Erlotinib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erlotinib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erlotinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.224837
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.152451
EEF2 eukaryotic translation elongation factor 2 0.0917726
VIM vimentin 0.0698316
RPL37 ribosomal protein L37 0.0698249
RPS8 ribosomal protein S8 0.0695494
RPLP0 ribosomal protein, large, P0 0.0585941
RPS12 ribosomal protein S12 0.0546901
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0511365
RPS3 ribosomal protein S3 0.0504071
PCBP2 poly(rC) binding protein 2 0.0500887
TPI1 triosephosphate isomerase 1 0.0485981
RPL11 ribosomal protein L11 0.048109
RPL12 ribosomal protein L12 0.0453644
RPS6 ribosomal protein S6 0.0452959
CSDE1 cold shock domain containing E1, RNA-binding 0.0451225
RPS21 ribosomal protein S21 0.0445411
RPL35A ribosomal protein L35a 0.044532
RPL37A ribosomal protein L37a 0.0419906
ZNF292 zinc finger protein 292 0.0413241
RPL26 ribosomal protein L26 0.0385262
RACK1 receptor for activated C kinase 1 0.0381746
POTEF POTE ankyrin domain family, member F 0.037668
EEF1G eukaryotic translation elongation factor 1 gamma 0.0371521
RPS2 ribosomal protein S2 0.0371281
RPS17 ribosomal protein S17 0.0370305
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0350776
EIF1 eukaryotic translation initiation factor 1 0.0344987
GOLGB1 golgin B1 0.0339973
TMSB10 thymosin beta 10 0.0326855
GOLGA4 golgin A4 0.0316334
COPA coatomer protein complex, subunit alpha 0.0313408
YBX1 Y box binding protein 1 0.0312736
RPL5 ribosomal protein L5 0.0311324
RPS27 ribosomal protein S27 0.0310286
LDHB lactate dehydrogenase B 0.0303626
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0303039
RPL9 ribosomal protein L9 0.0302369
GARS1 glycyl-tRNA synthetase 1 0.0299134
CAMTA1 calmodulin binding transcription activator 1 0.0297747
RPLP2 ribosomal protein, large, P2 0.0297093
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0295055
RAB6A RAB6A, member RAS oncogene family 0.0278334
RPS27A ribosomal protein S27a 0.0276784
UBC ubiquitin C 0.026849
RLF rearranged L-myc fusion 0.026421
RPS29 ribosomal protein S29 0.0263612
FTH1 ferritin, heavy polypeptide 1 0.0263047
RPL27 ribosomal protein L27 0.0262397
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0257978
RPS14 ribosomal protein S14 0.0257347
RPL34 ribosomal protein L34 0.0252604
KIF5B kinesin family member 5B 0.0244874
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0243599
TPM2 tropomyosin 2 (beta) 0.0240237
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0236602
RPL36 ribosomal protein L36 0.0234753
RPS13 ribosomal protein S13 0.0232126
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0232046
CBX3 chromobox homolog 3 0.02276
HDGF hepatoma-derived growth factor 0.0225368
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0221103
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0220774
MYO6 myosin VI 0.0220369
SET SET nuclear proto-oncogene 0.0219387
RPS19 ribosomal protein S19 0.0215584
ATP5F1E ATP synthase F1 subunit epsilon 0.021541
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.021502
ENO1 enolase 1, (alpha) 0.0213496
RPLP1 ribosomal protein, large, P1 0.0213162
SERINC3 serine incorporator 3 0.021293
NACA nascent polypeptide-associated complex alpha subunit 0.0212321
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0211564
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0210909
RPS23 ribosomal protein S23 0.0210467
KMT2E lysine (K)-specific methyltransferase 2E 0.0210009
PTMS parathymosin 0.0209147
KMT2C lysine (K)-specific methyltransferase 2C 0.0207347
DSTN destrin (actin depolymerizing factor) 0.0204739
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.020359
OSBPL8 oxysterol binding protein-like 8 0.020285
SERBP1 SERPINE1 mRNA binding protein 1 0.0201471
RPS4X ribosomal protein S4, X-linked 0.0197264
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0196724
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 0.0195741
TPM3 tropomyosin 3 0.0193625
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 0.0190866
RPL28 ribosomal protein L28 0.0189688
NAP1L1 nucleosome assembly protein 1-like 1 0.0189338
ZCCHC7 zinc finger, CCHC domain containing 7 0.0188178
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0187075
PFN1 profilin 1 0.0185733
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0184959
SRP54 signal recognition particle 54kDa 0.0184481
RB1CC1 RB1-inducible coiled-coil 1 0.0182837
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0182203
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0180081
KDM7A lysine (K)-specific demethylase 7A 0.0179985
SCAF11 SR-related CTD-associated factor 11 0.0179167
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0178864

decreased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B -0.178636
THSD4 thrombospondin, type I, domain containing 4 -0.124953
AKAP12 A kinase (PRKA) anchor protein 12 -0.107074
