| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/176870 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Erlotinib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIB3 | tribbles pseudokinase 3 | 1.48 |
| NRP1 | neuropilin 1 | 1.44 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 1.38 |
| NIBAN1 | niban apoptosis regulator 1 | 1.27 |
| IFRD1 | interferon-related developmental regulator 1 | 1.25 |
| UPP1 | uridine phosphorylase 1 | 1.09 |
| SLFN5 | schlafen family member 5 | 1.08 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 1.01 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.96 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.96 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.9 |
| HMGB2 | high mobility group box 2 | 0.85 |
| GTPBP2 | GTP binding protein 2 | 0.84 |
| H1-4 | H1.4 linker histone, cluster member | 0.83 |
| TSPAN3 | tetraspanin 3 | 0.81 |
| VGF | VGF nerve growth factor inducible | 0.81 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.8 |
| ULBP1 | UL16 binding protein 1 | 0.78 |
| GDF15 | growth differentiation factor 15 | 0.78 |
| SLC6A9 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | 0.76 |
| MAP1B | microtubule-associated protein 1B | 0.76 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 0.76 |
| STC2 | stanniocalcin 2 | 0.74 |
| SESN2 | sestrin 2 | 0.73 |
| JDP2 | Jun dimerization protein 2 | 0.71 |
| LAMC2 | laminin, gamma 2 | 0.68 |
| PLAU | plasminogen activator, urokinase | 0.65 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.64 |
| ROBO3 | roundabout, axon guidance receptor, homolog 3 (Drosophila) | 0.62 |
| COL13A1 | collagen, type XIII, alpha 1 | 0.62 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.62 |
| UCK1 | uridine-cytidine kinase 1 | 0.61 |
| R3HDM4 | R3H domain containing 4 | 0.61 |
| PRR3 | proline rich 3 | 0.61 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.61 |
| RIOK3 | RIO kinase 3 | 0.6 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.6 |
| GK5 | glycerol kinase 5 (putative) | 0.6 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.6 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.59 |
| PYGM | phosphorylase, glycogen, muscle | 0.59 |
| PLIN2 | perilipin 2 | 0.59 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.59 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.58 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.58 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.57 |
| KIAA1191 | KIAA1191 | 0.57 |
| LRATD2 | LRAT domain containing 2 | 0.56 |
| PYGB | phosphorylase, glycogen; brain | 0.55 |
| MYL12B | myosin, light chain 12B, regulatory | 0.54 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | 0.54 |
| KMT5A | lysine methyltransferase 5A | 0.53 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | 0.53 |
| CALB2 | calbindin 2 | 0.52 |
| ZNF354B | zinc finger protein 354B | 0.52 |
| PSPH | phosphoserine phosphatase | 0.51 |
| ATE1 | arginyltransferase 1 | 0.51 |
| STK19 | serine/threonine kinase 19 | 0.51 |
| CDV3 | CDV3 homolog (mouse) | 0.51 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.51 |
| ISL2 | ISL LIM homeobox 2 | 0.5 |
| S100A14 | S100 calcium binding protein A14 | 0.5 |
| SYNE3 | spectrin repeat containing, nuclear envelope family member 3 | 0.49 |
| FLYWCH1 | FLYWCH-type zinc finger 1 | 0.49 |
| MEGF8 | multiple EGF-like-domains 8 | 0.49 |
| SSB | Sjogren syndrome antigen B (autoantigen La) | 0.49 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.49 |
| TRIM7 | tripartite motif containing 7 | 0.49 |
| H1-5 | H1.5 linker histone, cluster member | 0.49 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.49 |
| AARS | alanyl-tRNA synthetase | 0.48 |
| RPL15 | ribosomal protein L15 | 0.48 |
| SGPL1 | sphingosine-1-phosphate lyase 1 | 0.48 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | 0.48 |
| KDM4A | lysine (K)-specific demethylase 4A | 0.48 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.48 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.48 |
| PCDH1 | protocadherin 1 | 0.48 |
| DUSP4 | dual specificity phosphatase 4 | 0.48 |
| TRIM16 | tripartite motif containing 16 | 0.48 |
| PLAUR | plasminogen activator, urokinase receptor | 0.48 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.47 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.47 |
| CCN2 | cellular communication network factor 2 | 0.47 |
| LAMA5 | laminin, alpha 5 | 0.46 |
| TAPT1 | transmembrane anterior posterior transformation 1 | 0.46 |
| TCEA3 | transcription elongation factor A (SII), 3 | 0.46 |
| PLEC | plectin | 0.46 |
| CLGN | calmegin | 0.46 |
| LAMB3 | laminin, beta 3 | 0.45 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 0.45 |
| ERLIN2 | ER lipid raft associated 2 | 0.45 |
| BTF3L4 | basic transcription factor 3-like 4 | 0.45 |
| ZFP62 | ZFP62 zinc finger protein | 0.45 |
| FLNB | filamin B, beta | 0.44 |
| CD22 | CD22 molecule | 0.44 |
| HIST2H2BC | histone cluster 2, H2bc (pseudogene) | 0.44 |
| PHGDH | phosphoglycerate dehydrogenase | 0.44 |
