Erlotinib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erlotinib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erlotinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PSD3 pleckstrin and Sec7 domain containing 3 0.0931772
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0575179
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0343511
NRCAM neuronal cell adhesion molecule 0.0337377
RAD51B RAD51 paralog B 0.0275495
PDE4D phosphodiesterase 4D, cAMP-specific 0.0257707
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0227542
NALF1 NALCN channel auxiliary factor 1 0.0222352
MSN moesin 0.0202918
RABGAP1L RAB GTPase activating protein 1-like 0.0192917
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0190167
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0188015
RAB3B RAB3B, member RAS oncogene family 0.0187156
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0186719
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0178563
GRAMD1B GRAM domain containing 1B 0.0176564
FTH1 ferritin, heavy polypeptide 1 0.0175676
BCAR3 breast cancer anti-estrogen resistance 3 0.0171675
MAML3 mastermind-like 3 (Drosophila) 0.0170525
SH3KBP1 SH3-domain kinase binding protein 1 0.0169499
NFE2L1 nuclear factor, erythroid 2-like 1 0.0168778
PCBP3 poly(rC) binding protein 3 0.0165519
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0164615
RPS2 ribosomal protein S2 0.0161166
DOCK4 dedicator of cytokinesis 4 0.0159402
NPAS2 neuronal PAS domain protein 2 0.0152083
VMP1 vacuole membrane protein 1 0.0143098
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0142806
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0141557
SMOC1 SPARC related modular calcium binding 1 0.0140574
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0138943
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.01326
APLP2 amyloid beta (A4) precursor-like protein 2 0.0132494
DISP1 dispatched homolog 1 (Drosophila) 0.0131224
SPTBN1 spectrin, beta, non-erythrocytic 1 0.012704
PAPPA2 pappalysin 2 0.0127037
RGS2 regulator of G-protein signaling 2 0.0125606
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0122185
CD109 CD109 molecule 0.0119266
COL4A5 collagen, type IV, alpha 5 0.0116296
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0113918
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0112575
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0112387
PRELID2 PRELI domain containing 2 0.0111758
EXOC4 exocyst complex component 4 0.0111673
NBEA neurobeachin 0.0110526
NIBAN1 niban apoptosis regulator 1 0.0110424
SKAP2 src kinase associated phosphoprotein 2 0.0110216
FBXL17 F-box and leucine-rich repeat protein 17 0.0109572
ANO6 anoctamin 6 0.0109172
ZMIZ1 zinc finger, MIZ-type containing 1 0.0108139
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0106515
DST dystonin 0.0106365
CCDC6 coiled-coil domain containing 6 0.010588
NTSR1 neurotensin receptor 1 (high affinity) 0.0104179
MCFD2 multiple coagulation factor deficiency 2 0.0103864
INHBA inhibin, beta A 0.0101063
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0100281
ZC3H12C zinc finger CCCH-type containing 12C 0.0100078
NHSL1 NHS-like 1 0.00984746
TENM3 teneurin transmembrane protein 3 0.00966593
CLMN calmin (calponin-like, transmembrane) 0.00950899
CARD16 caspase recruitment domain family, member 16 0.00946578
TENM2 teneurin transmembrane protein 2 0.00943009
MBD5 methyl-CpG binding domain protein 5 0.00932504
THSD4 thrombospondin, type I, domain containing 4 0.00927946
EFNA5 ephrin-A5 0.00926831
AUTS2 autism susceptibility candidate 2 0.00906368
GLIS3 GLIS family zinc finger 3 0.00893725
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.00885832
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 0.0088439
NRG1 neuregulin 1 0.00880895
ZFP36 ZFP36 ring finger protein 0.00863409
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.00857667
GPRIN3 GPRIN family member 3 0.00854637
POTEF POTE ankyrin domain family, member F 0.00846218
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.00843885
EXOC6B exocyst complex component 6B 0.00836185
PYGL phosphorylase, glycogen, liver 0.00831279
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.00830401
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.00827485
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.00827167
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.00825205
FER fer (fps/fes related) tyrosine kinase 0.0081735
ITPK1 inositol-tetrakisphosphate 1-kinase 0.00812154
ARB2A ARB2 cotranscriptional regulator A 0.00806436
CSRP1 cysteine and glycine-rich protein 1 0.00791517
EHBP1 EH domain binding protein 1 0.00773523
ZBTB20 zinc finger and BTB domain containing 20 0.00770447
CHL1 cell adhesion molecule L1-like 0.00769129
CCSER2 coiled-coil serine-rich protein 2 0.00767348
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.00764227
TBC1D5 TBC1 domain family, member 5 0.00763202
STK24 serine/threonine kinase 24 0.00753779
COL4A6 collagen, type IV, alpha 6 0.00747585
