Erlotinib_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erlotinib perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erlotinib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
BZW1 basic leucine zipper and W2 domains 1 0.0272759
TRIO trio Rho guanine nucleotide exchange factor 0.0267625
HJURP Holliday junction recognition protein 0.0250061
BASP1 brain abundant, membrane attached signal protein 1 0.0243775
DNER delta/notch-like EGF repeat containing 0.0242996
HILPDA hypoxia inducible lipid droplet-associated 0.0237354
SGO2 shugoshin 2 0.0212166
KIF5B kinesin family member 5B 0.0211592
RPS2 ribosomal protein S2 0.0199606
PNN pinin, desmosome associated protein 0.0193146
MIER1 mesoderm induction early response 1, transcriptional regulator 0.018877
ECT2 epithelial cell transforming 2 0.0174326
RAD51B RAD51 paralog B 0.0173411
NKTR natural killer cell triggering receptor 0.0170748
ANKRD12 ankyrin repeat domain 12 0.016982
SEC24A SEC24 family member A 0.0169517
FTH1 ferritin, heavy polypeptide 1 0.0166175
TTC1 tetratricopeptide repeat domain 1 0.0165384
YME1L1 YME1-like 1 ATPase 0.0162078
KIF4A kinesin family member 4A 0.0160948
CXCL8 chemokine (C-X-C motif) ligand 8 0.0160108
CKAP2 cytoskeleton associated protein 2 0.0154365
ZC3H15 zinc finger CCCH-type containing 15 0.0153349
RSRC2 arginine/serine-rich coiled-coil 2 0.0150804
NUP153 nucleoporin 153kDa 0.0149765
RPS17 ribosomal protein S17 0.0148288
SKIC3 SKI3 subunit of superkiller complex 0.0148012
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0147717
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0146183
TNRC6B trinucleotide repeat containing 6B 0.0144979
CENPF centromere protein F, 350/400kDa 0.0144561
SRRM1 serine/arginine repetitive matrix 1 0.0143791
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0142681
SMC5 structural maintenance of chromosomes 5 0.0140765
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0139072
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0138304
ATF4 activating transcription factor 4 0.0138177
UBE2W ubiquitin-conjugating enzyme E2W (putative) 0.0137644
PHF3 PHD finger protein 3 0.0136349
UBXN4 UBX domain protein 4 0.0134854
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.0132841
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0132408
ELP2 elongator acetyltransferase complex subunit 2 0.0131095
AURKA aurora kinase A 0.0130775
DTNA dystrobrevin, alpha 0.013067
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25 0.0129861
CCDC91 coiled-coil domain containing 91 0.0129287
NDC80 NDC80 kinetochore complex component 0.0128058
CHD7 chromodomain helicase DNA binding protein 7 0.0127558
AHCTF1 AT hook containing transcription factor 1 0.0126524
TAS2R14 taste receptor, type 2, member 14 0.0126198
MBNL1 muscleblind-like splicing regulator 1 0.0125238
APOLD1 apolipoprotein L domain containing 1 0.0124709
SERINC1 serine incorporator 1 0.0124108
ASTN2 astrotactin 2 0.0124021
SEC62 SEC62 homolog (S. cerevisiae) 0.0123994
TTC19 tetratricopeptide repeat domain 19 0.0122185
NAV2 neuron navigator 2 0.0122107
CBX1 chromobox homolog 1 0.0121822
FMN1 formin 1 0.0121687
SNX9 sorting nexin 9 0.0120846
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0120081
TGFBR1 transforming growth factor, beta receptor 1 0.0119791
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0119311
SCAPER S-phase cyclin A-associated protein in the ER 0.0118825
CENPE centromere protein E, 312kDa 0.0118578
CCNT2 cyclin T2 0.0117225
SRGN serglycin 0.011634
GOSR1 golgi SNAP receptor complex member 1 0.0115784
RSRC1 arginine/serine-rich coiled-coil 1 0.0115122
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.0114602
SEPTIN2 septin 2 0.0114236
SERP1 stress-associated endoplasmic reticulum protein 1 0.0113968
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0113533
EMSY EMSY transcriptional repressor, BRCA2 interacting 0.0113516
CEP57 centrosomal protein 57kDa 0.0113238
CEP170 centrosomal protein 170kDa 0.0111529
KIAA2026 KIAA2026 0.0110887
NR1D1 nuclear receptor subfamily 1, group D, member 1 0.0110641
LRP1B low density lipoprotein receptor-related protein 1B 0.0109538
CRY1 cryptochrome circadian clock 1 0.0108608
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 0.010844
KIAA1328 KIAA1328 0.0108221
SLMAP sarcolemma associated protein 0.0108119
DNM1L dynamin 1-like 0.0107875
SMC3 structural maintenance of chromosomes 3 0.0107732
SLFN11 schlafen family member 11 0.0107566
ZFR zinc finger RNA binding protein 0.0107315
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.0106839
CWC15 CWC15 spliceosome-associated protein 0.0106505
DZIP3 DAZ interacting zinc finger protein 3 0.0106164
EIF5 eukaryotic translation initiation factor 5 0.0105913
MAPK1 mitogen-activated protein kinase 1 0.0105024
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0105009
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0104827
TMEM51 transmembrane protein 51 0.0104688
NCEH1 neutral cholesterol ester hydrolase 1 0.0104612
SEC63 SEC63 homolog (S. cerevisiae) 0.0104377
