Erectile dysfunction_Penis Erectile Tissue_GSE2457 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Diseases
Category transcriptomics
Type disease perturbation
Description disease perturbation identified as [disease]_[tissue]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2457
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Genes

600 genes differentially expressed during Erectile dysfunction_Penis Erectile Tissue_GSE2457 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

increased expression

Symbol Name Standardized Value
ILF3 interleukin enhancer binding factor 3, 90kDa 3.96718
SIN3B SIN3 transcription regulator family member B 3.87799
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae) 3.74728
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 3.50741
EIF3A eukaryotic translation initiation factor 3, subunit A 3.35047
PLSCR3 phospholipid scramblase 3 3.30385
MDK midkine (neurite growth-promoting factor 2) 3.29206
RETSAT retinol saturase (all-trans-retinol 13,14-reductase) 3.23705
FNBP4 formin binding protein 4 3.19855
IDE insulin-degrading enzyme 3.19058
ZFAND5 zinc finger, AN1-type domain 5 3.17196
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 3.12825
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 3.11824
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa 3.10828
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 3.09405
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 3.02308
RTEL1 regulator of telomere elongation helicase 1 2.94703
PCGF3 polycomb group ring finger 3 2.94247
SRSF1 serine/arginine-rich splicing factor 1 2.9335
B2M beta-2-microglobulin 2.90639
HADH hydroxyacyl-CoA dehydrogenase 2.83157
EFR3A EFR3 homolog A (S. cerevisiae) 2.73806
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) 2.72942
FAM32A family with sequence similarity 32, member A 2.72411
YLPM1 YLP motif containing 1 2.69966
GRWD1 glutamate-rich WD repeat containing 1 2.6873
FLOT2 flotillin 2 2.65746
TRAK1 trafficking protein, kinesin binding 1 2.61748
YPEL3 yippee-like 3 (Drosophila) 2.61445
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 2.61408
STK25 serine/threonine kinase 25 2.61406
WDR74 WD repeat domain 74 2.59568
VWA8 von Willebrand factor A domain containing 8 2.59413
PRPF38B pre-mRNA processing factor 38B 2.58252
DMTF1 cyclin D binding myb-like transcription factor 1 2.56704
EIF3H eukaryotic translation initiation factor 3, subunit H 2.5297
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 2.5276
CHKB choline kinase beta 2.51534
MECR mitochondrial trans-2-enoyl-CoA reductase 2.50266
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) 2.48238
EHMT1 euchromatic histone-lysine N-methyltransferase 1 2.47274
RHOBTB1 Rho-related BTB domain containing 1 2.4524
RRAGC Ras-related GTP binding C 2.44863
AHCYL1 adenosylhomocysteinase-like 1 2.4484
PHF21A PHD finger protein 21A 2.44328
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.43778
WDR33 WD repeat domain 33 2.43677
USP33 ubiquitin specific peptidase 33 2.42453
KLHL6 kelch-like family member 6 2.42445
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase 2.42234
LPL lipoprotein lipase 2.41479
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 2.39498
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 2.39429
MBD6 methyl-CpG binding domain protein 6 2.38486
DAZAP2 DAZ associated protein 2 2.36292
KCTD18 potassium channel tetramerization domain containing 18 2.34102
EMC10 ER membrane protein complex subunit 10 2.32781
DNMBP dynamin binding protein 2.32207
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 2.31304
RPS2 ribosomal protein S2 2.3114
NCAPH2 non-SMC condensin II complex, subunit H2 2.30733
TEAD3 TEA domain family member 3 2.30292
CKAP5 cytoskeleton associated protein 5 2.28596
PTGES3 prostaglandin E synthase 3 (cytosolic) 2.26719
SMAD2 SMAD family member 2 2.25876
