEM123 transmembrane protein 123 -0.0224901
DLG1 discs, large homolog 1 (Drosophila) -0.0224731
GARS1 glycyl-tRNA synthetase 1 -0.0209564
NDFIP1 Nedd4 family interacting protein 1 -0.0201705
ANKRD28 ankyrin repeat domain 28 -0.0184604
SDC4 syndecan 4 -0.0174363
CCND1 cyclin D1 -0.0172365
FAM3C family with sequence similarity 3, member C -0.0171969
OSBPL3 oxysterol binding protein-like 3 -0.0168713
NFIA nuclear factor I/A -0.0167816
CDCP1 CUB domain containing protein 1 -0.0160494
AHNAK AHNAK nucleoprotein -0.0160169
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.0159998
GMDS GDP-mannose 4,6-dehydratase -0.01466
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0146449
CCNL1 cyclin L1 -0.0139402
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0131911
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -0.0130279
RBM39 RNA binding motif protein 39 -0.0129783
SPNS2 spinster homolog 2 (Drosophila) -0.012963
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0129461
PARD6B par-6 family cell polarity regulator beta -0.01275
TMEM39A transmembrane protein 39A -0.0126865
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0126437
TCERG1 transcription elongation regulator 1 -0.0125738
NT5C2 5'-nucleotidase, cytosolic II -0.0125344
NPEPPS aminopeptidase puromycin sensitive -0.0124503
EIF2A eukaryotic translation initiation factor 2A, 65kDa -0.0124141
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0123789
NUP214 nucleoporin 214kDa -0.012227
EPB41L4B erythrocyte membrane protein band 4.1 like 4B -0.0121729
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0119766
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0119584
CTSD cathepsin D -0.0117535
NAP1L4 nucleosome assembly protein 1-like 4 -0.011651
PPARG peroxisome proliferator-activated receptor gamma -0.0116429
FOSL1 FOS-like antigen 1 -0.0115324
RASA2 RAS p21 protein activator 2 -0.011456
COG5 component of oligomeric golgi complex 5 -0.0113794
VCL vinculin -0.011354
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.011319
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -0.0111859
FOXK1 forkhead box K1 -0.0111388
AZIN1 antizyme inhibitor 1 -0.0109451
LUC7L LUC7-like (S. cerevisiae) -0.0107845
VMP1 vacuole membrane protein 1 -0.0105357
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -0.0103731
LRPPRC leucine-rich pentatricopeptide repeat containing -0.01023
ZFAND6 zinc finger, AN1-type domain 6 -0.0102074
ADAM17 ADAM metallopeptidase domain 17 -0.0101793
FAR1 fatty acyl CoA reductase 1 -0.00999756
PDE8A phosphodiesterase 8A -0.00998514
PLAUR plasminogen activator, urokinase receptor -0.00990373
BRWD1 bromodomain and WD repeat domain containing 1 -0.00984911
SNX4 sorting nexin 4 -0.0096122
PTPRR protein tyrosine phosphatase, receptor type, R -0.00959039
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -0.00942898
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit -0.00941653
NEMF nuclear export mediator factor -0.00936749
DENND4C DENN/MADD domain containing 4C -0.00933499
ZNF460 zinc finger protein 460 -0.00922215
ZBTB46 zinc finger and BTB domain containing 46 -0.00921014
PDS5B PDS5 cohesin associated factor B -0.0092097
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.00920067
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 -0.00915668
EED embryonic ectoderm development -0.00914547
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.00912037
MED23 mediator complex subunit 23 -0.00910346
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.00901424
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.00898835
OGA O-GlcNAcase -0.00897047
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.00894077
U2SURP U2 snRNP-associated SURP domain containing -0.00893198
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.00888418
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 -0.00881981
RPL21 ribosomal protein L21 -0.0087116
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.00864459
UIMC1 ubiquitin interaction motif containing 1 -0.00839935
CLASRP CLK4-associating serine/arginine rich protein -0.00837655
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.00837647
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.00824705
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 -0.00812924
GPSM2 G-protein signaling modulator 2 -0.00810598
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa -0.00810253
WDR45B WD repeat domain 45B -0.00807543
PRKD3 protein kinase D3 -0.00802677
CACUL1 CDK2-associated, cullin domain 1 -0.00799895
RUFY2 RUN and FYVE domain containing 2 -0.0079846
USP24 ubiquitin specific peptidase 24 -0.00796265
FBXO28 F-box protein 28 -0.00791812
ECD ecdysoneless homolog (Drosophila) -0.0078824
WASHC4 WASH complex subunit 4 -0.0078464
PROSER2 proline and serine rich 2 -0.00781572
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.00781553
HACD2 3-hydroxyacyl-CoA dehydratase 2 -0.00780029
CDK19 cyclin-dependent kinase 19 -0.0076972
GID8 GID complex subunit 8 -0.00768763