Erlotinib_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erlotinib perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erlotinib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.128868
VIM vimentin 0.101033
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0939001
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0796939
RPS6 ribosomal protein S6 0.0580065
VEGFA vascular endothelial growth factor A 0.0559383
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0461682
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0438813
LDHA lactate dehydrogenase A 0.0407816
NALF1 NALCN channel auxiliary factor 1 0.0388139
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0381136
GOLGA4 golgin A4 0.0368319
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0350515
RPL26 ribosomal protein L26 0.0326711
GOLGB1 golgin B1 0.032029
EFNA5 ephrin-A5 0.0310568
CLIC4 chloride intracellular channel 4 0.0309597
RPS8 ribosomal protein S8 0.0290284
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0289297
CENPF centromere protein F, 350/400kDa 0.0286154
TPM4 tropomyosin 4 0.0276871
PDE10A phosphodiesterase 10A 0.027587
DOCK5 dedicator of cytokinesis 5 0.0266414
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0262414
RPS12 ribosomal protein S12 0.0253119
BZW1 basic leucine zipper and W2 domains 1 0.0252647
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0248778
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0246815
RPS2 ribosomal protein S2 0.0243099
TIMP1 TIMP metallopeptidase inhibitor 1 0.0240917
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0240657
RPL12 ribosomal protein L12 0.0240585
POTEF POTE ankyrin domain family, member F 0.0239334
TMSB4X thymosin beta 4, X-linked 0.023914
PTK2 protein tyrosine kinase 2 0.0237855
HP1BP3 heterochromatin protein 1, binding protein 3 0.0235719
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0232993
COL4A1 collagen, type IV, alpha 1 0.0232862
TM9SF3 transmembrane 9 superfamily member 3 0.0230594
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.022751
DLG1 discs, large homolog 1 (Drosophila) 0.0224847
MYH9 myosin, heavy chain 9, non-muscle 0.0224263
ANXA1 annexin A1 0.0223843
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0220569
GLS2 glutaminase 2 (liver, mitochondrial) 0.0219937
ATP13A3 ATPase type 13A3 0.0219912
DSTN destrin (actin depolymerizing factor) 0.0219002
VMP1 vacuole membrane protein 1 0.0217851
NFE2L1 nuclear factor, erythroid 2-like 1 0.0217388
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0216597
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0216298
RPL5 ribosomal protein L5 0.0215648
SNX9 sorting nexin 9 0.0215359
POSTN periostin, osteoblast specific factor 0.0215003
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0213541
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0212654
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.021012
RSRC1 arginine/serine-rich coiled-coil 1 0.0209479
IL6 interleukin 6 0.0207525
VCAN versican 0.0207388
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0203519
FTH1 ferritin, heavy polypeptide 1 0.020343
UBC ubiquitin C 0.0203361
PTBP2 polypyrimidine tract binding protein 2 0.0202904
CSDE1 cold shock domain containing E1, RNA-binding 0.0201825
TCEA1 transcription elongation factor A (SII), 1 0.0201697
RPL11 ribosomal protein L11 0.0200467
RPL7 ribosomal protein L7 0.0197722
TXNRD1 thioredoxin reductase 1 0.0196953
MSN moesin 0.0196389
NUP58 nucleoporin 58 0.0193768
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0193021
NIPBL Nipped-B homolog (Drosophila) 0.0192958
FCHSD2 FCH and double SH3 domains 2 0.0191703
RPLP0 ribosomal protein, large, P0 0.0190613
LGALS1 lectin, galactoside-binding, soluble, 1 0.0190413
AKAP13 A kinase (PRKA) anchor protein 13 0.0188085
SP100 SP100 nuclear antigen 0.0187507
EEF2 eukaryotic translation elongation factor 2 0.0187244
MBD5 methyl-CpG binding domain protein 5 0.0185036
ZNF654 zinc finger protein 654 0.0183916
SRGN serglycin 0.01838
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0182123
RPL37A ribosomal protein L37a 0.0181282
RACK1 receptor for activated C kinase 1 0.017948
ECT2 epithelial cell transforming 2 0.0178195
FER fer (fps/fes related) tyrosine kinase 0.017677
NBAS neuroblastoma amplified sequence 0.0173781
OPTN optineurin 0.017316
SMC4 structural maintenance of chromosomes 4 0.017238
ZSWIM6 zinc finger, SWIM-type containing 6 0.0169277
SETD2 SET domain containing 2 0.0168744
CDK19 cyclin-dependent kinase 19 0.0167452
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0167302
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0165737
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0165593
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0165226
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.0165122
TPM2 tropomyosin 2 (beta) 0.0164086
BTBD9 BTB (POZ) domain containing 9 0.016399

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.450441
