Erdafitinib _SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erdafitinib perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erdafitinib _SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.181851
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.135041
HMGA2 high mobility group AT-hook 2 0.125375
EGFR epidermal growth factor receptor 0.119411
LAMA4 laminin, alpha 4 0.106225
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0963517
EGR1 early growth response 1 0.0954241
RPS12 ribosomal protein S12 0.0933438
EEF2 eukaryotic translation elongation factor 2 0.0898055
ACTG1 actin gamma 1 0.0795416
RPS8 ribosomal protein S8 0.0782104
LAMB3 laminin, beta 3 0.0759971
RPL35A ribosomal protein L35a 0.0754015
RAD51B RAD51 paralog B 0.0744945
SGPP2 sphingosine-1-phosphate phosphatase 2 0.0739587
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0735262
RCOR1 REST corepressor 1 0.0708984
FHIT fragile histidine triad 0.0690191
LDHA lactate dehydrogenase A 0.0676147
RPL23 ribosomal protein L23 0.0671427
ATXN1 ataxin 1 0.0635655
HSPA8 heat shock 70kDa protein 8 0.0624066
ENO1 enolase 1, (alpha) 0.0601009
RPS17 ribosomal protein S17 0.0586767
SMAD3 SMAD family member 3 0.0581014
LOC102724023 ES1 protein homolog, mitochondrial 0.0580209
RPL26 ribosomal protein L26 0.0577826
ABR active BCR-related 0.0577204
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0573251
SEPTIN9 septin 9 0.0568923
SRRM2 serine/arginine repetitive matrix 2 0.0563126
RPLP1 ribosomal protein, large, P1 0.0554254
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0547617
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0545288
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0544904
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0536165
SGMS2 sphingomyelin synthase 2 0.0524177
RPS19 ribosomal protein S19 0.0523027
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0512807
RPS3 ribosomal protein S3 0.0484873
RPL37A ribosomal protein L37a 0.0482558
RPL12 ribosomal protein L12 0.0482178
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0475238
RPL31 ribosomal protein L31 0.047247
RPS4X ribosomal protein S4, X-linked 0.0470521
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0456335
VCL vinculin 0.0452207
MYH9 myosin, heavy chain 9, non-muscle 0.0446059
KRT18 keratin 18, type I 0.0442719
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0423303
DSPP dentin sialophosphoprotein 0.0410883
NTSR1 neurotensin receptor 1 (high affinity) 0.0409622
RACK1 receptor for activated C kinase 1 0.0403552
RPL34 ribosomal protein L34 0.0396717
EMP1 epithelial membrane protein 1 0.0392759
EFNB2 ephrin-B2 0.0390987
DST dystonin 0.0390767
MKI67 marker of proliferation Ki-67 0.0390624
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.038006
RPL7 ribosomal protein L7 0.0368438
USP9X ubiquitin specific peptidase 9, X-linked 0.036327
NCEH1 neutral cholesterol ester hydrolase 1 0.0361451
CANX calnexin 0.03591
ITPKC inositol-trisphosphate 3-kinase C 0.0358759
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0357151
DOCK5 dedicator of cytokinesis 5 0.0355041
CTSB cathepsin B 0.0352456
EXOC4 exocyst complex component 4 0.0349128
RPS27A ribosomal protein S27a 0.034665
LPP LIM domain containing preferred translocation partner in lipoma 0.0346272
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.034626
EXT1 exostosin glycosyltransferase 1 0.0345831
RPL4 ribosomal protein L4 0.0343953
BIRC3 baculoviral IAP repeat containing 3 0.0341998
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0339302
CD9 CD9 molecule 0.0337159
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0335798
RPL30 ribosomal protein L30 0.0329704
RPS27 ribosomal protein S27 0.0328391
ACTN4 actinin, alpha 4 0.0327898
RPL7A ribosomal protein L7a 0.0327809
ANXA2 annexin A2 0.0327321
FHL2 four and a half LIM domains 2 0.0325101
JARID2 jumonji, AT rich interactive domain 2 0.0324362
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0324192
ASPH aspartate beta-hydroxylase 0.0319799
SET SET nuclear proto-oncogene 0.0315378
EHBP1 EH domain binding protein 1 0.031295
SFTPA2 surfactant protein A2 0.0304436
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0299834
SMYD3 SET and MYND domain containing 3 0.0297563
TENM3 teneurin transmembrane protein 3 0.0296969
CALR calreticulin 0.0291846
ZHX2 zinc fingers and homeoboxes 2 0.0291795
PDE4D phosphodiesterase 4D, cAMP-specific 0.0291004
CCSER1 coiled-coil serine-rich protein 1 0.028948
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0285736
TMSB10 thymosin beta 10 0.0284506
LAMC2 laminin, gamma 2 0.0282055
ZSWIM6 zinc finger, SWIM-type containing 6 0.0274706

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.120397
CD36 CD36 molecule (thrombospondin receptor) -0.109024
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0847779
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.075387
