Erythromycin_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erythromycin perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erythromycin_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.131157
MT2A metallothionein 2A 0.104172
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0897684
STC1 stanniocalcin 1 0.063847
FTH1 ferritin, heavy polypeptide 1 0.058844
TM4SF1 transmembrane 4 L six family member 1 0.0420191
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0404946
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0400897
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0397967
MT1X metallothionein 1X 0.0324689
SMAD3 SMAD family member 3 0.031326
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0304471
WWTR1 WW domain containing transcription regulator 1 0.0260179
ERRFI1 ERBB receptor feedback inhibitor 1 0.0247967
SQLE squalene epoxidase 0.0243041
ATP13A3 ATPase type 13A3 0.0240701
PLAUR plasminogen activator, urokinase receptor 0.0220479
EIF1 eukaryotic translation initiation factor 1 0.0219863
IGFBP7 insulin-like growth factor binding protein 7 0.0215901
RPS2 ribosomal protein S2 0.021094
RPS6 ribosomal protein S6 0.0206133
TUBA1B tubulin, alpha 1b 0.0204714
AXL AXL receptor tyrosine kinase 0.0204034
INHBA inhibin, beta A 0.0197815
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0182322
HAS2 hyaluronan synthase 2 0.0180307
BHLHE40 basic helix-loop-helix family, member e40 0.0179822
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0172953
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0168534
ECE1 endothelin converting enzyme 1 0.0162977
VIM vimentin 0.0156062
ARHGAP29 Rho GTPase activating protein 29 0.0154141
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0154002
TNIP1 TNFAIP3 interacting protein 1 0.0153969
ARRDC3 arrestin domain containing 3 0.0153617
MKI67 marker of proliferation Ki-67 0.0153513
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0151526
ELL2 elongation factor, RNA polymerase II, 2 0.0140683
TLN1 talin 1 0.0137578
KMT2E lysine (K)-specific methyltransferase 2E 0.0133644
CENPF centromere protein F, 350/400kDa 0.0133203
LOX lysyl oxidase 0.0133193
KLF6 Kruppel-like factor 6 0.013048
ICAM1 intercellular adhesion molecule 1 0.0130312
DUSP6 dual specificity phosphatase 6 0.0128148
ANTXR2 anthrax toxin receptor 2 0.0128079
PFN1 profilin 1 0.0127868
HMGA2 high mobility group AT-hook 2 0.0125979
RPL4 ribosomal protein L4 0.0124061
CSF1 colony stimulating factor 1 (macrophage) 0.0120711
RIPK2 receptor-interacting serine-threonine kinase 2 0.0119032
PTMA prothymosin, alpha 0.0115221
RASA2 RAS p21 protein activator 2 0.0114999
EIF4H eukaryotic translation initiation factor 4H 0.011404
BZW1 basic leucine zipper and W2 domains 1 0.0112728
NFE2L1 nuclear factor, erythroid 2-like 1 0.0111988
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0109793
LOC112694756 uncharaterized LOC112694756 0.0109777
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0109574
LGALS1 lectin, galactoside-binding, soluble, 1 0.0109518
IFI6 interferon, alpha-inducible protein 6 0.0108989
SRGN serglycin 0.0107276
RPL18 ribosomal protein L18 0.010718
H1-4 H1.4 linker histone, cluster member 0.0106734
PRRC2C proline-rich coiled-coil 2C 0.0106621
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0105054
DPYSL3 dihydropyrimidinase-like 3 0.0104758
RACK1 receptor for activated C kinase 1 0.0104207
H1-0 H1.0 linker histone 0.0104176
TAPBP TAP binding protein (tapasin) 0.0103357
HSPA8 heat shock 70kDa protein 8 0.0103068
RBM25 RNA binding motif protein 25 0.0102201
EEF1G eukaryotic translation elongation factor 1 gamma 0.0102104
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0101724
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0100732
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.010045
TIMP1 TIMP metallopeptidase inhibitor 1 0.0100209
PGAM4 phosphoglycerate mutase family member 4 0.00994855
PTBP3 polypyrimidine tract binding protein 3 0.00973338
CD99 CD99 molecule 0.00967442
CD59 CD59 molecule, complement regulatory protein 0.00956647
EFCAB14 EF-hand calcium binding domain 14 0.00948173
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.00946461
MX2 MX dynamin-like GTPase 2 0.00941126
POSTN periostin, osteoblast specific factor 0.00937334
RPL12 ribosomal protein L12 0.00936388
YBX1 Y box binding protein 1 0.00926647
TPI1 triosephosphate isomerase 1 0.00925456
ANLN anillin, actin binding protein 0.00918802
HMGB2 high mobility group box 2 0.00911163
B2M beta-2-microglobulin 0.00902108
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.00900316
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.00896911
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.00881843
SOCS5 suppressor of cytokine signaling 5 0.00880419
SDC4 syndecan 4 0.00873442
SERF2 small EDRK-rich factor 2 0.00870666
SOX9 SRY (sex determining region Y)-box 9 0.00867509
RAB8B RAB8B, member RAS oncogene family 0.00866484
MSMO1 methylsterol monooxygenase 1 0.00864443

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.309524