PARP14 poly (ADP-ribose) polymerase family, member 14 2.25528
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 2.24496
CIRH1A cirrhosis, autosomal recessive 1A (cirhin) 2.23829
ZFAND2B zinc finger, AN1-type domain 2B 2.23239
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 2.22031
TBC1D25 TBC1 domain family, member 25 2.2163
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 2.20468
PARL presenilin associated, rhomboid-like 2.20351
ARID3B AT rich interactive domain 3B (BRIGHT-like) 2.19851
SCAF4 SR-related CTD-associated factor 4 2.18002
DEGS1 delta(4)-desaturase, sphingolipid 1 2.16517
MIER2 mesoderm induction early response 1, family member 2 2.15937
NUMA1 nuclear mitotic apparatus protein 1 2.14754
PPAN peter pan homolog (Drosophila) 2.14335
PRUNE2 prune homolog 2 (Drosophila) 2.13962
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 2.13611
WDR1 WD repeat domain 1 2.12716
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 2.11672
SOCS5 suppressor of cytokine signaling 5 2.09457
PHF2 PHD finger protein 2 2.08683
DGAT1 diacylglycerol O-acyltransferase 1 2.08414
BTF3 basic transcription factor 3 2.0719
MYO1B myosin IB 2.06625
ALDH16A1 aldehyde dehydrogenase 16 family, member A1 2.05618
CTNNBL1 catenin, beta like 1 2.05361
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal 2.0505
RBM10 RNA binding motif protein 10 2.04662
METTL14 methyltransferase like 14 2.044
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 2.03775
F2RL1 coagulation factor II (thrombin) receptor-like 1 2.03481
XAB2 XPA binding protein 2 2.03348
ZNF830 zinc finger protein 830 2.0303
GRK4 G protein-coupled receptor kinase 4 2.00699
TAAR1 trace amine associated receptor 1 1.99998
EHBP1 EH domain binding protein 1 1.99249
QTRT1 queuine tRNA-ribosyltransferase 1 1.98132
CCT2 chaperonin containing TCP1, subunit 2 (beta) 1.96889
SMAD4 SMAD family member 4 1.96694
DEPDC5 DEP domain containing 5 1.96395
KEAP1 kelch-like ECH-associated protein 1 1.95631
CAPN10 calpain 10 1.95309
NONO non-POU domain containing, octamer-binding 1.9507
SCG5 secretogranin V 1.94444
GNS glucosamine (N-acetyl)-6-sulfatase 1.94222
LIPT2 lipoyl(octanoyl) transferase 2 (putative) 1.931
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 1.92078
ACAA2 acetyl-CoA acyltransferase 2 1.91998
UBE2I ubiquitin-conjugating enzyme E2I 1.91828
XPO5 exportin 5 1.9104
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 1.9035
RPL7A ribosomal protein L7a 1.89991
TLN1 talin 1 1.89863
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 1.8977
CCT7 chaperonin containing TCP1, subunit 7 (eta) 1.89288
KREMEN1 kringle containing transmembrane protein 1 1.87484
MAEA macrophage erythroblast attacher 1.87471
TXNRD3 thioredoxin reductase 3 1.87292
TRIM41 tripartite motif containing 41 1.86349
KIDINS220 kinase D-interacting substrate, 220kDa 1.85647
HDAC2 histone deacetylase 2 1.85636
SAP130 Sin3A-associated protein, 130kDa 1.84735
SNX16 sorting nexin 16 1.84471
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 1.8363
HBP1 HMG-box transcription factor 1 1.83438
INSR insulin receptor 1.83247
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 1.82119
DENND6A DENN/MADD domain containing 6A 1.81705
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe) 1.81477
FAHD1 fumarylacetoacetate hydrolase domain containing 1 1.81477
PICALM phosphatidylinositol binding clathrin assembly protein 1.81287
CORO1B coronin, actin binding protein, 1B 1.79912
COMTD1 catechol-O-methyltransferase domain containing 1 1.79732
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 1.79621
YTHDC1 YTH domain containing 1 1.78637
ZC3H10 zinc finger CCCH-type containing 10 1.78306
ACADVL acyl-CoA dehydrogenase, very long chain 1.77769
RASSF4 Ras association (RalGDS/AF-6) domain family member 4 1.77737
ZMIZ2 zinc finger, MIZ-type containing 2 1.77668
IQCB1 IQ motif containing B1 1.76531
PCSK4 proprotein convertase subtilisin/kexin type 4 1.76312
