Erlotinib_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erlotinib perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erlotinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AREG amphiregulin 0.142638
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.112504
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.109063
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0969428
EHBP1 EH domain binding protein 1 0.0938622
ANXA1 annexin A1 0.0849838
DPYD dihydropyrimidine dehydrogenase 0.0495464
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0470422
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0441851
CENPF centromere protein F, 350/400kDa 0.0436971
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0420308
RASAL2 RAS protein activator like 2 0.0408952
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0392033
CLDN1 claudin 1 0.0377421
KIF5B kinesin family member 5B 0.0357541
STARD4 StAR-related lipid transfer (START) domain containing 4 0.033529
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0314438
CSNK1A1 casein kinase 1, alpha 1 0.0314122
GPBP1 GC-rich promoter binding protein 1 0.0312786
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0311227
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0306263
LDHB lactate dehydrogenase B 0.030216
BIRC3 baculoviral IAP repeat containing 3 0.030005
GARS1 glycyl-tRNA synthetase 1 0.0297327
RPS2 ribosomal protein S2 0.029317
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0292303
HMGA2 high mobility group AT-hook 2 0.0286969
POTEF POTE ankyrin domain family, member F 0.0282953
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0281745
RPS12 ribosomal protein S12 0.0280381
CARD16 caspase recruitment domain family, member 16 0.0279221
AKAP12 A kinase (PRKA) anchor protein 12 0.0276755
RPS3 ribosomal protein S3 0.027545
TXNRD1 thioredoxin reductase 1 0.026999
MMP12 matrix metallopeptidase 12 0.0269975
EXOC4 exocyst complex component 4 0.0255382
NAV3 neuron navigator 3 0.0255254
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0251088
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.024976
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.024663
WDR43 WD repeat domain 43 0.0244173
PLK2 polo-like kinase 2 0.0242295
ZCCHC7 zinc finger, CCHC domain containing 7 0.0224953
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0223877
CBX3 chromobox homolog 3 0.0211562
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0210804
BIRC6 baculoviral IAP repeat containing 6 0.0209625
U2SURP U2 snRNP-associated SURP domain containing 0.0207315
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0202755
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0201995
DST dystonin 0.0197702
BZW1 basic leucine zipper and W2 domains 1 0.0195338
SERINC1 serine incorporator 1 0.0194868
TCEA1 transcription elongation factor A (SII), 1 0.0194592
DENND1A DENN/MADD domain containing 1A 0.0193085
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0192159
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0192114
EDN1 endothelin 1 0.0187844
ASPH aspartate beta-hydroxylase 0.0187314
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0183318
RSL1D1 ribosomal L1 domain containing 1 0.0181495
MAP1B microtubule-associated protein 1B 0.0180283
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0179023
NSD1 nuclear receptor binding SET domain protein 1 0.0177766
LOC102724023 ES1 protein homolog, mitochondrial 0.0177672
MARCHF4 membrane associated ring-CH-type finger 4 0.0177575
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0176278
HDGF hepatoma-derived growth factor 0.0174833
CKAP5 cytoskeleton associated protein 5 0.0174001
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0171557
SLC38A1 solute carrier family 38, member 1 0.0167911
SPDYA speedy/RINGO cell cycle regulator family member A 0.0167004
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0166995
CUX1 cut-like homeobox 1 0.0166492
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0165486
HMGN1 high mobility group nucleosome binding domain 1 0.0164406
LIMA1 LIM domain and actin binding 1 0.0164055
PACS1 phosphofurin acidic cluster sorting protein 1 0.0162828
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0162197
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.0160548
RACK1 receptor for activated C kinase 1 0.0159365
THOC2 THO complex 2 0.0158668
RHBDD1 rhomboid domain containing 1 0.0155796
PAIP1 poly(A) binding protein interacting protein 1 0.0155016
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 0.0154592
ANK2 ankyrin 2, neuronal 0.0154349
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) 0.0153741
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0153289
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.0152996
RLF rearranged L-myc fusion 0.0151843
ZEB1 zinc finger E-box binding homeobox 1 0.0151216
PRDX1 peroxiredoxin 1 0.0150214
TRIO trio Rho guanine nucleotide exchange factor 0.0150141
VIM vimentin 0.0149386
TPM3 tropomyosin 3 0.01492
