Erlotinib_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erlotinib perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erlotinib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.131869
TMSB4X thymosin beta 4, X-linked 0.108861
RPS6 ribosomal protein S6 0.106301
RPS8 ribosomal protein S8 0.0952876
LDHA lactate dehydrogenase A 0.079156
RPLP0 ribosomal protein, large, P0 0.0768519
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0730075
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0650199
RPL35A ribosomal protein L35a 0.0631172
RACK1 receptor for activated C kinase 1 0.0573855
EEF2 eukaryotic translation elongation factor 2 0.0565604
CD47 CD47 molecule 0.0550864
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0529002
GOLGA4 golgin A4 0.0524663
RPL12 ribosomal protein L12 0.0521582
NAP1L1 nucleosome assembly protein 1-like 1 0.0513172
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0510729
S100A6 S100 calcium binding protein A6 0.0468576
RPLP1 ribosomal protein, large, P1 0.0466892
RPL37A ribosomal protein L37a 0.0445618
RPL13A ribosomal protein L13a 0.0443295
CENPF centromere protein F, 350/400kDa 0.0436298
NFIA nuclear factor I/A 0.0407278
SSBP2 single-stranded DNA binding protein 2 0.0399548
RPL26 ribosomal protein L26 0.038255
RPS12 ribosomal protein S12 0.0382397
SMC3 structural maintenance of chromosomes 3 0.0381478
RPS19 ribosomal protein S19 0.0374827
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0367993
TMEM263 transmembrane protein 263 0.0365007
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0357761
ECT2 epithelial cell transforming 2 0.0353562
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.035144
ZNF292 zinc finger protein 292 0.0348994
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.034433
RBM25 RNA binding motif protein 25 0.0336951
PNISR PNN-interacting serine/arginine-rich protein 0.033641
EIF1 eukaryotic translation initiation factor 1 0.0333204
LDHB lactate dehydrogenase B 0.0332859
DSTN destrin (actin depolymerizing factor) 0.033169
RPS21 ribosomal protein S21 0.0331278
TXNIP thioredoxin interacting protein 0.0330003
TPI1 triosephosphate isomerase 1 0.0327024
FHIT fragile histidine triad 0.0324011
ANKRD12 ankyrin repeat domain 12 0.0318753
RPS3 ribosomal protein S3 0.0316771
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0315814
PFN1 profilin 1 0.0311266
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.030557
EZR ezrin 0.0301766
RPL18 ribosomal protein L18 0.0301421
RPL34 ribosomal protein L34 0.0299676
NBEA neurobeachin 0.0298348
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.029353
RPL31 ribosomal protein L31 0.0292258
BZW1 basic leucine zipper and W2 domains 1 0.029018
RSL1D1 ribosomal L1 domain containing 1 0.0289398
RPL11 ribosomal protein L11 0.0286796
CBX3 chromobox homolog 3 0.0279622
PRDX2 peroxiredoxin 2 0.0278317
CPED1 cadherin-like and PC-esterase domain containing 1 0.0275442
POTEF POTE ankyrin domain family, member F 0.0269818
CSDE1 cold shock domain containing E1, RNA-binding 0.0268529
TPT1 tumor protein, translationally-controlled 1 0.0267063
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0264134
GPBP1 GC-rich promoter binding protein 1 0.0262962
KIF5B kinesin family member 5B 0.0256812
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0252868
VMP1 vacuole membrane protein 1 0.0249606
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0249484
EEF1G eukaryotic translation elongation factor 1 gamma 0.0246259
RPLP2 ribosomal protein, large, P2 0.0245286
PIBF1 progesterone immunomodulatory binding factor 1 0.024382
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0243464
RPL27A ribosomal protein L27a 0.024321
SMC4 structural maintenance of chromosomes 4 0.0242862
RPL9 ribosomal protein L9 0.0242117
RPL30 ribosomal protein L30 0.0241888
RAD21 RAD21 homolog (S. pombe) 0.0240434
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0239628
TPX2 TPX2, microtubule-associated 0.0237939
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.023786
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0235865
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0233133
B2M beta-2-microglobulin 0.0232498
CCNL1 cyclin L1 0.0231613
SBF2 SET binding factor 2 0.02299
PCBP2 poly(rC) binding protein 2 0.0229888
RPL27 ribosomal protein L27 0.0225906
HDGF hepatoma-derived growth factor 0.0224654
TCEA1 transcription elongation factor A (SII), 1 0.0222539
TMSB10 thymosin beta 10 0.0216656
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 0.0215986
RSRC2 arginine/serine-rich coiled-coil 2 0.0214522
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0211976
LPP LIM domain containing preferred translocation partner in lipoma 0.0211545
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0211219
PIAS1 protein inhibitor of activated STAT, 1 0.0206985
RPL23 ribosomal protein L23 0.0203972
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.019953

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.149127
AHNAK AHNAK nucleoprotein -0.119066
