| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus). (Chemical Entities of Biological Interest Ontology, CHEBI_48923) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/12560 |
| Similar Terms | |
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198 proteins with high or low expression in Erythromycin relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM1 | Mdm1 nuclear protein homolog (mouse) | 2.11 |
| MIGA2 | mitoguardin 2 | 1.6 |
| ABHD18 | abhydrolase domain containing 18 | 1.1 |
| ADCY10 | adenylate cyclase 10 (soluble) | 1.01 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.98 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.82 |
| FER1L5 | fer-1-like family member 5 | 0.57 |
| INO80D | INO80 complex subunit D | 0.56 |
| RPS26 | ribosomal protein S26 | 0.56 |
| KLHL24 | kelch-like family member 24 | 0.54 |
| CNPY2 | canopy FGF signaling regulator 2 | 0.49 |
| SET | SET nuclear proto-oncogene | 0.48 |
| PRELID1 | PRELI domain containing 1 | 0.48 |
| PLD6 | phospholipase D family, member 6 | 0.47 |
| ENO1 | enolase 1, (alpha) | 0.44 |
| HSCB | HscB mitochondrial iron-sulfur cluster co-chaperone | 0.44 |
| SPRTN | SprT-like N-terminal domain | 0.44 |
| ERCC8 | excision repair cross-complementation group 8 | 0.42 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.41 |
| B3GALNT1 | beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) | 0.41 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.4 |
| RUNDC1 | RUN domain containing 1 | 0.4 |
| LZTS1 | leucine zipper, putative tumor suppressor 1 | 0.4 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.39 |
| PML | promyelocytic leukemia | 0.38 |
| COL6A3 | collagen, type VI, alpha 3 | 0.36 |
| PPM1H | protein phosphatase, Mg2+/Mn2+ dependent, 1H | 0.36 |
| SNRPC | small nuclear ribonucleoprotein polypeptide C | 0.34 |
| RPS21 | ribosomal protein S21 | 0.33 |
| ALG14 | ALG14, UDP-N-acetylglucosaminyltransferase subunit | 0.33 |
| ZNF428 | zinc finger protein 428 | 0.33 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.33 |
| FZD3 | frizzled class receptor 3 | 0.32 |
| TSSC4 | tumor suppressing subtransferable candidate 4 | 0.32 |
| ALKBH6 | alkB, alkylation repair homolog 6 (E. coli) | 0.32 |
| LEPROTL1 | leptin receptor overlapping transcript-like 1 | 0.32 |
| CNEP1R1 | CTD nuclear envelope phosphatase 1 regulatory subunit 1 | 0.31 |
| PGBD1 | piggyBac transposable element derived 1 | 0.31 |
| RASSF1 | Ras association (RalGDS/AF-6) domain family member 1 | 0.3 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | 0.29 |
| ZNF776 | zinc finger protein 776 | 0.29 |
| TRIM37 | tripartite motif containing 37 | 0.29 |
| TTC31 | tetratricopeptide repeat domain 31 | 0.29 |
| RASGRP2 | RAS guanyl releasing protein 2 (calcium and DAG-regulated) | 0.28 |
| TMC4 | transmembrane channel-like 4 | 0.28 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.28 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 0.28 |
| PARPBP | PARP1 binding protein | 0.27 |
| COMMD6 | COMM domain containing 6 | 0.27 |
| TOR1AIP2 | torsin A interacting protein 2 | 0.27 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | 0.27 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.27 |
| PPIL2 | peptidylprolyl isomerase (cyclophilin)-like 2 | 0.26 |
| ZDHHC8 | zinc finger, DHHC-type containing 8 | 0.26 |
| PMPCA | peptidase (mitochondrial processing) alpha | 0.26 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.26 |
| SPTBN5 | spectrin, beta, non-erythrocytic 5 | 0.26 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | 0.26 |
| VWA1 | von Willebrand factor A domain containing 1 | 0.25 |
| MIER2 | mesoderm induction early response 1, family member 2 | 0.25 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.25 |
| DCAF10 | DDB1 and CUL4 associated factor 10 | 0.25 |