AP2M1 adaptor-related protein complex 2, mu 1 subunit 1.76187
LYPLA2 lysophospholipase II 1.7596
ZFYVE26 zinc finger, FYVE domain containing 26 1.7567
CNOT8 CCR4-NOT transcription complex, subunit 8 1.7508
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 1.74913
CTSZ cathepsin Z 1.74814
SMAD5 SMAD family member 5 1.74774
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 1.74332
GOLGA7 golgin A7 1.74091
CHMP2A charged multivesicular body protein 2A 1.73549
LEPROT leptin receptor overlapping transcript 1.73458
FBXO7 F-box protein 7 1.72985
NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) 1.72908
MAU2 MAU2 sister chromatid cohesion factor 1.72807
CDK11A cyclin-dependent kinase 11A 1.72691
UBR5 ubiquitin protein ligase E3 component n-recognin 5 1.72394
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 1.72387
MAP3K12 mitogen-activated protein kinase kinase kinase 12 1.72381
TRA2A transformer 2 alpha homolog (Drosophila) 1.71886
ACADL acyl-CoA dehydrogenase, long chain 1.71685
TOR1AIP2 torsin A interacting protein 2 1.71178
BMPR1A bone morphogenetic protein receptor, type IA 1.70849
LDB1 LIM domain binding 1 1.70613
KCTD10 potassium channel tetramerization domain containing 10 1.70597
TRIM28 tripartite motif containing 28 1.69781
RALBP1 ralA binding protein 1 1.69749
COX15 cytochrome c oxidase assembly homolog 15 (yeast) 1.69281
VAT1 vesicle amine transport 1 1.68165
NOP16 NOP16 nucleolar protein 1.67748
CNPPD1 cyclin Pas1/PHO80 domain containing 1 1.67381
PRSS23 protease, serine, 23 1.6691
FBXL3 F-box and leucine-rich repeat protein 3 1.66647
ADGRE5 adhesion G protein-coupled receptor E5 1.66199
RAD50 RAD50 homolog (S. cerevisiae) 1.65723
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.64809
TROAP trophinin associated protein 1.64547
CLK1 CDC-like kinase 1 1.64184
ZNF574 zinc finger protein 574 1.6416
CLK4 CDC-like kinase 4 1.64127
KPNB1 karyopherin (importin) beta 1 1.62952
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 1.62441
TNK2 tyrosine kinase, non-receptor, 2 1.62194
ZUFSP zinc finger with UFM1-specific peptidase domain 1.61573
EP400 E1A binding protein p400 1.61125
SLC30A3 solute carrier family 30 (zinc transporter), member 3 1.61005
CTCF CCCTC-binding factor (zinc finger protein) 1.60675
USP19 ubiquitin specific peptidase 19 1.60622
UBXN6 UBX domain protein 6 1.60529
CHD2 chromodomain helicase DNA binding protein 2 1.60043
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 1.59982
SF3A3 splicing factor 3a, subunit 3, 60kDa 1.5996
C3 complement component 3 1.59756
PRIM1 primase, DNA, polypeptide 1 (49kDa) 1.59701
DNASE2 deoxyribonuclease II, lysosomal 1.59676
TCF20 transcription factor 20 (AR1) 1.5939
FBXW8 F-box and WD repeat domain containing 8 1.5924
HEXIM1 hexamethylene bis-acetamide inducible 1 1.58928
GUSB glucuronidase, beta 1.58894
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) 1.58583
ZNF597 zinc finger protein 597 1.58565
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 1.58522
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 1.58298
OXA1L oxidase (cytochrome c) assembly 1-like 1.5828
KLHL25 kelch-like family member 25 1.58259
ADCY4 adenylate cyclase 4 1.58215
SERINC3 serine incorporator 3 1.58042
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 1.5783
MNT MAX network transcriptional repressor 1.57461
SNX1 sorting nexin 1 1.57447
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 1.5718
MAK16 MAK16 homolog (S. cerevisiae) 1.57098
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 1.57041
FGFR2 fibroblast growth factor receptor 2 1.56994
PHF5A PHD finger protein 5A 1.5689
FBP2 fructose-1,6-bisphosphatase 2 1.56849
MITF microphthalmia-associated transcription factor 1.56723
SLC25A27 solute carrier family 25, member 27 1.5638
CD46 CD46 molecule, complement regulatory protein 1.56369
ARMCX3 armadillo repeat containing, X-linked 3 1.5549
