Erythromycin_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Erythromycin perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Erythromycin_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
APOB apolipoprotein B 0.216784
ERRFI1 ERBB receptor feedback inhibitor 1 0.196433
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.194066
A2M alpha-2-macroglobulin 0.0963333
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0794133
ELL2 elongation factor, RNA polymerase II, 2 0.0777239
MAML2 mastermind-like 2 (Drosophila) 0.0772704
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0738378
LRMDA leucine rich melanocyte differentiation associated 0.0728807
DSPP dentin sialophosphoprotein 0.071131
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0689589
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.068713
TRIM26 tripartite motif containing 26 0.0612928
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.059141
EGR1 early growth response 1 0.0568605
BHLHE40 basic helix-loop-helix family, member e40 0.055447
CFB complement factor B 0.0536572
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0507482
TNS1 tensin 1 0.0489812
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0462514
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.043697
TIMP1 TIMP metallopeptidase inhibitor 1 0.0429016
CCNL1 cyclin L1 0.042898
FNDC3B fibronectin type III domain containing 3B 0.0424118
RBM39 RNA binding motif protein 39 0.0411807
TGFBI transforming growth factor, beta-induced, 68kDa 0.0403052
VCL vinculin 0.040199
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0399947
WNK1 WNK lysine deficient protein kinase 1 0.0372327
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0363894
ATP11A ATPase, class VI, type 11A 0.0346643
PDGFB platelet-derived growth factor beta polypeptide 0.0342575
TRIO trio Rho guanine nucleotide exchange factor 0.0339633
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0338756
EPAS1 endothelial PAS domain protein 1 0.0326808
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0325584
ITGA1 integrin, alpha 1 0.0318964
KIF5B kinesin family member 5B 0.0315891
DNAH17 dynein, axonemal, heavy chain 17 0.031507
SAMD4A sterile alpha motif domain containing 4A 0.0301114
ARHGAP9 Rho GTPase activating protein 9 0.0297508
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0296343
NPAS2 neuronal PAS domain protein 2 0.0295719
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0293898
PCBP2 poly(rC) binding protein 2 0.0292699
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0291032
MBNL3 muscleblind-like splicing regulator 3 0.0290733
LAMB1 laminin, beta 1 0.0290333
RUNX1 runt-related transcription factor 1 0.0289189
FHIT fragile histidine triad 0.0289184
MTUS1 microtubule associated tumor suppressor 1 0.0280985
PRICKLE2 prickle homolog 2 (Drosophila) 0.0278423
DOCK5 dedicator of cytokinesis 5 0.0275743
SLMAP sarcolemma associated protein 0.0271719
DOCK4 dedicator of cytokinesis 4 0.0267187
TF transferrin 0.026536
SRSF11 serine/arginine-rich splicing factor 11 0.0262811
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0261403
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0259799
FGA fibrinogen alpha chain 0.0259614
RNASET2 ribonuclease T2 0.0258978
IL4R interleukin 4 receptor 0.02558
RPS2 ribosomal protein S2 0.0254812
PTBP3 polypyrimidine tract binding protein 3 0.0254552
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0254144
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0248514
VMP1 vacuole membrane protein 1 0.0248361
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0247803
PPARD peroxisome proliferator-activated receptor delta 0.0247191
EML4 echinoderm microtubule associated protein like 4 0.0244508
PELI1 pellino E3 ubiquitin protein ligase 1 0.0238775
MPZL2 myelin protein zero-like 2 0.0237842
STAU1 staufen double-stranded RNA binding protein 1 0.0235754
SCARB1 scavenger receptor class B, member 1 0.0233956
AFF4 AF4/FMR2 family, member 4 0.0233827
SOX9 SRY (sex determining region Y)-box 9 0.0229944
CDK19 cyclin-dependent kinase 19 0.022945
HLF hepatic leukemia factor 0.0226209
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 0.0225922
BCL6 B-cell CLL/lymphoma 6 0.0224503
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.0223965
PLAC8 placenta-specific 8 0.0222242
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0222127
WWC1 WW and C2 domain containing 1 0.021707
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0216154
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0215241
CHD6 chromodomain helicase DNA binding protein 6 0.021485
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.0214671
IL6ST interleukin 6 signal transducer 0.0213639
RAI14 retinoic acid induced 14 0.0213362
NCOR2 nuclear receptor corepressor 2 0.0210704
KDM1A lysine (K)-specific demethylase 1A 0.020966
PTMA prothymosin, alpha 0.020754
RNF24 ring finger protein 24 0.0206028
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0205973
