Erlotinib_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erlotinib perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erlotinib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.0666908
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0464942
SERINC1 serine incorporator 1 0.0384613
CDH13 cadherin 13 0.0320227
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0312959
PDE10A phosphodiesterase 10A 0.0289813
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0278359
GLIS3 GLIS family zinc finger 3 0.0262026
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0261856
ZBTB38 zinc finger and BTB domain containing 38 0.0247025
GPC6 glypican 6 0.0245528
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0236586
SMYD3 SET and MYND domain containing 3 0.0235391
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0215654
ARFGEF3 ARFGEF family member 3 0.0213062
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0211857
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.0208474
PRELID2 PRELI domain containing 2 0.02055
GOLGB1 golgin B1 0.0197665
ATM ATM serine/threonine kinase 0.019112
VMP1 vacuole membrane protein 1 0.0189038
FBXL7 F-box and leucine-rich repeat protein 7 0.0186884
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0185553
TMEM132D transmembrane protein 132D 0.0184962
BZW1 basic leucine zipper and W2 domains 1 0.0177462
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0172331
CXCL8 chemokine (C-X-C motif) ligand 8 0.0170266
SLC35F3 solute carrier family 35, member F3 0.0168943
XRN1 5'-3' exoribonuclease 1 0.016847
AFF3 AF4/FMR2 family, member 3 0.0167876
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0167792
ZC3H12B zinc finger CCCH-type containing 12B 0.0162601
RPL26 ribosomal protein L26 0.0160528
RAD51B RAD51 paralog B 0.0157934
ABTB3 ankyrin repeat and BTB domain containing 3 0.0156504
ANXA1 annexin A1 0.0156407
RPS2 ribosomal protein S2 0.0154969
CRYBG3 beta-gamma crystallin domain containing 3 0.0151664
HMGA2 high mobility group AT-hook 2 0.015033
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0150287
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0150205
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0149358
NFE2L1 nuclear factor, erythroid 2-like 1 0.0144692
MBD5 methyl-CpG binding domain protein 5 0.0142792
ZC3H12C zinc finger CCCH-type containing 12C 0.0140314
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0139224
KLF12 Kruppel-like factor 12 0.0138913
TBC1D5 TBC1 domain family, member 5 0.0138379
MAPK8 mitogen-activated protein kinase 8 0.0137746
RB1CC1 RB1-inducible coiled-coil 1 0.0135529
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0132869
FNIP1 folliculin interacting protein 1 0.0131751
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.0131048
CEP128 centrosomal protein 128kDa 0.0130597
CDCP1 CUB domain containing protein 1 0.0130529
ZEB1 zinc finger E-box binding homeobox 1 0.0128523
CLMN calmin (calponin-like, transmembrane) 0.012752
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0124127
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0123836
SAFB2 scaffold attachment factor B2 0.0123068
ZHX2 zinc fingers and homeoboxes 2 0.0122176
RNF130 ring finger protein 130 0.0119327
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0118971
FCHO2 FCH domain only 2 0.0118792
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0117554
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0117534
TCEA1 transcription elongation factor A (SII), 1 0.0116705
FRMPD4 FERM and PDZ domain containing 4 0.0115956
DPYD dihydropyrimidine dehydrogenase 0.0115638
IL1RAP interleukin 1 receptor accessory protein 0.0115137
TMSB4X thymosin beta 4, X-linked 0.0113689
EXOC6B exocyst complex component 6B 0.011286
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0110027
BACE2 beta-site APP-cleaving enzyme 2 0.0109471
RNF217 ring finger protein 217 0.0108238
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0108055
AHNAK2 AHNAK nucleoprotein 2 0.0107602
CD47 CD47 molecule 0.0107542
CEP112 centrosomal protein 112kDa 0.0106982
BRCA1 breast cancer 1, early onset 0.0106608
AKAP9 A kinase (PRKA) anchor protein 9 0.0104407
PRKCE protein kinase C, epsilon 0.0103799
DMXL2 Dmx-like 2 0.0103407
NALF1 NALCN channel auxiliary factor 1 0.0102276
SENP5 SUMO1/sentrin specific peptidase 5 0.0102086
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.0101418
FAM120B family with sequence similarity 120B 0.0101174
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0100666
KIF11 kinesin family member 11 0.0100478
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.00995737
BCAS3 breast carcinoma amplified sequence 3 0.00995038
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0099233
SYNE2 spectrin repeat containing, nuclear envelope 2 0.00987573
APAF1 apoptotic peptidase activating factor 1 0.00981844
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.00979109