ITGA6 integrin, alpha 6 0.00747504
ATM ATM serine/threonine kinase 0.00746698
KLF12 Kruppel-like factor 12 0.00745943
TMEM178B transmembrane protein 178B 0.00745627
LRP12 low density lipoprotein receptor-related protein 12 0.00735228

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.25398
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.236717
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.220679
PTMA prothymosin, alpha -0.175348
FTL ferritin, light polypeptide -0.124487
FN1 fibronectin 1 -0.118713
TMSB10 thymosin beta 10 -0.111587
TM4SF1 transmembrane 4 L six family member 1 -0.100515
TPT1 tumor protein, translationally-controlled 1 -0.0883305
VIM vimentin -0.0845455
SPAG9 sperm associated antigen 9 -0.0817092
ASPH aspartate beta-hydroxylase -0.0788533
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0766138
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0765809
PGK1 phosphoglycerate kinase 1 -0.0761658
CANX calnexin -0.0720888
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.069101
RPLP1 ribosomal protein, large, P1 -0.0690217
NAP1L1 nucleosome assembly protein 1-like 1 -0.0674497
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0626568
RPS24 ribosomal protein S24 -0.0601596
RPS6 ribosomal protein S6 -0.0557241
RPL35A ribosomal protein L35a -0.0555801
S100A10 S100 calcium binding protein A10 -0.0553156
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0537786
GNAS GNAS complex locus -0.0536687
WSB1 WD repeat and SOCS box containing 1 -0.0536022
ELL2 elongation factor, RNA polymerase II, 2 -0.0517121
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0513374
ACTG1 actin gamma 1 -0.0506413
RPL19 ribosomal protein L19 -0.0503277
ANXA2 annexin A2 -0.0502449
TFPI2 tissue factor pathway inhibitor 2 -0.0488431
RPS19 ribosomal protein S19 -0.0485102
NDRG1 N-myc downstream regulated 1 -0.0484278
RBM39 RNA binding motif protein 39 -0.0482961
RPL12 ribosomal protein L12 -0.0482494
RPS8 ribosomal protein S8 -0.0474689
RPL23 ribosomal protein L23 -0.0465455
WDR45B WD repeat domain 45B -0.0459213
RPS27A ribosomal protein S27a -0.0451491
MORF4L2 mortality factor 4 like 2 -0.0448243
RPL31 ribosomal protein L31 -0.0447025
MT2A metallothionein 2A -0.0441024
KDM3A lysine (K)-specific demethylase 3A -0.044092
S100A6 S100 calcium binding protein A6 -0.043816
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0428134
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0422086
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0421236
RPL37A ribosomal protein L37a -0.0415936
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0413547
TXNRD1 thioredoxin reductase 1 -0.0407554
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0405799
RPL34 ribosomal protein L34 -0.0401585
DDIT4 DNA-damage-inducible transcript 4 -0.0400747
GOLGA4 golgin A4 -0.0397389
CALR calreticulin -0.0390294
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0374136
KPNB1 karyopherin (importin) beta 1 -0.0368361
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0357223
RPL7A ribosomal protein L7a -0.03546
RPL36A ribosomal protein L36a -0.0353422
RPS23 ribosomal protein S23 -0.0352762
PALLD palladin, cytoskeletal associated protein -0.0348646
RPLP2 ribosomal protein, large, P2 -0.0347874
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0346449
PDIA4 protein disulfide isomerase family A, member 4 -0.0345903
OGA O-GlcNAcase -0.0345638
RTN4 reticulon 4 -0.0345235
HLA-B major histocompatibility complex, class I, B -0.0344507
TGFBI transforming growth factor, beta-induced, 68kDa -0.0341466
RPS3 ribosomal protein S3 -0.0341294
MYOF myoferlin -0.0341042
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0340623
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0338979
RPS29 ribosomal protein S29 -0.0338301
USP3 ubiquitin specific peptidase 3 -0.0337993
PRRC2C proline-rich coiled-coil 2C -0.0337524
WAC WW domain containing adaptor with coiled-coil -0.0336722
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0336436
PDIA3 protein disulfide isomerase family A, member 3 -0.0332088
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0331273
RPL38 ribosomal protein L38 -0.0331268
LAMA1 laminin, alpha 1 -0.0327444
COL5A2 collagen, type V, alpha 2 -0.0327352
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0327242
RAP1B RAP1B, member of RAS oncogene family -0.0323561
VDAC1 voltage-dependent anion channel 1 -0.0323085
PKM pyruvate kinase, muscle -0.0323054
SOD2 superoxide dismutase 2, mitochondrial -0.0319931
KMT2E lysine (K)-specific methyltransferase 2E -0.031964
LMAN1 lectin, mannose-binding, 1 -0.0319511
KMT2C lysine (K)-specific methyltransferase 2C -0.0317056
RPS16 ribosomal protein S16 -0.0315625
RPL26 ribosomal protein L26 -0.0313909
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0313565
TRIO trio Rho guanine nucleotide exchange factor -0.0312092
GDA guanine deaminase -0.0310344
SMYD3 SET and MYND domain containing 3 -0.0300954
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.029942