NDRG1 N-myc downstream regulated 1 -0.180463
CDH13 cadherin 13 -0.164104
COL6A3 collagen, type VI, alpha 3 -0.15478
CADM1 cell adhesion molecule 1 -0.111451
FNDC3B fibronectin type III domain containing 3B -0.106488
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.103464
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.103348
FBN1 fibrillin 1 -0.0878462
TRIO trio Rho guanine nucleotide exchange factor -0.0870656
EXT1 exostosin glycosyltransferase 1 -0.0854083
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0826082
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0813691
PSD3 pleckstrin and Sec7 domain containing 3 -0.0777542
FN1 fibronectin 1 -0.0770991
COL5A1 collagen, type V, alpha 1 -0.0709302
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0668362
JARID2 jumonji, AT rich interactive domain 2 -0.0667607
PDE10A phosphodiesterase 10A -0.062913
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0625466
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0604709
COL1A2 collagen, type I, alpha 2 -0.0573089
VEGFA vascular endothelial growth factor A -0.0555315
EGFR epidermal growth factor receptor -0.0537143
NALF1 NALCN channel auxiliary factor 1 -0.0475487
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0469374
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0461236
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0451291
TRPS1 trichorhinophalangeal syndrome I -0.0437631
DPYD dihydropyrimidine dehydrogenase -0.0434957
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0434419
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.04311
LPP LIM domain containing preferred translocation partner in lipoma -0.0405046
ATXN1 ataxin 1 -0.0402097
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0372418
TPM4 tropomyosin 4 -0.0372188
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0372154
GOLGB1 golgin B1 -0.0371742
COL6A1 collagen, type VI, alpha 1 -0.03595
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0351958
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0346822
CALD1 caldesmon 1 -0.0345648
PTPRG protein tyrosine phosphatase, receptor type, G -0.034471
COL7A1 collagen, type VII, alpha 1 -0.0337114
IARS1 isoleucyl-tRNA synthetase 1 -0.0333661
ZBTB20 zinc finger and BTB domain containing 20 -0.033264
RAB2A RAB2A, member RAS oncogene family -0.0331614
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0330962
MTDH metadherin -0.0310254
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0309672
RPL35A ribosomal protein L35a -0.0307078
F3 coagulation factor III (thromboplastin, tissue factor) -0.0305229
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0301677
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0301218
PRELID2 PRELI domain containing 2 -0.0298907
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0295426
TGFBI transforming growth factor, beta-induced, 68kDa -0.0294874
IER3 immediate early response 3 -0.0294724
SMYD3 SET and MYND domain containing 3 -0.0293499
RUNX1 runt-related transcription factor 1 -0.0292354
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0290783
PTK2 protein tyrosine kinase 2 -0.0288604
ABI3BP ABI family, member 3 (NESH) binding protein -0.0286699
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0269754
SQSTM1 sequestosome 1 -0.0265377
MACF1 microtubule-actin crosslinking factor 1 -0.0257713
FNIP1 folliculin interacting protein 1 -0.025751
ANKHD1 ankyrin repeat and KH domain containing 1 -0.025645
PDIA5 protein disulfide isomerase family A, member 5 -0.0256106
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0254788
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0253295
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0251158
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0251002
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0248657
ACTG1 actin gamma 1 -0.0248239
CNTN5 contactin 5 -0.0246965
ZFPM2 zinc finger protein, FOG family member 2 -0.0246135
SPDYA speedy/RINGO cell cycle regulator family member A -0.0244492
PICALM phosphatidylinositol binding clathrin assembly protein -0.0242296
PDE4D phosphodiesterase 4D, cAMP-specific -0.02422
AHNAK AHNAK nucleoprotein -0.0242121
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0241785
TTC3 tetratricopeptide repeat domain 3 -0.0237328
GLIS3 GLIS family zinc finger 3 -0.0236801
SOD2 superoxide dismutase 2, mitochondrial -0.0236106
ANKRD11 ankyrin repeat domain 11 -0.0236008
DST dystonin -0.023237
AFF3 AF4/FMR2 family, member 3 -0.0230687
ARF4 ADP-ribosylation factor 4 -0.022777
GRB10 growth factor receptor-bound protein 10 -0.0227401
CUX1 cut-like homeobox 1 -0.0227009
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0226027
ASPH aspartate beta-hydroxylase -0.0225553
PDLIM5 PDZ and LIM domain 5 -0.0223416
COL6A2 collagen, type VI, alpha 2 -0.0222963
ZFAND3 zinc finger, AN1-type domain 3 -0.0222563
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme -0.0222495
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0221347
SEC31A SEC31 homolog A (S. cerevisiae) -0.0220922
NAV1 neuron navigator 1 -0.022006