TELO2 telomere maintenance 2 1.55239
EIF4B eukaryotic translation initiation factor 4B 1.55196
IVNS1ABP influenza virus NS1A binding protein 1.5511
CYTH3 cytohesin 3 1.551
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 1.54461
RNPS1 RNA binding protein S1, serine-rich domain 1.53529
NUP93 nucleoporin 93kDa 1.53453
SESTD1 SEC14 and spectrin domains 1 1.53215
PARG poly (ADP-ribose) glycohydrolase 1.528
NGDN neuroguidin, EIF4E binding protein 1.52743
CALCOCO1 calcium binding and coiled-coil domain 1 1.52386
CNOT10 CCR4-NOT transcription complex, subunit 10 1.52182
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 1.52007
EREG epiregulin 1.51918
ZFP36L1 ZFP36 ring finger protein-like 1 1.51404
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 1.50766
CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6 1.50146
GRN granulin 1.49749
XPC xeroderma pigmentosum, complementation group C 1.4969
TSPAN4 tetraspanin 4 1.4949
FAM134A family with sequence similarity 134, member A 1.49473
CCDC51 coiled-coil domain containing 51 1.49253
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit 1.49034
PHKG2 phosphorylase kinase, gamma 2 (testis) 1.48918
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 1.48795
TPP1 tripeptidyl peptidase I 1.48783
TXNIP thioredoxin interacting protein 1.48651
LIMS2 LIM and senescent cell antigen-like domains 2 1.48571
CTSS cathepsin S 1.48528
CCDC115 coiled-coil domain containing 115 1.48221
PCBP2 poly(rC) binding protein 2 1.48212
RAD21 RAD21 homolog (S. pombe) 1.48091
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 1.47588
NCDN neurochondrin 1.47471
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 1.47343
PNPLA7 patatin-like phospholipase domain containing 7 1.47178
SP1 Sp1 transcription factor 1.47007
ITM2B integral membrane protein 2B 1.4693
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 1.46861
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae) 1.4675
SIRPA signal-regulatory protein alpha 1.46707
MNAT1 MNAT CDK-activating kinase assembly factor 1 1.46621
KLC4 kinesin light chain 4 1.46046
FTH1 ferritin, heavy polypeptide 1 1.45434
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 1.44646
LTV1 LTV1 ribosome biogenesis factor 1.4456
SIGMAR1 sigma non-opioid intracellular receptor 1 1.44506
SLU7 SLU7 splicing factor homolog (S. cerevisiae) 1.44496
PLIN3 perilipin 3 1.44287
FRMD6 FERM domain containing 6 1.44175
A1CF APOBEC1 complementation factor 1.43634
RAB24 RAB24, member RAS oncogene family 1.43229
SEPHS1 selenophosphate synthetase 1 1.43076
DCLRE1B DNA cross-link repair 1B 1.42878
ACTL6A actin-like 6A 1.42876
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) 1.42752
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 1.42684
BRI3 brain protein I3 1.42616
ACIN1 apoptotic chromatin condensation inducer 1 1.41873
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 1.41635
CSRP1 cysteine and glycine-rich protein 1 1.41609
EIF3F eukaryotic translation initiation factor 3, subunit F 1.41137
PTPN23 protein tyrosine phosphatase, non-receptor type 23 1.41117
SYNJ1 synaptojanin 1 1.41094
RAB11B RAB11B, member RAS oncogene family 1.40794
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 1.40771
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 1.40608
INSL3 insulin-like 3 (Leydig cell) 1.40561
NUPL2 nucleoporin like 2 1.4031
LMO7 LIM domain 7 1.40188
ZFYVE27 zinc finger, FYVE domain containing 27 1.40073
SH3GL1 SH3-domain GRB2-like 1 1.39608
KLRD1 killer cell lectin-like receptor subfamily D, member 1 1.3947
NR1D2 nuclear receptor subfamily 1, group D, member 2 1.39219
TBK1 TANK-binding kinase 1 1.39205
APLP2 amyloid beta (A4) precursor-like protein 2 1.39201

decreased expression

Symbol Name Standardized Value
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) -4.23382
C1QTNF6 C1q and tumor necrosis factor related protein 6 -3.47548