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0147686
SRBD1 S1 RNA binding domain 1 0.0146558
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0143293
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0143043
MARS1 methionyl-tRNA synthetase 1 0.0141995

decreased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 -0.133261
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.101234
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0862838
PDE4D phosphodiesterase 4D, cAMP-specific -0.0765811
TMSB10 thymosin beta 10 -0.0749442
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0694673
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.060555
MYL12B myosin, light chain 12B, regulatory -0.0478377
FTL ferritin, light polypeptide -0.0469619
CXADR coxsackie virus and adenovirus receptor -0.04651
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0446239
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0427094
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0410595
ACTG1 actin gamma 1 -0.0396508
PTMA prothymosin, alpha -0.0377058
MGAT4C MGAT4 family, member C -0.0376975
RPL35A ribosomal protein L35a -0.0365086
TMEM123 transmembrane protein 123 -0.0364944
CELF2 CUGBP, Elav-like family member 2 -0.0362491
USP34 ubiquitin specific peptidase 34 -0.0353183
AHNAK AHNAK nucleoprotein -0.0336056
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0334808
TNPO1 transportin 1 -0.0329244
KDM3A lysine (K)-specific demethylase 3A -0.0329212
MARCHF6 membrane associated ring-CH-type finger 6 -0.0328924
CCND1 cyclin D1 -0.0324136
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0312421
AXIN2 axin 2 -0.0302622
RPL23 ribosomal protein L23 -0.030247
RPS24 ribosomal protein S24 -0.029628
WWOX WW domain containing oxidoreductase -0.0295225
RPL34 ribosomal protein L34 -0.0288814
CALR calreticulin -0.0288726
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0287771
FUS FUS RNA binding protein -0.0275831
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 -0.0273957
RPS29 ribosomal protein S29 -0.0273937
RPLP1 ribosomal protein, large, P1 -0.0273433
TPT1 tumor protein, translationally-controlled 1 -0.0272006
NFE2L2 nuclear factor, erythroid 2-like 2 -0.027059
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0267748
KPNB1 karyopherin (importin) beta 1 -0.0266837
NCAPD2 non-SMC condensin I complex, subunit D2 -0.026559
IPO7 importin 7 -0.026369
WNK1 WNK lysine deficient protein kinase 1 -0.0257424
CLTC clathrin, heavy chain (Hc) -0.0256083
ATAD2 ATPase family, AAA domain containing 2 -0.0255087
JMJD1C jumonji domain containing 1C -0.0250289
YAP1 Yes-associated protein 1 -0.0249097
PDGFC platelet derived growth factor C -0.0247732
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0244556
PGK1 phosphoglycerate kinase 1 -0.0244506
TENT4A terminal nucleotidyltransferase 4A -0.0243789
EPHA6 EPH receptor A6 -0.0242623
KCMF1 potassium channel modulatory factor 1 -0.0239322
IL6ST interleukin 6 signal transducer -0.0237122
CPOX coproporphyrinogen oxidase -0.0233698
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0233389
ZNF217 zinc finger protein 217 -0.0232657
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0231855
RTN4 reticulon 4 -0.0225729
OXR1 oxidation resistance 1 -0.0225469
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0220124
MED13L mediator complex subunit 13-like -0.0218618
RPL19 ribosomal protein L19 -0.0218303
CNRIP1 cannabinoid receptor interacting protein 1 -0.0217548
VCL vinculin -0.0213919
RPS15 ribosomal protein S15 -0.0212137
CEP192 centrosomal protein 192kDa -0.0211988
RTN3 reticulon 3 -0.0210005
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0209887
SQSTM1 sequestosome 1 -0.020963
OGA O-GlcNAcase -0.0208648
KLHL24 kelch-like family member 24 -0.0208573
PUM2 pumilio RNA-binding family member 2 -0.020695
LARP1 La ribonucleoprotein domain family, member 1 -0.0206941
SETD5 SET domain containing 5 -0.0203594
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0202955
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0198286
WDR45B WD repeat domain 45B -0.0197017
TUBB6 tubulin, beta 6 class V -0.0196416
XPO1 exportin 1 -0.0196305
EDARADD EDAR-associated death domain -0.0193396
TJP1 tight junction protein 1 -0.019218
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0190044
NSD2 nuclear receptor binding SET domain protein 2 -0.0189381
ZDHHC2 zinc finger, DHHC-type containing 2 -0.0185718
RRM2 ribonucleotide reductase M2 -0.0185187
RBM39 RNA binding motif protein 39 -0.0184919
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0184279
RPS19 ribosomal protein S19 -0.0184159
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0182497
ATP11A ATPase, class VI, type 11A -0.0181907
GNAS GNAS complex locus -0.0179922
CLPTM1L CLPTM1-like -0.0179655
ELF2 E74-like factor 2 (ets domain transcription factor) -0.017894
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.0177503
NCOR1 nuclear receptor corepressor 1 -0.0177463
HMGA1 high mobility group AT-hook 1 -0.0176838
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0176212