Erythromycin_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erythromycin perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erythromycin_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.144473
VGF VGF nerve growth factor inducible 0.0626898
VCL vinculin 0.0457743
GOLGA4 golgin A4 0.0445055
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0414256
SEPTIN9 septin 9 0.036291
LPIN1 lipin 1 0.0355304
TIMP2 TIMP metallopeptidase inhibitor 2 0.0337475
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.033462
NFE2L1 nuclear factor, erythroid 2-like 1 0.032547
TIMP3 TIMP metallopeptidase inhibitor 3 0.032376
NCOR2 nuclear receptor corepressor 2 0.0316852
ANTXR1 anthrax toxin receptor 1 0.0311167
EGR1 early growth response 1 0.0306469
RPS2 ribosomal protein S2 0.0296167
RARA retinoic acid receptor, alpha 0.0284496
PGAM4 phosphoglycerate mutase family member 4 0.0271548
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0270192
RBM33 RNA binding motif protein 33 0.026968
PDE8A phosphodiesterase 8A 0.026553
PRRC2C proline-rich coiled-coil 2C 0.0259252
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 0.0251284
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.024795
HSPA8 heat shock 70kDa protein 8 0.0246964
SREBF2 sterol regulatory element binding transcription factor 2 0.0246116
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0244965
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0242
PIBF1 progesterone immunomodulatory binding factor 1 0.0241319
RPS6 ribosomal protein S6 0.0229602
PCBP2 poly(rC) binding protein 2 0.0226657
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0225705
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0222932
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0220062
CTNND1 catenin (cadherin-associated protein), delta 1 0.0219752
BRD4 bromodomain containing 4 0.0218972
ZMIZ1 zinc finger, MIZ-type containing 1 0.0218811
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.0215964
EIF4B eukaryotic translation initiation factor 4B 0.0215065
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0213653
IGFBP4 insulin-like growth factor binding protein 4 0.020803
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.0207665
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0207174
FAM13B family with sequence similarity 13, member B 0.0206871
VIRMA vir like m6A methyltransferase associated 0.0206762
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0206075
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0204356
RARS1 arginyl-tRNA synthetase 1 0.020269
PLAT plasminogen activator, tissue 0.0202682
NAP1L1 nucleosome assembly protein 1-like 1 0.0201144
MIDEAS mitotic deacetylase associated SANT domain protein 0.0199614
KDM5C lysine (K)-specific demethylase 5C 0.019879
ARID4A AT rich interactive domain 4A (RBP1-like) 0.0198245
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0197592
SCARB1 scavenger receptor class B, member 1 0.0196472
MMP2 matrix metallopeptidase 2 0.0193796
CREB3L2 cAMP responsive element binding protein 3-like 2 0.019215
HDAC5 histone deacetylase 5 0.0192039
SRRM2 serine/arginine repetitive matrix 2 0.0191495
BCLAF1 BCL2-associated transcription factor 1 0.0188124
HMGB2 high mobility group box 2 0.018692
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0182847
MYO1E myosin IE 0.0182099
BHLHE40 basic helix-loop-helix family, member e40 0.0180923
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0180689
TPM3 tropomyosin 3 0.0180532
RPL4 ribosomal protein L4 0.0180397
ZNF146 zinc finger protein 146 0.0179907
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0179482
MPRIP myosin phosphatase Rho interacting protein 0.0177966
RPL5 ribosomal protein L5 0.017604
TRA2A transformer 2 alpha homolog (Drosophila) 0.0175353
FAM219A family with sequence similarity 219, member A 0.0173727
KDM3B lysine (K)-specific demethylase 3B 0.0173628
TNRC6B trinucleotide repeat containing 6B 0.0172841
EZR ezrin 0.0172248
ATN1 atrophin 1 0.0171476
CD99 CD99 molecule 0.0169323
TGFB1 transforming growth factor, beta 1 0.016738
MDK midkine (neurite growth-promoting factor 2) 0.0166689
SSBP3 single stranded DNA binding protein 3 0.0165537
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0164773
EXT1 exostosin glycosyltransferase 1 0.0164737
MBTD1 mbt domain containing 1 0.016466
TERF2IP telomeric repeat binding factor 2, interacting protein 0.0163706
ZFP36 ZFP36 ring finger protein 0.0163453
PRPF4B pre-mRNA processing factor 4B 0.0162749
SFTPA2 surfactant protein A2 0.0162455
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0162194
TMF1 TATA element modulatory factor 1 0.016152
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0159363
CCNL1 cyclin L1 0.0157796
MAB21L2 mab-21-like 2 (C. elegans) 0.0157408
BRD2 bromodomain containing 2 0.0156933
GOLGB1 golgin B1 0.0151223
CADM1 cell adhesion molecule 1 0.0151105
SBF2 SET binding factor 2 0.015064
SNX2 sorting nexin 2 0.0149809
TPI1 triosephosphate isomerase 1 0.0149387
UBA6 ubiquitin-like modifier activating enzyme 6 0.0149097
IGFBP5 insulin-like growth factor binding protein 5 0.014862