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) -3.35312
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) -3.18678
NID1 nidogen 1 -3.17881
CSRP2BP CSRP2 binding protein -3.11195
UBE2N ubiquitin-conjugating enzyme E2N -3.08619
MORF4L2 mortality factor 4 like 2 -3.07088
FAM96A family with sequence similarity 96, member A -3.02092
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 -2.88383
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like -2.84112
CALU calumenin -2.75461
LTBP3 latent transforming growth factor beta binding protein 3 -2.71776
NMBR neuromedin B receptor -2.62201
CEP350 centrosomal protein 350kDa -2.61766
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.59964
PDAP1 PDGFA associated protein 1 -2.59808
UBE2L3 ubiquitin-conjugating enzyme E2L 3 -2.56872
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 -2.54786
ERH enhancer of rudimentary homolog (Drosophila) -2.54343
FLAD1 flavin adenine dinucleotide synthetase 1 -2.53573
TRIAP1 TP53 regulated inhibitor of apoptosis 1 -2.51103
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 -2.50766
PEBP1 phosphatidylethanolamine binding protein 1 -2.42444
DARS aspartyl-tRNA synthetase -2.4205
TM2D2 TM2 domain containing 2 -2.41761
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.39377
IMPAD1 inositol monophosphatase domain containing 1 -2.32949
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -2.32947
TGFB3 transforming growth factor, beta 3 -2.32373
PHPT1 phosphohistidine phosphatase 1 -2.31662
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) -2.30855
MRPS16 mitochondrial ribosomal protein S16 -2.28612
CLDN16 claudin 16 -2.28608
MRPL17 mitochondrial ribosomal protein L17 -2.27522
TMEM69 transmembrane protein 69 -2.25931
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.24379
OXCT1 3-oxoacid CoA transferase 1 -2.2102
CBFB core-binding factor, beta subunit -2.20937
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) -2.20467
RYK receptor-like tyrosine kinase -2.18328
TUBGCP2 tubulin, gamma complex associated protein 2 -2.15469
DPP4 dipeptidyl-peptidase 4 -2.10001
NUBP1 nucleotide binding protein 1 -2.09043
DNLZ DNL-type zinc finger -2.08749
GMFB glia maturation factor, beta -2.07679
NECAB2 N-terminal EF-hand calcium binding protein 2 -2.06434
DPH3 diphthamide biosynthesis 3 -2.04751
NPHP1 nephronophthisis 1 (juvenile) -2.03181
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -2.00172
GEMIN2 gem (nuclear organelle) associated protein 2 -1.99878
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae) -1.97989
GATA4 GATA binding protein 4 -1.96192
BDKRB1 bradykinin receptor B1 -1.96171
FKBP15 FK506 binding protein 15, 133kDa -1.95329
TSPAN9 tetraspanin 9 -1.94917
PPT1 palmitoyl-protein thioesterase 1 -1.94001
SLC38A5 solute carrier family 38, member 5 -1.92167
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 -1.91422
TSPAN5 tetraspanin 5 -1.91208
SFRP4 secreted frizzled-related protein 4 -1.90867
DPCD deleted in primary ciliary dyskinesia homolog (mouse) -1.90525
AAMP angio-associated, migratory cell protein -1.88206
PPP1R13B protein phosphatase 1, regulatory subunit 13B -1.87202
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 -1.86789
CLTB clathrin, light chain B -1.85996
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) -1.84611
EXOC2 exocyst complex component 2 -1.84573
ADK adenosine kinase -1.84561
COA3 cytochrome c oxidase assembly factor 3 -1.84513
SDHAF2 succinate dehydrogenase complex assembly factor 2 -1.84448
MAOA monoamine oxidase A -1.84145
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) -1.8358
DCTN6 dynactin 6 -1.83249
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -1.83015
HSBP1 heat shock factor binding protein 1 -1.82529
COL8A1 collagen, type VIII, alpha 1 -1.82056
RNF25 ring finger protein 25 -1.81974
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -1.81903
