Erlotinib_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erlotinib perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erlotinib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ANXA1 annexin A1 0.10892
TRIO trio Rho guanine nucleotide exchange factor 0.0912932
MBNL2 muscleblind-like splicing regulator 2 0.0690396
TIMP3 TIMP metallopeptidase inhibitor 3 0.0653918
TMSB4X thymosin beta 4, X-linked 0.05281
NAMPT nicotinamide phosphoribosyltransferase 0.050766
EMP1 epithelial membrane protein 1 0.0478297
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0477068
EZR ezrin 0.0452767
ESYT2 extended synaptotagmin-like protein 2 0.0404755
EFNA5 ephrin-A5 0.0399733
BZW1 basic leucine zipper and W2 domains 1 0.0393977
NRG1 neuregulin 1 0.0387788
JMJD1C jumonji domain containing 1C 0.0366351
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0333164
EFHD2 EF-hand domain family, member D2 0.0327095
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0307643
DSTN destrin (actin depolymerizing factor) 0.0303528
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0289168
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0286308
MEF2A myocyte enhancer factor 2A 0.0284447
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0272517
PIBF1 progesterone immunomodulatory binding factor 1 0.0256393
DUSP6 dual specificity phosphatase 6 0.0252247
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.024492
QKI QKI, KH domain containing, RNA binding 0.0235969
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease 0.022582
DLG1 discs, large homolog 1 (Drosophila) 0.0220738
MORF4L2 mortality factor 4 like 2 0.0218455
FAM13A family with sequence similarity 13, member A 0.0216226
RND3 Rho family GTPase 3 0.021554
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0209487
COPB1 coatomer protein complex, subunit beta 1 0.0206578
RUNX1 runt-related transcription factor 1 0.0205189
LMO7 LIM domain 7 0.0204637
TMEM263 transmembrane protein 263 0.0195763
SAMD9 sterile alpha motif domain containing 9 0.0193004
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0185813
RAI14 retinoic acid induced 14 0.0183569
GOLGB1 golgin B1 0.0181836
CLDN1 claudin 1 0.0181536
SLC38A1 solute carrier family 38, member 1 0.0176818
AKAP9 A kinase (PRKA) anchor protein 9 0.0170386
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0169774
ANKRD33B ankyrin repeat domain 33B 0.016883
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0168646
DST dystonin 0.01671
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0166107
TMF1 TATA element modulatory factor 1 0.0165856
SSBP2 single-stranded DNA binding protein 2 0.0162851
OPTN optineurin 0.0161306
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0160853
SGMS2 sphingomyelin synthase 2 0.0159285
FN1 fibronectin 1 0.0159251
DSPP dentin sialophosphoprotein 0.0157293
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0154964
TBC1D22A TBC1 domain family, member 22A 0.0153561
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0152836
CD44 CD44 molecule (Indian blood group) 0.0152469
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0151878
FNBP1L formin binding protein 1-like 0.0151794
SCFD1 sec1 family domain containing 1 0.0151489
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0148163
STK17B serine/threonine kinase 17b 0.0148053
YEATS2 YEATS domain containing 2 0.0147537
FNIP1 folliculin interacting protein 1 0.0146448
RPL26 ribosomal protein L26 0.0145242
PDE4D phosphodiesterase 4D, cAMP-specific 0.0144983
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0144598
ELL2 elongation factor, RNA polymerase II, 2 0.0143529
CRY1 cryptochrome circadian clock 1 0.0143232
EREG epiregulin 0.0143148
IL1RAP interleukin 1 receptor accessory protein 0.0142916
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.0141581
ALCAM activated leukocyte cell adhesion molecule 0.0140547
AHR aryl hydrocarbon receptor 0.0140197
RPL30 ribosomal protein L30 0.0140023
MLF1 myeloid leukemia factor 1 0.0138627
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0137977
TAS2R14 taste receptor, type 2, member 14 0.0137899
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 0.0137735
HMBOX1 homeobox containing 1 0.0136576
BHLHE40 basic helix-loop-helix family, member e40 0.0134957
ARFGEF3 ARFGEF family member 3 0.0133754
PPARG peroxisome proliferator-activated receptor gamma 0.0133265
OSBPL9 oxysterol binding protein-like 9 0.0130998
PHF3 PHD finger protein 3 0.0130932
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0130255
SLC45A4 solute carrier family 45, member 4 0.0129271
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0129063
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0128247
PLAC8 placenta-specific 8 0.0128245
ANKIB1 ankyrin repeat and IBR domain containing 1 0.012807
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0127563
GLS2 glutaminase 2 (liver, mitochondrial) 0.0127202