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.48552
SYT1 synaptotagmin I -0.124794
PCDH9 protocadherin 9 -0.0803308
RPS24 ribosomal protein S24 -0.0713929
NALF1 NALCN channel auxiliary factor 1 -0.0705964
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0652954
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0630121
RPL35A ribosomal protein L35a -0.0619597
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0618566
MAP1B microtubule-associated protein 1B -0.0602478
LSAMP limbic system-associated membrane protein -0.0576013
RPLP1 ribosomal protein, large, P1 -0.0558903
NAMPT nicotinamide phosphoribosyltransferase -0.0555572
MEIS2 Meis homeobox 2 -0.0534539
SOS1 son of sevenless homolog 1 (Drosophila) -0.0517395
RPL19 ribosomal protein L19 -0.0511753
RPL23 ribosomal protein L23 -0.0507683
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0506921
ADGRG6 adhesion G protein-coupled receptor G6 -0.0504021
FMN1 formin 1 -0.0495583
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0481393
VIM vimentin -0.0477211
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0445575
RPL31 ribosomal protein L31 -0.0442012
CD36 CD36 molecule (thrombospondin receptor) -0.0429331
ZBTB20 zinc finger and BTB domain containing 20 -0.0420547
RPLP0 ribosomal protein, large, P0 -0.0420181
FAM13A family with sequence similarity 13, member A -0.0413209
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0411136
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0407999
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0404445
RPL34 ribosomal protein L34 -0.0401951
DTNA dystrobrevin, alpha -0.0399312
RAD21 RAD21 homolog (S. pombe) -0.0397088
HAND2 heart and neural crest derivatives expressed 2 -0.0388482
CSDE1 cold shock domain containing E1, RNA-binding -0.0387888
AHNAK AHNAK nucleoprotein -0.0387631
BIRC6 baculoviral IAP repeat containing 6 -0.0385699
PTPRD protein tyrosine phosphatase, receptor type, D -0.0379798
CADM2 cell adhesion molecule 2 -0.037288
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0371601
FAM162A family with sequence similarity 162, member A -0.0364484
IFI16 interferon, gamma-inducible protein 16 -0.0359058
TPT1 tumor protein, translationally-controlled 1 -0.0350979
TRIB2 tribbles pseudokinase 2 -0.034688
PDIA3 protein disulfide isomerase family A, member 3 -0.034214
ZNF804A zinc finger protein 804A -0.0338964
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0338853
KLHL13 kelch-like family member 13 -0.0333087
BPTF bromodomain PHD finger transcription factor -0.0332547
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0327292
RPL38 ribosomal protein L38 -0.0322078
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0321956
RPS5 ribosomal protein S5 -0.0318104
NF1 neurofibromin 1 -0.0315735
MED13 mediator complex subunit 13 -0.0315533
NCAM2 neural cell adhesion molecule 2 -0.03083
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0308021
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0305245
COL3A1 collagen, type III, alpha 1 -0.0304933
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0303129
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.02958
TPST1 tyrosylprotein sulfotransferase 1 -0.0295586
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.029147
GPBP1 GC-rich promoter binding protein 1 -0.0289759
ACTG1 actin gamma 1 -0.0280457
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0278741
RAP1B RAP1B, member of RAS oncogene family -0.0275278
RPL27 ribosomal protein L27 -0.027305
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.027295
UNC5C unc-5 homolog C (C. elegans) -0.0266294
WDR26 WD repeat domain 26 -0.0266265
RPS11 ribosomal protein S11 -0.0257452
VDAC1 voltage-dependent anion channel 1 -0.0253373
ZNF609 zinc finger protein 609 -0.0253289
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0253059
PTK2 protein tyrosine kinase 2 -0.0251459
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0251248
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.024923
DNAH14 dynein, axonemal, heavy chain 14 -0.0248033
C1ORF21 chromosome 1 open reading frame 21 -0.024768
LUM lumican -0.024735
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0243018
WDR45B WD repeat domain 45B -0.0242418
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.0242407
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.023853
SENP6 SUMO1/sentrin specific peptidase 6 -0.0237294
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0235571
RPS8 ribosomal protein S8 -0.0235394
EYA1 EYA transcriptional coactivator and phosphatase 1 -0.0233685
HMBOX1 homeobox containing 1 -0.0233163
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -0.0232469
SLC38A2 solute carrier family 38, member 2 -0.0230769
NRG1 neuregulin 1 -0.0230393
RBMX RNA binding motif protein, X-linked -0.0229968
FNDC3B fibronectin type III domain containing 3B -0.0226245
DST dystonin -0.0225676
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0224965
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0224073
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0223768