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha -1.81426
CTLA4 cytotoxic T-lymphocyte-associated protein 4 -1.80813
ATP5F1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 -1.7999
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 -1.79578
EIF2D eukaryotic translation initiation factor 2D -1.78869
G6PC glucose-6-phosphatase, catalytic subunit -1.78669
PEX2 peroxisomal biogenesis factor 2 -1.77072
FAM114A2 family with sequence similarity 114, member A2 -1.76886
MRPS24 mitochondrial ribosomal protein S24 -1.76578
ZMYND8 zinc finger, MYND-type containing 8 -1.74777
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) -1.74544
PLBD2 phospholipase B domain containing 2 -1.72876
RNASEK ribonuclease, RNase K -1.72653
PRKCA protein kinase C, alpha -1.7224
BOLA3 bolA family member 3 -1.7198
INHA inhibin, alpha -1.71052
GPX4 glutathione peroxidase 4 -1.70182
ALKBH3 alkB, alkylation repair homolog 3 (E. coli) -1.70061
NOL6 nucleolar protein 6 (RNA-associated) -1.69311
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -1.69159
MRPS7 mitochondrial ribosomal protein S7 -1.68804
POMP proteasome maturation protein -1.67883
PPA2 pyrophosphatase (inorganic) 2 -1.67722
MAPK9 mitogen-activated protein kinase 9 -1.67589
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 -1.67533
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -1.67242
CRABP2 cellular retinoic acid binding protein 2 -1.67164
CWC15 CWC15 spliceosome-associated protein -1.66861
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) -1.66722
EMC6 ER membrane protein complex subunit 6 -1.66667
LOX lysyl oxidase -1.65592
PARP1 poly (ADP-ribose) polymerase 1 -1.65296
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -1.65057
RPL27 ribosomal protein L27 -1.65002
PURB purine-rich element binding protein B -1.6303
PIAS2 protein inhibitor of activated STAT, 2 -1.62346
CD99L2 CD99 molecule-like 2 -1.6209
DHODH dihydroorotate dehydrogenase (quinone) -1.61519
HBS1L HBS1-like translational GTPase -1.61087
ARGLU1 arginine and glutamate rich 1 -1.60488
FAM65B family with sequence similarity 65, member B -1.60476
MRPL20 mitochondrial ribosomal protein L20 -1.60426
RDH13 retinol dehydrogenase 13 (all-trans/9-cis) -1.60061
GNG11 guanine nucleotide binding protein (G protein), gamma 11 -1.60039
CHCHD1 coiled-coil-helix-coiled-coil-helix domain containing 1 -1.59942
XPO1 exportin 1 -1.59358
HINT3 histidine triad nucleotide binding protein 3 -1.59043
BABAM1 BRISC and BRCA1 A complex member 1 -1.58939
AACS acetoacetyl-CoA synthetase -1.58286
PET100 PET100 homolog (S. cerevisiae) -1.57791
GABRD gamma-aminobutyric acid (GABA) A receptor, delta -1.57759
MAPK15 mitogen-activated protein kinase 15 -1.57579
IRF2BPL interferon regulatory factor 2 binding protein-like -1.55846
NCOR2 nuclear receptor corepressor 2 -1.55778
LMAN2 lectin, mannose-binding 2 -1.55763
CAMK2A calcium/calmodulin-dependent protein kinase II alpha -1.55762
TMEM119 transmembrane protein 119 -1.55745
UFD1L ubiquitin fusion degradation 1 like (yeast) -1.55203
TXNDC15 thioredoxin domain containing 15 -1.54868
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -1.54328
SEC13 SEC13 homolog (S. cerevisiae) -1.54265
PPP1R3C protein phosphatase 1, regulatory subunit 3C -1.5386
EIF5B eukaryotic translation initiation factor 5B -1.53659
SLC41A3 solute carrier family 41, member 3 -1.53208
YBEY ybeY metallopeptidase (putative) -1.52941
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) -1.52421
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -1.52084
COPG2 coatomer protein complex, subunit gamma 2 -1.51509
ACADSB acyl-CoA dehydrogenase, short/branched chain -1.51465
YAE1D1 Yae1 domain containing 1 -1.51278
CSNK1D casein kinase 1, delta -1.51233
TNNT3 troponin T type 3 (skeletal, fast) -1.50485
CRYBG3 beta-gamma crystallin domain containing 3 -1.50458
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -1.4947