| CTHRC1 | collagen triple helix repeat containing 1 | 0.44 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.43 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MCOLN2 | mucolipin 2 | -3.07 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | -2.09 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -1.11 |
| METTL6 | methyltransferase like 6 | -1.08 |
| EPHX4 | epoxide hydrolase 4 | -1.08 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | -1.02 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.97 |
| HAPLN3 | hyaluronan and proteoglycan link protein 3 | -0.94 |
| CNTLN | centlein, centrosomal protein | -0.93 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | -0.91 |
| DEPDC7 | DEP domain containing 7 | -0.87 |
| RNF115 | ring finger protein 115 | -0.87 |
| HSD11B2 | hydroxysteroid (11-beta) dehydrogenase 2 | -0.83 |
| MIGA2 | mitoguardin 2 | -0.81 |
| ENO1 | enolase 1, (alpha) | -0.76 |
| RASSF7 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 | -0.73 |
| HOXA7 | homeobox A7 | -0.73 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.72 |
| BDNF | brain-derived neurotrophic factor | -0.72 |
| TMC6 | transmembrane channel-like 6 | -0.7 |
| UNC80 | unc-80 homolog (C. elegans) | -0.69 |
| TMEM231 | transmembrane protein 231 | -0.68 |
| TRIB1 | tribbles pseudokinase 1 | -0.67 |
| DENND3 | DENN/MADD domain containing 3 | -0.67 |
| USP53 | ubiquitin specific peptidase 53 | -0.66 |
| KITLG | KIT ligand | -0.65 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -0.65 |
| PRAME | preferentially expressed antigen in melanoma | -0.64 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | -0.63 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.63 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.62 |
| ANKRD22 | ankyrin repeat domain 22 | -0.62 |
| CCAR2 | cell cycle and apoptosis regulator 2 | -0.62 |
| GALNT11 | polypeptide N-acetylgalactosaminyltransferase 11 | -0.61 |
| CEP55 | centrosomal protein 55kDa | -0.61 |
| PRELID1 | PRELI domain containing 1 | -0.61 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.61 |
| ANKRD10 | ankyrin repeat domain 10 | -0.61 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.6 |
| UQCRH | ubiquinol-cytochrome c reductase hinge protein | -0.6 |
| CALU | calumenin | -0.59 |
| METTL26 | methyltransferase like 26 | -0.59 |
| SQLE | squalene epoxidase | -0.59 |
| SCARA3 | scavenger receptor class A, member 3 | -0.58 |
| OTC | ornithine carbamoyltransferase | -0.58 |
| FKBP7 | FK506 binding protein 7 | -0.58 |
| FAR1 | fatty acyl CoA reductase 1 | -0.58 |
| TP73 | tumor protein p73 | -0.58 |
| NES | nestin | -0.57 |
| TSR2 | TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) | -0.57 |
| AXIN2 | axin 2 | -0.57 |
| CCDC85C | coiled-coil domain containing 85C | -0.56 |
| TC2N | tandem C2 domains, nuclear | -0.56 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | -0.55 |
| BTG3 | BTG family, member 3 | -0.55 |
| GMNN | geminin, DNA replication inhibitor | -0.55 |
| KLHL21 | kelch-like family member 21 | -0.55 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.55 |
| TYRO3 | TYRO3 protein tyrosine kinase | -0.55 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.54 |
| CDC6 | cell division cycle 6 | -0.54 |
| TOB1 | transducer of ERBB2, 1 | -0.54 |
| DUSP14 | dual specificity phosphatase 14 | -0.54 |
| MTMR4 | myotubularin related protein 4 | -0.54 |
| CDK14 | cyclin-dependent kinase 14 | -0.54 |
| MAGEA12 | melanoma antigen family A12 | -0.54 |
| REEP1 | receptor accessory protein 1 | -0.54 |
| EGFL7 | EGF-like-domain, multiple 7 | -0.53 |
| RMND5B | required for meiotic nuclear division 5 homolog B (S. cerevisiae) | -0.53 |
| MEX3A | mex-3 RNA binding family member A | -0.53 |
| CD320 | CD320 molecule | -0.53 |
| SYTL3 | synaptotagmin-like 3 | -0.53 |
| PAIP2 | poly(A) binding protein interacting protein 2 | -0.53 |
| CRABP2 | cellular retinoic acid binding protein 2 | -0.52 |
| TGFBR3 | transforming growth factor, beta receptor III | -0.52 |
| AMMECR1L | AMMECR1-like | -0.52 |
| PLK1 | polo-like kinase 1 | -0.52 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | -0.52 |
| METRN | meteorin, glial cell differentiation regulator | -0.52 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.51 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.51 |
| CLASP1 | cytoplasmic linker associated protein 1 | -0.51 |
| ZNF483 | zinc finger protein 483 | -0.51 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.5 |
| UBE2S | ubiquitin-conjugating enzyme E2S | -0.5 |
| TTN | titin | -0.5 |
| LANCL3 | LanC lantibiotic synthetase component C-like 3 (bacterial) | -0.5 |
| ERICH5 | glutamate-rich 5 | -0.5 |
| PCLAF | PCNA clamp associated factor | -0.49 |
| RAD54B | RAD54 homolog B (S. cerevisiae) | -0.49 |
| TCTN3 | tectonic family member 3 | -0.49 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | -0.49 |
| NPHP1 | nephronophthisis 1 (juvenile) | -0.49 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | -0.49 |
| RFWD3 | ring finger and WD repeat domain 3 | -0.49 |
| PRKX | protein kinase, X-linked | -0.49 |
| GNB5 | guanine nucleotide binding protein (G protein), beta 5 | -0.49 |
| SKA3 | spindle and kinetochore associated complex subunit 3 | -0.49 |
| CENPM | centromere protein M | -0.48 |