PKM pyruvate kinase, muscle -0.106154
EGFR epidermal growth factor receptor -0.0767028
BMP10 bone morphogenetic protein 10 -0.0640383
EML4 echinoderm microtubule associated protein like 4 -0.0527262
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0473574
ADAM10 ADAM metallopeptidase domain 10 -0.0469882
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0440983
VCL vinculin -0.0432077
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0404815
RBM39 RNA binding motif protein 39 -0.0402931
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0400319
GLI2 GLI family zinc finger 2 -0.0360055
EXT1 exostosin glycosyltransferase 1 -0.0349786
MYO5C myosin VC -0.0335642
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0329602
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0329254
HSPA8 heat shock 70kDa protein 8 -0.0328896
RTN4 reticulon 4 -0.0327909
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0316919
WSB1 WD repeat and SOCS box containing 1 -0.0308223
CAMTA1 calmodulin binding transcription activator 1 -0.0303317
GSE1 Gse1 coiled-coil protein -0.0299878
NFE2L2 nuclear factor, erythroid 2-like 2 -0.029914
ATP9B ATPase, class II, type 9B -0.0294963
DUSP4 dual specificity phosphatase 4 -0.0294254
TM4SF1 transmembrane 4 L six family member 1 -0.0293912
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0289331
APP amyloid beta (A4) precursor protein -0.0285523
USP34 ubiquitin specific peptidase 34 -0.0280459
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0279125
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.02706
BMP2K BMP2 inducible kinase -0.0269542
OSMR oncostatin M receptor -0.0264651
CCND1 cyclin D1 -0.0259189
IARS1 isoleucyl-tRNA synthetase 1 -0.0258381
CLTC clathrin, heavy chain (Hc) -0.0258064
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0254774
NCEH1 neutral cholesterol ester hydrolase 1 -0.0253472
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0248324
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0245829
MED13 mediator complex subunit 13 -0.0242905
PDE4B phosphodiesterase 4B, cAMP-specific -0.0238343
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0231293
HM13 histocompatibility (minor) 13 -0.0231248
ZBTB10 zinc finger and BTB domain containing 10 -0.0230512
LIMD1 LIM domains containing 1 -0.0227684
STAU1 staufen double-stranded RNA binding protein 1 -0.0227041
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0225078
DOCK1 dedicator of cytokinesis 1 -0.022199
PGK1 phosphoglycerate kinase 1 -0.0221337
RPL3 ribosomal protein L3 -0.0214487
ZNF608 zinc finger protein 608 -0.0210238
TACC2 transforming, acidic coiled-coil containing protein 2 -0.0210223
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0209982
TENT4A terminal nucleotidyltransferase 4A -0.0208157
ZNF217 zinc finger protein 217 -0.0207214
SQSTM1 sequestosome 1 -0.0205287
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0204148
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0202457
ACBD3 acyl-CoA binding domain containing 3 -0.0202067
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0200481
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0198307
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.019825
PARD3 par-3 family cell polarity regulator -0.0197916
KLF3 Kruppel-like factor 3 (basic) -0.0197828
TJP1 tight junction protein 1 -0.0197379
IRS1 insulin receptor substrate 1 -0.0196843
S100A10 S100 calcium binding protein A10 -0.0196306
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0196108
KANK1 KN motif and ankyrin repeat domains 1 -0.019328
DOCK3 dedicator of cytokinesis 3 -0.0192654
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0192537
ZNF438 zinc finger protein 438 -0.0191945
TRIP12 thyroid hormone receptor interactor 12 -0.0191683
ARID1A AT rich interactive domain 1A (SWI-like) -0.0191553
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0191148
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) -0.0190754
FAM91A1 family with sequence similarity 91, member A1 -0.0190024
FOXJ3 forkhead box J3 -0.0189901
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0186318
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) -0.0185806
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0184474
SFTPA2 surfactant protein A2 -0.0182628
MACF1 microtubule-actin crosslinking factor 1 -0.0182
RPS18 ribosomal protein S18 -0.0181843
ZMYND8 zinc finger, MYND-type containing 8 -0.0179473
PIWIL1 piwi-like RNA-mediated gene silencing 1 -0.0178495
RPL21 ribosomal protein L21 -0.0178088
NIPBL Nipped-B homolog (Drosophila) -0.0178074
TMCO3 transmembrane and coiled-coil domains 3 -0.0176555
IFI16 interferon, gamma-inducible protein 16 -0.0175545
ANKRD10 ankyrin repeat domain 10 -0.0174674
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0174102
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0173844
FUS FUS RNA binding protein -0.0173127
DOCK5 dedicator of cytokinesis 5 -0.0172483
XPO1 exportin 1 -0.0171837
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0171439