SET SET nuclear proto-oncogene -1.49256
FBXW5 F-box and WD repeat domain containing 5 -1.49242
MBNL2 muscleblind-like splicing regulator 2 -1.49195
RPL30 ribosomal protein L30 -1.48887
PRNP prion protein -1.48881
GALK1 galactokinase 1 -1.48697
GLB1 galactosidase, beta 1 -1.48384
CNBP CCHC-type zinc finger, nucleic acid binding protein -1.48322
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled -1.48228
LAPTM4A lysosomal protein transmembrane 4 alpha -1.4767
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -1.47522
CIT citron rho-interacting serine/threonine kinase -1.47239
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit -1.46227
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 -1.45778
GZF1 GDNF-inducible zinc finger protein 1 -1.4574
TRAK2 trafficking protein, kinesin binding 2 -1.45584
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 -1.45451
GSPT1 G1 to S phase transition 1 -1.443
CMC2 C-x(9)-C motif containing 2 -1.44175
ZNHIT1 zinc finger, HIT-type containing 1 -1.44028
KCMF1 potassium channel modulatory factor 1 -1.43752
GPR150 G protein-coupled receptor 150 -1.4343
MAST2 microtubule associated serine/threonine kinase 2 -1.43155
TMEM230 transmembrane protein 230 -1.43014
SPRYD4 SPRY domain containing 4 -1.42929
SMC6 structural maintenance of chromosomes 6 -1.425
EML1 echinoderm microtubule associated protein like 1 -1.41972
COX7B cytochrome c oxidase subunit VIIb -1.41946
LENG8 leukocyte receptor cluster (LRC) member 8 -1.41736
SSC5D scavenger receptor cysteine rich family, 5 domains -1.41661
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 -1.41472
ENO2 enolase 2 (gamma, neuronal) -1.41467
PMEPA1 prostate transmembrane protein, androgen induced 1 -1.41392
CNGA1 cyclic nucleotide gated channel alpha 1 -1.41002
MYEOV2 myeloma overexpressed 2 -1.40591
USP9X ubiquitin specific peptidase 9, X-linked -1.40589
EAPP E2F-associated phosphoprotein -1.40392
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -1.40226
MPI mannose phosphate isomerase -1.40132
CFAP36 cilia and flagella associated protein 36 -1.3989
ZFR zinc finger RNA binding protein -1.39828
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa -1.38893
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha -1.38678
PGLS 6-phosphogluconolactonase -1.38635
ATXN10 ataxin 10 -1.3863
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -1.38458
TMEM9B TMEM9 domain family, member B -1.38325
OTUD7B OTU deubiquitinase 7B -1.37563
ORAI1 ORAI calcium release-activated calcium modulator 1 -1.37168
NTAN1 N-terminal asparagine amidase -1.37017
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) -1.36931
POLR2M polymerase (RNA) II (DNA directed) polypeptide M -1.36575
MRFAP1 Morf4 family associated protein 1 -1.36239
GPRC5C G protein-coupled receptor, class C, group 5, member C -1.35929
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa -1.35655
MTMR7 myotubularin related protein 7 -1.35628
MLF2 myeloid leukemia factor 2 -1.3519
UMOD uromodulin -1.35089
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa -1.3497
TRAPPC5 trafficking protein particle complex 5 -1.34766
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -1.34689
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -1.34606
GTF3C6 general transcription factor IIIC, polypeptide 6, alpha 35kDa -1.34511
CREBZF CREB/ATF bZIP transcription factor -1.3443
WDR77 WD repeat domain 77 -1.34411
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -1.34407
ALG2 ALG2, alpha-1,3/1,6-mannosyltransferase -1.34091
ANAPC13 anaphase promoting complex subunit 13 -1.33243
ANKRD11 ankyrin repeat domain 11 -1.33155
KLHL2 kelch-like family member 2 -1.33141
GPX7 glutathione peroxidase 7 -1.31657
NDE1 nudE neurodevelopment protein 1 -1.31542
MTMR2 myotubularin related protein 2 -1.31357
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) -1.31252