SCAPER S-phase cyclin A-associated protein in the ER 0.00976565
MAP1B microtubule-associated protein 1B 0.00973575
INVS inversin 0.00972952
DOCK5 dedicator of cytokinesis 5 0.00965422
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0096231

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.188027
SOD2 superoxide dismutase 2, mitochondrial -0.173799
FTL ferritin, light polypeptide -0.131648
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.12997
HLA-B major histocompatibility complex, class I, B -0.124371
FN1 fibronectin 1 -0.120199
UGCG UDP-glucose ceramide glucosyltransferase -0.117934
VIM vimentin -0.114332
PGK1 phosphoglycerate kinase 1 -0.107669
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.101904
MARCKS myristoylated alanine-rich protein kinase C substrate -0.101096
PTMA prothymosin, alpha -0.0798255
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0782673
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0759222
TMSB10 thymosin beta 10 -0.071761
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0704545
WTAP Wilms tumor 1 associated protein -0.0692722
ADM adrenomedullin -0.0636318
TSC22D2 TSC22 domain family, member 2 -0.063254
ANXA2 annexin A2 -0.0623103
IER3 immediate early response 3 -0.0603043
WSB1 WD repeat and SOCS box containing 1 -0.0600335
NDRG1 N-myc downstream regulated 1 -0.0568192
PKM pyruvate kinase, muscle -0.053329
ZNF292 zinc finger protein 292 -0.0527408
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0512381
SPAG9 sperm associated antigen 9 -0.05009
FNDC3B fibronectin type III domain containing 3B -0.0491527
FRMD4A FERM domain containing 4A -0.0489321
MT2A metallothionein 2A -0.048795
QKI QKI, KH domain containing, RNA binding -0.0482068
WDR45B WD repeat domain 45B -0.0472132
TGFBI transforming growth factor, beta-induced, 68kDa -0.0465259
VCL vinculin -0.0457661
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0453905
EGR1 early growth response 1 -0.0442751
ICAM1 intercellular adhesion molecule 1 -0.0436938
RYBP RING1 and YY1 binding protein -0.0436414
SFTPA2 surfactant protein A2 -0.0434685
CCNL1 cyclin L1 -0.0419209
RTN4 reticulon 4 -0.0418392
CD44 CD44 molecule (Indian blood group) -0.0411323
B2M beta-2-microglobulin -0.0407977
CALR calreticulin -0.0402274
EXT1 exostosin glycosyltransferase 1 -0.0399494
ZNF207 zinc finger protein 207 -0.0399468
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0398775
RBM39 RNA binding motif protein 39 -0.0394317
ELL2 elongation factor, RNA polymerase II, 2 -0.0390398
PDIA3 protein disulfide isomerase family A, member 3 -0.0388721
NT5C2 5'-nucleotidase, cytosolic II -0.0383185
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0375757
SETD5 SET domain containing 5 -0.0373962
TMEM123 transmembrane protein 123 -0.0369872
ACTG1 actin gamma 1 -0.0365929
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0359076
CTSD cathepsin D -0.0358864
HMGA1 high mobility group AT-hook 1 -0.0356615
RPL23 ribosomal protein L23 -0.0356248
FOXO3 forkhead box O3 -0.0346921
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0345001
TNIP1 TNFAIP3 interacting protein 1 -0.0341214
RAB6A RAB6A, member RAS oncogene family -0.0339254
RAB1A RAB1A, member RAS oncogene family -0.0338407
COL6A3 collagen, type VI, alpha 3 -0.0336614
MX1 MX dynamin-like GTPase 1 -0.0335325
FLNA filamin A, alpha -0.0332367
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0330316
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0328846
RPL35A ribosomal protein L35a -0.0328231
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0327381
RPS14 ribosomal protein S14 -0.0324203
AFF4 AF4/FMR2 family, member 4 -0.0321785
NPEPPS aminopeptidase puromycin sensitive -0.032012
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0319071
MORF4L2 mortality factor 4 like 2 -0.0317527
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0311295
PLIN2 perilipin 2 -0.0309699
YBX1 Y box binding protein 1 -0.0309207
THBS1 thrombospondin 1 -0.0306608
PHIP pleckstrin homology domain interacting protein -0.0302554
RNF213 ring finger protein 213 -0.0302551
UBE2H ubiquitin-conjugating enzyme E2H -0.0300931
OGA O-GlcNAcase -0.0296972
PAWR PRKC, apoptosis, WT1, regulator -0.0292752
NABP1 nucleic acid binding protein 1 -0.0291938
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0290625
IFITM3 interferon induced transmembrane protein 3 -0.0289044
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0289043
BICC1 BicC family RNA binding protein 1 -0.0289033
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0288276
RPS6 ribosomal protein S6 -0.0285302
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0285246
RPS24 ribosomal protein S24 -0.0284761
GNAS GNAS complex locus -0.0283821
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -0.0281189
LDHA lactate dehydrogenase A -0.0277588
TPM4 tropomyosin 4 -0.0277566
NAP1L1 nucleosome assembly protein 1-like 1 -0.0275484
HELZ helicase with zinc finger -0.0274386