| DZIP3 | DAZ interacting zinc finger protein 3 | 0.25 |
| CST6 | cystatin E/M | 0.25 |
| GNPTAB | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits | 0.25 |
| RBPJL | recombination signal binding protein for immunoglobulin kappa J region-like | 0.25 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | 0.25 |
| RGN | regucalcin | 0.25 |
| GPHRA | golgi pH regulator A | 0.25 |
| OTUD5 | OTU deubiquitinase 5 | 0.25 |
| GPSM2 | G-protein signaling modulator 2 | 0.24 |
| ZIC2 | Zic family member 2 | 0.24 |
| WASHC2C | WASH complex subunit 2C | 0.24 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | 0.24 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.24 |
| DNAJC22 | DnaJ (Hsp40) homolog, subfamily C, member 22 | 0.24 |
| RASSF7 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 | 0.24 |
| TFDP1 | transcription factor Dp-1 | 0.24 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.24 |
| MAGEA2 | melanoma antigen family A2 | 0.24 |
| DTD2 | D-tyrosyl-tRNA deacylase 2 (putative) | 0.24 |
| BPTF | bromodomain PHD finger transcription factor | 0.23 |
| CCDC97 | coiled-coil domain containing 97 | 0.23 |
| KMT5C | lysine methyltransferase 5C | 0.23 |
| TEX15 | testis expressed 15 | 0.23 |
| NAV3 | neuron navigator 3 | 0.23 |
| SNX24 | sorting nexin 24 | 0.23 |
| SLC41A3 | solute carrier family 41, member 3 | 0.23 |
| TDG | thymine-DNA glycosylase | 0.23 |
| PWWP2B | PWWP domain containing 2B | 0.23 |
| PPP1R14B | protein phosphatase 1, regulatory (inhibitor) subunit 14B | 0.23 |
| DGCR2 | DiGeorge syndrome critical region gene 2 | 0.22 |
| KBTBD8 | kelch repeat and BTB (POZ) domain containing 8 | 0.22 |
| GRAMD1A | GRAM domain containing 1A | 0.22 |
| ESRRA | estrogen-related receptor alpha | 0.22 |
| TSLIG3C | tRNA splicing ligase complex subunit 3C | 0.22 |
| FLYWCH1 | FLYWCH-type zinc finger 1 | 0.22 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.22 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | 0.22 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NUDT18 | nudix (nucleoside diphosphate linked moiety X)-type motif 18 | -0.67 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.66 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.63 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.58 |
| SGSH | N-sulfoglucosamine sulfohydrolase | -0.57 |
| ZNF195 | zinc finger protein 195 | -0.55 |
| TRIM41 | tripartite motif containing 41 | -0.54 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.54 |
| ZNF264 | zinc finger protein 264 | -0.52 |
| ZCCHC24 | zinc finger, CCHC domain containing 24 | -0.52 |
| ATP7B | ATPase, Cu++ transporting, beta polypeptide | -0.47 |
| BAIAP3 | BAI1-associated protein 3 | -0.47 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | -0.46 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.46 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | -0.46 |
| TANK | TRAF family member-associated NFKB activator | -0.45 |
| TFCP2L1 | transcription factor CP2-like 1 | -0.43 |
| ARSD | arylsulfatase D | -0.42 |
| MXRA7 | matrix-remodelling associated 7 | -0.41 |
| CC2D2A | coiled-coil and C2 domain containing 2A | -0.4 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | -0.4 |
| CMTM4 | CKLF-like MARVEL transmembrane domain containing 4 | -0.4 |
| SC5D | sterol-C5-desaturase | -0.4 |
| ISCA2 | iron-sulfur cluster assembly 2 | -0.39 |
| NUDT14 | nudix (nucleoside diphosphate linked moiety X)-type motif 14 | -0.39 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | -0.38 |
| CHCHD4 | coiled-coil-helix-coiled-coil-helix domain containing 4 | -0.37 |
| TCTN2 | tectonic family member 2 | -0.37 |
| RIN3 | Ras and Rab interactor 3 | -0.36 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.36 |
| YAP1 | Yes-associated protein 1 | -0.36 |