HAUS7 HAUS augmin-like complex, subunit 7 -1.31103
ERCC8 excision repair cross-complementation group 8 -1.30681
PIEZO2 piezo-type mechanosensitive ion channel component 2 -1.30654
DUSP19 dual specificity phosphatase 19 -1.30423
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -1.30143
SAR1B secretion associated, Ras related GTPase 1B -1.30029
STK24 serine/threonine kinase 24 -1.29896
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -1.29843
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 -1.29823
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -1.29358
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) -1.29347
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -1.29313
HEATR5A HEAT repeat containing 5A -1.2928
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -1.2855
ANXA4 annexin A4 -1.28524
GHDC GH3 domain containing -1.28364
TTC7B tetratricopeptide repeat domain 7B -1.27928
TRAPPC2L trafficking protein particle complex 2-like -1.27467
CLDN12 claudin 12 -1.27121
MRPL35 mitochondrial ribosomal protein L35 -1.27107
ZMAT2 zinc finger, matrin-type 2 -1.27039
CES1 carboxylesterase 1 -1.26974
MAP1S microtubule-associated protein 1S -1.26719
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa -1.26619
PRKG2 protein kinase, cGMP-dependent, type II -1.26436
MRPL45 mitochondrial ribosomal protein L45 -1.26385
DNM3 dynamin 3 -1.25988
GRHPR glyoxylate reductase/hydroxypyruvate reductase -1.25578
PHTF1 putative homeodomain transcription factor 1 -1.25543
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -1.25378
GRPR gastrin-releasing peptide receptor -1.25083
NSMCE1 non-SMC element 1 homolog (S. cerevisiae) -1.25024
PHF20L1 PHD finger protein 20-like 1 -1.24743
TEP1 telomerase-associated protein 1 -1.24594
CDK19 cyclin-dependent kinase 19 -1.24205
RHOBTB3 Rho-related BTB domain containing 3 -1.24126
NID2 nidogen 2 (osteonidogen) -1.24032
EMC3 ER membrane protein complex subunit 3 -1.23851
TREH trehalase (brush-border membrane glycoprotein) -1.23351
CREB3 cAMP responsive element binding protein 3 -1.23309
VCAN versican -1.23231
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -1.22996
STRAP serine/threonine kinase receptor associated protein -1.22599
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -1.22551
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa -1.22358
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 -1.22037
CLEC2L C-type lectin domain family 2, member L -1.21809
HARS2 histidyl-tRNA synthetase 2, mitochondrial -1.21769
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) -1.2152
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -1.21224
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -1.20809
ICT1 immature colon carcinoma transcript 1 -1.20695
UBA3 ubiquitin-like modifier activating enzyme 3 -1.20669
KCTD17 potassium channel tetramerization domain containing 17 -1.20422
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L -1.20389
TXNDC17 thioredoxin domain containing 17 -1.2017
RAB34 RAB34, member RAS oncogene family -1.20165
SYS1 Sys1 golgi trafficking protein -1.20007
PITX3 paired-like homeodomain 3 -1.19906
NXN nucleoredoxin -1.19873
MKNK2 MAP kinase interacting serine/threonine kinase 2 -1.19517
TRAFD1 TRAF-type zinc finger domain containing 1 -1.19342
FAM98A family with sequence similarity 98, member A -1.19071
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) -1.18867
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 -1.18818
NR2C2 nuclear receptor subfamily 2, group C, member 2 -1.18775
TFRC transferrin receptor -1.18731
EMC2 ER membrane protein complex subunit 2 -1.18711
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) -1.18381
ANKRD24 ankyrin repeat domain 24 -1.18122
WDFY1 WD repeat and FYVE domain containing 1 -1.17736
RHOQ ras homolog family member Q -1.17403
PITPNB phosphatidylinositol transfer protein, beta -1.17304
Funding