IGF1R insulin-like growth factor 1 receptor -0.101382
YBX3 Y box binding protein 3 -0.0912595
PDE10A phosphodiesterase 10A -0.082516
OSMR oncostatin M receptor -0.0810846
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0791068
NABP1 nucleic acid binding protein 1 -0.0642717
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0640937
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0635729
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.063406
RAD51B RAD51 paralog B -0.0632479
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0625378
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0605297
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0579867
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0575376
TAS2R14 taste receptor, type 2, member 14 -0.0574904
VCL vinculin -0.056677
EXT1 exostosin glycosyltransferase 1 -0.0551997
HMGA2 high mobility group AT-hook 2 -0.0551562
RIMS2 regulating synaptic membrane exocytosis 2 -0.0550272
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0542644
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.05342
TFPI2 tissue factor pathway inhibitor 2 -0.0531647
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0530905
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0525549
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.051175
EML4 echinoderm microtubule associated protein like 4 -0.0500144
RNF213 ring finger protein 213 -0.0492691
ELL2 elongation factor, RNA polymerase II, 2 -0.0486736
DOCK5 dedicator of cytokinesis 5 -0.0484772
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0480179
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0475947
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0472809
AHNAK AHNAK nucleoprotein -0.0472623
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0469022
EXOC4 exocyst complex component 4 -0.0466491
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0463855
NF1 neurofibromin 1 -0.0458456
FUS FUS RNA binding protein -0.0450823
PDE4D phosphodiesterase 4D, cAMP-specific -0.0441094
ACTG1 actin gamma 1 -0.043761
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0436036
ATP11A ATPase, class VI, type 11A -0.0433191
DNAH14 dynein, axonemal, heavy chain 14 -0.0430401
USP34 ubiquitin specific peptidase 34 -0.0422512
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0420635
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0419873
ATXN1 ataxin 1 -0.041512
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0412768
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0410669
MCL1 myeloid cell leukemia 1 -0.0407801
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0404586
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0403774
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0403442
RRM2 ribonucleotide reductase M2 -0.040151
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0401436
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0397014
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0392099
AEBP2 AE binding protein 2 -0.0391587
NCOA7 nuclear receptor coactivator 7 -0.0391096
WWOX WW domain containing oxidoreductase -0.0389681
FMNL2 formin-like 2 -0.0388346
E2F3 E2F transcription factor 3 -0.0379099
EHBP1 EH domain binding protein 1 -0.0373921
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0364896
SPIDR scaffolding protein involved in DNA repair -0.0363749
NCOR1 nuclear receptor corepressor 1 -0.0362989
FBXO11 F-box protein 11 -0.0360746
PRH1 proline-rich protein HaeIII subfamily 1 -0.0356953
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0355052
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0352074
CTTN cortactin -0.0351732
AGO2 argonaute RISC catalytic component 2 -0.0349924
YAP1 Yes-associated protein 1 -0.0343526
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0342781
CMIP c-Maf inducing protein -0.0338553
ATG7 autophagy related 7 -0.0334898
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0333472
ZNF638 zinc finger protein 638 -0.0331549
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.03305
DOCK1 dedicator of cytokinesis 1 -0.033008
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0329652
BICD1 bicaudal D homolog 1 (Drosophila) -0.0329423
TIAM1 T-cell lymphoma invasion and metastasis 1 -0.0325673
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0321665
RBM39 RNA binding motif protein 39 -0.0320851
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0320602
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0312681
LARP4B La ribonucleoprotein domain family, member 4B -0.0310154
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0304751
R3HDM2 R3H domain containing 2 -0.0302366
GPATCH8 G patch domain containing 8 -0.0301437
EGFR epidermal growth factor receptor -0.03013
TRIP12 thyroid hormone receptor interactor 12 -0.0299144
TRIO trio Rho guanine nucleotide exchange factor -0.0298529
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0296238
ARMH4 armadillo like helical domain containing 4 -0.0295123
PDLIM5 PDZ and LIM domain 5 -0.0294473