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.074129
HILPDA hypoxia inducible lipid droplet-associated -0.0665542
AREG amphiregulin -0.0660231
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0648553
GOLGA4 golgin A4 -0.0645872
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0586437
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.057135
COG5 component of oligomeric golgi complex 5 -0.0569233
PDE4B phosphodiesterase 4B, cAMP-specific -0.0564893
USP3 ubiquitin specific peptidase 3 -0.056359
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0549702
GARS1 glycyl-tRNA synthetase 1 -0.0549502
RNF145 ring finger protein 145 -0.0532441
OXR1 oxidation resistance 1 -0.0527921
WAC WW domain containing adaptor with coiled-coil -0.052322
KDM6A lysine (K)-specific demethylase 6A -0.052007
EREG epiregulin -0.0496631
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0486565
RUNX2 runt-related transcription factor 2 -0.0451086
TOP1 topoisomerase (DNA) I -0.044385
RBM39 RNA binding motif protein 39 -0.0439668
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0438533
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.043121
ZNF292 zinc finger protein 292 -0.0414072
LMO7 LIM domain 7 -0.0413653
BRWD1 bromodomain and WD repeat domain containing 1 -0.0407079
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0400517
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0395839
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0395765
PUM2 pumilio RNA-binding family member 2 -0.0391624
TXNRD1 thioredoxin reductase 1 -0.0376614
NEK7 NIMA-related kinase 7 -0.0372448
NAMPT nicotinamide phosphoribosyltransferase -0.0372139
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0370591
TSC22D2 TSC22 domain family, member 2 -0.0369817
PTBP2 polypyrimidine tract binding protein 2 -0.0368063
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0367878
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0362948
NUP58 nucleoporin 58 -0.0361587
KMT2C lysine (K)-specific methyltransferase 2C -0.0361248
SLMAP sarcolemma associated protein -0.0359086
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0351736
PNISR PNN-interacting serine/arginine-rich protein -0.0351129
PTMA prothymosin, alpha -0.0349
CDC73 cell division cycle 73 -0.0344681
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.033447
RNF43 ring finger protein 43 -0.0332633
RAB6A RAB6A, member RAS oncogene family -0.0324473
NPEPPS aminopeptidase puromycin sensitive -0.0321913
STRN3 striatin, calmodulin binding protein 3 -0.0321069
ZMYM2 zinc finger, MYM-type 2 -0.0320235
NCOR1 nuclear receptor corepressor 1 -0.0316947
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0311926
RBM25 RNA binding motif protein 25 -0.0310031
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0302093
TRA2A transformer 2 alpha homolog (Drosophila) -0.0300752
OSBPL3 oxysterol binding protein-like 3 -0.0297169
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0295919
NEMF nuclear export mediator factor -0.0295843
WDR45B WD repeat domain 45B -0.0294472
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0293644
RLF rearranged L-myc fusion -0.029307
CCNL1 cyclin L1 -0.0292002
OGA O-GlcNAcase -0.0286097
ATP11B ATPase, class VI, type 11B -0.0284868
PARD3 par-3 family cell polarity regulator -0.0284484
BIRC6 baculoviral IAP repeat containing 6 -0.0280386
FAR1 fatty acyl CoA reductase 1 -0.0274156
MARCHF6 membrane associated ring-CH-type finger 6 -0.0273089
BBX bobby sox homolog (Drosophila) -0.0272324
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0271315
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0267159
TXNIP thioredoxin interacting protein -0.026657
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0263183
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0262213
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0260748
NDRG1 N-myc downstream regulated 1 -0.0260338
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0259944
RAB1A RAB1A, member RAS oncogene family -0.025478
MIS18BP1 MIS18 binding protein 1 -0.0254096
SEC24D SEC24 family member D -0.0253252
PPP4R3A protein phosphatase 4 regulatory subunit 3A -0.0252448
WDR43 WD repeat domain 43 -0.0250657
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0249872
NCKAP1 NCK-associated protein 1 -0.0248816
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.02488
RFX7 regulatory factor X, 7 -0.0248778
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0248266
SEC63 SEC63 homolog (S. cerevisiae) -0.024335
NKTR natural killer cell triggering receptor -0.0240469
ITPRID2 ITPR interacting domain containing 2 -0.0237555
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0237058
SEC24B SEC24 family member B -0.023628
GDF15 growth differentiation factor 15 -0.023507
RANBP9 RAN binding protein 9 -0.0234644
ADAM9 ADAM metallopeptidase domain 9 -0.0229543