PGAM4 phosphoglycerate mutase family member 4 0.0203299
MALT1 MALT1 paracaspase 0.0203224
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0202004
AFDN afadin, adherens junction formation factor 0.020131
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.0197304

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.221363
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.143973
MT2A metallothionein 2A -0.127531
AKAP12 A kinase (PRKA) anchor protein 12 -0.0937716
RPS24 ribosomal protein S24 -0.0774635
AHSG alpha-2-HS-glycoprotein -0.0751851
RPL11 ribosomal protein L11 -0.0734378
RPS8 ribosomal protein S8 -0.0731887
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0729979
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0682248
PLIN2 perilipin 2 -0.0664073
TPT1 tumor protein, translationally-controlled 1 -0.0627979
RPLP1 ribosomal protein, large, P1 -0.0616223
ENO1 enolase 1, (alpha) -0.0599808
PEG3 paternally expressed 3 -0.0577998
RPL12 ribosomal protein L12 -0.0570756
RPL35A ribosomal protein L35a -0.0568326
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0555434
RPL34 ribosomal protein L34 -0.0553372
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0547297
RPL23 ribosomal protein L23 -0.0542847
RPLP0 ribosomal protein, large, P0 -0.0541843
ZFAND3 zinc finger, AN1-type domain 3 -0.0514858
ASPH aspartate beta-hydroxylase -0.0495661
FTL ferritin, light polypeptide -0.0492788
CP ceruloplasmin (ferroxidase) -0.0487194
HMGA1 high mobility group AT-hook 1 -0.0481993
GPC3 glypican 3 -0.0477386
RPS27A ribosomal protein S27a -0.0458427
TXNRD1 thioredoxin reductase 1 -0.0447657
LDHA lactate dehydrogenase A -0.0446688
ATXN1 ataxin 1 -0.0428205
RPS19 ribosomal protein S19 -0.0411764
CANX calnexin -0.0411604
INTS6 integrator complex subunit 6 -0.0406365
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0399124
SLC38A1 solute carrier family 38, member 1 -0.0391058
FN1 fibronectin 1 -0.0389911
FAM107B family with sequence similarity 107, member B -0.0389879
RPS16 ribosomal protein S16 -0.0385431
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.038107
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0375898
RPS5 ribosomal protein S5 -0.0373781
RPS13 ribosomal protein S13 -0.0369474
RPS6 ribosomal protein S6 -0.0360477
GMDS GDP-mannose 4,6-dehydratase -0.0359872
GCLC glutamate-cysteine ligase, catalytic subunit -0.0358769
UGDH UDP-glucose 6-dehydrogenase -0.0346184
RPL5 ribosomal protein L5 -0.0345117
RPS14 ribosomal protein S14 -0.034441
DLC1 DLC1 Rho GTPase activating protein -0.0343742
RPLP2 ribosomal protein, large, P2 -0.0341113
LOC112694756 uncharaterized LOC112694756 -0.0340368
SOD2 superoxide dismutase 2, mitochondrial -0.0338151
SEC31A SEC31 homolog A (S. cerevisiae) -0.0337449
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0318422
WDR45B WD repeat domain 45B -0.0316926
MT1G metallothionein 1G -0.0306463
RPL27A ribosomal protein L27a -0.028669
RPL26 ribosomal protein L26 -0.0280742
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0276479
PARD3 par-3 family cell polarity regulator -0.0275153
HDLBP high density lipoprotein binding protein -0.0274257
HM13 histocompatibility (minor) 13 -0.0271573
CLTC clathrin, heavy chain (Hc) -0.0270582
RPS21 ribosomal protein S21 -0.0270041
RPS20 ribosomal protein S20 -0.0269098
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0268187
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0267471
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0262488
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 -0.0261677
RPS10 ribosomal protein S10 -0.0257582
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.025613
ANKRD11 ankyrin repeat domain 11 -0.025359
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0252881
RACK1 receptor for activated C kinase 1 -0.025277
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0252702
IARS1 isoleucyl-tRNA synthetase 1 -0.0252
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0249291
KIF21A kinesin family member 21A -0.0249118
MBNL2 muscleblind-like splicing regulator 2 -0.024888
OSBPL10 oxysterol binding protein-like 10 -0.0247893
RPL8 ribosomal protein L8 -0.0247602
RPL38 ribosomal protein L38 -0.0247564
RPL7 ribosomal protein L7 -0.0247223
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0247136
BIRC6 baculoviral IAP repeat containing 6 -0.0245868
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0245729
SNX14 sorting nexin 14 -0.0243309
AKR1C1 aldo-keto reductase family 1, member C1 -0.0242864
TTC3 tetratricopeptide repeat domain 3 -0.0242689
PICALM phosphatidylinositol binding clathrin assembly protein -0.0241544
QKI QKI, KH domain containing, RNA binding -0.0240994
CDK13 cyclin-dependent kinase 13 -0.0240912
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0239678
RPL27 ribosomal protein L27 -0.0239495
HOOK2 hook microtubule-tethering protein 2 -0.0237123
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0236907
RPL9 ribosomal protein L9 -0.0236499
EXT1 exostosin glycosyltransferase 1 -0.0235226