IGFBP3 insulin-like growth factor binding protein 3 -0.209776
COL1A1 collagen, type I, alpha 1 -0.15755
COL6A3 collagen, type VI, alpha 3 -0.1557
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.139114
CALR calreticulin -0.0988849
EXT1 exostosin glycosyltransferase 1 -0.0964052
NDRG1 N-myc downstream regulated 1 -0.0791442
TGFBI transforming growth factor, beta-induced, 68kDa -0.0790784
MT2A metallothionein 2A -0.0762633
LOX lysyl oxidase -0.0706405
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0623181
TMSB10 thymosin beta 10 -0.0620055
COL1A2 collagen, type I, alpha 2 -0.0565748
CD44 CD44 molecule (Indian blood group) -0.054623
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0524747
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0511431
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0478379
IER3 immediate early response 3 -0.0472879
CALU calumenin -0.0454942
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0448555
COL5A1 collagen, type V, alpha 1 -0.0441563
ELL2 elongation factor, RNA polymerase II, 2 -0.0425836
TM4SF1 transmembrane 4 L six family member 1 -0.04203
LTBP1 latent transforming growth factor beta binding protein 1 -0.0418935
FTL ferritin, light polypeptide -0.0406506
AHNAK AHNAK nucleoprotein -0.0395307
ANXA2 annexin A2 -0.0387354
PLEC plectin -0.038546
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0346977
PTMA prothymosin, alpha -0.0338967
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0332195
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0325853
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0323162
LMAN1 lectin, mannose-binding, 1 -0.0321063
CTSB cathepsin B -0.0319077
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0317611
MT1X metallothionein 1X -0.0312188
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.03108
ASPH aspartate beta-hydroxylase -0.0305175
ZNF292 zinc finger protein 292 -0.030052
WSB1 WD repeat and SOCS box containing 1 -0.0298401
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.02834
NAMPT nicotinamide phosphoribosyltransferase -0.0280607
OSMR oncostatin M receptor -0.0272667
COL6A2 collagen, type VI, alpha 2 -0.0262188
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0256706
PALLD palladin, cytoskeletal associated protein -0.0256113
MAP4 microtubule-associated protein 4 -0.0255555
GANAB glucosidase, alpha; neutral AB -0.02521
DPYSL3 dihydropyrimidinase-like 3 -0.0251384
MTSS1 metastasis suppressor 1 -0.0249596
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0244288
VCL vinculin -0.0242844
HLA-B major histocompatibility complex, class I, B -0.0241883
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0240216
ICAM1 intercellular adhesion molecule 1 -0.0239289
UGDH UDP-glucose 6-dehydrogenase -0.0239176
ADM adrenomedullin -0.0238433
PGK1 phosphoglycerate kinase 1 -0.023657
S100A10 S100 calcium binding protein A10 -0.0234467
COL6A1 collagen, type VI, alpha 1 -0.0230871
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0230477
NPEPPS aminopeptidase puromycin sensitive -0.0229222
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0224864
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0219539
KDM3A lysine (K)-specific demethylase 3A -0.0215747
RAP1B RAP1B, member of RAS oncogene family -0.0214854
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0213266
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0210447
BRD4 bromodomain containing 4 -0.0209153
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0209042
FBXO32 F-box protein 32 -0.020785
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0206965
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0203869
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0203826
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0202776
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0199614
PSD3 pleckstrin and Sec7 domain containing 3 -0.0198622
DPYD dihydropyrimidine dehydrogenase -0.0198507
FAM20C family with sequence similarity 20, member C -0.0197422
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0196041
ZFAND3 zinc finger, AN1-type domain 3 -0.0194999
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0193728
TGFB1 transforming growth factor, beta 1 -0.0192298
TRPS1 trichorhinophalangeal syndrome I -0.0190351
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0188457
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0187089
TNIP1 TNFAIP3 interacting protein 1 -0.0185011
MTDH metadherin -0.0184272
JUN jun proto-oncogene -0.0182451
ABI3BP ABI family, member 3 (NESH) binding protein -0.0181993
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0180493
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0180125
SMYD3 SET and MYND domain containing 3 -0.0179593
PXDN peroxidasin -0.0178473
GLIS3 GLIS family zinc finger 3 -0.0177541
SMAD5 SMAD family member 5 -0.0176955
HAS2 hyaluronan synthase 2 -0.0176062
SDCBP syndecan binding protein (syntenin) -0.017602