LITAF lipopolysaccharide-induced TNF factor 0.0126656
FBXL2 F-box and leucine-rich repeat protein 2 0.0125676
NKTR natural killer cell triggering receptor 0.0125557
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0124992
PFDN4 prefoldin subunit 4 0.0124625

decreased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein -0.0880046
POTEF POTE ankyrin domain family, member F -0.0842029
PTMA prothymosin, alpha -0.0830592
TMSB10 thymosin beta 10 -0.0822287
ENO1 enolase 1, (alpha) -0.0791922
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0707039
ACTN4 actinin, alpha 4 -0.0643321
PKM pyruvate kinase, muscle -0.0614175
PLEC plectin -0.0608021
UBC ubiquitin C -0.0596372
SULF1 sulfatase 1 -0.0508738
B2M beta-2-microglobulin -0.0487159
SLC35F3 solute carrier family 35, member F3 -0.0473513
MT2A metallothionein 2A -0.0469202
SULF2 sulfatase 2 -0.0460234
SRRM2 serine/arginine repetitive matrix 2 -0.0453732
HLA-B major histocompatibility complex, class I, B -0.0442516
PGK1 phosphoglycerate kinase 1 -0.0440992
MTSS1 metastasis suppressor 1 -0.0432425
PRRC2C proline-rich coiled-coil 2C -0.0410099
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0404161
TXNIP thioredoxin interacting protein -0.0395753
MYH9 myosin, heavy chain 9, non-muscle -0.0390558
RPS3 ribosomal protein S3 -0.0388811
HSPG2 heparan sulfate proteoglycan 2 -0.0387825
RPL23 ribosomal protein L23 -0.0386602
TSC22D1 TSC22 domain family, member 1 -0.0385319
EEF2 eukaryotic translation elongation factor 2 -0.0384889
BCAR3 breast cancer anti-estrogen resistance 3 -0.0376834
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0372305
TGM2 transglutaminase 2 -0.0370174
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0364857
RPS27A ribosomal protein S27a -0.036322
NDRG1 N-myc downstream regulated 1 -0.0358467
RPLP2 ribosomal protein, large, P2 -0.035452
WSB1 WD repeat and SOCS box containing 1 -0.0348719
CD59 CD59 molecule, complement regulatory protein -0.0348321
LMNA lamin A/C -0.0346703
GNAS GNAS complex locus -0.0343625
PTK2 protein tyrosine kinase 2 -0.0340167
IGF2 insulin-like growth factor 2 -0.0339937
WASF2 WAS protein family, member 2 -0.0338784
IFITM1 interferon induced transmembrane protein 1 -0.0336043
KRT17 keratin 17, type I -0.0335363
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0334395
MSN moesin -0.0328831
ECE1 endothelin converting enzyme 1 -0.0323131
LOC112694756 uncharaterized LOC112694756 -0.0322755
S100A11 S100 calcium binding protein A11 -0.0307159
IGFBP4 insulin-like growth factor binding protein 4 -0.0304577
IFI6 interferon, alpha-inducible protein 6 -0.0304209
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0304
CALU calumenin -0.0301167
CD9 CD9 molecule -0.0300427
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0299612
MYO10 myosin X -0.0295362
LAMA5 laminin, alpha 5 -0.0295079
PCDH1 protocadherin 1 -0.0293214
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.028891
FLNB filamin B, beta -0.0288384
ANO1 anoctamin 1, calcium activated chloride channel -0.0285162
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0284848
IFITM3 interferon induced transmembrane protein 3 -0.028434
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0278349
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0271448
DIAPH1 diaphanous-related formin 1 -0.0270552
RPL8 ribosomal protein L8 -0.0270445
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0267939
KRT14 keratin 14, type I -0.0267404
PLS3 plastin 3 -0.0266213
RPS13 ribosomal protein S13 -0.0264614
NAV2 neuron navigator 2 -0.0262838
RPS19 ribosomal protein S19 -0.026248
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0260607
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0260489
LRRC8A leucine rich repeat containing 8 family, member A -0.0258035
TNIP1 TNFAIP3 interacting protein 1 -0.0257854
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0254817
OGA O-GlcNAcase -0.0253677
RPL37 ribosomal protein L37 -0.0251155
SRPK2 SRSF protein kinase 2 -0.0247358
TPM4 tropomyosin 4 -0.0246817
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0245279
RPL36 ribosomal protein L36 -0.0244271
FLNA filamin A, alpha -0.0243698
RPL37A ribosomal protein L37a -0.0242221
EPHA2 EPH receptor A2 -0.0241637
MCL1 myeloid cell leukemia 1 -0.0240706
RPL7A ribosomal protein L7a -0.0240656
MARCHF6 membrane associated ring-CH-type finger 6 -0.0240267
PCBP2 poly(rC) binding protein 2 -0.0234973
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0233095
ITGA6 integrin, alpha 6 -0.0230964
HMGA2 high mobility group AT-hook 2 -0.0230588
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0230147
CALR calreticulin -0.0229432
IFI27 interferon, alpha-inducible protein 27 -0.0228269
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0226983
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0226931
PALLD palladin, cytoskeletal associated protein -0.022407