| FAM3A | family with sequence similarity 3, member A | -0.36 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | -0.36 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.36 |
| MCFD2 | multiple coagulation factor deficiency 2 | -0.35 |
| TMEM63A | transmembrane protein 63A | -0.34 |
| FAM193A | family with sequence similarity 193, member A | -0.34 |
| PLAUR | plasminogen activator, urokinase receptor | -0.33 |
| TTC14 | tetratricopeptide repeat domain 14 | -0.33 |
| ZNF276 | zinc finger protein 276 | -0.33 |
| RNF123 | ring finger protein 123 | -0.32 |
| DIPK1A | divergent protein kinase domain 1A | -0.32 |
| UBIAD1 | UbiA prenyltransferase domain containing 1 | -0.32 |
| C18ORF32 | chromosome 18 open reading frame 32 | -0.32 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | -0.31 |
| GORAB | golgin, RAB6-interacting | -0.31 |
| SRD5A3 | steroid 5 alpha-reductase 3 | -0.31 |
| BRPF3 | bromodomain and PHD finger containing, 3 | -0.31 |
| UQCRH | ubiquinol-cytochrome c reductase hinge protein | -0.31 |
| PTK2B | protein tyrosine kinase 2 beta | -0.31 |
| BMP4 | bone morphogenetic protein 4 | -0.3 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | -0.3 |
| ATG13 | autophagy related 13 | -0.3 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | -0.3 |
| ATG4C | autophagy related 4C, cysteine peptidase | -0.3 |
| DNM1L | dynamin 1-like | -0.29 |
| PLIN2 | perilipin 2 | -0.29 |
| BOK | BCL2-related ovarian killer | -0.29 |
| SYT7 | synaptotagmin VII | -0.29 |
| SLC30A3 | solute carrier family 30 (zinc transporter), member 3 | -0.28 |
| HSP90AA4P | heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene | -0.28 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.28 |
| METTL26 | methyltransferase like 26 | -0.28 |
| IRX4 | iroquois homeobox 4 | -0.28 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.28 |
| C12ORF57 | chromosome 12 open reading frame 57 | -0.28 |
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | -0.28 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | -0.28 |
| ATG2A | autophagy related 2A | -0.28 |
| RASSF3 | Ras association (RalGDS/AF-6) domain family member 3 | -0.28 |
| FBXL14 | F-box and leucine-rich repeat protein 14 | -0.27 |
| NUS1 | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) | -0.27 |
| MIS12 | MIS12 kinetochore complex component | -0.27 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | -0.27 |
| SUCO | SUN domain containing ossification factor | -0.27 |
| HEXIM2 | hexamethylene bis-acetamide inducible 2 | -0.27 |
| POLE4 | polymerase (DNA-directed), epsilon 4, accessory subunit | -0.26 |
| RNF170 | ring finger protein 170 | -0.26 |
| CKM | creatine kinase, muscle | -0.26 |
| DISP2 | dispatched homolog 2 (Drosophila) | -0.26 |
| TSC22D2 | TSC22 domain family, member 2 | -0.26 |
| RNPEPL1 | arginyl aminopeptidase (aminopeptidase B)-like 1 | -0.26 |
| H1-0 | H1.0 linker histone | -0.26 |
| NUCB1 | nucleobindin 1 | -0.25 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | -0.25 |
| BLOC1S4 | biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino | -0.25 |
| AGPAT2 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | -0.25 |
| ZFYVE26 | zinc finger, FYVE domain containing 26 | -0.25 |
| FBXW9 | F-box and WD repeat domain containing 9 | -0.25 |
| SLX4 | SLX4 structure-specific endonuclease subunit | -0.25 |
| PFDN1 | prefoldin subunit 1 | -0.25 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.24 |
| ATP9B | ATPase, class II, type 9B | -0.24 |
| KIAA1107 | KIAA1107 | -0.24 |
| CENPU | centromere protein U | -0.24 |
| IL6ST | interleukin 6 signal transducer | -0.24 |
| DMXL2 | Dmx-like 2 | -0.24 |
| HLA-F | major histocompatibility complex, class I, F | -0.24 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | -0.24 |