RUFY2 RUN and FYVE domain containing 2 0.0104045
ZDHHC20 zinc finger, DHHC-type containing 20 0.0103752

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.406649
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0694275
UBC ubiquitin C -0.0560313
PKM pyruvate kinase, muscle -0.0532651
LOC112694756 uncharaterized LOC112694756 -0.0503706
AHNAK AHNAK nucleoprotein -0.0497567
VIM vimentin -0.0485862
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0478904
OSMR oncostatin M receptor -0.0458004
TMSB10 thymosin beta 10 -0.044577
RBM39 RNA binding motif protein 39 -0.0404462
PTMA prothymosin, alpha -0.0403518
PRKCA protein kinase C, alpha -0.0388111
DSCAM Down syndrome cell adhesion molecule -0.0372061
NF1 neurofibromin 1 -0.0370955
CALU calumenin -0.0369038
PHIP pleckstrin homology domain interacting protein -0.035282
ENO1 enolase 1, (alpha) -0.034433
FTL ferritin, light polypeptide -0.0321155
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.030794
ZMYND8 zinc finger, MYND-type containing 8 -0.0307064
DST dystonin -0.0304287
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.03003
EEF2 eukaryotic translation elongation factor 2 -0.029396
RPS13 ribosomal protein S13 -0.0292131
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0288015
SETD5 SET domain containing 5 -0.0284402
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0283807
NAMPT nicotinamide phosphoribosyltransferase -0.0283559
RPS3 ribosomal protein S3 -0.0281219
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0275658
RPL23 ribosomal protein L23 -0.0274029
FUS FUS RNA binding protein -0.0270448
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0265328
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0261165
ANKRD28 ankyrin repeat domain 28 -0.0260558
SQSTM1 sequestosome 1 -0.0253333
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0252894
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0249265
YBX3 Y box binding protein 3 -0.0247692
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0247532
ANXA2 annexin A2 -0.0244026
RAB5A RAB5A, member RAS oncogene family -0.0243875
RPL37 ribosomal protein L37 -0.0243172
MYH9 myosin, heavy chain 9, non-muscle -0.024265
MBNL2 muscleblind-like splicing regulator 2 -0.0242304
OXSR1 oxidative stress responsive 1 -0.0231144
SUN1 Sad1 and UNC84 domain containing 1 -0.0230482
TUT4 terminal uridylyl transferase 4 -0.0230244
RPS27A ribosomal protein S27a -0.0229003
RPLP2 ribosomal protein, large, P2 -0.0228522
CSDE1 cold shock domain containing E1, RNA-binding -0.0226937
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0226456
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.022626
CD44 CD44 molecule (Indian blood group) -0.0224833
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.022237
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0222089
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0221246
SMYD3 SET and MYND domain containing 3 -0.0220612
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0216074
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0215357
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0213491
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0212991
PRRC2B proline-rich coiled-coil 2B -0.0210451
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0210426
PCBP2 poly(rC) binding protein 2 -0.0207808
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0204433
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0204131
PNISR PNN-interacting serine/arginine-rich protein -0.020411
NAP1L1 nucleosome assembly protein 1-like 1 -0.0203926
TOP1 topoisomerase (DNA) I -0.0199401
TPI1 triosephosphate isomerase 1 -0.0198732
ZNF292 zinc finger protein 292 -0.0198523
KMT2A lysine (K)-specific methyltransferase 2A -0.0198463
TUBB4B tubulin, beta 4B class IVb -0.0197862
GNAS GNAS complex locus -0.0197633
IL6ST interleukin 6 signal transducer -0.0197088
SPAG9 sperm associated antigen 9 -0.0194903
ASPH aspartate beta-hydroxylase -0.0193548
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0193357
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0192826
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0192007
HOOK2 hook microtubule-tethering protein 2 -0.0191333
DENND4A DENN/MADD domain containing 4A -0.0189583
NDRG1 N-myc downstream regulated 1 -0.0189351
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0188748
TPT1 tumor protein, translationally-controlled 1 -0.0187835
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0187733
MCL1 myeloid cell leukemia 1 -0.0186857
SAMD4A sterile alpha motif domain containing 4A -0.0184638
NT5E 5'-nucleotidase, ecto (CD73) -0.0184194
TNIP1 TNFAIP3 interacting protein 1 -0.0183176
MPRIP myosin phosphatase Rho interacting protein -0.0180843
UBE2H ubiquitin-conjugating enzyme E2H -0.0180823
NUP58 nucleoporin 58 -0.0178061
USP22 ubiquitin specific peptidase 22 -0.0176986
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.017645
ATXN1 ataxin 1 -0.0174798
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0174056
GLG1 golgi glycoprotein 1 -0.0172323